Castleman Disease

Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.

Synonym
Castleman Disease

Excerpt	Reference
"Multicentric Castleman disease is a rare but distinct disorder that may present initially with ocular signs and symptoms."	( Fujisawa, N; Kawaguchi, K; Kurokawa, T; Suzuki, S; Yoshimura, N, 1999)
"Multicentric Castleman disease is a rare lymphoproliferative disorder of unknown cause."	( Baserga, M; Rosin, M; Schoen, M; Young, G, 2005)
"Castleman disease is an unusual complication in patients with HIV-1 and HHV-8 infection, but it should be included in the differential diagnosis of patients who exhibit a relapsing systemic inflammatory syndrome and lymphoadenopathy."	( Minami, R; Yamamoto, M, 2006)
"Castleman disease is a rare lymphoproliferative disorder that can be classified into 3 types: hyaline-vascular, plasma cell, and mixed."	( Aiani, L; Bertolotti, E; Carrafiello, G; Fugazzola, C; Imperatori, A; Mangini, M; Paddeu, A; Rotolo, N; Uccella, S, 2007)
"Multicentric Castleman disease is a systemic lymphoproliferative disease with incomplete understood etiology."	( Hara, S; Hoshino, J; Katori, H; Miyakoshi, S; Ogita, M; Sawa, N; Sogawa, Y; Takaichi, K; Takemoto, F; Ubara, Y, 2007)
"Castleman disease is a rare lymphoproliferative disorder."	( Gonda, A; Illes, A; Miltenyi, Z; Remenyik, E; Tar, I; Toth, J, 2009)
"Multicentric Castleman disease is a rare lymphoproliferative disorder mostly seen in adults with HIV."	( Bernard, C; Drolet, JP; Lefebvre, MA; Mazer, B; McCusker, C; Mitchell, D, 2010)
"Multicentric Castleman disease is a lymphoproliferative disorder which when seen in the setting of HIV/AIDS is often associated with human herpes virus 8 (HHV-8) infection."	( Angus, PW; Crowley, P; Lim, EJ; Mitchell, CA, 2011)
"Castleman disease is a rare hematologic disorder, closely linked to the HHV-8, and most commonly observed in immunocompromised individuals."	( Axt, J; Bonatti, HJ; Correa, H; Frangoul, H; Gillis, L; Hunter, EB; Kelly, B; Lott, SL, 2012)
"Castleman disease is an uncommon disorder characterized by the proliferation of lymphoid tissue."	( Dong, A; Dong, H; Zuo, C, 2014)
"Castleman disease is a rare lymphoproliferative disorder that has many presentations ranging from unifocal or multifocal mass lesions to a monoclonal gammopathy."	( Jiang, H; Jing, Y; Tian, G; Wang, J; Zhang, X, 2014)
"Castleman disease is a rare lymphoproliferative disorder which etiology is unknown."	( Hu, Y; Liu, Y; Shi, H, 2018)
"Castleman disease is a benign and rare lympholiferative disease, and easy to be ignored in clinical."	( Hu, Y; Liu, Y; Shi, H, 2018)
"Castleman disease is a rare cause of lymphoid hyperplasia and may result in localized symptoms or an aggressive, multisystem disorder."	( Abrahams, AD; Dei-Adomakoh, YA; Dey, DI; Quarcoopome, L; Segbefia, CI, 2018)
"Multicentric Castleman disease is a rare polyclonal lymphoproliferative disorder mainly associated with two renal manifestations: thrombotic microangiopathy and amyloidosis."	( Duss, FR; Halfon, M; Nunes, MB; Rotman, S, 2020)
"Adrenal Castleman disease is very rare."	( Cheng, X; Ding, J; Hou, G; Huo, L; Jing, H, 2021)
"Colonic Castleman disease is very rare."	( Cai, H; Li, F; Li, L; Xiao, L, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	5 (1.33)	23.3326
1990's	57 (15.20)	12.5806
2000's	105 (28.00)	18.1394
2010's	142 (37.87)	28.8240
2020's	66 (17.60)	9.53

Drug	Relationship Strength	Studies	Trials
citric acid, anhydrous	low	2	0
hydrochloric acid	low	1	0
salicylic acid	low	1	0
cytosine	low	2	0
formaldehyde	low	1	0
azathioprine	low	7	0
chlorambucil	low	4	0
ciprofloxacin	low	1	0
pentetic acid	low	3	0
fluconazole	low	1	0
foscarnet	low	1	0
hydroxychloroquine	low	2	0
iohexol	low	1	0
iopromide	low	1	0
ioversol	low	1	0
mesalamine	medium	1	1
mitoxantrone	low	2	0
streptonigrin	low	1	0
ticlopidine	low	1	0
urethane	low	1	0
prednisolone	low	60	0
thyroxine	low	2	0
prednisolone acetate	low	1	0
galactose	low	1	0
colchicine	low	3	0
cytarabine	low	1	0
methylprednisolone	low	13	0
pyridostigmine bromide	low	2	0
pyrroles	low	1	0
thiophenes	low	1	0
meglumine	low	3	0
pyrazines	low	8	0
reticulin	low	12	0
sulfur hexafluoride	low	1	0
fluorescein-5-isothiocyanate	low	1	0
cladribine	low	2	0
vidarabine	low	1	0
technetium	low	1	0
gadolinium	low	1	0
barium sulfate	low	1	0
trolamine salicylate	low	4	0
daunorubicin	low	1	0
calcium oxalate	low	1	0
gallium citrate	low	1	0
vindesine	low	1	0
epirubicin	low	1	0
propiconazole	low	2	0
cidofovir anhydrous	low	2	0
iopamidol	low	1	0
fluorodeoxyglucose f18	low	46	0
fibrinogen	medium	3	2
deoxyglucose	low	1	0
iodofiltic acid	low	1	0
methotrexate	low	6	0
naproxen	low	1	0
technetium tc 99m pentetate	low	1	0
organophosphonates	low	2	0
lenalidomide	low	7	0
inositol 3-phosphate	low	1	0
tretinoin	low	1	0
tacrolimus	low	5	0
mycophenolic acid	low	3	0
melphalan	low	8	0
fludarabine	low	1	0
thioguanine anhydrous	low	1	0
calcitriol	low	1	0
amphotericin b	low	1	0
isotretinoin	low	1	0
phenylephrine hydrochloride	low	1	0
dorzolamide	low	1	0
gallium	low	1	0
indinavir sulfate	low	1	0
beta-escin	low	1	0
gadolinium dtpa	low	4	0
staurosporine	low	1	0
shu 508	low	1	0
mocetinostat	low	1	0
tofacitinib	low	1	0
losartan potassium	low	4	0
technetium tc 99m sestamibi	low	2	0
incb-018424	low	2	0
baricitinib	low	1	0
piperidines	low	1	0
interleukin-8	medium	2	1
minocycline	low	1	0
warfarin	low	1	0
cyclin d1	low	1	0
technetium tc 99m sulfur colloid	low	1	0
lewis x antigen	low	3	0
cyclosporine	low	14	0
gallium ga 68 dotatate	low	1	0
technetium tc-99m tetrofosmin	low	1	0
rifampin	low	1	0
ganciclovir	medium	14	1

Protein Targets (1,453)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Ferritin light chain	12	0	0	12
Thymidine kinase	0	3	0	3
thioredoxin reductase	14	0	0	14
phosphopantetheinyl transferase	13	0	0	13
GLS protein	10	0	0	10
TDP1 protein	35	0	0	35
Smad3	10	0	0	10
thyroid stimulating hormone receptor	7	0	0	7
EWS/FLI fusion protein	26	0	0	26
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	25	0	0	25
activating transcription factor 6	13	0	0	13
Histone H2A.x	15	0	0	15
Bloom syndrome protein isoform 1	13	0	0	13
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lamin isoform A-delta10	24	0	0	24
Solute carrier family 22 member 1	0	4	0	6
ATP-binding cassette sub-family C member 3	0	29	0	29
Multidrug resistance-associated protein 4	0	29	0	30
Solute carrier family 22 member 6	0	4	0	7
Bile salt export pump	0	7	0	7
Bile salt export pump	0	38	0	38
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	6
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2C9	0	14	2	17
Cytochrome P450 2J2	0	6	0	6
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	4	0	10
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	3	0	8
Canalicular multispecific organic anion transporter 1	0	30	0	31
Thymidine kinase	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	25	0	0	25
AR protein	33	0	0	33
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
glucocorticoid receptor [Homo sapiens]	30	0	0	30
estrogen-related nuclear receptor alpha	28	0	0	28
pregnane X nuclear receptor	24	0	0	24
estrogen nuclear receptor alpha	44	0	0	44
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	21	0	0	21
nuclear factor erythroid 2-related factor 2 isoform 2	16	0	0	16
heat shock protein beta-1	8	0	0	8
importin subunit beta-1 isoform 1	7	0	0	7
snurportin-1	7	0	0	7
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Cyclin-dependent kinase 1	0	1	4	5
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	16	1	0	17
Xanthine dehydrogenase/oxidase	0	2	0	2
TAR DNA-binding protein 43	7	1	0	8
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	2	4
ATPase family AAA domain-containing protein 5	17	0	0	17
Ataxin-2	19	0	0	19
Chain A, Cruzipain	5	0	0	5
interleukin 8	6	0	0	6
farnesoid X nuclear receptor	17	0	0	17
peroxisome proliferator-activated receptor delta	19	0	0	19
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	25	0	0	25
peripheral myelin protein 22	18	0	0	18
Cytochrome P450 1A2	0	4	1	6
Cytochrome P450 3A4	0	18	1	21
Cytochrome P450 2D6	0	12	1	13
Cytochrome P450 2C19	0	8	1	9
Nuclear receptor ROR-gamma	6	1	1	8
Potassium voltage-gated channel subfamily H member 2	0	7	0	8
Aurora kinase B	0	1	4	5
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
acetylcholinesterase	8	0	0	8
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	9	0	0	9
SMAD family member 3	6	0	0	6
GLI family zinc finger 3	23	0	0	23
Microtubule-associated protein tau	9	0	0	9
thioredoxin glutathione reductase	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
retinoid X nuclear receptor alpha	23	0	0	23
G	13	0	0	13
polyprotein	9	0	0	9
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	19	0	0	19
IDH1	13	0	0	13
aryl hydrocarbon receptor	11	0	0	11
thyroid stimulating hormone receptor	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
peripheral myelin protein 22 isoform 1	4	0	0	4
cellular tumor antigen p53 isoform a	7	0	0	7
thyroid hormone receptor beta isoform 2	22	0	0	22
DNA polymerase iota isoform a (long)	13	0	0	13
geminin	31	0	0	31
survival motor neuron protein isoform d	13	0	0	13
cytochrome P450 3A4 isoform 1	12	0	0	12
M-phase phosphoprotein 8	7	0	0	7
muscleblind-like protein 1 isoform 1	8	0	0	8
muscarinic acetylcholine receptor M1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	12	1	0	13
Interferon beta	24	0	0	24
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Cellular tumor antigen p53	28	0	0	28
Gamma-aminobutyric acid receptor subunit beta-1	12	1	0	13
Gamma-aminobutyric acid receptor subunit delta	12	1	0	13
Gamma-aminobutyric acid receptor subunit gamma-2	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-5	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-3	12	1	0	13
Gamma-aminobutyric acid receptor subunit gamma-1	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-2	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-4	12	1	0	13
Gamma-aminobutyric acid receptor subunit gamma-3	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-6	12	1	0	13
Gamma-aminobutyric acid receptor subunit alpha-1	12	1	0	13
Gamma-aminobutyric acid receptor subunit beta-3	12	1	0	13
Gamma-aminobutyric acid receptor subunit beta-2	12	1	0	13
GABA theta subunit	12	1	0	13
Inositol hexakisphosphate kinase 1	13	0	0	13
Gamma-aminobutyric acid receptor subunit epsilon	12	1	0	13
Protein-arginine deiminase type-4	0	6	0	6
cytochrome P450 2C9, partial	13	0	0	13
PPM1D protein	12	0	0	12
Bone morphogenetic protein receptor type-1B	0	0	4	4
Membrane-associated progesterone receptor component 1	0	0	2	2
Serine/threonine-protein kinase PLK4	0	0	4	4
ATP-dependent RNA helicase DDX3X	0	0	4	4
Pyridoxal kinase	0	0	4	4
Citron Rho-interacting kinase	0	0	4	4
Serine/threonine-protein kinase Chk1	0	1	4	5
Aurora kinase A	0	0	4	4
Cyclin-G-associated kinase	0	2	4	6
Ephrin type-B receptor 6	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 3	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 2	0	0	4	4
Dynamin-like 120 kDa protein, mitochondrial	0	0	4	4
Tyrosine-protein kinase JAK2	0	6	5	14
Eukaryotic translation initiation factor 5B	0	0	3	3
Rho-associated protein kinase 2	0	1	4	5
Serine/threonine-protein kinase ULK1	0	0	4	4
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	4	4
Ribosomal protein S6 kinase alpha-5	0	1	4	5
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	4	4
Ribosomal protein S6 kinase alpha-4	0	0	4	4
Serine/threonine-protein kinase 16	0	0	4	4
Serine/threonine-protein kinase 10	0	0	4	4
Serine/threonine-protein kinase D3	0	0	4	4
Structural maintenance of chromosomes protein 2	0	0	3	3
Mitogen-activated protein kinase kinase kinase 6	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	4	4
Serine/threonine-protein kinase LATS1	0	0	4	4
Serine/threonine-protein kinase PAK 4	0	0	4	4
Tyrosine-protein kinase ABL1	0	0	5	6
Epidermal growth factor receptor	0	2	4	6
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	2	2
ADP/ATP translocase 2	0	0	4	4
Protein kinase C beta type	0	1	4	5
Insulin receptor	0	1	4	5
Tyrosine-protein kinase Lck	0	1	4	5
Tyrosine-protein kinase Fyn	0	2	4	6
Glycogen phosphorylase, liver form	0	0	4	4
Tyrosine-protein kinase Fes/Fps	0	0	4	4
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	0	4	4
Tyrosine-protein kinase Lyn	0	0	4	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	4	4
Insulin-like growth factor 1 receptor	0	0	4	4
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	4	4
Hepatocyte growth factor receptor	0	0	4	4
Tyrosine-protein kinase HCK	0	0	4	4
Platelet-derived growth factor receptor beta	0	0	4	4
Serine/threonine-protein kinase A-Raf	0	0	4	4
Glycogen phosphorylase, brain form	0	0	4	4
Breakpoint cluster region protein	0	0	4	5
Serine/threonine-protein kinase pim-1	0	1	4	5
Fibroblast growth factor receptor 1	0	0	4	4
DNA topoisomerase 2-alpha	0	3	4	17
Cyclin-dependent kinase 4	0	0	4	4
ADP/ATP translocase 3	0	0	4	4
Inosine-5'-monophosphate dehydrogenase 2	0	2	3	5
Proto-oncogene tyrosine-protein kinase Src	0	1	4	5
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	3	3
Serine/threonine-protein kinase B-raf	0	0	4	4
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	4	4
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	4	4
Tyrosine-protein kinase Fer	0	0	4	4
Protein kinase C alpha type	0	1	4	5
cAMP-dependent protein kinase catalytic subunit alpha	0	0	4	4
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	4	4
Casein kinase II subunit alpha'	0	1	4	5
Ras-related protein Rab-6A	0	0	3	3
Ephrin type-A receptor 1	0	0	4	4
Multifunctional protein ADE2	0	0	4	4
cAMP-dependent protein kinase catalytic subunit gamma	0	0	3	3
cAMP-dependent protein kinase catalytic subunit beta	0	0	4	4
Ferrochelatase, mitochondrial	0	0	4	4
Ribosomal protein S6 kinase beta-1	0	1	4	5
Tyrosine-protein kinase JAK1	0	6	6	15
Cyclin-dependent kinase 2	0	1	5	6
Beta-adrenergic receptor kinase 1	0	0	4	4
Probable ATP-dependent RNA helicase DDX6	0	0	4	4
Mitogen-activated protein kinase 3	0	1	4	5
MAP/microtubule affinity-regulating kinase 3	0	0	4	4
Deoxycytidine kinase	0	0	4	6
Mitogen-activated protein kinase 1	0	2	4	6
Ephrin type-A receptor 2	0	0	4	4
Ephrin type-B receptor 2	0	0	4	4
Non-receptor tyrosine-protein kinase TYK2	0	6	6	15
UMP-CMP kinase	0	0	2	3
Phosphatidylethanolamine-binding protein 1	0	0	3	3
Wee1-like protein kinase	0	0	4	4
Heme oxygenase 2	0	0	4	4
S-adenosylmethionine synthase isoform type-2	0	0	4	4
DnaJ homolog subfamily A member 1	0	0	4	4
RAC-alpha serine/threonine-protein kinase	0	1	4	5
RAC-beta serine/threonine-protein kinase	0	0	4	4
DNA replication licensing factor MCM4	0	0	3	3
Myosin-10	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 2	0	0	4	4
Receptor-type tyrosine-protein kinase FLT3	0	0	4	4
Bone morphogenetic protein receptor type-1A	0	0	4	4
Activin receptor type-1B	0	0	4	4
TGF-beta receptor type-1	0	0	4	4
Serine/threonine-protein kinase receptor R3	0	0	4	4
TGF-beta receptor type-2	0	0	4	4
Electron transfer flavoprotein subunit beta	0	0	3	3
Tyrosine-protein kinase CSK	0	1	4	5
Glycine--tRNA ligase	0	0	4	4
Protein kinase C iota type	0	0	4	4
Exosome RNA helicase MTR4	0	0	4	4
Tyrosine-protein kinase Tec	0	1	4	5
Tyrosine-protein kinase ABL2	0	0	4	4
Tyrosine-protein kinase FRK	0	0	4	4
G protein-coupled receptor kinase 6	0	0	2	2
Tyrosine-protein kinase SYK	0	0	4	4
26S proteasome regulatory subunit 6B	0	1	4	5
Mitogen-activated protein kinase 8	0	1	4	5
Mitogen-activated protein kinase 9	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 3	0	0	4	4
Casein kinase I isoform alpha	0	0	4	4
Casein kinase I isoform delta	0	0	4	4
MAP kinase-activated protein kinase 2	0	1	4	5
Elongation factor Tu, mitochondrial	0	0	4	4
Cysteine--tRNA ligase, cytoplasmic	0	0	4	4
Casein kinase I isoform epsilon	0	0	4	4
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	4	4
Dual specificity protein kinase CLK1	0	0	4	4
Dual specificity protein kinase CLK2	0	0	4	4
Dual specificity protein kinase CLK3	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	4	4
Glycogen synthase kinase-3 beta	0	1	4	5
Cyclin-dependent kinase 7	0	0	4	4
Cyclin-dependent kinase 9	0	0	4	4
Ras-related protein Rab-27A	0	0	3	3
Interleukin-1 receptor-associated kinase 1	0	0	4	4
Ribosomal protein S6 kinase alpha-3	0	1	4	5
Serine/threonine-protein kinase Nek2	0	0	4	4
Serine/threonine-protein kinase Nek3	0	0	4	4
Tyrosine-protein kinase JAK3	0	6	3	13
Dual specificity mitogen-activated protein kinase kinase 6	0	0	4	4
LIM domain kinase 1	0	0	4	4
LIM domain kinase 2	0	0	4	4
Mitogen-activated protein kinase 10	0	0	4	4
Tyrosine--tRNA ligase, cytoplasmic	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-1	0	0	4	5
Ephrin type-B receptor 3	0	0	4	4
Ephrin type-A receptor 5	0	0	4	4
Ephrin type-B receptor 4	0	0	4	4
Ephrin type-A receptor 4	0	0	4	4
Adenylate kinase 2, mitochondrial	0	0	4	5
Adenosine kinase	0	0	4	4
Ras-related protein Rab-10	0	0	4	4
Actin-related protein 3	0	0	4	4
Actin-related protein 2	0	0	3	3
GTP-binding nuclear protein Ran	0	0	4	4
Casein kinase I isoform gamma-2	0	0	4	4
Cyclin-dependent kinase 3	0	0	3	3
Cyclin-dependent kinase 6	0	0	4	4
Cyclin-dependent-like kinase 5	0	1	4	5
Cyclin-dependent kinase 16	0	0	4	4
Cyclin-dependent kinase 17	0	0	4	4
ATP-dependent 6-phosphofructokinase, platelet type	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 1	0	0	4	4
DNA topoisomerase 2-beta	0	1	5	13
Protein kinase C theta type	0	0	4	4
Activin receptor type-1	0	0	4	4
Macrophage-stimulating protein receptor	0	0	4	4
Focal adhesion kinase 1	0	0	4	4
Protein kinase C delta type	0	0	4	4
Tyrosine-protein kinase BTK	0	2	4	6
Activated CDC42 kinase 1	0	0	4	4
Epithelial discoidin domain-containing receptor 1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	4	4
Serine/threonine-protein kinase 4	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	4	5
Dual specificity mitogen-activated protein kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase 7	0	0	4	4
Serine/threonine-protein kinase PAK 2	0	0	4	4
Serine/threonine-protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 1	0	0	4	4
Integrin-linked protein kinase	0	0	4	4
Rho-associated protein kinase 1	0	0	4	4
Non-receptor tyrosine-protein kinase TNK1	0	0	4	4
Serine/threonine-protein kinase ATR	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	4	4
Activin receptor type-2B	0	0	4	4
Bone morphogenetic protein receptor type-2	0	0	4	4
Protein-tyrosine kinase 6	0	0	4	4
cGMP-dependent protein kinase 1	0	0	4	4
Cyclin-dependent kinase 13	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	4	4
Protein-tyrosine kinase 2-beta	0	0	4	4
Maternal embryonic leucine zipper kinase	0	0	4	4
Structural maintenance of chromosomes protein 1A	0	0	3	3
Chromodomain-helicase-DNA-binding protein 4	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 1	0	0	3	3
Ephrin type-A receptor 7	0	0	3	3
Delta(24)-sterol reductase	0	0	3	3
Ribosomal protein S6 kinase alpha-1	0	0	4	4
Dual specificity testis-specific protein kinase 1	0	0	4	4
Myosin light chain kinase, smooth muscle	0	0	4	4
Mitogen-activated protein kinase 11	0	1	4	5
Serine/threonine-protein kinase STK11	0	0	4	4
Serine/threonine-protein kinase N1	0	0	4	4
Serine/threonine-protein kinase N2	0	0	4	4
Mitogen-activated protein kinase 14	0	2	4	6
Calcium/calmodulin-dependent protein kinase type IV	0	0	4	4
Mitogen-activated protein kinase kinase kinase 11	0	0	4	4
MAP kinase-activated protein kinase 3	0	0	1	1
Discoidin domain-containing receptor 2	0	0	4	4
AP2-associated protein kinase 1	0	2	4	6
Myosin light chain kinase 3	0	0	4	4
Uncharacterized aarF domain-containing protein kinase 5	0	0	3	3
Putative heat shock protein HSP 90-beta 2	0	0	4	4
Rab-like protein 3	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	4	4
Serine/threonine-protein kinase MRCK gamma	0	0	4	4
Acyl-CoA dehydrogenase family member 10	0	0	4	4
Serine/threonine-protein kinase ULK3	0	0	4	4
Uncharacterized protein FLJ45252	0	0	4	4
Acyl-CoA dehydrogenase family member 11	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	4	4
Serine/threonine-protein kinase MARK2	0	0	4	4
ATP-dependent RNA helicase DHX30	0	0	3	3
Serine/threonine-protein kinase TAO1	0	0	4	4
STE20-related kinase adapter protein alpha	0	0	4	4
Myosin-14	0	0	4	4
AarF domain-containing protein kinase 1	0	0	4	4
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	4	4
MAP kinase-activated protein kinase 5	0	1	4	5
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	2	2
Misshapen-like kinase 1	0	0	4	4
Atypical kinase COQ8A, mitochondrial	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	4	4
Mitogen-activated protein kinase 15	0	0	4	4
Serine/threonine-protein kinase Nek9	0	0	4	4
ATP-dependent RNA helicase DDX1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1G	0	0	4	4
Serine/threonine-protein kinase Nek1	0	0	4	4
PAS domain-containing serine/threonine-protein kinase	0	0	4	4
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	4	4
EKC/KEOPS complex subunit TP53RK	0	0	4	4
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase kinase kinase 3	0	0	4	4
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	4	4
Nucleolar GTP-binding protein 1	0	0	4	4
Serine/threonine-protein kinase D2	0	0	4	4
NUAK family SNF1-like kinase 2	0	0	3	3
RNA cytidine acetyltransferase	0	0	4	4
Serine/threonine-protein kinase SIK2	0	0	4	4
STE20-like serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO3	0	0	4	4
dCTP pyrophosphatase 1	0	0	4	4
Dual specificity protein kinase CLK4	0	0	4	4
Casein kinase I isoform gamma-1	0	0	4	4
Serine/threonine-protein kinase PAK 6	0	0	3	3
Phenylalanine--tRNA ligase beta subunit	0	0	4	4
Isoleucine--tRNA ligase, mitochondrial	0	0	3	3
BMP-2-inducible protein kinase	0	0	4	4
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	4	4
Interleukin-1 receptor-associated kinase 4	0	0	4	4
Mitogen-activated protein kinase kinase kinase 20	0	0	4	4
Cyclin-dependent kinase 12	0	0	4	4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	3	3
Serine/threonine-protein kinase 26	0	0	4	4
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	4	4
Serine/threonine-protein kinase NLK	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-2	0	0	4	5
Serine/threonine-protein kinase TBK1	0	1	4	5
Septin-9	0	0	4	4
Ribosomal protein S6 kinase alpha-6	0	0	4	4
TRAF2 and NCK-interacting protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO2	0	0	4	4
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	4	4
RAC-gamma serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase 38-like	0	0	3	3
Serine/threonine-protein kinase SIK3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 2	0	0	4	4
Thyroid hormone receptor-associated protein 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 3	0	0	4	4
Serine/threonine-protein kinase MRCK beta	0	0	4	4
Interleukin-1 receptor-associated kinase 3	0	0	4	4
Serine/threonine-protein kinase 24	0	0	4	4
Casein kinase I isoform gamma-3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 4	0	0	4	4
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
caspase 7, apoptosis-related cysteine protease	6	0	0	6
estrogen receptor 2 (ER beta)	12	0	0	12
progesterone receptor	16	0	0	16
caspase-3	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
Caspase-7	6	0	0	6
caspase-3	6	0	0	6
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	4	0	4
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	4	0	5
Prothrombin	0	1	0	2
Chymotrypsinogen A	0	2	0	2
Carbonic anhydrase 1	0	7	0	9
Carbonic anhydrase 2	0	8	2	11
Carbonic anhydrase 3	0	3	0	4
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Carbonic anhydrase 4	0	6	0	7
Carbonic anhydrase 6	0	4	0	5
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	3
Carbonic anhydrase 5A, mitochondrial	0	5	0	6
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Carbonic anhydrase 7	0	4	0	5
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	5	0	5
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	7	0	8
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	2	0	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	4	0	4
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	3	0	3
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	5	0	5
Carbonic anhydrase 14	0	3	0	4
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	0	5
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	18	0	0	18
mitogen-activated protein kinase 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	10	0	0	10
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	4	0	4
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	5	7
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Luciferase	8	0	0	8
NFKB1 protein, partial	3	0	0	3
GALC protein	3	0	0	3
Thrombopoietin	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
chromobox protein homolog 1	14	0	0	14
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
Spike glycoprotein	19	0	1	20
Solute carrier organic anion transporter family member 1B3	0	8	0	11
ATP-dependent phosphofructokinase	13	0	0	13
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Thymidine kinase	0	0	0	1
cytochrome P450 2D6	9	0	0	9
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	5	0	0	5
DNA polymerase kappa isoform 1	11	0	0	11
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	4	0	5
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
ATP-dependent translocase ABCB1	0	9	0	12
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Histamine H2 receptor	0	2	0	2
Histamine H1 receptor	0	0	3	3
Histamine H2 receptor	8	2	1	11
Potassium-transporting ATPase subunit beta	0	1	0	1
Aldehyde oxidase	0	1	0	1
Solute carrier family 22 member 1	0	3	0	3
Multidrug and toxin extrusion protein 2	0	3	0	3
Multidrug and toxin extrusion protein 1	0	3	0	3
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	1	0	3
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
cytochrome P450 2C9 precursor	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	3	0	3
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	11	0	0	11
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
glp-1 receptor, partial	9	0	0	9
67.9K protein	13	0	0	13
huntingtin isoform 2	3	0	0	3
tyrosine-protein kinase Yes	5	0	0	5
relaxin receptor 1 isoform 1	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	2	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Integrin beta-3	5	0	0	5
Integrin alpha-IIb	5	0	0	5
Adenosine receptor A3	0	2	0	2
Rap guanine nucleotide exchange factor 4	2	0	0	2
endonuclease IV	5	0	0	5
PAX8	0	0	0	2
pregnane X receptor	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
glucocerebrosidase	2	0	0	2
cytochrome P450 2D6 isoform 1	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
flap endonuclease 1	5	0	0	5
ras-related protein Rab-9A	3	0	0	3
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
lethal factor (plasmid)	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier family 22 member 3	0	3	0	3
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	2	0	3
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	1	0	0	1
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Transthyretin	0	2	0	3
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	1	1	0	2
Glutamate receptor 3	1	1	0	2
Glutamate receptor 4	1	1	0	2
Platelet-activating factor receptor	2	0	0	2
Multidrug resistance-associated protein 1	0	3	0	5
Inositol monophosphatase 1	3	0	0	3
Reverse transcriptase/RNaseH	0	4	4	13
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
Androgen receptor	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 13	0	3	0	4
Genome polyprotein	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
DNA topoisomerase 2	0	0	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
apical membrane antigen 1, AMA1	5	0	0	5
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	2	0	2
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	2	1	3
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
5'-nucleotidase	0	1	0	1
Adenosine deaminase	0	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
ClpP	2	0	0	2
Transitional endoplasmic reticulum ATPase	0	1	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	3	0	3
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	3	1	4
Replicase polyprotein 1ab	0	4	1	5
Muscarinic acetylcholine receptor M1	0	3	0	3
Alpha-2B adrenergic receptor	0	5	0	5
Alpha-2C adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Leukotriene C4 synthase	0	0	2	2
Cell division cycle 7-related protein kinase	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	2	2
Serine/threonine-protein kinase 25	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	2	2
Serine/threonine-protein kinase RIO3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 7	0	1	2	3
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	2	3
Peripheral plasma membrane protein CASK	0	0	2	2
Serine/threonine-protein kinase DCLK1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	2	2
Muscle, skeletal receptor tyrosine-protein kinase	0	0	2	2
Mitogen-activated protein kinase 13	0	1	2	3
3-phosphoinositide-dependent protein kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 13	0	0	2	2
Death-associated protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	3	3
NUAK family SNF1-like kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	2	2
Serine/threonine-protein kinase PAK 3	0	0	2	2
Cyclin-dependent kinase-like 5	0	0	3	3
Serine/threonine-protein kinase 17B	0	0	2	2
Cyclin-dependent kinase 14	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	2	2
Serine/threonine-protein kinase Chk2	0	0	2	2
RAF proto-oncogene serine/threonine-protein kinase	0	0	2	2
Receptor tyrosine-protein kinase erbB-2	0	2	2	4
High affinity nerve growth factor receptor	0	0	3	3
Macrophage colony-stimulating factor 1 receptor	0	0	2	2
Proto-oncogene tyrosine-protein kinase ROS	0	1	2	3
Tyrosine-protein kinase Fgr	0	0	3	3
Wee1-like protein kinase 2	0	0	2	2
Uncharacterized serine/threonine-protein kinase SBK3	0	0	2	2
Mast/stem cell growth factor receptor Kit	0	0	2	2
Insulin receptor-related protein	0	0	2	2
Platelet-derived growth factor receptor alpha	0	0	2	2
Vascular endothelial growth factor receptor 1	0	0	2	2
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	2	2
Cyclin-dependent kinase 11B	0	0	2	2
Fibroblast growth factor receptor 2	0	0	2	2
Receptor tyrosine-protein kinase erbB-3	0	0	2	2
Fibroblast growth factor receptor 4	0	0	2	2
Fibroblast growth factor receptor 3	0	0	2	2
Protein kinase C eta type	0	0	2	2
Activin receptor type-2A	0	0	2	2
Ephrin type-A receptor 3	0	0	2	2
Ephrin type-A receptor 8	0	0	2	2
Leukocyte tyrosine kinase receptor	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	0	2	2
Mitogen-activated protein kinase 4	0	0	2	2
G protein-coupled receptor kinase 4	0	0	2	2
Dual specificity protein kinase TTK	0	0	3	3
Prostaglandin G/H synthase 2	0	4	2	6
Tyrosine-protein kinase receptor Tie-1	0	0	2	2
Vascular endothelial growth factor receptor 3	0	0	2	2
Vascular endothelial growth factor receptor 2	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	2	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	2	2
Serine/threonine-protein kinase mTOR	0	2	3	5
Megakaryocyte-associated tyrosine-protein kinase	0	0	2	2
Tyrosine-protein kinase TXK	0	1	2	3
Tyrosine-protein kinase ZAP-70	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	2	2
Cyclin-dependent kinase 8	0	0	2	2
Tyrosine-protein kinase Blk	0	1	2	3
Cytoplasmic tyrosine-protein kinase BMX	0	1	2	3
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	2	2
Serine/threonine-protein kinase PLK1	0	0	3	3
Death-associated protein kinase 1	0	0	2	2
Mitogen-activated protein kinase 12	0	1	2	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	2	3
Ephrin type-B receptor 1	0	0	2	2
Oxysterols receptor LXR-beta	0	1	0	1
Hormonally up-regulated neu tumor-associated kinase	0	0	2	2
Serine/threonine-protein kinase SIK1	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 4	0	0	2	2
Cell division control protein 2 homolog	0	0	2	2
Calcium-dependent protein kinase 1	0	0	2	2
Casein kinase II subunit alpha	0	1	2	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	2	2
SRSF protein kinase 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 9	0	0	2	2
Serine/threonine-protein kinase PknB	0	0	2	2
Cyclin-dependent kinase-like 1	0	0	2	2
Protein kinase C epsilon type	0	1	2	3
Angiopoietin-1 receptor	0	0	2	2
Mitogen-activated protein kinase kinase kinase 10	0	0	2	2
Tyrosine-protein kinase receptor TYRO3	0	0	2	2
Cyclin-dependent kinase 18	0	0	3	3
Tyrosine-protein kinase ITK/TSK	0	1	2	3
Myotonin-protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	2	2
Tyrosine-protein kinase Mer	0	0	3	3
Serine/threonine-protein kinase PAK 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	2	2
Serine/threonine-protein kinase PRP4 homolog	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1	0	0	2	2
Serine/threonine-protein kinase D1	0	0	2	2
Serine/threonine-protein kinase 38	0	0	2	2
Receptor tyrosine-protein kinase erbB-4	0	1	2	3
Ribosomal protein S6 kinase alpha-2	0	0	2	2
Rhodopsin kinase GRK1	0	0	2	2
NT-3 growth factor receptor	0	0	2	2
BDNF/NT-3 growth factors receptor	0	0	2	2
Mitogen-activated protein kinase 6	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	2	2
Serine/threonine-protein kinase SBK1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 19	0	0	2	2
Serine/threonine-protein kinase TNNI3K	0	0	2	2
Tyrosine-protein kinase JAK2	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	2	2
Serine/threonine-protein kinase N3	0	0	2	2
Dual serine/threonine and tyrosine protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 15	0	0	2	2
Serine/threonine-protein kinase tousled-like 2	0	0	2	2
Serine/threonine-protein kinase 32C	0	0	2	2
Serine/threonine-protein kinase pim-3	0	0	2	2
Serine/threonine-protein kinase VRK2	0	0	2	2
Myosin light chain kinase family member 4	0	0	2	2
Homeodomain-interacting protein kinase 1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1D	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	2	2
Serine/threonine-protein kinase BRSK2	0	0	2	2
Serine/threonine-protein kinase NIM1	0	0	2	2
Serine/threonine-protein kinase ULK2	0	0	2	2
Serine/threonine-protein kinase DCLK2	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	2	2
Casein kinase I isoform alpha-like	0	0	2	2
Homeodomain-interacting protein kinase 4	0	0	2	2
Myosin-IIIa	0	0	2	2
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	2	2
Serine/threonine-protein kinase Nek11	0	0	2	2
Serine/threonine-protein kinase BRSK1	0	0	2	2
Serine/threonine-protein kinase 35	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	2	2
Rhodopsin kinase GRK7	0	0	2	2
Serine/threonine-protein kinase 32A	0	0	2	2
Myosin-IIIb	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	2	2
Cyclin-dependent kinase-like 2	0	0	2	2
Serine/threonine-protein kinase Sgk3	0	0	2	2
Atypical kinase COQ8B, mitochondrial	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	3	3
Cyclin-dependent kinase 15	0	0	2	2
SRSF protein kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO2	0	0	2	2
Cyclin-dependent kinase 19	0	0	2	2
Transient receptor potential cation channel subfamily M member 6	0	0	2	2
Testis-specific serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase 33	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	2	2
Homeodomain-interacting protein kinase 2	0	0	2	2
Tyrosine-protein kinase Srms	0	0	2	2
Homeodomain-interacting protein kinase 3	0	0	2	2
Serine/threonine-protein kinase PLK3	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	2	2
Serine/threonine-protein kinase Nek6	0	0	2	2
SNF-related serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase LATS2	0	0	2	2
Serine/threonine-protein kinase 36	0	0	2	2
Serine/threonine-protein kinase 32B	0	0	2	2
Serine/threonine-protein kinase PLK2	0	0	2	2
Serine/threonine-protein kinase MARK1	0	0	2	2
Serine/threonine-protein kinase pim-2	0	0	2	2
Serine/threonine-protein kinase PAK 5	0	0	2	2
eIF-2-alpha kinase GCN2	0	0	2	2
Phosphatidylinositol 4-kinase beta	0	0	2	2
Serine/threonine-protein kinase 17A	0	0	2	2
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	2	2
Ephrin type-A receptor 6	0	0	2	2
Death-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase tousled-like 1	0	0	2	2
ALK tyrosine kinase receptor	0	0	2	2
SRSF protein kinase 3	0	0	2	2
Cyclin-dependent kinase 11A	0	0	2	2
Aurora kinase C	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	2	2
Microtubule-associated serine/threonine-protein kinase 1	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	3	3
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Albumin	0	1	4	7
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Alpha-1B adrenergic receptor	0	7	0	7
Substance-K receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Alpha-1A adrenergic receptor	0	7	0	7
Thromboxane-A synthase	0	0	0	1
Genome polyprotein	0	1	0	1
Protease	0	4	2	8
Protease	0	2	1	3
Protease	0	1	0	1
regulator of G-protein signaling 4	5	0	0	5
Parkin	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
serine/threonine-protein kinase PLK1	3	0	0	3
DNA polymerase eta isoform 1	5	0	0	5
Ornithine decarboxylase	0	0	0	2
Adenosine receptor A3	0	6	0	6
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
Cellular retinoic acid-binding protein 1	0	0	2	2
Olfactory receptor 51E2	0	1	0	1
Cereblon isoform 4	0	4	0	4
Bromodomain-containing protein 4	0	1	0	1
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Protein cereblon	0	6	2	11
Zinc finger protein Aiolos	0	0	1	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
15-lipoxygenase, partial	7	0	0	7
Large neutral amino acids transporter small subunit 1	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Tumor necrosis factor	0	1	0	1
Neuraminidase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	3	0	3
Cystathionine gamma-lyase	0	2	0	2
Caspase-7	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Cystine/glutamate transporter	0	1	0	1
Hydroxyacid oxidase 1	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	7
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase beta	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
nonstructural protein 1	5	0	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	5	5
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Stromelysin-1	0	1	1	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
WRN	2	0	0	2
DNA polymerase III, partial	1	0	0	1
hypothetical protein, conserved	2	0	0	2
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
pyruvate kinase	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
phospholipase A2, group III	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
interferon gamma precursor	0	0	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
protein AF-9 isoform a	0	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
Vpr	2	0	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Amyloid-beta precursor protein	1	1	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Ornithine decarboxylase	1	0	0	2
Angiotensin-converting enzyme	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Guanine nucleotide-binding protein G	3	0	0	3
Casein kinase II subunit beta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
Single-stranded DNA cytosine deaminase	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
phosphoglycerate kinase	2	0	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Alpha-synuclein	2	2	0	4
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	3
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	1	1	0	2
Caspase-1	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Caspase-9	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Acetylcholinesterase	0	2	0	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Cytochrome P450 2B6	0	2	1	3
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Protein kinase C zeta type	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Dual specificity testis-specific protein kinase 2	0	0	2	2
Target of rapamycin complex subunit LST8	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
NS5	0	0	1	1
RNA-directed RNA polymerase	0	1	2	4
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
MPI protein	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
galactokinase	1	0	0	1
protein-arginine deiminase type-4	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
DNA repair and recombination protein RAD54-like	0	0	1	1
Sentrin-specific protease 6	0	1	0	1
Sentrin-specific protease 2	0	1	0	1
Sentrin-specific protease 1	0	1	0	1
Protein-arginine deiminase type-1	0	1	0	1
Protein-arginine deiminase type-3	0	1	0	1
Protein-arginine deiminase type-2	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Adenylate kinase isoenzyme 1	0	0	0	1
Capsid protein	0	0	1	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Apoptosis regulator Bcl-2	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Bcl-2-like protein 1	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Cytochrome P450 2C8	0	2	0	2
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	1	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Tubulin alpha-1A chain	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, orotidine 5'-monophosphate decarboxylase	0	1	0	1
Chain B, orotidine 5'-monophosphate decarboxylase	0	1	0	1
Chain A, orotidine 5'-monophosphate decarboxylase	0	1	0	1
Chain A, orotidine monophosphate decarboxylase	0	1	0	1
Chain A, orotidine monophosphate decarboxylase	0	1	0	1
Chain B, orotidine monophosphate decarboxylase	0	1	0	1
Chain B, PyrR bifunctional protein	0	0	1	1
Orotidine 5'-phosphate decarboxylase	0	1	0	1
Uridine 5'-monophosphate synthase	0	1	0	1
Orotidine 5'-phosphate decarboxylase	0	1	0	1
Protein argonaute-2	0	0	1	1
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
pyruvate kinase PKM isoform a	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
DNA polymerase beta	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (375)

Protein Targets (1,453)

Castleman Disease

Synonyms(1)

Research Excerpts

Overview

Research

Studies (375)

Drugs Studied (116)

Protein Targets (1,453)