Page last updated: 2024-09-27

epitrate

Description

(S)-adrenaline : The S-enantiomer of adrenaline. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID247704
CHEMBL ID42280
CHEBI ID40751
SCHEMBL ID11647
MeSH IDM0007584

Synonyms (62)

Synonym
gtpl4450
4-[(1s)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol
SDCCGMLS-0066643.P001
brn 2938799
l-(+)-adrenaline
benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, (+)-
einecs 205-752-5
1, 4-[1-hydroxy-2-(methylamino)ethyl]-, (r)-
1-adrenaline
epitrate
vaponefrin
1-epirenamine
d-epifrin
3,4-dihydroxy-.alpha.-[(methylamino)methyl]benzyl alcohol
IOP ,
wln: qr bq dyq1m1 -l
nsc62786
benzyl alcohol,4-dihydroxy-.alpha.-[(methylamino)methyl]-, (-)-
NCGC00178888-01
(s)-(+)-adrenaline
(s)-4-(1-hydroxy-2-(methylamino)ethyl)pyrocatechol
CHEBI:40751 ,
(+)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
4-[(1s)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
xde ,
d-adrenaline
150-05-0
(+)-adrenaline
(s)-adrenaline
d-epinephrine
4-[(1r)-1-hydroxy-2-methylamino-ethyl]benzene-1,2-diol
uctwmzqnuqwslp-secbinfhsa-
inchi=1/c9h13no3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13h,5h2,1h3/t9-/m1/s1
bdbm50087512
CHEMBL42280 ,
2-hydroxy-4-[1-hydroxy-2-(methylazaniumyl)ethyl]phenolate
AKOS006271962
2-13-00-00525 (beilstein handbook reference)
unii-na71gr3tnv
na71gr3tnv ,
racepinefrine, (s)-
d-(+)-epinephrine
SCHEMBL11647
(+)-(s)-epinephrine
d(+)-adrenaline
4-((1s)-1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
benzyl alcohol, 3,4-dihydroxy-.alpha.-((methylamino)methyl)-, (+)-
(+)-1-(3,4-dihydroxyphenyl)-2-methylaminoethanol
1,2-benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (s)-
1,2-benzenediol, 4-((1s)-1-hydroxy-2-(methylamino)ethyl)-
epinephrine, d-
AB00053471_02
(+)-epinephrine
(s)-4-[1-hydroxy-2-(methylamino)ethyl]pyrocatechol
SBI-0051363.P003
Z1198154207
Q27074317
(s)-racepinefrine
1,2-benzenediol, 4-[(1s)-1-hydroxy-2-(methylamino)ethyl]-
D95540
AS-77747
DTXSID301047668

Drug Classes (1)

ClassDescription
4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diolA catecholamine in which the aminoethyl side-chain is hydroxy-substituted at C-1 and methylated on nitrogen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (32)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki20.00000.00010.949010.0000AID37459
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)Ki13.00000.00000.667310.0000AID40408
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)Ki0.04500.00000.929610.0000AID219797
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)Ki0.04500.00000.970810.0000AID219797
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)Ki0.04500.00000.937510.0000AID219797
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)Ki20.00000.00000.575110.0000AID37459
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki20.00000.00000.965010.0000AID37459
Beta-2 adrenergic receptorCanis lupus familiaris (dog)Ki3.70000.14001.61333.7000AID41478
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
NPYLR7BAedes aegypti (yellow fever mosquito)EC50 (µMol)0.03900.03902.289918.3000AID1259426
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 12Homo sapiens (human)Ka0.41000.24000.81921.6700AID318346; AID387537
Carbonic anhydrase 1Homo sapiens (human)KA0.09000.02001.72197.4000AID291061; AID318343; AID365827; AID387526; AID409984; AID462829; AID725228
Carbonic anhydrase 2Homo sapiens (human)Ka96.00000.01101.42737.8000AID291063; AID318344; AID365828; AID387527; AID409986; AID414329; AID462830; AID464319; AID725229
Carbonic anhydrase 3Homo sapiens (human)Ka36.26670.09100.72851.1200AID365829; AID387530; AID409993
Carbonic anhydrase 4Homo sapiens (human)Ka45.00000.07904.45607.3000AID365830; AID375786; AID387531
Carbonic anhydrase 6Homo sapiens (human)KA58.00001.20005.82769.5400AID462831
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ka63.00000.01002.79269.8100AID387532
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)KA60.00000.71003.79009.7400AID291065
Carbonic anhydrase 7Homo sapiens (human)KA60.00000.71003.875610.0000AID291065; AID387535
Carbonic anhydraseSaccharomyces cerevisiae S288CKa0.95000.95005.12509.3000AID414331; AID464321
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)KA60.00000.71003.79009.7400AID291065
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)KA60.00000.71003.79009.7400AID291065
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)KA60.00000.71003.79009.7400AID291065
Carbonic anhydrase 9Homo sapiens (human)Ka0.87000.00904.24939.7100AID318345; AID387536
Carbonic anhydraseCandida albicans SC5314KA13.20000.96003.95338.4000AID458784
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)KA60.00000.71003.79009.7400AID291065
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ka10.80007.10008.30009.5000AID464322
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)KA60.00000.71003.79009.7400AID291065
Carbonic anhydrase 15Mus musculus (house mouse)KA6.90004.00007.68579.5000AID375787
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)KA60.00000.71003.79009.7400AID291065
Carbonic anhydrase 14Homo sapiens (human)KA36.05000.01002.28947.2100AID291067; AID387539
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
estrous cycleCarbonic anhydrase 12Homo sapiens (human)
chloride ion homeostasisCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
response to bacteriumCarbonic anhydrase 3Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 3Homo sapiens (human)
bicarbonate transportCarbonic anhydrase 4Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 4Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of bitter tasteCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 7Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 7Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 7Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 7Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 7Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 7Homo sapiens (human)
receptor-mediated endocytosisBeta-2 adrenergic receptorCanis lupus familiaris (dog)
regulation of smooth muscle contractionBeta-2 adrenergic receptorCanis lupus familiaris (dog)
positive regulation of MAPK cascadeBeta-2 adrenergic receptorCanis lupus familiaris (dog)
negative regulation of G protein-coupled receptor signaling pathwayBeta-2 adrenergic receptorCanis lupus familiaris (dog)
adenylate cyclase-activating adrenergic receptor signaling pathwayBeta-2 adrenergic receptorCanis lupus familiaris (dog)
positive regulation of autophagosome maturationBeta-2 adrenergic receptorCanis lupus familiaris (dog)
positive regulation of lipophagyBeta-2 adrenergic receptorCanis lupus familiaris (dog)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (11)

Processvia Protein(s)Taxonomy
zinc ion bindingCarbonic anhydrase 12Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 12Homo sapiens (human)
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 3Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 3Homo sapiens (human)
nickel cation bindingCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 4Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 6Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 6Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 7Homo sapiens (human)
beta2-adrenergic receptor activityBeta-2 adrenergic receptorCanis lupus familiaris (dog)
protein homodimerization activityBeta-2 adrenergic receptorCanis lupus familiaris (dog)
norepinephrine bindingBeta-2 adrenergic receptorCanis lupus familiaris (dog)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (28)

Processvia Protein(s)Taxonomy
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
membraneCarbonic anhydrase 12Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 12Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 12Homo sapiens (human)
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytoplasmCarbonic anhydrase 3Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 4Homo sapiens (human)
rough endoplasmic reticulumCarbonic anhydrase 4Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentCarbonic anhydrase 4Homo sapiens (human)
Golgi apparatusCarbonic anhydrase 4Homo sapiens (human)
trans-Golgi networkCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
external side of plasma membraneCarbonic anhydrase 4Homo sapiens (human)
cell surfaceCarbonic anhydrase 4Homo sapiens (human)
membraneCarbonic anhydrase 4Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 4Homo sapiens (human)
transport vesicle membraneCarbonic anhydrase 4Homo sapiens (human)
secretory granule membraneCarbonic anhydrase 4Homo sapiens (human)
brush border membraneCarbonic anhydrase 4Homo sapiens (human)
perinuclear region of cytoplasmCarbonic anhydrase 4Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
extracellular regionCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
cytosolCarbonic anhydrase 6Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
cytosolCarbonic anhydrase 7Homo sapiens (human)
cytoplasmCarbonic anhydrase 7Homo sapiens (human)
early endosomeBeta-2 adrenergic receptorCanis lupus familiaris (dog)
Golgi apparatusBeta-2 adrenergic receptorCanis lupus familiaris (dog)
receptor complexBeta-2 adrenergic receptorCanis lupus familiaris (dog)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
membraneCarbonic anhydrase 14Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 14Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 14Homo sapiens (human)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (63)

Assay IDTitleYearJournalArticle
AID318346Activation of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID464320Activation of archaea Methanobacterium thermoautotrophicum recombinant carbonic anhydrase by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID387539Activation of human recombinant CA14 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID387536Activation of human recombinant CA9 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID318345Activation of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID725227Activation of Sulfurihydrogenibium yellowstonense recombinant CA by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID375786Activation of human recombinant carbonic anhydrase 4 lacking 20 amino terminal residues by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID462830Activation of human recombinant CA2by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID725229Activation of human recombinant CA2 by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID725226Activation of Sulfurihydrogenibium azorense recombinant alpha carbonic anhydrase by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID458787Activation of Cryptococcus neoformans beta-carbonic anhydrase Can2 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
AID387532Activation of human recombinant CA5A after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID399397Increase in sheep placental cotyledons COX2 activity assessed as PGE2 production at 1 mM after 15 mins1998Journal of natural products, Jan, Volume: 61, Issue:1
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
AID464321Activation of Saccharomyces cerevisiae recombinant Nce103p by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID375787Activation of membrane associated mouse recombinant carbonic anhydrase 15 isoform by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID387537Activation of human recombinant CA12 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID365828Activation of human recombinant CA2 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID414331Activation of yeast recombinant CA by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID387538Activation of mouse recombinant CA13 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID409988Activation of Methanobacterium thermoautotrophicum beta-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID464322Activation of Candida glabrata recombinant carbonic anhydrase by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID387534Activation of human recombinant CA6 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID40408Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes2000Journal of medicinal chemistry, Apr-20, Volume: 43, Issue:8
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.
AID291067Activation of of human recombinant CA14 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID387527Activation of human recombinant CA2 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID399400Increase in sheep placental cotyledons COX2 activity assessed as PGE2 production at 1.95 mM1998Journal of natural products, Jan, Volume: 61, Issue:1
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
AID409990Activation of Methanosarcina thermophila Zinc(2)-derived gamma-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID691715Activity of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant CA expressed in Escherichia coli BL21(DE3) after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID291065Activation of human recombinant CA7 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID365829Activation of human recombinant CA3 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID409992Activation of Methanosarcina thermophila cobalt(2)-derived gamma-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID414330Activation of Methanothermobacter thermautotrophicus recombinant Cab by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID365830Activation of human recombinant truncated CA4 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID462829Activation of human recombinant CA1 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID291063Activation of human recombinant CA2 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID409986Activation of human recombinant CA2 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID458784Activation of Candida albicans beta-carbonic anhydrase Nce103 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
AID41478Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes2000Journal of medicinal chemistry, Apr-20, Volume: 43, Issue:8
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.
AID725228Activation of human recombinant CA1 by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID399399Increase in bovine seminal microsomal COX1 activity assessed as PGE2 production at 1.95 mM1998Journal of natural products, Jan, Volume: 61, Issue:1
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
AID37459Binding of [3H]prazosin to alpha-1 adrenergic receptor of rat cerebral cortical membranes2000Journal of medicinal chemistry, Apr-20, Volume: 43, Issue:8
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.
AID387530Activation of human recombinant CA3 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID387535Activation of human recombinant CA7 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID219797Binding of [3H]clonidine to alpha-2-adrenergic receptor of rat cerebral cortical membranes2000Journal of medicinal chemistry, Apr-20, Volume: 43, Issue:8
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.
AID387533Activation of human recombinant CA5B after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID464319Activation of human recombinant carbonic anhydrase isoenzyme 2 by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID365827Activation of human recombinant CA1 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID387529Activation of human recombinant CA2 after 72 hrs by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID387531Activation of human recombinant CA4 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID414329Activation of human recombinant CA2 by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID409984Activation of human recombinant CA1 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID462832Activation of Stylophora pistillata carbonic anhydrase STPCA by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID291061Activation of human recombinant CA1 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID318344Activation of human recombinant CA2 by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID409993Activation of human recombinant CA3 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID462831Activation of human full length CA6 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID318343Activation of human recombinant CA1 by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID387526Activation of human recombinant CA1 after 15 mins by stopped-flow CO2 hydration assay2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
AID399398Increase in bovine seminal microsomal COX1 activity assessed as PGE2 production at 4 mM after 15 mins1998Journal of natural products, Jan, Volume: 61, Issue:1
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1345908Human alpha1A-adrenoceptor (Adrenoceptors)1995Molecular pharmacology, Aug, Volume: 48, Issue:2
KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues.
AID1345971Human alpha1D-adrenoceptor (Adrenoceptors)1995Molecular pharmacology, Aug, Volume: 48, Issue:2
KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues.
AID1346000Human alpha1B-adrenoceptor (Adrenoceptors)1995Molecular pharmacology, Aug, Volume: 48, Issue:2
KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (12.50)18.2507
2000's8 (50.00)29.6817
2010's6 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]