Page last updated: 2024-09-27

Neurogenic Bowel

Loss or absence of normal intestinal function due to nerve damage or birth defects. It is characterized by the inability to control the elimination of stool from the body.

Synonyms(1)

Synonym
Neurogenic Bowel

Research

Studies (16)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (6.25)18.1394
2010's12 (75.00)28.8240
2020's3 (18.75)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
glycerol0low10
histamine0low10
8-cyclopentyl-1,3-dimethylxanthine0low10
theophylline0low10
bisacodyl0low10
cimetidine0low10
dimaprit0low10
loperamide0low10
mecamylamine0low10
neostigmine0medium11
propane0low10
glycopyrrolate0medium11
fomesafen0low50
adenosine0low10
1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine0low10
n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine0low10
2-chloro-n(6)cyclopentyladenosine0low10
8-cyclopentyl-3-(3-((4-(fluorosulfonyl)benzoyl)oxy)propyl)-1-propylxanthine0low10
mrs 11910low10
dihydropyridines0low10
cocaine0low10
leuprolide0low10
alvimopan anhydrous0low10
rs 396040low10
piperidines0low20
exudates0low20

Protein Targets (477)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Adenosine receptor A109213
Adenosine receptor A10707
Adenosine receptor A2b07213
Adenosine receptor A2a08317
Adenosine receptor A2a0202
interferon gamma precursor0001
5-hydroxytryptamine receptor 1A0202
Adenosine receptor A309314
Adenosine receptor A30505
Adenosine receptor A2a06513
Adenosine receptor A2b0439
Adenosine receptor A108516
Delta-type opioid receptor0101
Delta-type opioid receptor0202
Adenylate cyclase type 50202
Adenosine receptor A10101
Adenosine receptor A10213
Adenosine receptor A2a0202
Adenosine receptor A30202
Cannabinoid receptor 20011
dopamine D1 receptor1001
NFKB1 protein, partial2002
GLS protein5005
TDP1 protein6006
estrogen-related nuclear receptor alpha6006
arylsulfatase A8008
euchromatic histone-lysine N-methyltransferase 27007
peripheral myelin protein 22 isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 23003
mitogen-activated protein kinase 13003
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 15005
muscarinic acetylcholine receptor M15005
lamin isoform A-delta109009
Gamma-aminobutyric acid receptor subunit pi5005
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Alpha-synuclein1001
Adenosine receptor A10213
Gamma-aminobutyric acid receptor subunit alpha-15005
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
GABA theta subunit5005
Gamma-aminobutyric acid receptor subunit epsilon5005
ATP-dependent phosphofructokinase5005
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Ferritin light chain1001
aldehyde dehydrogenase 1 family, member A13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
thyroid stimulating hormone receptor5005
regulator of G-protein signaling 45005
Parkin1001
pyruvate kinase1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Bloom syndrome protein isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C9 precursor2002
atrial natriuretic peptide receptor 1 precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d5005
ras-related protein Rab-9A2002
eyes absent homolog 2 isoform a1001
geminin6006
neuropeptide S receptor isoform A1001
Histamine H2 receptor3228
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
AR protein7007
signal transducer and activator of transcription 6, interleukin-4 induced2002
glucocorticoid receptor [Homo sapiens]5005
retinoid X nuclear receptor alpha5005
estrogen nuclear receptor alpha8008
NPYLR7B0011
IDH13003
Histone H2A.x2002
glycogen synthase kinase-3 beta isoform 10011
flap endonuclease 11001
nuclear receptor ROR-gamma isoform 12002
peripheral myelin protein 225005
high affinity choline transporter 1 isoform a0202
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit3003
Rap guanine nucleotide exchange factor 31001
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0101
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20101
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0001
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0112
Glutamate receptor 23003
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenylate kinase 2, mitochondrial0101
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine kinase0001
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10202
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Bile salt export pump0707
Potassium voltage-gated channel subfamily E member 10101
Mu-type opioid receptor0404
Delta-type opioid receptor0314
Kappa-type opioid receptor0101
Kappa-type opioid receptor0505
Potassium voltage-gated channel subfamily KQT member 10101
Potassium voltage-gated channel subfamily H member 20303
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0202
Canalicular multispecific organic anion transporter 10505
Chain A, 2-oxoglutarate Oxygenase1001
acetylcholinesterase1001
Mcl-10101
RAR-related orphan receptor gamma3003
SMAD family member 22002
SMAD family member 32002
GLI family zinc finger 33003
thioredoxin glutathione reductase1001
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor3003
cytochrome P450 family 3 subfamily A polypeptide 42002
farnesoid X nuclear receptor2002
pregnane X nuclear receptor3003
G3003
cytochrome P450 2D64004
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid stimulating hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
thyroid hormone receptor beta isoform a2002
heat shock protein beta-11001
G-protein coupled receptor 35 isoform a0101
G-protein coupled receptor 550101
nuclear factor erythroid 2-related factor 2 isoform 14004
lethal factor (plasmid)3003
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Cellular tumor antigen p535005
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Cytochrome P450 2C9 0202
Aryl hydrocarbon receptor0011
Nuclear receptor ROR-gamma2002
Spike glycoprotein2013
Sodium-dependent dopamine transporter 0404
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
Carbonic anhydrase 10102
Carbonic anhydrase 20103
Carbonic anhydrase 40102
Carbonic anhydrase0102
Carbonic anhydrase 150102
interleukin 81001
phosphopantetheinyl transferase3003
alpha-galactosidase1001
cytochrome P450 2C19 precursor1001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
Solute carrier family 22 member 10101
Solute carrier family 22 member 20204
Solute carrier family 22 member 1 0304
Solute carrier family 22 member 60202
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10203
Cytochrome P450 3A40101
Cytochrome P450 2D60202
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10101
Histamine H2 receptor0628
Histamine H1 receptor0134
Potassium-transporting ATPase subunit beta0101
Cytochrome P450 2J20101
Aldehyde oxidase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 10304
Multidrug and toxin extrusion protein 20101
Solute carrier family 22 member 80203
Multidrug and toxin extrusion protein 10101
Histamine H4 receptor0336
Solute carrier family 22 member 110101
Solute carrier family 22 member 20304
Solute carrier family 22 member 40101
Solute carrier family 22 member 80202
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
5-hydroxytryptamine receptor 2C0202
Tryptophan 5-hydroxylase 10101
5-hydroxytryptamine receptor 2A0303
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
D0101
5-hydroxytryptamine receptor 1A0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Liver carboxylesterase 10001
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Sodium-dependent serotonin transporter0404
Sodium-dependent serotonin transporter0203
5-hydroxytryptamine receptor 7 0101
Gamma-aminobutyric acid receptor subunit alpha-30101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Glutamate receptor ionotropic, NMDA 1 0102
5-hydroxytryptamine receptor 3A0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0303
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0102
5-hydroxytryptamine receptor 4 0202
Gamma-aminobutyric acid receptor subunit gamma-10101
Glutamate receptor ionotropic, NMDA 3B0102
Sigma non-opioid intracellular receptor 10404
Gamma-aminobutyric acid receptor subunit gamma-30101
5-hydroxytryptamine receptor 3B0101
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0102
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
67.9K protein1001
Luciferase1001
hypoxia-inducible factor 1 alpha subunit1001
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
retinoic acid nuclear receptor alpha variant 13003
activating transcription factor 61001
thyroid hormone receptor beta isoform 24004
vitamin D3 receptor isoform VDRA1001
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30202
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Chain A, Beta-lactamase2002
aryl hydrocarbon receptor nuclear translocator0001
thioredoxin reductase2002
USP1 protein, partial2002
GALC protein1001
apical membrane antigen 1, AMA11001
EWS/FLI fusion protein3003
bromodomain adjacent to zinc finger domain 2B2002
transforming acidic coiled-coil-containing protein 30001
DNA polymerase iota isoform a (long)1001
Carbonic anhydrase 120001
Solute carrier family 22 member 30102
Plasma kallikrein0001
Carbonic anhydrase 30001
Macrophage migration inhibitory factor0202
Carbonic anhydrase 60001
5-hydroxytryptamine receptor 1D0001
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0001
Histamine H1 receptor0224
Carbonic anhydrase 70001
Carbonic anhydrase0002
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0002
Carbonic anhydrase0002
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 130001
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Histamine H3 receptor0123
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
15-lipoxygenase, partial1001
ATAD5 protein, partial3003
PPM1D protein1001
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
polyunsaturated fatty acid lipoxygenase ALOX121001
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase mTOR isoform 11001
Menin0101
Cocaine esterase0202
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
Beta-2 adrenergic receptor0202
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0213
D(2) dopamine receptor0101
D(4) dopamine receptor0101
Mu-type opioid receptor0101
D(3) dopamine receptor0202
Nociceptin receptor0101
5-hydroxytryptamine receptor 2B0303
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 70101
Calmodulin 0112
Disintegrin and metalloproteinase domain-containing protein 171001
Mu-type opioid receptor0011
Inositol monophosphatase 12002
Angiopoietin-1 receptor0011
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Angiotensin-converting enzyme 2 0011
Acetylcholine receptor subunit alpha0011
Neuronal acetylcholine receptor subunit alpha-30011
Acetylcholine receptor subunit gamma0011
Neuronal acetylcholine receptor subunit alpha-40011
Acetylcholine receptor subunit beta0011
Neuronal acetylcholine receptor subunit alpha-20011
Neuronal acetylcholine receptor subunit beta-20011
Neuronal acetylcholine receptor subunit beta-30011
Neuronal acetylcholine receptor subunit beta-40011
Neuronal acetylcholine receptor subunit beta-20102
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40102
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-60011
Neuronal acetylcholine receptor subunit alpha-90011
Neuronal acetylcholine receptor subunit alpha-40102
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit alpha-70011
Acetylcholine receptor subunit delta0011
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-100011
glp-1 receptor, partial1001
Smad31001
chromobox protein homolog 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
relaxin receptor 1 isoform 11001
Thyroid hormone receptor beta0202
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 2C0101
Alpha-1A adrenergic receptor0101
Beta-secretase 10101
Adenosine receptor A2b0012
Acetylcholinesterase0101
Cholinesterase0202
Acetylcholinesterase0202
Cholinesterase0101
Chain A, Pyridoxal kinase0101
Chain A, Pyridoxal Kinase0101
Phosphodiesterase 0202
transcriptional regulator ERG isoform 31001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Potassium channel subfamily K member 20011
Renin0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
D(3) dopamine receptor0101
Vasopressin V2 receptor0001
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Adenosine receptor A10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Guanine nucleotide-binding protein G1001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
Adenylate cyclase type 10001
TAR DNA-binding protein 431001
Chitotriosidase-10101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Sigma non-opioid intracellular receptor 10101
Palmitoleoyl-protein carboxylesterase NOTUM0011
Endochitinase B10101
Phospholipase A-2-activating protein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]