cavidine profile

cavidine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	193148
CHEMBL ID	453544
MeSH ID	M0057297

Synonym
cavidine
CHEMBL453544
(+)-cavidine
32728-75-9
9-dimethoxy-6-methyl-6,6a,11,14-tetrahydro-8,12h-benzo(a)-1,3-benzodioxolo(4,5-g)quinolizine
AKOS032946015
(12s,13r)-16,17-dimethoxy-12-methyl-5,7-dioxa-1-azapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaene
DTXSID00954392
8,9-dimethoxy-6-methyl-6,11,12,14-tetrahydro-2h,6ah-[1,3]dioxolo[4,5-h]isoquinolino[2,1-b]isoquinoline

Research Excerpts

Overview

Cavidine is an isoquinoline alkaloid. It is isolated from Corydalis impatiens.

Excerpt	Reference	Relevance
"Cavidine is an isoquinoline alkaloid which is isolated from Corydalis impatiens. "	( Anti-inflammatory effects of cavidine in vitro and in vivo, a selective COX-2 inhibitor in LPS-induced peritoneal macrophages of mouse. Li, W; Mu, Q; Niu, X; Wang, Y; Yao, H; Zhang, H, 2015)	2.15

Treatment

Excerpt	Reference	Relevance
"Cavidine pre-treatment also ameliorated the contents of malonaldehyde (MDA) and myeloperoxidase (MPO) activity, and increased the mucosa levels of glutathione (GSH), superoxide dismutase (SOD) and prostaglandin E2 (PGE2), relative to the model group."	( Anti-ulcerogenic effect of cavidine against ethanol-induced acute gastric ulcer in mice and possible underlying mechanism. He, Z; Li, W; Liu, F; Niu, X; Wang, X; Wang, Y; Zhang, H; Zhi, W, 2016)	1.45

Bioavailability

Excerpt	Reference	Relevance
" Although the absorption rate constants of dehydrocavidine in duodenum and jejunum are more than that in ileum and colon, there is no significance difference between them."	( [Absorption kinetics of dehydrocavidine in rats' stomachs and intestines]. Chen, M; Feng, J; Jin, C; Liu, X, 2009)	0.89

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (25.00)	29.6817
2010's	9 (75.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	7.11	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
hydroxyproline Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.	2.06	1	4-hydroxyproline; L-alpha-amino acid zwitterion	human metabolite; mouse metabolite; plant metabolite
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	7.06	1	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.06	1	dialdehyde	biomarker
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.13	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	2.52	2	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent

Condition	Relationship Strength	Studies
Lung Injury, Acute [description not available]	2.15	1
Innate Inflammatory Response [description not available]	2.15	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.15	1
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	7.15	1
Cognition Disorders Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.	2.17	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.54	2
Age-Related Memory Disorders [description not available]	2.17	1
Memory Disorders Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.	2.17	1
Colitis Gravis [description not available]	2.11	1
Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.	2.11	1
Endotoxin Shock [description not available]	2.13	1
Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	2.13	1
Gastric Ulcer [description not available]	7.13	1
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	2.13	1
Abnormalities, Autosome [description not available]	2.05	1
Injury, Ischemia-Reperfusion [description not available]	2.05	1
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.05	1
Acute Liver Injury, Drug-Induced [description not available]	2.46	2
Cirrhosis, Liver [description not available]	2.06	1
Weight Reduction [description not available]	2.06	1
Liver Cirrhosis Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.	2.06	1
Weight Loss Decrease in existing BODY WEIGHT.	2.06	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.46	2
Carbon Tetrachloride Poisoning Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.	2.04	1

Assay ID	Title	Year	Journal	Article
AID400829	Spasmolytic activity against guinea pig ileum assessed as inhibition of spasmogen-induced contraction at 10 ug
AID400864	Spasmolytic activity in isolated guinea pig ileum assessed as spasmogen-induced inhibition of smooth muscle contraction
AID400863	Spasmolytic activity in isolated guinea pig ileum assessed as spasmogen-induced inhibition of smooth muscle contraction at 10 ug
AID400862	Spasmolytic activity in isolated guinea pig ileum assessed as spasmogen-induced inhibition of smooth muscle contraction at 10 ug
AID400830	Spasmolytic activity against guinea pig ileum assessed as inhibition of spasmogen-induced contraction at 50 ug
AID400831	Spasmolytic activity against guinea pig ileum assessed as inhibition of spasmogen-induced contraction
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

cavidine

Description

Cross-References

Synonyms (9)

Research Excerpts

Overview

Treatment

Bioavailability

Bioassays (6)

Research

Studies (12)

Market Indicators

Research Demand Index: 26.51

Study Types

cavidine

Description

Cross-References

Synonyms (9)

Research Excerpts

Overview

Treatment

Bioavailability

Bioassays (6)

Research

Studies (12)

Market Indicators

Research Demand Index: 26.51

Study Types

Related Drugs (6)

Related Conditions (24)