Any inhibitor that interferes with the synthesis of hyaluronic acid (HA, also known as hyaluronan).
ChEBI ID: 145253
| Member | Definition | Class |
|---|---|---|
| 4-methylesculetin | A hydroxycoumarin that is 4-methylcuomarin which is substituted by hydroxy groups at positions 3 and 4. A hyaluronan synthesis inhibitor. It has also been used as a fluorescent sensor to monitor the consumption of a boronic acid in Suzuki coupling reactions; fluorescence is readily detectable by the naked eye using a standard 365 nm UV lamp. | 6,7-dihydroxy-4-methylcoumarin |
| 4-methylumbelliferyl glucuronide | A beta-D-glucosiduronic acid having a 4-methylumbelliferyl substituent at the anomeric position. A hyaluronan synthesis inhibitor, it is anti-tumourigenic for various malignant tumours. | 4-methylumbelliferone beta-D-glucuronide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 21 (18.10) | 18.7374 |
| 1990's | 41 (35.34) | 18.2507 |
| 2000's | 21 (18.10) | 29.6817 |
| 2010's | 28 (24.14) | 24.3611 |
| 2020's | 5 (4.31) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.85%) | 5.53% |
| Reviews | 3 (2.54%) | 6.00% |
| Case Studies | 1 (0.85%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 113 (95.76%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 25.6651 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 22.7406 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 3.9811 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0708 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 64.4000 | 1 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | IC50 | 6.2800 | 1 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | Ki | 1.1900 | 1 | 1 |
| Sorbitol dehydrogenase | Homo sapiens (human) | IC50 | 212.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 246.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | Kd | 1,500.0000 | 1 | 1 |