Page last updated: 2024-09-28

Encephalitis, Saint Louis

A viral encephalitis caused by the St. Louis encephalitis virus (ENCEPHALITIS VIRUS, ST. LOUIS), a FLAVIVIRUS. It is transmitted to humans and other vertebrates primarily by mosquitoes of the genus CULEX. The primary animal vectors are wild birds and the disorder is endemic to the midwestern and southeastern United States. Infections may be limited to an influenza-like illness or present as an ASEPTIC MENINGITIS or ENCEPHALITIS. Clinical manifestations of the encephalitic presentation may include SEIZURES, lethargy, MYOCLONUS, focal neurologic signs, COMA, and DEATH. (From Adams et al., Principles of Neurology, 6th ed, p750)

Synonyms(10)

Synonym
Encephalitis, St. Louis
Encephalitis, Saint Louis
Meningoencephalitis, St. Louis
St. Louis Meningoencephalitis
St. Louis Encephalitis
Saint Louis Encephalitis
St. Louis Viral Encephalitis
Lethargic Encephalitis, Type C
Encephalitis, Viral, St. Louis
Type C Lethargic Encephalitis

Research Excerpts

Research

Studies (30)

TimeframeStudies, This Condition (%)All Conditions %
pre-199022 (73.33)23.3326
1990's0 (0.00)12.5806
2000's5 (16.67)18.1394
2010's3 (10.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetone0low10
formaldehyde0low10
glycerol0low10
mercaptoethanol0low10
malathion0low20
metyrapone0low10
thymidine0low10
prednisone0low10
lysine0low10
uridine0low20
leucine0low20
cycloheximide0low10
pyrazines0low10
mannose0low10
streptomycin0low10
magnesium sulfate0low10
glutamic acid0low10
ribavirin0low10
dactinomycin0low20
thioguanine anhydrous0low20
lithium0low10
morphine0low10
arsenic0low10
mocetinostat0low10
pituitrin0low10
kaolinite0low10
acyclovir0low10

Protein Targets (482)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
TDP1 protein110011
glucocorticoid receptor [Homo sapiens]6006
estrogen-related nuclear receptor alpha8008
thyroid hormone receptor beta isoform 28008
lamin isoform A-delta107007
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain2002
Thymidine kinase 0203
thioredoxin reductase3003
phosphopantetheinyl transferase5005
GLS protein4004
Smad34004
thyroid stimulating hormone receptor2002
EWS/FLI fusion protein4004
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 28008
activating transcription factor 66006
Histone H2A.x6006
Bloom syndrome protein isoform 12002
hemoglobin subunit beta2002
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
Solute carrier family 22 member 1 0102
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Solute carrier family 22 member 60001
Bile salt export pump0202
Bile salt export pump0808
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0205
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0202
Cytochrome P450 2J20202
Disintegrin and metalloproteinase domain-containing protein 173003
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60001
Thymidine kinase 0101
Solute carrier family 22 member 80001
Canalicular multispecific organic anion transporter 10303
Thymidine kinase0102
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
interleukin 84004
glp-1 receptor, partial3003
pregnane X receptor2002
RAR-related orphan receptor gamma5005
ATAD5 protein, partial3003
Fumarate hydratase2002
USP1 protein, partial3003
PPM1D protein3003
GLI family zinc finger 38008
AR protein9009
aldehyde dehydrogenase 1 family, member A19009
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor4004
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha5005
farnesoid X nuclear receptor5005
estrogen nuclear receptor alpha8008
polyprotein2002
67.9K protein3003
P531001
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
RPL19A0011
IDH13003
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Spike glycoprotein0022
Replicase polyprotein 1ab0022
NPC intracellular cholesterol transporter 1 precursor2002
cellular tumor antigen p53 isoform a2002
chromobox protein homolog 16006
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 24004
nuclear factor NF-kappa-B p105 subunit isoform 12002
ras-related protein Rab-9A2002
heat shock protein HSP 90-alpha isoform 20001
nuclear factor erythroid 2-related factor 2 isoform 17007
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
nuclear receptor ROR-gamma isoform 13003
transactivating tegument protein VP16 [Human herpesvirus 1]0101
geminin6006
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 15005
COUP transcription factor 2 isoform a0101
lethal factor (plasmid)1001
Gamma-aminobutyric acid receptor subunit pi5005
Transmembrane protease serine 20022
Glucose transporter0101
Voltage-dependent calcium channel gamma-2 subunit4004
Hexose transporter 1 0101
Interferon beta6006
Cellular tumor antigen p538008
Procathepsin L0022
Polyunsaturated fatty acid 5-lipoxygenase0202
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0123
Solute carrier family 2, facilitated glucose transporter member 10101
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Glutamate receptor 24217
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Alpha-synuclein1001
Nuclear receptor ROR-gamma5005
Spike glycoprotein4026
Eukaryotic initiation factor 4A-I0101
Gamma-aminobutyric acid receptor subunit alpha-15005
Peptidyl-prolyl cis-trans isomerase FKBP1A0202
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
TAR DNA-binding protein 431001
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Hypoxia-inducible factor 1-alpha0101
GABA theta subunit5005
ATPase family AAA domain-containing protein 52002
Ataxin-24004
Endothelial PAS domain-containing protein 10101
Angiotensin-converting enzyme 2 0022
Gamma-aminobutyric acid receptor subunit epsilon5005
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
heat shock protein 90, putative0001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, Cruzipain1001
15-lipoxygenase, partial2002
hypoxia-inducible factor 1 alpha subunit3003
Microtubule-associated protein tau1001
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
cytochrome P450 family 3 subfamily A polypeptide 46006
pregnane X nuclear receptor5005
caspase-31001
RAD510101
Caspase-71001
vitamin D3 receptor isoform VDRA6006
caspase-31001
huntingtin isoform 21001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
peripheral myelin protein 223003
caspase-1 isoform alpha precursor1001
ATP-dependent translocase ABCB10204
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-71001
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
regulator of G-protein signaling 44004
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0404
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Carbonic anhydrase 10001
Carbonic anhydrase 20001
Integrin beta-31012
Integrin alpha-IIb1012
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, NMDA 1 0213
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0213
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0213
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0213
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Large neutral amino acids transporter small subunit 10101
Proton-coupled amino acid transporter 10102
Phospholipase A-2-activating protein0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
potassium voltage-gated channel subfamily H member 2 isoform d2002
Cationic amino acid transporter 30101
Luciferase2002
acetylcholinesterase2002
G3003
cytochrome P450 2D62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
heat shock protein beta-11001
histone acetyltransferase KAT2A isoform 12002
HLA class I histocompatibility antigen, B alpha chain 3003
Carboxylic ester hydrolase 0101
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
ATP-dependent phosphofructokinase3003
transcriptional regulator ERG isoform 32002
DNA polymerase kappa isoform 11001
Alpha-mannosidase 2C10101
Fucose-binding lectin PA-IIL0101
CD209 antigen0101
Glutaminyl-peptide cyclotransferase0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
GALC protein2002
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Cytochrome P450 1A20101
Cytochrome P450 3A40516
Cytochrome P450 2C80101
Cytochrome P450 2D60303
Aromatase0101
Cytochrome P450 11B1, mitochondrial 0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Cytochrome P450 2C190303
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Histone deacetylase 40101
Potassium voltage-gated channel subfamily H member 20606
Histone deacetylase 10202
Histone deacetylase 70101
Histone deacetylase 20202
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
Opioid receptor, delta 1b 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30303
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0415
Muscarinic acetylcholine receptor M20303
Translocator protein0011
Histidine decarboxylase0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0102
Delta-type opioid receptor0214
Kappa-type opioid receptor0214
Mu-type opioid receptor0216
Kappa-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0214
Kappa-type opioid receptor0202
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10303
5-hydroxytryptamine receptor 3E0101
lysosomal alpha-glucosidase preproprotein1001
mitogen-activated protein kinase 11001
FAD-linked sulfhydryl oxidase ALR0001
5-hydroxytryptamine receptor 40404
5-hydroxytryptamine receptor 3B0101
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40606
5-hydroxytryptamine receptor 1A0112
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50606
Muscarinic acetylcholine receptor M10528
Glucose-6-phosphate 1-dehydrogenase0202
Polyunsaturated fatty acid lipoxygenase ALOX150202
Angiotensin-converting enzyme0303
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0303
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0404
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0101
Muscarinic acetylcholine receptor M30404
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Alpha-2C adrenergic receptor0101
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Sodium-dependent noradrenaline transporter 0314
Adenosine receptor A10101
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0415
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0101
Histamine H1 receptor0213
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0303
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60202
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0303
Inositol monophosphatase 12002
Sigma non-opioid intracellular receptor 10101
Transporter0101
Nuclear receptor subfamily 3 group C member 3 0303
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
Transporter0202
dopamine D1 receptor1001
cytochrome P450 2D6 isoform 11001
D(1A) dopamine receptor2002
muscarinic acetylcholine receptor M12002
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor DM10101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor0101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M20101
thioredoxin glutathione reductase1001
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
NS5 0011
Thrombopoietin1001
alpha-galactosidase1001
peripheral myelin protein 22 isoform 11001
glycogen synthase kinase-3 beta isoform 10011
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Rap guanine nucleotide exchange factor 33003
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0011
Adenosine receptor A30303
Adenosylhomocysteinase0002
Adenosine receptor A2a0101
Adenosine receptor A10101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Adenosine receptor A10101
Genome polyprotein0011
Chain A, Beta-lactamase1001
nonstructural protein 12002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
Aldo-keto reductase family 1 member B10202
Transcriptional activator protein LuxR0101
Sodium-dependent dopamine transporter0101
D(1B) dopamine receptor0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Melanocortin receptor 50202
D(1A) dopamine receptor1001
Sodium-dependent dopamine transporter 0213
Envelope glycoprotein0011
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Protein-arginine deiminase type-40202
Chain A, JmjC domain-containing histone demethylation protein 3A1001
PAX80001
apical membrane antigen 1, AMA11001
hypothetical protein, conserved1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Hypoxanthine-guanine phosphoribosyltransferase0001
Apoptosis regulator Bcl-20101
Prostaglandin G/H synthase 10101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Mitogen-activated protein kinase 3 0101
Xanthine dehydrogenase/oxidase0101
Bcl-2-like protein 10101
Thymidine kinase0102
Thymidylate synthase0001
Thymidine phosphorylase0001
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Chain A, Cytidine Deaminase0101
DNA polymerase iota isoform a (long)1001
Sodium/nucleoside cotransporter 10202
Sodium/nucleoside cotransporter 20202
Cytidine deaminase0101
Equilibrative nucleoside transporter 20202
Protein cereblon0202
Equilibrative nucleoside transporter 10202
Uridine-cytidine kinase 1 0001
Solute carrier family 28 member 30202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]