Page last updated: 2024-09-28

Heartwater Disease

A tick-borne septicemic disease of domestic and wild ruminants caused by EHRLICHIA RUMINANTIUM.

Synonyms(1)

Synonym
Heartwater Disease

Research

Studies (60)

TimeframeStudies, This Condition (%)All Conditions %
pre-199025 (41.67)23.3326
1990's19 (31.67)12.5806
2000's11 (18.33)18.1394
2010's5 (8.33)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetone0low10
benzaldehyde0low10
benzyl alcohol0low10
chlorine0low10
lactic acid0low10
dimethyl sulfoxide0low10
glycine0low10
histamine0low10
urea0low10
furosemide0medium11
methyl salicylate0low10
alanine0low10
serine0low10
aspartic acid0low10
glutamine0low20
2,3,4,6-tetrachlorophenol0low10
edetic acid0low10
ampicillin0low10
asparagine0low10
tryptophan0low10
arginine0low10
2,6-dichlorophenol0low10
n-vinyl-2-pyrrolidinone0low10
2-nitrophenol0low10
benzothiazole0low10
pelargonic acid0low10
thiazoles0low10
chlorfenvinphos0low10
fusarium0low10
imidocarb0low10
amitraz0low20
permethrin0low10
nsc-1727550low20
fibrinogen0low10
cyfluthrin0low10
proline0low10
depsidomycin0low30
bradykinin0low10
bilirubin0low10
ammonium sulfate0low10
fenpyroximate0low10
mocetinostat0low10
lipid a0low10
dextrothyroxine0low10
clove0low40
interleukin-80low10
tetracycline0low10
oxytetracycline, anhydrous0low120
salicylates0low10
sybr green i0low10
pyrethrins0low10
nitrophenols0low10
hyaluronoglucosaminidase0low10
moxidectin0low10
cyclosporine0low10
concanavalin a0low30

Protein Targets (482)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
estrogen nuclear receptor alpha130013
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Luciferase4004
interleukin 82002
RAR-related orphan receptor gamma130013
GLI family zinc finger 39009
AR protein150015
thyroid stimulating hormone receptor6006
estrogen receptor 2 (ER beta)7007
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor6006
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 1160016
retinoid X nuclear receptor alpha9009
estrogen-related nuclear receptor alpha150015
farnesoid X nuclear receptor8008
pregnane X nuclear receptor8008
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma6006
aryl hydrocarbon receptor100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
Histone H2A.x5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
thyroid hormone receptor beta isoform 2120012
heat shock protein beta-13003
mitogen-activated protein kinase 12002
nuclear factor erythroid 2-related factor 2 isoform 1110011
Voltage-dependent calcium channel gamma-2 subunit3003
Cellular tumor antigen p538008
Glutamate receptor 23003
Nuclear receptor ROR-gamma1001
Peroxisome proliferator-activated receptor alpha2002
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Pentachlorophenol 4-monooxygenase0011
TDP1 protein1001
lamin isoform A-delta10110011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE8008
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Carbonic anhydrase 103010
Carbonic anhydrase 203011
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0003
Glutamate receptor ionotropic, NMDA 1 0518
Proton-coupled amino acid transporter 10404
Adenosine deaminase0001
Carbonic anhydrase 40003
hypoxia-inducible factor 1 alpha subunit3003
cytochrome P450 family 3 subfamily A polypeptide 45005
cytochrome P450 2D64004
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
v-jun sarcoma virus 17 oncogene homolog (avian)7007
thyroid hormone receptor beta isoform a4004
potassium voltage-gated channel subfamily H member 2 isoform d3003
geminin8008
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Alpha-2A adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
Chain A, Mutant Al2 6e7p9g0011
Chain A, Beta-lactamase3003
Chain A, 2-oxoglutarate Oxygenase5005
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Cruzipain3003
Beta-lactamase 0001
acid sphingomyelinase1001
GLS protein6006
apical membrane antigen 1, AMA14004
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
euchromatic histone-lysine N-methyltransferase 29009
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
chromobox protein homolog 15005
DNA polymerase beta3003
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)7007
DNA polymerase kappa isoform 15005
60 kDa heat shock protein, mitochondrial0101
Beta-lactamase OXA-70001
Solute carrier family 15 member 10202
Solute carrier family 15 member 10101
Spike glycoprotein4004
10 kDa heat shock protein, mitochondrial0101
Angiopoietin-1 receptor0011
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Thiosulfate sulfurtransferase0101
Metallo-beta-lactamase VIM-130102
Efflux transporter 0001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Class D beta-lactamase0001
60 kDa chaperonin 0101
Metallo-beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
10 kDa chaperonin 0101
Metallo-b-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0102
Beta-lactamase class B VIM-2 0001
Beta-lactamase VIM-1 0102
ATP-dependent phosphofructokinase4004
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase6006
phosphopantetheinyl transferase7007
NFKB1 protein, partial1001
alpha-galactosidase1001
cytochrome P450 2C19 precursor2002
flap endonuclease 14004
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)5005
Cytochrome P450 3A40102
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Neutral amino acid transporter A0404
Neutral amino acid transporter B(0)0404
Carbonic anhydrase-like protein, putative0005
Amino acid transporter0404
Chain A, Ferritin light chain2002
aldehyde dehydrogenase 1 family, member A17007
arylsulfatase A3003
Bloom syndrome protein isoform 14004
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0316
Glutamate receptor ionotropic, NMDA 2B0316
Glutamate receptor ionotropic, NMDA 2C0316
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Glutamate receptor ionotropic, NMDA 2D0316
Glutamate receptor ionotropic, NMDA 3B0316
Glutamate receptor ionotropic, NMDA 3A0316
Chain B, SARS CORONAVIRUS MAIN PROTEINASE0101
Smad31001
Polyphenol oxidase 20101
Botulinum neurotoxin type A 0101
Cytochrome P450 2A60101
Tyrosinase0101
Cytochrome P450 2A50101
Indoleamine 2,3-dioxygenase 10203
Mu-type opioid receptor0101
TAR DNA-binding protein 432002
acetylcholinesterase3003
peripheral myelin protein 221001
Gamma-aminobutyric acid receptor subunit alpha-10011
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit beta-30011
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
USP1 protein, partial3003
Microtubule-associated protein tau4004
vitamin D3 receptor isoform VDRA2002
caspase-1 isoform alpha precursor1001
Caspase-71001
Inositol monophosphatase 11001
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10203
histone acetyltransferase KAT2A isoform 12002
Angiotensin-converting enzyme 0203
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20033
Carbonic anhydrase 40205
Carbonic anhydrase0103
Carbonic anhydrase 150103
thyroid stimulating hormone receptor6006
endonuclease IV1001
nonstructural protein 11001
glucocerebrosidase1001
peripheral myelin protein 22 isoform 13003
M-phase phosphoprotein 82002
neuropeptide S receptor isoform A1001
Cereblon isoform 40202
Insulin-like growth factor-binding protein 50011
Choline O-acetyltransferase 0101
Protein cereblon0202
Eyes absent homolog 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Amyloid-beta precursor protein0101
Histamine H2 receptor1012
Beta-lactamase 0101
Beta-lactamase 0101
pregnane X receptor2002
SMAD family member 22002
SMAD family member 32002
NADH-ubiquinone oxidoreductase chain 10101
EWS/FLI fusion protein4004
thyrotropin-releasing hormone receptor1001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Solute carrier family 22 member 60101
Carbonic anhydrase 120104
Bile salt export pump0101
Bile salt export pump0303
Albumin0101
Carbonic anhydrase 30103
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0101
Carbonic anhydrase 60104
Serum paraoxonase/arylesterase 10202
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0104
Carbonic anhydrase 70104
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20101
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90104
Canalicular multispecific organic anion transporter 10202
Multidrug and toxin extrusion protein 10101
Carbonic anhydrase 130104
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140104
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Carbonic anhydrase 5B, mitochondrial0104
Chain A, Glutamine Binding Protein0011
15-lipoxygenase, partial1001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Asc-type amino acid transporter 10101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10202
Serine racemase0101
Sodium- and chloride-dependent glycine transporter 20101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein1001
regulator of G-protein signaling 42002
bromodomain adjacent to zinc finger domain 2B4004
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Solute carrier family 22 member 30102
Plasma kallikrein0002
Macrophage migration inhibitory factor0202
Histamine H2 receptor0123
Adenosine receptor A10001
Adenosine receptor A2a0001
Histamine H1 receptor0123
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Histamine H1 receptor0224
Carbonic anhydrase0003
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 0003
Carbonic anhydrase0003
Carbonic anhydrase0003
Solute carrier family 22 member 10102
Carbonic anhydrase 0003
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Histamine H4 receptor0123
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Histamine H3 receptor0123
Glucose transporter0101
Cdk-related protein kinase 60101
Protein kinase domain-containing protein0101
Hexose transporter 1 0101
Solute carrier family 2, facilitated glucose transporter member 10101
Acetylcholinesterase0101
Calcium-dependent protein kinase 10101
Mitogen-activated protein kinase 0101
Proline--tRNA ligase0101
Calcium-dependent protein kinase 40101
Lysine--tRNA ligase 0101
cellular tumor antigen p53 isoform a1001
Integrin beta-31001
Integrin alpha-IIb1001
histone deacetylase 9 isoform 31001
PPM1D protein1001
G1001
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Cytochrome P450 2D60101
Integrin alpha-40101
Cytochrome P450 2C190101
Histone deacetylase 40101
Potassium voltage-gated channel subfamily H member 20101
Histone deacetylase 10202
Histone deacetylase 70101
Inositol hexakisphosphate kinase 11001
Histone deacetylase 20202
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
cytochrome P450 2C9, partial1001
activating transcription factor 61001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
WRN1001
Valosin-containing protein0101
thioredoxin glutathione reductase2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
lysosomal alpha-glucosidase preproprotein1001
transcriptional regulator ERG isoform 31001
microphthalmia-associated transcription factor isoform 90101
importin subunit beta-1 isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
eukaryotic translation initiation factor 4E isoform 10101
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Rap guanine nucleotide exchange factor 32002
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
phosphoglycerate kinase1001
G-protein coupled receptor 840011
serine-protein kinase ATM isoform a1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Glutamate 5-kinase0001
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Cholinesterase0101
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Stromelysin-10202
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-synuclein0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
Solute carrier family 22 member 80001
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Solute carrier family 22 member 70001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
SLC16A10 protein0001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Monocarboxylate transporter 100001
Phospholipase A-2-activating protein0101
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Urease subunit alpha0101
Urease subunit beta0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]