pyrroxamycin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

pyrroxamycin: isolated from Streptomyces sp. S46506; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	129138
CHEBI ID	188711
MeSH ID	M0151621

Synonyms (24)

Synonym
(-)-2,3-dichloro-5-(6,8-dichloro-4h-1,3-benzodioxin-4-yl)-4-nitro-1h-pyrrole
al-r2081
1h-pyrrole, 2,3-dichloro-5-(6,8-dichloro-4h-1,3-benzodioxin-4-yl)-4-nitro-, (-)-
ll-f42248-alpha
4,5-dichloro-2-(6',8'-dichloro-4'-h-1,3-benzodioxin-4'-yl)-3-nitropyrrole
pyrroxamycin
from streptomyces mg796-af7
nsc619798
nsc-619798
dioxapyrrolomycin
105888-54-8
CHEBI:188711
2,3-dichloro-5-[(4s)-6,8-dichloro-4h-1,3-benzodioxin-4-yl]-4-nitro-1h-pyrrole
2,3-dichloro-5-(6,8-dichloro-4h-1,3-benzodioxin-4-yl)-4-nitro-1h-pyrrole
unii-v9axn5h81t
v9axn5h81t ,
2,3-dichloro-5-((4s)-6,8-dichloro-4h-1,3-benzodioxin-4-yl)-4-nitro-1h-pyrrole
ss-46506a
1h-pyrrole, 2,3-dichloro-5-((4s)-6,8-dichloro-4h-1,3-benzodioxin-4-yl)-4-nitro-
antibiotic al-r 2081
ll-f 42248.alpha.
Q27291695
DTXSID601140134
AKOS040749253

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
benzodioxine	Any organic heterobicyclic compound containing ortho-fused benzene and dioxine rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (33.33)	18.7374
1990's	2 (22.22)	18.2507
2000's	3 (33.33)	29.6817
2010's	1 (11.11)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	2.03	1	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	3.6	9	pyrrole; secondary amine
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2.05	1	dihydrogen
substance p [no description available]	1.97	1	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent
chlorfenapyr chlorfenapyr: an experimental pour-on formulation, a new generation pyrethroid available to producers. chlorfenapyr : A member of the class of pyrroles that is 4-bromo-1H-pyrrole-3-carbonitrile which is substituted at positions 1, 2 and 5 by ethoxymethyl, p-chlorophenyl and trifluoromethyl groups, respectively. A proinsecticide used for termite control and crop protection against several insects and mite pests.	2.1	1	hemiaminal ether; monochlorobenzenes; nitrile; organochlorine acaricide; organochlorine insecticide; organofluorine acaricide; organofluorine insecticide; pyrroles	proacaricide; proinsecticide
pyrrolomycin c pyrrolomycin C: from Streptomyces strain SF-2080; structure given in first source	2.02	1
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	1.97	1	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent
tln 4601 diazepinomicin: an alkaloid from the culture of a marine actinomycete of the genus Micromonospora; structure in first source	2.05	1	dibenzodiazepine; farnesane sesquiterpenoid; olefinic compound; secondary amine; triol	antineoplastic agent; antioxidant; cathepsin L (EC 3.4.22.15) inhibitor
pyrethrins [no description available]	2.1	1

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