Childhood Tic Disorders

Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)

Synonym
Tic Disorders, Motor
Tic Disorders, Vocal
Post-Traumatic Tic Disorder
Transient Tic Disorder
Chronic Motor or Vocal Tic Disorder
Childhood Tic Disorders
Motor or Vocal Tic Disorder, Chronic
Motor Tic Disorders
Tic Disorder, Chronic Motor or Vocal
Tic Disorder, Post-Traumatic
Tic Disorder, Transient
Vocal Tic Disorders
Tic Disorders
Tic Disorders, Childhood

Excerpt	Reference
"Tic disorders are classified into three subtypes in DSM-III."	( Miyamoto, S, 1993)
"Tic disorders are childhood onset neuropsychiatric disorders characterized by motor and/or vocal tics."	( Bihun, EC; Black, KJ; Greene, DJ; Koller, JM; Robichaux-Viehoever, A; Schlaggar, BL, 2015)

Excerpt	Reference
"Tic disorders affect ~5% of the population and are frequently comorbid with obsessive-compulsive disorder, autism, and attention deficit disorder."	( Bito, H; Frick, L; Ohtsu, H; Pittenger, C; Pogorelov, V; Rapanelli, M, 2017)

Excerpt	Reference
"Six males and one female with chronic tic disorders, whose ages ranged from 12 to 31 years, were evaluated before treatment, after 1 month on placebo, after a single 10 mg nifedipine dose (three patients), and monthly while on flunarizine 10-15 mg (mean dose of 13 mg)."	( Casas Parera, I; Fernandez Pardal, M; Gatto, M; Lekhuniec, E; Mangone, C; Micheli, F; Pikielny, R, 1990)
"Subjects from a specialty tic disorders clinic were randomly assigned to receive 8 weeks of treatment with guanfacine or placebo under double-blind conditions."	( Arnsten, AF; Chappell, PB; Cohen, DJ; Katsovich, L; Kim, YS; Leckman, JF; Scahill, L; Schultz, RT; Shepherd, E, 2001)
"Subjects from a specialty tic disorders clinic were randomly assigned to receive 8 weeks of treatment with lofexidine or placebo under double-blind conditions."	( Mair, A; Niederhofer, H; Staffen, W, 2003)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	125 (35.11)	23.3326
1990's	79 (22.19)	12.5806
2000's	69 (19.38)	18.1394
2010's	57 (16.01)	28.8240
2020's	26 (7.30)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	4	0
5-hydroxytryptophan	low	1	0
carbamates	low	1	0
choline	medium	1	1
creatine	medium	1	1
histamine	low	1	0
dihydroxyphenylalanine	low	4	0
kynurenine	low	1	0
methanol	low	1	0
pyrazinamide	low	1	0
1-(3-chlorophenyl)piperazine	medium	2	1
homovanillic acid	low	2	0
phenytoin	low	8	0
amantadine	low	1	0
dan 2163	low	1	0
amitriptyline	low	1	0
aspirin	low	1	0
baclofen	low	1	0
caffeine	low	1	0
carbamazepine	low	12	0
chlorpromazine	medium	5	1
clomipramine	low	6	0
clonazepam	medium	5	1
clonidine	medium	35	6
desipramine	medium	5	1
amphetamine	low	2	0
diazepam	medium	5	1
valproic acid	low	4	0
donepezil	medium	1	1
doxepin	low	1	0
fluphenazine	low	3	0
fluoxetine	low	6	0
gabapentin	low	1	0
guaifenesin	low	1	0
guanfacine	medium	11	2
haloperidol	medium	67	8
hydroxyzine	medium	1	1
phenelzine	low	1	0
lamotrigine	low	3	0
lorazepam	low	1	0
meprobamate	low	2	0
mescaline	low	1	0
methylphenidate	medium	43	13
mirtazapine	low	1	0
muscimol	low	1	0
nifedipine	medium	1	1
nortriptyline	low	1	0
orphenadrine	medium	1	1
oxotremorine	low	1	0
oxybutynin	medium	1	1
pemoline	low	3	0
perphenazine	low	2	0
phenobarbital	low	2	0
piracetam	low	1	0
pirenzepine	low	1	0
procaine	low	2	0
prochlorperazine	low	1	0
promazine	medium	1	1
promethazine	low	2	0
propranolol	low	3	0
risperidone	medium	23	3
sulpiride	low	4	0
thioridazine	medium	5	1
trazodone	medium	1	1
tremorine	low	1	0
trifluoperazine	low	1	0
trifluperidol	low	1	0
triflupromazine	medium	1	1
trihexyphenidyl	medium	2	1
prednisolone	low	1	0
lysergic acid diethylamide	low	1	0
reserpine	low	2	0
dextroamphetamine	medium	15	2
carbachol	low	1	0
triiodothyronine	low	1	0
carbon tetrachloride	low	1	0
aspartic acid	medium	1	1
glutamine	low	1	0
cyanides	low	1	0
physostigmine	low	2	0
tetrabenazine	medium	6	1
kanamycin a	low	1	0
carbostyril	medium	12	4
levodopa	low	8	0
phenylalanine	low	1	0
cycloserine	low	1	0
tryptophan	low	3	0
phencyclidine	low	2	0
deanol	medium	3	1
allyl cyanide	low	1	0
mephobarbital	low	1	0
1-naphthylamine	low	1	0
yohimbine	low	1	0
diphenhydramine hydrochloride	low	1	0
isoxazoles	low	1	0
thiazoles	low	2	0
benactyzine	low	1	0
galantamine	low	1	0
methysergide	low	2	0
bicuculline	low	4	0
thiazolidines	low	1	0
psilocybin	low	1	0
lithium carbonate	low	2	0
pyrithioxin	low	1	0
s,n,n'-tripropylthiocarbamate	medium	1	1
dronabinol	low	1	0
pimozide	medium	15	1
silver	low	1	0
barium sulfate	low	1	0
selegiline	low	2	0
lofexidine	medium	2	1
pregnanolone	low	1	0
glutamic acid	low	1	0
penfluridol	low	1	0
oxcarbazepine	low	1	0
paroxetine	medium	2	1
pergolide	medium	1	1
fomesafen	low	6	0
atomoxetine hydrochloride	medium	15	2
aripiprazole	medium	21	4
ziprasidone	low	2	0
venlafaxine hydrochloride	low	1	0
n-acetylaspartic acid	medium	1	1
cephalosporin c	medium	1	1
sertraline	medium	4	1
methotrimeprazine	low	1	0
nicotine	low	1	0
fibrinogen	low	1	0
alpha-glutamyltryptophan	low	1	0
ecopipam	low	1	0
mebikar	low	1	0
emoxypine succinate	low	1	0
(3,4-dihydroxyphenylamino)-2-imidazoline	low	1	0
pyro(l-alpha-aminoadipyl)-l-histidyl-l-thiazolidine-4-carboxamide	low	1	0
escitalopram	low	1	0
atropine	low	1	0
oxytocin	low	1	0
inositol 3-phosphate	low	2	0
ergonovine	low	1	0
cocaine	low	5	0
zithromax	low	1	0
crotononitrile	low	1	0
cannabidiol	low	1	0
arginine vasopressin	low	1	0
chlorprothixene	low	1	0
flunarizine	medium	1	1
benztropine	low	1	0
ethionamide	low	1	0
lithium	medium	4	1
raclopride	low	1	0
quinine	low	1	0
4-(1h-imidazol-4-ylmethyl)piperidine	low	1	0
humulene	low	1	0
codeine	low	1	0
levetiracetam	low	1	0
naloxone	medium	1	1
oxycodone	low	1	0
topiramate	low	1	0
fluticasone	low	2	0
mdl 100907	low	1	0
fluvoxamine	medium	8	2
lead	low	1	0
naltrexone	low	1	0
tiapridex	low	4	0
tiapamil hydrochloride	medium	2	1
lisdexamfetamine dimesylate	low	1	0
cefdinir	medium	1	1
technetium tc 99m exametazime	medium	4	1
scopolamine hydrobromide	low	1	0
jaw	low	1	0
beta-endorphin	low	1	0
thimerosal	low	1	0
picrotoxin	low	1	0
quetiapine fumarate	low	5	0
gw 1000	medium	2	1
piperidines	medium	3	1
oxytetracycline, anhydrous	low	1	0
rome	low	1	0
acyclovir	low	1	0
viomycin	low	1	0
neopterin	low	2	0
clozapine	low	4	0
olanzapine	low	3	0
carbidopa	low	1	0
ego	low	2	0

Protein Targets (1,257)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	19	0	0	19
5-hydroxytryptamine receptor 3E	0	7	0	7
acetylcholinesterase	25	0	0	25
TDP1 protein	64	0	0	64
cytochrome P450 2D6	49	0	0	49
v-jun sarcoma virus 17 oncogene homolog (avian)	28	0	0	28
cytochrome P450 2D6 isoform 1	30	0	0	30
cellular tumor antigen p53 isoform a	14	0	0	14
cytochrome P450 2C19 precursor	20	0	0	20
cytochrome P450 2C9 precursor	13	0	0	13
thyroid hormone receptor beta isoform a	15	0	0	15
thyroid hormone receptor beta isoform 2	46	0	0	46
huntingtin isoform 2	9	0	0	9
peripheral myelin protein 22	38	0	0	38
cytochrome P450 3A4 isoform 1	26	0	0	26
muscarinic acetylcholine receptor M1	35	0	0	35
Gamma-aminobutyric acid receptor subunit pi	26	13	3	42
Polyunsaturated fatty acid lipoxygenase ALOX15B	19	0	0	19
ATP-binding cassette sub-family C member 3	0	53	0	53
Multidrug resistance-associated protein 4	0	53	0	53
5-hydroxytryptamine receptor 3B	0	7	0	7
Bile salt export pump	0	84	0	84
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	20	9	29
5-hydroxytryptamine receptor 2C	0	27	5	32
D(2) dopamine receptor	0	60	8	76
5-hydroxytryptamine receptor 2A	0	32	7	39
Gamma-aminobutyric acid receptor subunit beta-1	26	13	3	42
Alpha-1B adrenergic receptor	0	34	3	37
Gamma-aminobutyric acid receptor subunit delta	26	13	3	42
Gamma-aminobutyric acid receptor subunit gamma-2	26	13	5	44
D	0	25	0	25
5-hydroxytryptamine receptor 1A	0	55	5	61
Gamma-aminobutyric acid receptor subunit alpha-5	26	13	3	42
Gamma-aminobutyric acid receptor subunit alpha-3	26	13	3	42
Gamma-aminobutyric acid receptor subunit gamma-1	26	13	3	42
Gamma-aminobutyric acid receptor subunit alpha-2	26	13	3	42
Alpha-1D adrenergic receptor	0	27	3	30
5-hydroxytryptamine receptor 2A	0	66	7	76
5-hydroxytryptamine receptor 2C	0	64	5	69
Gamma-aminobutyric acid receptor subunit alpha-4	26	13	3	42
Gamma-aminobutyric acid receptor subunit gamma-3	26	13	3	42
5-hydroxytryptamine receptor 1B	0	45	3	48
5-hydroxytryptamine receptor 1D	0	13	3	16
Gamma-aminobutyric acid receptor subunit alpha-6	26	13	3	42
5-hydroxytryptamine receptor 1F	0	13	3	16
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	24	5	29
Sodium-dependent serotonin transporter	0	62	7	69
5-hydroxytryptamine receptor 7	0	16	3	19
5-hydroxytryptamine receptor 7	0	17	1	18
Alpha-1B adrenergic receptor	0	10	2	13
Glutamate receptor ionotropic, NMDA 1	0	11	2	17
5-hydroxytryptamine receptor 2B	0	60	4	64
Alpha-1A adrenergic receptor	0	38	4	42
5-hydroxytryptamine receptor 3A	0	9	0	9
Histamine H2 receptor	27	5	1	39
5-hydroxytryptamine receptor 6	0	50	1	52
Beta-2 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	38	3	42
Gamma-aminobutyric acid receptor subunit alpha-1	26	14	5	45
Gamma-aminobutyric acid receptor subunit beta-3	26	13	3	42
Gamma-aminobutyric acid receptor subunit beta-2	26	13	5	44
Glutamate receptor ionotropic, NMDA 2A	0	11	2	17
Glutamate receptor ionotropic, NMDA 2B	0	12	2	18
Glutamate receptor ionotropic, NMDA 2C	0	11	2	18
Glutamate receptor ionotropic, NMDA 2D	0	11	2	17
5-hydroxytryptamine receptor 3D	0	7	0	7
Glutamate receptor ionotropic, NMDA 3B	0	11	2	17
5-hydroxytryptamine receptor 3C	0	7	0	7
GABA theta subunit	26	13	3	42
Canalicular multispecific organic anion transporter 1	0	52	0	52
Gamma-aminobutyric acid receptor subunit epsilon	26	13	3	42
Glutamate receptor ionotropic, NMDA 3A	0	11	2	17
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	26	0	0	26
Chain A, HADH2 protein	16	0	0	16
Chain B, HADH2 protein	16	0	0	16
RAR-related orphan receptor gamma	35	0	0	35
GLI family zinc finger 3	46	0	0	46
AR protein	56	0	0	56
aldehyde dehydrogenase 1 family, member A1	24	0	0	24
thyroid stimulating hormone receptor	36	0	0	36
estrogen receptor 2 (ER beta)	22	0	0	22
nuclear receptor subfamily 1, group I, member 3	35	0	0	35
progesterone receptor	27	0	0	27
glucocorticoid receptor [Homo sapiens]	45	0	0	45
retinoic acid nuclear receptor alpha variant 1	36	0	0	36
estrogen-related nuclear receptor alpha	43	0	0	43
pregnane X nuclear receptor	40	0	0	40
estrogen nuclear receptor alpha	58	0	0	58
aryl hydrocarbon receptor	21	0	0	21
thyroid stimulating hormone receptor	26	0	0	26
activating transcription factor 6	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	20	0	0	20
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	41	0	0	41
Voltage-dependent calcium channel gamma-2 subunit	17	0	0	17
Glutamate receptor 2	18	2	2	22
Kelch-like ECH-associated protein 1	0	0	1	1
Histone acetyltransferase KAT8	0	1	0	1
regulator of G-protein signaling 4	36	0	0	36
Histamine H2 receptor	0	32	4	36
Histamine H4 receptor	0	6	5	11
Histamine H3 receptor	0	2	0	5
Histamine H3 receptor	0	13	3	16
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Chain A, Ferritin light chain	7	0	0	7
Thymidine kinase	0	1	0	1
thioredoxin reductase	42	0	0	42
phosphopantetheinyl transferase	24	0	0	24
GLS protein	43	0	0	43
Smad3	13	0	0	13
EWS/FLI fusion protein	23	0	0	23
arylsulfatase A	35	0	0	35
euchromatic histone-lysine N-methyltransferase 2	72	0	0	72
Histone H2A.x	15	0	0	15
Bloom syndrome protein isoform 1	23	0	0	23
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	9	0	0	9
lamin isoform A-delta10	45	0	0	45
Solute carrier family 22 member 1	0	23	0	29
Solute carrier family 22 member 6	0	1	0	2
Bile salt export pump	0	11	0	11
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	19	0	20
Cytochrome P450 2J2	0	16	0	17
Disintegrin and metalloproteinase domain-containing protein 17	6	0	0	6
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Thymidine kinase	0	1	0	1
NFKB1 protein, partial	16	0	0	16
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
putative alpha-glucosidase	1	0	0	1
heat shock protein beta-1	12	0	0	12
histone acetyltransferase KAT2A isoform 1	21	0	0	21
Solute carrier family 22 member 2	0	7	0	11
Glutamate receptor ionotropic, NMDA 2D	0	5	0	5
Glutamate receptor ionotropic, NMDA 3B	0	5	0	5
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	31	3	8	42
Glutamate receptor ionotropic, NMDA 1	0	6	0	6
Glutamate receptor ionotropic, NMDA 2A	0	6	0	6
Glutamate receptor ionotropic, NMDA 2B	0	6	0	6
Glutamate receptor ionotropic, NMDA 2C	0	5	0	5
Solute carrier family 22 member 1	0	10	0	14
Glutamate receptor ionotropic, NMDA 3A	0	5	0	5
Multidrug and toxin extrusion protein 1	0	6	0	6
Solute carrier family 22 member 2	0	7	0	10
ATP-dependent phosphofructokinase	38	0	0	38
USP1 protein, partial	27	0	0	27
cytochrome P450 family 3 subfamily A polypeptide 4	43	0	0	43
D(1A) dopamine receptor	38	0	0	38
chromobox protein homolog 1	40	0	0	40
atrial natriuretic peptide receptor 2 precursor	18	0	0	18
serine/threonine-protein kinase mTOR isoform 1	23	0	0	23
Voltage-dependent L-type calcium channel subunit alpha-1F	0	13	0	13
5-hydroxytryptamine receptor 4	0	54	0	54
Albumin	0	0	11	11
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	39	0	39
Muscarinic acetylcholine receptor M2	0	49	8	63
Muscarinic acetylcholine receptor M4	0	51	6	61
Muscarinic acetylcholine receptor M1	0	23	3	30
Muscarinic acetylcholine receptor M3	0	20	3	26
Muscarinic acetylcholine receptor M4	0	20	2	25
Muscarinic acetylcholine receptor M5	0	19	2	24
Muscarinic acetylcholine receptor M5	0	50	5	59
Alpha-2A adrenergic receptor	0	62	5	68
Muscarinic acetylcholine receptor M2	0	23	3	30
Muscarinic acetylcholine receptor M1	0	55	9	71
Angiotensin-converting enzyme	0	30	0	30
Alpha-2B adrenergic receptor	0	61	3	65
Alpha-2C adrenergic receptor	0	54	4	59
Muscarinic acetylcholine receptor M3	0	53	7	64
D(1A) dopamine receptor	0	44	2	49
D(1B) dopamine receptor	0	12	0	15
UDP-glucuronosyltransferase 1A4	0	1	0	6
Sodium-dependent noradrenaline transporter	0	54	6	60
Alpha-1D adrenergic receptor	0	46	2	49
5-hydroxytryptamine receptor 6	0	7	3	10
Histamine H1 receptor	0	12	1	13
5-hydroxytryptamine receptor 5A	0	7	3	10
5-hydroxytryptamine receptor 5B	0	7	3	10
Histamine H1 receptor	0	51	6	60
D(3) dopamine receptor	0	55	6	69
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	8	0	11
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	9	3	12
D(1A) dopamine receptor	17	1	0	18
5-hydroxytryptamine receptor 7	0	15	0	15
Voltage-dependent N-type calcium channel subunit alpha-1B	0	7	0	7
Sodium channel protein type 7 subunit alpha	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	13	0	13
Sodium-dependent dopamine transporter	0	43	4	47
Potassium voltage-gated channel subfamily H member 2	0	54	0	54
Voltage-dependent L-type calcium channel subunit alpha-1S	0	13	0	13
Voltage-dependent L-type calcium channel subunit alpha-1C	0	15	0	16
Sodium channel protein type 5 subunit alpha	0	12	0	12
Sodium channel protein type 9 subunit alpha	0	9	0	9
Sigma non-opioid intracellular receptor 1	0	9	3	12
5-hydroxytryptamine receptor 4	0	7	3	10
Nuclear receptor subfamily 3 group C member 3	0	29	0	29
Sodium channel protein type 2 subunit alpha	0	8	0	8
Ataxin-2	37	0	0	37
Sigma non-opioid intracellular receptor 1	0	54	1	55
5-hydroxytryptamine receptor 3B	0	9	3	12
Sodium channel protein type 3 subunit alpha	0	8	0	8
Sodium channel protein type 11 subunit alpha	0	5	0	5
Sodium channel protein type 8 subunit alpha	0	5	0	5
Sodium channel protein type 10 subunit alpha	0	6	0	6
Solute carrier family 22 member 3	0	2	0	2
Phenylethanolamine N-methyltransferase	0	3	0	3
Cytochrome P450 2A6	0	5	1	6
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	2	0	2
Sodium-dependent dopamine transporter	0	25	1	26
Beta-2 adrenergic receptor	0	4	1	7
Sigma non-opioid intracellular receptor 1	0	13	2	15
vitamin D3 receptor isoform VDRA	18	0	0	18
Translocator protein	0	3	2	6
Vasopressin V2 receptor	0	3	2	6
Oxytocin receptor	0	3	3	6
Vasopressin V1a receptor	0	1	2	3
Vasopressin V1a receptor	0	4	3	7
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	1	0	2
Oxytocin receptor	0	2	0	2
Vasopressin V2 receptor	0	2	1	3
Chain A, JmjC domain-containing histone demethylation protein 3A	13	0	0	13
hypoxia-inducible factor 1 alpha subunit	15	0	0	15
SMAD family member 2	6	0	0	6
Fumarate hydratase	19	0	0	19
PPM1D protein	6	0	0	6
SMAD family member 3	6	0	0	6
Microtubule-associated protein tau	24	0	0	24
retinoid X nuclear receptor alpha	25	0	0	25
farnesoid X nuclear receptor	22	0	0	22
G	19	0	0	19
polyprotein	19	0	0	19
67.9K protein	15	0	0	15
peroxisome proliferator-activated receptor delta	26	0	0	26
peroxisome proliferator activated receptor gamma	24	0	0	24
vitamin D (1,25- dihydroxyvitamin D3) receptor	19	0	0	19
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	7	0	0	7
lysosomal alpha-glucosidase preproprotein	4	0	0	4
mu-type opioid receptor isoform MOR-1	0	0	2	2
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
potassium voltage-gated channel subfamily H member 2 isoform d	35	0	0	35
transcriptional regulator ERG isoform 3	7	0	0	7
nuclear receptor ROR-gamma isoform 1	16	0	0	16
geminin	46	0	0	46
5-hydroxytryptamine receptor 2A	0	0	2	2
neuropeptide S receptor isoform A	7	0	0	7
5-hydroxytryptamine receptor 3A	0	2	1	3
Interferon beta	26	0	0	26
HLA class I histocompatibility antigen, B alpha chain	19	0	0	19
Cellular tumor antigen p53	30	0	0	30
ATP-dependent translocase ABCB1	0	22	0	29
Cytochrome P450 3A4	0	20	0	22
Neuronal acetylcholine receptor subunit alpha-4	2	6	2	11
Neuronal acetylcholine receptor subunit beta-2	2	6	2	11
D(4) dopamine receptor	0	26	2	33
D(4) dopamine receptor	0	18	0	18
Histamine H1 receptor	0	6	3	10
Alpha-1A adrenergic receptor	0	14	3	18
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	5	0	5
Inositol monophosphatase 1	17	0	0	17
Multidrug and toxin extrusion protein 2	0	4	0	4
Inositol hexakisphosphate kinase 1	19	0	0	19
cytochrome P450 2C9, partial	19	0	0	19
lethal factor (plasmid)	20	0	0	20
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	9	0	18
Carbonic anhydrase 2	0	9	1	20
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	3	0	5
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	7
Carbonic anhydrase 4	0	3	0	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	16	0	0	16
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	5	0	0	5
hypothetical protein, conserved	3	0	0	3
glucocerebrosidase	10	0	0	10
Rac1 protein	0	0	1	1
IDH1	20	0	0	20
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase iota isoform a (long)	17	0	0	17
DNA polymerase kappa isoform 1	14	0	0	14
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	7	0	7
Fatty acid-binding protein, liver	0	4	0	4
Integrin beta-3	11	1	1	13
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	11	1	1	13
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	7	0	11
Adenosine receptor A2a	0	4	1	10
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	7	0	0	7
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
glp-1 receptor, partial	20	0	0	20
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	7	0	0	7
short transient receptor potential channel 6 isoform 1	0	0	2	2
Muscarinic acetylcholine receptor M1	0	2	3	7
Muscarinic acetylcholine receptor M4	0	3	1	5
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	5	2	8
ATAD5 protein, partial	27	0	0	27
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	12	0	0	12
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
Rap guanine nucleotide exchange factor 3	4	0	0	4
Spike glycoprotein	0	3	8	11
Replicase polyprotein 1ab	0	3	8	11
Transmembrane protease serine 2	0	3	8	11
Procathepsin L	0	3	8	11
Replicase polyprotein 1a	0	3	8	11
Replicase polyprotein 1ab	0	3	8	11
Replicase polyprotein 1ab	0	5	8	13
Replicase polyprotein 1ab	0	7	8	15
Sodium-dependent serotonin transporter	0	15	2	18
Angiotensin-converting enzyme 2	0	3	8	11
importin subunit beta-1 isoform 1	8	0	0	8
snurportin-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit pi	0	12	0	12
Gamma-aminobutyric acid receptor subunit delta	0	12	0	12
Gamma-aminobutyric acid receptor subunit alpha-1	0	13	4	17
Gamma-aminobutyric acid receptor subunit beta-1	0	12	2	14
Gamma-aminobutyric acid receptor subunit gamma-2	0	13	3	16
Gamma-aminobutyric acid receptor subunit beta-3	0	13	3	16
Gamma-aminobutyric acid receptor subunit alpha-5	0	13	4	17
Gamma-aminobutyric acid receptor subunit alpha-3	0	13	3	16
Gamma-aminobutyric acid receptor subunit alpha-2	0	13	3	16
Gamma-aminobutyric acid receptor subunit beta-2	0	12	3	15
Gamma-aminobutyric acid receptor subunit alpha-4	0	12	2	14
Gamma-aminobutyric acid receptor subunit epsilon	0	12	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	0	12	2	14
Gamma-aminobutyric acid receptor subunit gamma-1	0	12	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	0	12	0	12
Gamma-aminobutyric acid receptor subunit theta	0	12	0	12
Acetylcholine receptor subunit alpha	0	3	1	4
Acetylcholine receptor subunit gamma	0	3	1	4
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	3	1	4
UDP-glucuronosyltransferase 2B7	0	3	0	7
Neuronal acetylcholine receptor subunit beta-2	0	3	1	5
UDP-glucuronosyltransferase 1-6	0	1	0	2
Cytochrome P450 2B6	0	2	1	5
UDP-glucuronosyltransferase 1A1	0	1	0	2
Neuronal acetylcholine receptor subunit beta-4	0	3	1	5
Neuronal acetylcholine receptor subunit alpha-3	0	3	1	4
Cytochrome P450 2C19	0	10	0	11
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	3	1	5
Acetylcholine receptor subunit delta	0	3	1	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
Potassium channel subfamily K member 2	0	6	6	12
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	8	0	8
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	8	1	9
Amine oxidase [flavin-containing] A	0	9	0	9
Acetylcholinesterase	0	9	3	14
Amine oxidase [flavin-containing] B	0	10	1	11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	2	7
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	1	4
Adenosine receptor A1	0	6	1	9
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	5
Guanine deaminase	0	1	0	1
Acetylcholinesterase	0	9	0	10
L-lactate dehydrogenase A chain	0	2	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	6	1	7
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	27	1	30
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Cannabinoid receptor 1	0	3	1	4
Cytochrome P450 3A5	0	1	0	1
Cannabinoid receptor 1	0	5	1	8
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	0	1	1
Cannabinoid receptor 2	0	3	2	7
Mu-type opioid receptor	0	23	8	34
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Delta-type opioid receptor	0	17	5	25
Kappa-type opioid receptor	0	18	5	27
Cholinesterase	0	8	0	9
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	3	0	3
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	2	1	3
Transient receptor potential cation channel subfamily V member 2	0	2	1	3
G-protein coupled receptor 55	0	1	2	3
Diacylglycerol lipase-alpha	0	1	0	1
Chain A, Beta-lactamase	12	0	0	12
GALC protein	9	0	0	9
thyrotropin-releasing hormone receptor	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-2	0	4	2	7
Neuronal acetylcholine receptor subunit beta-3	0	4	2	7
Neuronal acetylcholine receptor subunit beta-4	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-5	0	4	2	7
Delta-type opioid receptor	0	14	2	20
Neuronal acetylcholine receptor subunit alpha-6	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-9	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-7	0	6	2	9
Muscarinic acetylcholine receptor M3	0	1	2	6
Muscarinic acetylcholine receptor M2	0	1	1	6
Neuronal acetylcholine receptor subunit alpha-10	0	4	2	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	20	0	0	20
mitogen-activated protein kinase 1	23	0	0	23
Vpr	3	0	0	3
Major prion protein	0	0	5	5
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 2 subunit alpha	0	8	0	8
Sodium channel protein type 3 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	3	0	3
pregnane X receptor	6	0	0	6
Cytochrome P450 2E1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	11	0	0	11
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	3	0	8
Carbonic anhydrase 3	0	3	0	7
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	3	0	8
Carbonic anhydrase 6	0	3	0	8
Carbonic anhydrase 5A, mitochondrial	0	3	1	9
Carbonic anhydrase 7	0	3	0	8
Carbonic anhydrase 9	0	3	0	9
Carbonic anhydrase 13	0	2	0	4
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	2	0	7
Carbonic anhydrase 5B, mitochondrial	0	3	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	0	5
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	0	5
Cholecystokinin receptor type A	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	16	0	0	16
caspase 7, apoptosis-related cysteine protease	11	0	0	11
NADPH oxidase 1	0	4	0	4
Snq2p	0	0	0	11
caspase-3	11	0	0	11
Adenylate cyclase type 1	0	4	0	4
Caspase-7	7	0	0	7
caspase-3	7	0	0	7
histone deacetylase 9 isoform 3	2	0	0	2
ras-related protein Rab-9A	12	0	0	12
survival motor neuron protein isoform d	16	0	0	16
M-phase phosphoprotein 8	19	0	0	19
Proteasome subunit alpha type-7	0	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Albumin	0	1	5	7
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	5	0	5
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	4	2	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Sphingomyelin phosphodiesterase	0	1	0	1
D(3) dopamine receptor	0	22	1	23
Alpha-2B adrenergic receptor	0	18	3	21
D(2) dopamine receptor	0	7	0	7
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
Adenylate cyclase type 3	0	4	0	4
Alpha-2C adrenergic receptor	0	18	3	21
Alpha-2A adrenergic receptor	0	18	3	21
D(1B) dopamine receptor	0	16	0	16
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	14	0	14
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	6	0	6
Pleiotropic ABC efflux transporter of multiple drugs	0	11	0	22
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	4	5
Calmodulin	0	1	4	5
Aldehyde oxidase 1	0	1	0	1
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Aldehyde oxidase	0	3	0	5
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
D	0	7	0	7
Proteasome subunit beta type-7	0	0	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	2	0	3
High affinity choline transporter 1	0	1	0	1
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	3	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Translocator protein	0	2	0	2
Translocator protein	0	3	0	3
Chain A, Cruzipain	2	0	0	2
Beta-1 adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	4	0	5
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	1	0	2
Mu-type opioid receptor	0	10	2	13
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	3	0	3
Nischarin	0	2	0	2
Luciferase	14	0	0	14
bromodomain adjacent to zinc finger domain 2B	12	0	0	12
peripheral myelin protein 22 isoform 1	13	0	0	13
transient receptor potential cation channel subfamily V member 1	3	0	0	3
Beta-2 adrenergic receptor	0	6	0	7
Beta-1 adrenergic receptor	0	5	1	7
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Beta-3 adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 5A	0	4	0	4
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	6	0	6
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
ATPase family AAA domain-containing protein 5	16	0	0	16
Transporter	0	15	1	17
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	1	3	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	4	0	4
Liver carboxylesterase 1	0	2	0	3
Lysosomal Pro-X carboxypeptidase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Leukotriene B4 receptor 2	0	1	0	2
Cytochrome P450 2D1	0	3	0	3
Cytochrome P450 2D26	0	3	0	3
Cytochrome P450 2D3	0	3	0	3
Kappa-type opioid receptor	0	4	2	8
Mu-type opioid receptor	0	5	2	10
Cytochrome P450 2D4	0	3	0	3
Mas-related G-protein coupled receptor member X2	0	0	1	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	4	0	4
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase 15	0	3	0	7
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
D-alanine--D-alanine ligase	0	1	0	1
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	0	1	0	1
15-lipoxygenase, partial	10	0	0	10
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
Amine oxidase [flavin-containing] B	0	5	0	6
Amine oxidase [flavin-containing] B	0	3	0	3
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Gamma-aminobutyric acid	0	2	2	4
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit delta	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit pi	0	2	2	4
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	2	4
Gamma-aminobutyric acid receptor subunit theta	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	2	4
endonuclease IV	9	0	0	9
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Glutamate receptor 1	1	2	2	5
Glutamate receptor 3	1	2	2	5
Glutamate receptor 4	1	2	2	5
Caspase-7	2	0	0	2
eyes absent homolog 2 isoform a	2	0	0	2
Alpha-synuclein	3	2	0	5
TAR DNA-binding protein 43	8	0	0	8
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Acetylcholinesterase	0	4	0	4
Amine oxidase [flavin-containing] A	0	3	0	4
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	4	0	4
Acetylcholinesterase	0	4	0	4
Acetylcholinesterase	0	3	0	3
Glycogen synthase kinase-3 beta	0	1	0	1
Beta-secretase 1	0	1	0	1
Cholinesterase	0	3	0	3
Acetylcholine receptor subunit epsilon	0	1	1	2
Acyl-CoA:cholesterol acyltransferase	0	2	0	2
Carboxylic ester hydrolase	0	2	0	3
Carboxylic ester hydrolase	0	5	0	5
Fatty-acid amide hydrolase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	2
Glycine receptor subunit alpha-1	0	0	3	3
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	3	0	3
Polyphenol oxidase 2	0	1	0	3
Delta-type opioid receptor	0	11	3	14
Mu-type opioid receptor	0	12	4	16
Kappa-type opioid receptor	0	6	3	9
Kappa-type opioid receptor	0	9	1	11
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	2	2
Voltage-dependent T-type calcium channel subunit alpha-1H	0	0	1	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Potassium channel subfamily K member 2	0	2	0	2
Voltage-dependent T-type calcium channel subunit alpha-1I	0	0	1	1
Prostaglandin D2 receptor 2	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	8	0	0	8
flap endonuclease 1	16	0	0	16
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
muscleblind-like protein 1 isoform 1	6	0	0	6
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
NPC intracellular cholesterol transporter 1 precursor	9	0	0	9
Sodium-dependent noradrenaline transporter	0	2	0	2
Cytochrome P450 2C8	0	5	0	5
Dipeptidyl peptidase 4	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sigma intracellular receptor 2	0	5	0	5
Sodium-dependent serotonin transporter	0	2	0	2
Beta-3 adrenergic receptor	0	6	1	7
Androgen receptor	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
thioredoxin glutathione reductase	5	0	0	5
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	2
Chain A, ACETYLCHOLINESTERASE	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	9	0	0	9
Histone deacetylase 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	4	4
Gamma-aminobutyric acid receptor subunit rho-2	0	0	2	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	8	0	0	8
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Cocaine esterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
UDP-glucuronosyltransferase 1A9	0	1	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	4	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	0	4
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	2	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	9	0	0	9
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	4
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase	0	2	0	7
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	2	0	7
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase	0	2	0	7
Carbonic anhydrase	0	2	0	7
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	1	0	6
ClpP	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Chymotrypsinogen A	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
dopamine D1 receptor	8	0	0	8
WRN	2	0	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	3	0	0	3
glucokinase regulatory protein	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	4
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	2	0	0	2
Beta-2 adrenergic receptor	0	4	1	5
Catechol O-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 1E	0	2	0	2
D	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
DNA polymerase III, partial	2	0	0	2
alpha-galactosidase	1	0	0	1
Type-2 angiotensin II receptor	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
D-amino-acid oxidase	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
Histidine decarboxylase	0	0	2	2
UDP-glucuronosyltransferase 1A8	0	0	0	2
Nociceptin receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Parkin	2	0	0	2
tumor necrosis factor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	2	0	2
MCOLN3 protein	0	0	1	1
transient receptor potential cation channel, subfamily N, member 1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	2	0	2
Mineralocorticoid receptor	0	0	1	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Oxytocin receptor	0	0	1	1
Quinolone resistance protein NorA	0	2	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Aldehyde oxidase 1	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M5	0	1	1	3
Lysine-specific histone demethylase 1A	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Membrane primary amine oxidase	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Phospholipase A-2-activating protein	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Acetylcholinesterase	0	1	0	1
XBP1	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
DNA damage-inducible transcript 3 protein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	2	0	2
WD repeat-containing protein 48	0	2	0	2
5-hydroxytryptamine receptor 1B	0	3	1	4
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	3	0	3
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Mcl-1	0	1	0	1
neutrophil cytosol factor 1	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Histidine-rich protein PFHRP-II	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
DNA topoisomerase 1	0	2	0	2
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	3	1	4
Synaptic vesicular amine transporter	0	3	1	4
Synaptic vesicular amine transporter	0	2	0	2
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
Amine oxidase [flavin-containing] B	0	0	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Nrf2	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
toll-like receptor 9	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
neurotensin receptor type 1	0	0	1	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
large T antigen	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
Cathepsin D	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Genome polyprotein	0	1	0	1
Lysozyme C-1	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Protein kinase C alpha type	0	1	0	1
Beta-glucuronidase	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Protein kinase C theta type	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	0	0	1
Thyroid hormone receptor alpha	0	2	2	4
Thyroid hormone receptor beta	0	2	2	4
Proliferating cell nuclear antigen	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Stromelysin-1	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
POsterior Segregation	0	0	1	1
Estrogen receptor beta	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Estrogen receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
streptokinase A precursor	0	0	1	1
twin arginine protein translocation system - TatA protein	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(14)

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Overview

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Treatment

Research

Studies (356)

Protein Targets (1,257)

Childhood Tic Disorders

Synonyms(14)

Research Excerpts

Overview

Actions

Treatment

Research

Studies (356)

Drugs Studied (201)

Protein Targets (1,257)