Steatitis

A disease of cats and mink characterized by a marked inflammation of adipose tissue and the deposition of ceroid pigment in the interstices of the adipose cells. It is believed to be caused by feeding diets containing too much unsaturated fatty acid and too little vitamin E. (Merck Veterinary Manual, 5th ed; Stedman, 25th ed)

Synonym
Steatitis

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	20 (51.28)	23.3326
1990's	5 (12.82)	12.5806
2000's	9 (23.08)	18.1394
2010's	5 (12.82)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
pyridoxine	low	1
urea	low	1
carprofen	low	1
valproic acid	low	1
gentamicin	low	1
isoniazid	low	1
stearic acid	low	1
prednisolone	low	2
sorbitol	low	1
ethinyl estradiol	low	1
thiazoles	low	1
betamethasone	low	1
nandrolone	low	1
fluorobenzenes	low	1
d-alpha tocopherol	low	11
cetylpyridinium chloride anhydrous	low	1
ursodeoxycholic acid	low	1
sudan black b	low	1
taurohyodeoxycholic acid	low	1
aflatoxin b1	low	1
oleic acid	low	1
cocaine	low	1
sodium taurodeoxycholate	low	1
bilirubin	low	1
selenium	low	5
mocetinostat	low	1
oxadiazoles	low	1
acid phosphatase	low	2
mobic	low	1

Protein Targets (380)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
pregnane X receptor	3	0	0	3
GLI family zinc finger 3	9	0	0	9
AR protein	11	0	0	11
progesterone receptor	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
glucocorticoid receptor [Homo sapiens]	8	0	0	8
estrogen-related nuclear receptor alpha	9	0	0	9
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	5	0	0	5
estrogen nuclear receptor alpha	13	0	0	13
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
IDH1	2	0	0	2
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
thyroid hormone receptor beta isoform a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	7	0	7
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	10	0	10
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glutamate receptor 2	5	0	0	5
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Canalicular multispecific organic anion transporter 1	0	5	0	5
ORF73	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, Cruzipain	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
USP1 protein, partial	5	0	0	5
Microtubule-associated protein tau	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
vitamin D3 receptor isoform VDRA	3	0	0	3
DNA polymerase kappa isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	4	0	0	4
Caspase-7	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, Beta-lactamase	3	0	0	3
Luciferase	6	0	0	6
RAR-related orphan receptor gamma	9	0	0	9
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
nonstructural protein 1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	4	0	0	4
67.9K protein	4	0	0	4
peroxisome proliferator-activated receptor delta	6	0	0	6
peroxisome proliferator activated receptor gamma	6	0	0	6
activating transcription factor 6	5	0	0	5
histone deacetylase 9 isoform 3	1	0	0	1
geminin	9	0	0	9
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Complement C5	0	0	1	1
Cellular tumor antigen p53	7	0	0	7
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Chain A, Ferritin light chain	1	0	0	1
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
TDP1 protein	7	0	0	7
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
caspase-3	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
thyroid hormone receptor beta isoform 2	4	0	0	4
heat shock protein beta-1	4	0	0	4
mitogen-activated protein kinase 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
survival motor neuron protein isoform d	1	0	0	1
Caspase-2	0	0	1	1
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	2	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
interleukin 8	1	0	0	1
Fumarate hydratase	1	0	0	1
PPM1D protein	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
G	3	0	0	3
polyprotein	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vpr	1	0	0	1
peripheral myelin protein 22	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Estrogen receptor	0	4	1	5
Sex hormone-binding globulin	0	0	2	2
Aldo-keto reductase family 1 member B1	0	3	0	3
Cytochrome P450 3A4	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Adenosine receptor A3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Androgen receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Cytochrome P450 2B6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Adenosine receptor A2a	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor ROR-gamma	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
GABA theta subunit	2	0	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
Estrogen receptor beta	0	3	1	4
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
cytochrome P450 2C9, partial	3	0	0	3
ATP-dependent phosphofructokinase	1	0	0	1
Histone H2A.x	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
GLS protein	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	1	0	1
Bile salt export pump	0	3	0	3
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	2	0	2
Macrophage migration inhibitory factor	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
alpha-galactosidase	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cytochrome P450 2D6	1	0	0	1
Histone deacetylase 3	0	4	0	4
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 5	0	3	0	3
Nuclear receptor corepressor 2	0	1	0	1
thioredoxin reductase	2	0	0	2
glucocerebrosidase	1	0	0	1
chromobox protein homolog 1	5	0	0	5
Solute carrier family 22 member 1	0	1	0	1
Corticosteroid-binding globulin	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
ATAD5 protein, partial	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Fatty acid-binding protein, liver	0	0	1	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Coagulation factor VII	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Aromatase	0	1	0	1
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	2	1	3
Protein kinase C alpha type	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Fatty acid-binding protein 5	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	2	3
Rap guanine nucleotide exchange factor 4	1	0	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	1	0	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Pyridoxal kinase	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Ileal sodium/bile acid cotransporter	0	2	0	2
G-protein coupled bile acid receptor 1	0	0	3	3
flap endonuclease 1	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Acetylcholinesterase	0	2	0	2
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
Alpha-synuclein	2	0	0	2
C-terminal-binding protein 1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Vitamin D3 receptor	0	1	1	2
Guanine nucleotide-binding protein G	1	0	0	1
Sodium/bile acid cotransporter	0	1	0	1
Bile acid receptor	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Polyamine deacetylase HDAC10	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 9	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research

Studies (39)

Protein Targets (380)

Steatitis

Synonyms(1)

Research

Studies (39)

Drugs Studied (43)

Protein Targets (380)