Compounds > antileukinate
Page last updated: 2024-12-11

antileukinate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID9876474
SCHEMBL ID22597782
MeSH IDM0304752

Synonyms (8)

Synonym
antileukinate
138559-60-1
AKOS027250749
(2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-5-(diamino
ac-arg-arg-trp-trp-cys-arg-nh2
SCHEMBL22597782
CS-0092315
HY-125567

Research Excerpts

Treatment

Antileukinate protected mice against acute pancreatitis and associated lung injury. Anti-chemokine therapy may be of value in this condition.

ExcerptReferenceRelevance
"Antileukinate-treated Tg mice had significantly decreased pulmonary inflammation and oxidative stress compared to Antileukinate-treated WT mice (p < 0.05) or Antileukinate-non-treated Tg mice (p < 0.05)."( Synergistic protection against hyperoxia-induced lung injury by neutrophils blockade and EC-SOD overexpression.
Ahmed, MN; Codipilly, CN; Miller, EJ; Min, JH; Nasim, S, 2012)		1.82
"Treatment with antileukinate protected mice against acute pancreatitis and associated lung injury, showing thereby that anti-chemokine therapy may be of value in this condition."( Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury.
Bhatia, M; Hegde, A, 2007)		1.03

Dosage Studied

ExcerptRelevanceReference
" Because the role of activated neutrophils in the development of allograft rejection is believed to be biphasic, we used specific CXC receptor inhibition with antileukinate in 2 dosing regimens."( Prevention of neutrophil migration ameliorates rat lung allograft rejection.
Higuchi, T; Hirayama, S; Miller, EJ; Shiraishi, T; Shirakusa, T, )		0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's7 (70.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.98 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.47 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		7.0110
sb 225002
[no description available]		3.110nitrophenol
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		2.0310aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
interleukin-8
Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.		2.420
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Listeria
[description not available]		02.0710
Hyperoxia
An abnormal increase in the amount of oxygen in the tissues and organs.		02.0710
Chronic Lung Injury
[description not available]		02.0710
Acute Respiratory Distress Syndrome
[description not available]		02.7130
Respiratory Distress Syndrome
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.		02.7130
Eosinophilia, Tropical
[description not available]		02.0110
Innate Inflammatory Response
[description not available]		02.4220
Eosinophilia
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.		02.0110
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.4220
Blood Poisoning
[description not available]		02.4220
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0210
Bleeding
[description not available]		02.0210
Hemorrhage
Bleeding or escape of blood from a vessel.		02.0210
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.		02.4220
Experimental Lung Inflammation
Inflammation of any part, segment or lobe, of the lung parenchyma.		02.0210
Pneumonia
Infection of the lung often accompanied by inflammation.		02.0210
Disease, Pulmonary
[description not available]		02.0310
Acute Edematous Pancreatitis
[description not available]		02.0310
Lung Diseases
Pathological processes involving any part of the LUNG.		02.0310
Pancreatitis
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.		07.0310
Adenocarcinoma, Basal Cell
[description not available]		0210
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		0210