Page last updated: 2024-10-06

Histidine Metabolism

Proteins (17)

ProteinSynonymsTaxonomy
Amine oxidase [flavin-containing] AEC 1.4.3.4; Monoamine oxidase type A; MAO-AHomo sapiens (human)
Aldehyde dehydrogenase, mitochondrialEC 1.2.1.3; ALDH class 2; ALDH-E2; ALDHIHomo sapiens (human)
Formimidoyltransferase-cyclodeaminaseFormiminotransferase-cyclodeaminase; FTCD; LCHC1Homo sapiens (human)
Histamine N-methyltransferaseHMT; EC 2.1.1.8Homo sapiens (human)
Histidine decarboxylaseHDC; EC 4.1.1.22Homo sapiens (human)
Protein arginine N-methyltransferase 3EC 2.1.1.-; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3Homo sapiens (human)
Histidine--tRNA ligase, cytoplasmicEC 6.1.1.21; Histidyl-tRNA synthetase; HisRSHomo sapiens (human)
Histidine ammonia-lyaseHistidase; EC 4.3.1.3Homo sapiens (human)
Carnosine synthase 1EC 6.3.2.11; ATP-grasp domain-containing protein 1Homo sapiens (human)
Amiloride-sensitive amine oxidase [copper-containing]DAO; Diamine oxidase; EC 1.4.3.22; Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase; KAOHomo sapiens (human)
Aldehyde dehydrogenase, dimeric NADP-preferring EC 1.2.1.5; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1Homo sapiens (human)
Cytosolic non-specific dipeptidaseEC 3.4.13.18; CNDP dipeptidase 2; Carnosine dipeptidase II; Epididymis secretory protein Li 13; Glutamate carboxypeptidase-like protein 1; Peptidase AHomo sapiens (human)
Beta-Ala-His dipeptidaseEC 3.4.13.20; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinaseHomo sapiens (human)
Urocanate hydrataseUrocanase; EC 4.2.1.49; Imidazolonepropionate hydrolaseHomo sapiens (human)
Probable imidazolonepropionaseEC 3.5.2.7; Amidohydrolase domain-containing protein 1Homo sapiens (human)
Histidine--tRNA ligase, mitochondrialEC 6.1.1.21; Histidine--tRNA ligase-like; Histidyl-tRNA synthetase; HisRSHomo sapiens (human)
Carnosine N-methyltransferaseEC 2.1.1.22Homo sapiens (human)

Compounds (29)

CompoundDescription
hydronium ion
Orthophosphate
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
histamineAn amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
imidazol-4-one-5-propionic acidstructure
1-methylimidazol-3-ylacetaldehyde
beta-alanineAn amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.
tele-methylhistaminehistamine methyltransferase antagonist
formiminoglutamic acidMeasurement of this acid in the urine after oral administration of histidine provides the basis for the diagnostic test of folic acid deficiency and of megaloblastic anemia of pregnancy.
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
histidineAn essential amino acid that is required for the production of HISTAMINE.
3-methylhistidinemarker for myofibrillar-protein breakdown; RN given refers to (L)-isomer
urocanic acid4-Imidazoleacrylic acid.
anserineA dipeptide containing BETA-ALANINE.
1H-imidazole-4-acetaldehyde
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
carnosineA naturally occurring dipeptide neuropeptide found in muscles.
creolinfrom refined coal tar oils
pyrophosphate
methylimidazoleacetic acidurinary metabolite of histamine & end product of histamine metabolism; RN given refers to parent cpd