Mucopolysaccharidosis IV

Genetic disorder of mucopolysaccharide metabolism characterized by skeletal abnormalities, joint instability, development of cervical myelopathy, and excessive urinary keratan sulfate. There are two biochemically distinct forms, each due to a deficiency of a different enzyme.

Synonym
Mucopolysaccharidosis IV

Excerpt	Reference
"Morquio syndrome (mucopolysaccharidosis IV) is a hereditary lysosomal storage disease characterized by dwarfism, spondyloepiphyseal and dental abnormalities, corneal opacification, and normal intelligence."	( Green, WR; Iwamoto, M; Matalon, R; Maumenee, IH; Nawa, Y; Young-Ramsaran, J, 1990)
"Mucopolysaccharidosis IVA is a lysosomal storage disorder leading to an increase in glycosaminoglycans storage."	( Biancini, GB; Burin, M; Deon, M; Fracasso, R; Garcia, SC; Giugliani, L; Giugliani, R; Goethel, G; Negretto, GW; Ribas, G; Vargas, CR, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	139 (60.70)	23.3326
1990's	16 (6.99)	12.5806
2000's	19 (8.30)	18.1394
2010's	43 (18.78)	28.8240
2020's	12 (5.24)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	1	0
hydrogen	low	1	0
methanol	low	1	0
inositol	low	1	0
toluene	low	1	0
aspirin	low	1	0
bupivacaine	low	1	0
cetylpyridinium	low	2	0
fentanyl	low	2	0
flumazenil	low	1	0
isoflurane	low	1	0
2-propanol	low	2	0
ketamine	low	1	0
ono 1078	low	1	0
temazepam	low	1	0
thymidine	low	1	0
hydroxyproline	low	1	0
thyroxine	low	1	0
aldosterone	low	1	0
estrone	low	1	0
triiodothyronine	low	1	0
serine	low	5	0
aspartic acid	low	2	0
glutamine	low	1	0
lysine	low	1	0
galactose	low	11	0
tyrosine	low	2	0
methylene blue	low	1	0
histidine	low	1	0
threonine	low	4	0
tryptophan	low	1	0
arginine	low	2	0
carbazole	low	1	0
boric acid	low	1	0
phosphoadenosine phosphosulfate	low	1	0
galactitol	low	1	0
durapatite	low	3	0
fucose	low	4	0
fluorescein-5-isothiocyanate	low	1	0
mannose	low	2	0
argon	low	1	0
acetylglucosamine	low	3	0
galactosamine	low	4	0
galactose	low	4	0
trolamine salicylate	low	4	0
1-deoxynojirimycin	low	7	0
cetylpyridinium chloride anhydrous	low	1	0
acetylgalactosamine	low	8	0
fomesafen	low	1	0
thomsen-friedenreich antigen	low	1	0
5-bromo-4-chloro-3-indolyl beta-galactoside	low	1	0
metaperiodate	low	1	0
nojirimycin	low	1	0
4-methylumbelliferyl sulfate	low	1	0
fibrinogen	low	1	0
dityrosine	low	1	0
1,9-dimethylmethylene blue	low	1	0
xylose	low	1	0
ezetimibe	low	1	0
galactose 6-sulfate	low	1	0
n-acetylglucosaminitol	low	1	0
n-acetylgalactosaminitol	low	1	0
angiotensin ii	low	1	0
migalastat	low	5	0
valienamine	low	2	0
leupeptins	low	1	0
glycogen	low	1	0
glucosamine	low	8	0
elastin	low	3	0
n-acetyllactosamine	low	1	0
n-acetylglucosamine-6-sulfate	low	1	0
metrizamide	low	1	0
retinol	low	1	0
keratan sulfate	medium	55	8
isofagomine	low	3	0
bromochloroacetic acid	medium	8	1
thiopental	low	1	0
dermatan sulfate	low	8	0
psychosine	low	1	0
hymecromone	low	2	0
genistein	low	1	0
gallium	low	1	0
cysteine	low	2	0
staurosporine	low	1	0
n-octyl-beta-valienamine	low	3	0
mocetinostat	low	1	0
g(m2) ganglioside	low	1	0
g(m1) ganglioside	low	6	0
acid phosphatase	low	3	0
glycolipids	low	3	0
chondroitin	low	40	0
heparitin sulfate	low	9	0
g(m3) ganglioside	low	1	0
hyaluronoglucosaminidase	low	7	0
chondroitin sulfates	low	18	0
exudates	low	1	0
deoxyguanosine	low	1	0
8-hydroxy-2'-deoxyguanosine	low	1	0
eye	low	1	0

Protein Targets (736)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
glucocerebrosidase	8	0	0	8
Alpha-mannosidase	0	2	0	2
alpha-galactosidase	5	0	0	5
Trehalase	0	1	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	5	0	5
Trehalase	0	1	0	1
Lysosomal acid glucosylceramidase	0	3	0	4
Alpha-galactosidase A	0	2	0	2
Alpha-glucosidase MAL62	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Lysosomal alpha-glucosidase	0	3	0	3
Beta-glucosidase A	0	2	0	2
Sucrase-isomaltase, intestinal	0	3	0	3
Alpha-1B adrenergic receptor	0	2	0	2
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Beta-glucosidase	0	2	0	2
Protein-lysine 6-oxidase	0	2	0	2
Alpha-mannosidase 2	0	1	0	1
Glycogen debranching enzyme	0	2	0	2
Glycogen debranching enzyme	0	2	0	2
Alpha-glucosidase MAL32	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Oligo-1,6-glucosidase IMA1	0	1	0	1
Alpha-glucosidase MAL12	0	2	0	2
Oxysterols receptor LXR-beta	0	2	0	2
Spike glycoprotein	6	0	0	6
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	2	0	2
Lactase-phlorizin hydrolase	0	3	0	3
Oxysterols receptor LXR-alpha	0	2	0	2
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	2	0	2
Lysosomal acid glucosylceramidase	0	2	0	2
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	3	0	3
Putative alpha-glucosidase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	15	0	0	15
GLI family zinc finger 3	10	0	0	10
AR protein	18	0	0	18
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	12	0	0	12
estrogen nuclear receptor alpha	21	0	0	21
peroxisome proliferator-activated receptor delta	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
activating transcription factor 6	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	8	0	0	8
thyroid hormone receptor beta isoform a	7	0	0	7
heat shock protein beta-1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
lamin isoform A-delta10	15	0	0	15
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Glutamate receptor 2	8	0	0	8
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	4
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	2	0	3
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
glucocorticoid receptor [Homo sapiens]	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
geminin	11	0	0	11
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	4	0	4
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Guanine nucleotide-binding protein G	2	0	0	2
DNA polymerase kappa isoform 1	8	0	0	8
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	12	0	0	12
phosphopantetheinyl transferase	8	0	0	8
NFKB1 protein, partial	2	0	0	2
GLS protein	6	0	0	6
thyroid stimulating hormone receptor	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
cytochrome P450 2C19 precursor	4	0	0	4
chromobox protein homolog 1	9	0	0	9
flap endonuclease 1	10	0	0	10
DNA polymerase iota isoform a (long)	8	0	0	8
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Ferritin light chain	7	0	0	7
arylsulfatase A	6	0	0	6
Bloom syndrome protein isoform 1	9	0	0	9
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	6	0	12
Carbonic anhydrase 2	0	6	1	13
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	0	6
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	0	6
Glutamate receptor ionotropic, NMDA 2B	0	3	0	6
Glutamate receptor ionotropic, NMDA 2C	0	3	0	6
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	3	0	6
Glutamate receptor ionotropic, NMDA 3B	0	3	0	6
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
hypothetical protein, conserved	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
EWS/FLI fusion protein	8	0	0	8
estrogen-related nuclear receptor alpha	16	0	0	16
cytochrome P450 2D6	6	0	0	6
Rac1 protein	0	0	1	1
IDH1	5	0	0	5
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	7
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	10	0	10
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	2	1	0	3
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	1	0	3
Adenosine receptor A2a	0	2	0	4
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	4	1	9
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
thyroid hormone receptor beta isoform 2	13	0	0	13
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
thyroid stimulating hormone receptor	4	0	0	4
Cellular tumor antigen p53	13	0	0	13
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Luciferase	6	0	0	6
ClpP	2	0	0	2
progesterone receptor	12	0	0	12
pregnane X nuclear receptor	12	0	0	12
aryl hydrocarbon receptor	7	0	0	7
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
histone deacetylase 9 isoform 3	3	0	0	3
TDP1 protein	15	0	0	15
Smad3	2	0	0	2
67.9K protein	5	0	0	5
interferon gamma precursor	0	0	0	1
Alpha-synuclein	2	2	0	4
acetylcholinesterase	5	0	0	5
SMAD family member 2	6	0	0	6
USP1 protein, partial	7	0	0	7
SMAD family member 3	6	0	0	6
Microtubule-associated protein tau	6	0	0	6
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	9	0	0	9
farnesoid X nuclear receptor	7	0	0	7
peroxisome proliferator activated receptor gamma	14	0	0	14
caspase-3	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
vitamin D3 receptor isoform VDRA	4	0	0	4
mitogen-activated protein kinase 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	5	0	0	5
survival motor neuron protein isoform d	6	0	0	6
Caspase-2	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
dopamine D1 receptor	2	0	0	2
regulator of G-protein signaling 4	2	0	0	2
hexokinase-4 isoform 1	3	0	0	3
glucokinase regulatory protein	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
M-phase phosphoprotein 8	4	0	0	4
Thymidine kinase, cytosolic	0	3	0	6
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
endonuclease IV	2	0	0	2
ATAD5 protein, partial	5	0	0	5
GALC protein	3	0	0	3
nonstructural protein 1	1	0	0	1
G	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
peripheral myelin protein 22 isoform 1	4	0	0	4
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	3	1	8
Rap guanine nucleotide exchange factor 3	3	0	0	3
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Estrogen receptor	0	4	2	7
Steryl-sulfatase	0	1	0	1
Aromatase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 1	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit delta	4	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-2	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-5	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-3	4	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-2	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-4	4	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-3	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-6	4	3	1	8
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	3	2	5
5-hydroxytryptamine receptor 2B	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	4	3	1	8
Gamma-aminobutyric acid receptor subunit beta-2	4	3	1	8
Mu-type opioid receptor	0	2	1	3
TAR DNA-binding protein 43	5	0	0	5
Cytochrome P450 1B1	0	1	0	1
GABA theta subunit	4	3	1	8
Inositol hexakisphosphate kinase 1	9	0	0	9
Estrogen receptor beta	0	3	2	6
Ghrelin O-acyltransferase	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	3	1	8
cytochrome P450 2C9, partial	9	0	0	9
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
neuropeptide S receptor isoform A	3	0	0	3
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
ATP-dependent translocase ABCB1	0	1	1	2
D(2) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	1	3
cytochrome P450 2D6 isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Bile salt export pump	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
5-hydroxytryptamine receptor 1A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
Beta-galactosidase	0	4	0	4
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
acid sphingomyelinase	2	0	0	2
glp-1 receptor, partial	3	0	0	3
BRCA1	1	0	0	1
15-lipoxygenase, partial	5	0	0	5
PPM1D protein	3	0	0	3
Thrombopoietin	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
Neuraminidase	0	1	0	1
Parkin	1	0	0	1
P53	1	0	0	1
pyruvate kinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
DNA polymerase beta	3	0	0	3
ras-related protein Rab-9A	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
peripheral myelin protein 22	6	0	0	6
pyruvate kinase PKM isoform b	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Steroid hormone receptor ERR2	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Pancreatic triacylglycerol lipase	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Transthyretin	0	2	0	4
Glucocorticoid receptor	0	0	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Androgen receptor	0	2	0	3
Sialidase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Tyrosinase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Cyclin-dependent kinase 4	0	1	0	1
Ornithine decarboxylase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	4
Protein kinase C alpha type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Cruzipain	0	3	0	3
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	4	0	4
Sodium-dependent serotonin transporter	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Tyrosine-protein kinase CSK	0	1	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
Tyrosine-protein kinase SYK	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Histamine H2 receptor	2	0	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Cytoplasmic tyrosine-protein kinase BMX	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
MO15-related protein kinase Pfmrk	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Aldehyde oxidase	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Dipeptidyl peptidase 3	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
Sialidase-2	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	4
Chain A, Glutamine Binding Protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	3	0	3
Amino acid transporter	0	3	0	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	2	0	5
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	1	0	4
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 4	0	2	0	5
Carbonic anhydrase 6	0	1	0	4
Carbonic anhydrase 5A, mitochondrial	0	2	0	5
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 7	0	1	0	4
Carbonic anhydrase	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	3	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	3	0	6
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 15	0	1	0	4
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	1	0	4
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
Proton-coupled amino acid transporter 1	0	2	0	2
caspase-1 isoform alpha precursor	2	0	0	2
Acetylcholinesterase	0	3	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Genome polyprotein	0	1	0	1
Caspase-7	2	0	0	2
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Cholinesterase	0	3	0	3
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Oleandomycin glycosyltransferase	0	0	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Amyloid-beta precursor protein	0	3	0	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Translocator protein	0	1	0	1
Fatty-acid amide hydrolase 1	1	1	0	2
Beta-galactosidase	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
transcriptional regulator ERG isoform 3	2	0	0	2
Alpha-mannosidase 2C1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase eta isoform 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	3
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
Fumarate hydratase	2	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
polyprotein	2	0	0	2
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
huntingtin isoform 2	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Vpr	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Sodium-dependent noradrenaline transporter	0	0	1	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Beta-galactosidase	0	1	0	1
Alpha-galactosidase	0	2	0	2
Beta-galactosidase	0	1	0	1
Beta-galactosidase	0	1	0	1
Alpha-galactosidase C	0	1	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, SusD homolog	0	0	1	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Galectin-1	0	0	1	1
Galectin-3	0	0	1	1
Galectin-7	0	0	1	1
Glucoamylase, intracellular sporulation-specific	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Cysteinyl leukotriene receptor 1	0	1	0	1
Bile acid receptor	0	1	1	2
Cysteinyl leukotriene receptor 2	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Chain A, NUCLEOSIDE DIPHOSPHATE KINASE	0	0	1	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Chain A, Cruzipain	1	0	0	1
pregnane X receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	3
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	2	0	2
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Translocator protein	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
apical membrane antigen 1, AMA1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Endolysin	0	0	1	1
Prothrombin	0	0	1	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Hsf1 protein	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (229)

Protein Targets (736)

Mucopolysaccharidosis IV

Synonyms(1)

Research Excerpts

Overview

Research

Studies (229)

Drugs Studied (117)

Protein Targets (736)