Page last updated: 2024-09-28

Congo Virus Infection

A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).

Synonyms(6)

Synonym
Crimean-Congo Hemorrhagic Fever
Crimean-Congo Haemorrhagic Fever
Hemorrhagic Fever, Crimean
Congo Virus Infection
Infection, Congo Virus
Congo-Crimean Hemorrhagic Fever

Research Excerpts

Research

Studies (176)

TimeframeStudies, This Condition (%)All Conditions %
pre-19909 (5.11)23.3326
1990's3 (1.70)12.5806
2000's37 (21.02)18.1394
2010's103 (58.52)28.8240
2020's24 (13.64)9.53
DrugIndicatedRelationship StrengthStudiesTrials
n(g),n(g')-dimethyl-l-arginine0low10
creatine0low10
ether0low10
metformin0low10
saccharin0low10
tilorone0medium11
tranexamic acid0low10
prednisolone0low10
idoxuridine0low10
alanine0low10
leucine0low10
chloroform0low10
dithionitrobenzoic acid0low10
arginine0low10
methylprednisolone0medium31
acridines0medium22
pyrazines0low50
malondialdehyde0low10
deoxycytidine0low10
ribavirin0medium1045
10-carboxymethyl-9-acridanone0medium22
fibrinogen0low40
2'-fluoro-2'-deoxycytidine0low10
n,n-dimethylarginine0low10
umifenovir0low10
deoxycholic acid0low10
favipiravir0low60
amphotericin b0low10
phenylephrine hydrochloride0low10
flumethrin0low10
mocetinostat0low20
clove0low20
cytochrome c-t0low10
natriuretic peptide, c-type0low10
endothelin-10low30
interleukin-80low10
tigecycline0low20
calca protein, human0low10
sybr green i0low10
pyrethrins0low10
exudates0low10
neopterin0low10
ridostin0medium11

Protein Targets (322)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, Ferritin light chain3003
acid sphingomyelinase1001
thioredoxin reductase5005
hypoxia-inducible factor 1 alpha subunit4004
SMAD family member 21001
SMAD family member 31001
TDP1 protein100010
GLI family zinc finger 35005
AR protein8008
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor5005
glucocorticoid receptor [Homo sapiens]6006
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha3003
farnesoid X nuclear receptor4004
estrogen nuclear receptor alpha110011
G3003
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
alpha-galactosidase4004
euchromatic histone-lysine N-methyltransferase 26006
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Stimulator of interferon genes protein0011
chromobox protein homolog 15005
thyroid hormone receptor beta isoform 24004
heat shock protein beta-11001
importin subunit beta-1 isoform 12002
flap endonuclease 14004
snurportin-12002
nuclear factor erythroid 2-related factor 2 isoform 16006
GTP-binding nuclear protein Ran isoform 11001
geminin110011
peripheral myelin protein 224004
Trypsin0001
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 3003
Cellular tumor antigen p537007
TAR DNA-binding protein 433003
Stimulator of interferon genes protein0011
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
Deoxycytidine kinase0002
Cytidine deaminase0002
Microtubule-associated protein tau2002
Smad32002
aldehyde dehydrogenase 1 family, member A12002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)3003
DNA topoisomerase 2-alpha0001
Acetylcholinesterase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Carbonic anhydrase 10102
Carbonic anhydrase 20102
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0101
Proton-coupled amino acid transporter 10304
Adenosine deaminase0001
Carbonic anhydrase 40001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Cruzipain1001
interleukin 83003
phosphopantetheinyl transferase2002
GLS protein2002
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA1001
lamin isoform A-delta107007
Cytochrome P450 1A20101
Cytochrome P450 3A40203
Cytochrome P450 2D60202
Cytochrome P450 2C9 0202
Cytochrome P450 2C190202
Nuclear receptor ROR-gamma3003
Potassium voltage-gated channel subfamily H member 20202
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
NFKB1 protein, partial2002
thyroid stimulating hormone receptor3003
cytochrome P450 2C19 precursor2002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0102
Nitric oxide synthase, brain 0102
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase2002
Luciferase2002
RAR-related orphan receptor gamma7007
estrogen-related nuclear receptor alpha100010
Histone H2A.x4004
Voltage-dependent calcium channel gamma-2 subunit4004
Glutamate receptor 24004
Sodium- and chloride-dependent creatine transporter 10101
Chain A, STEROID DELTA-ISOMERASE0011
nuclear factor erythroid 2-related factor 2 isoform 24004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Steroid Delta-isomerase0011
Vitamin D3 receptor0112
Ileal sodium/bile acid cotransporter0101
G-protein coupled bile acid receptor 10011
Bile acid receptor0011
Thymidine kinase 2 0101
Probable deoxycytidylate deaminase0001
AAA family ATPase 0001
Reverse transcriptase/RNaseH 0011
Thymidylate kinase0101
Ribonuclease T0001
Cell death-related nuclease 40001
Endothelin-1 receptor0101
Thymidine kinase 0101
67.9K protein1001
Vpr2002
Thymidine kinase, cytosolic0101
Thymidine phosphorylase0001
Thymidine kinase0001
ATPase family AAA domain-containing protein 53003
Ataxin-24004
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Large neutral amino acids transporter small subunit 10101
Phospholipase A-2-activating protein0101
[tau protein] kinase 0101
Glycogen synthase kinase-3 alpha0101
Glycogen synthase kinase-3 beta0101
EWS/FLI fusion protein4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
histone acetyltransferase KAT2A isoform 11001
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Bile salt export pump0606
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10001
Canalicular multispecific organic anion transporter 10606
Multidrug and toxin extrusion protein 10101
acetylcholinesterase2002
PPM1D protein2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 11001
pregnane X nuclear receptor4004
bromodomain adjacent to zinc finger domain 2B2002
IDH13003
nuclear receptor subfamily 1, group I, member 22002
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor04110
Glycine receptor subunit alpha-10404
Androgen receptor0303
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 family 3 subfamily A polypeptide 43003
cytochrome P450 2D61001
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Histone deacetylase 40101
Histone deacetylase 10202
Histone deacetylase 70101
Histone deacetylase 20202
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
arylsulfatase A2002
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10102
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
Chain A, 2-oxoglutarate Oxygenase2002
glp-1 receptor, partial2002
GALC protein1001
thyroid stimulating hormone receptor3003
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 11001
lysosomal alpha-glucosidase preproprotein2002
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Spike glycoprotein1012
luciferase0001
aryl hydrocarbon receptor2002
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
NS5 0011
Thrombopoietin1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
peripheral myelin protein 22 isoform 11001
glycogen synthase kinase-3 beta isoform 10011
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Transmembrane protease serine 20011
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Rap guanine nucleotide exchange factor 31001
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30101
Replicase polyprotein 1ab0112
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Adenosylhomocysteinase0002
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Adenosine receptor A2a0101
Gamma-aminobutyric acid receptor subunit alpha-61001
Adenosine receptor A10101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Adenosine receptor A10101
Genome polyprotein0011
GABA theta subunit1001
Angiotensin-converting enzyme 2 0011
Gamma-aminobutyric acid receptor subunit epsilon1001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
thyroid hormone receptor beta isoform a1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Carbonic anhydrase 120101
Cholinesterase0101
Carbonic anhydrase 30101
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Alpha-1D adrenergic receptor0101
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0101
Alpha-1A adrenergic receptor0101
Carbonic anhydrase 70101
Carbonic anhydrase0101
Taste receptor type 2 member 310011
Disintegrin and metalloproteinase domain-containing protein 171001
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 90101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
RmtA0101
Protein arginine N-methyltransferase 10101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
Fumarate hydratase2002
polyprotein2002
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase kappa isoform 11001
Neuronal acetylcholine receptor subunit beta-20011
Neuronal acetylcholine receptor subunit beta-40011
Neuronal acetylcholine receptor subunit alpha-30011
Neuronal acetylcholine receptor subunit alpha-70011
Neuronal acetylcholine receptor subunit alpha-40011
DNA primase0101
Neuronal acetylcholine receptor subunit alpha-70011
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Plasminogen0213
Urokinase-type plasminogen activator0101
Chain A, Beta-lactamase1001
apical membrane antigen 1, AMA11001
Glycoprotein hormones alpha chain1001
Hemagglutinin0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]