Target type: molecularfunction
Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine. [PMID:1711890]
Selenol Se-methyltransferase activity catalyzes the transfer of a methyl group from a donor molecule, such as S-adenosyl methionine (SAM), to a selenol (-SeH) group on a substrate. This reaction involves the formation of a transient covalent intermediate between the enzyme and the donor molecule, followed by the transfer of the methyl group to the selenol. The resulting product is a selenoether (-SeCH3), which often has altered properties compared to the original selenol. Selenol Se-methyltransferases play a crucial role in a variety of biological processes, including the biosynthesis of selenoproteins, the detoxification of reactive oxygen species, and the regulation of enzyme activity. For example, in the biosynthesis of selenoproteins, selenol Se-methyltransferases are involved in the post-translational modification of selenocysteine residues, converting them to selenomethionine residues. These selenoproteins are essential for a wide range of cellular functions, including antioxidant defense, thyroid hormone metabolism, and DNA synthesis. In detoxification, selenol Se-methyltransferases can methylate toxic selenols, rendering them less reactive and facilitating their excretion. Furthermore, selenol Se-methyltransferases can regulate enzyme activity by altering the properties of selenol residues within active sites, influencing their catalytic activity and substrate specificity. The specific functions of selenol Se-methyltransferases vary depending on the enzyme and its substrate. However, all selenol Se-methyltransferases share the common function of catalyzing the transfer of a methyl group to a selenol group, thereby influencing the properties and functions of the target molecule.'
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Protein | Definition | Taxonomy |
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Histamine N-methyltransferase | A histamine N-methyltransferase that is encoded in the genome of rat. [OMA:Q01984, PRO:DNx] | Rattus norvegicus (Norway rat) |
Compound | Definition | Classes | Roles |
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histamine | aralkylamino compound; imidazoles | human metabolite; mouse metabolite; neurotransmitter | |
tacrine | tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. | acridines; aromatic amine | EC 3.1.1.7 (acetylcholinesterase) inhibitor |