| Assay ID | Title | Year | Journal | Article |
|---|
| AID1065630 | Inhibition of HDAC4 in human Jurkat E6.1 cells using Boc-Lys-Ac as substrate incubated for 2 hrs prior to substrate addition measured after 3 hrs by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID440829 | Inhibition of class 2a HDAC in HEK293T cells after 16 hrs by whole cell assay | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1514623 | Inhibition of recombinant human HDAC6 expressed in HEK293 cells using Lys-Ac-AMC as substrate measured after 60 mins by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID1514619 | Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID1065634 | Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID1514617 | Inhibition of human C-terminal His-tagged HDAC5 catalytic domain (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID440826 | Inhibition of recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus at 20 uM after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1260646 | Inhibition of human recombinant HDAC10 at 20 uM using Boc-Lys(Ac)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID1260640 | Inhibition of human recombinant HDAC4 at 20 uM using Boc-Lys(Tfa)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID1260639 | Inhibition of human recombinant HDAC3 at 20 uM using Boc-Lys(Ac)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID1260643 | Inhibition of human recombinant HDAC7 at 20 uM using Boc-Lys(Tfa)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID1816955 | Inhibition of recombinant human HDAC8 using Boc-Lys (trifluoroacetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by micro plate reader analysis | 2021 | Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
| Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPARĪ³ and HDACs: Design, Synthesis, and Investigations of their |
| AID440828 | Inhibition of class 1 HDAC in HEK293T cells after 16 hrs by whole cell assay | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1260641 | Inhibition of human recombinant HDAC5 at 20 uM using Boc-Lys(Tfa)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID1260637 | Inhibition of human recombinant HDAC1 at 20 uM using Boc-Lys(Ac)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID440823 | Inhibition of human recombinant N-terminal FLAG-tagged HDAC7 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1065636 | Inhibition of human recombinant HDAC7 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID1514618 | Inhibition of HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID1065631 | Inhibition of HDAC4 in human Jurkat E6.1 cells using Boc-Lys-TFA as substrate incubated for 2 hrs prior to substrate addition measured after 3 hrs by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID440819 | Inhibition of recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID440820 | Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID440821 | Inhibition of human recombinant N-terminal FLAG-tagged HDAC4 (612-1034) expressed in baculovirus after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1065635 | Inhibition of human recombinant HDAC9 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID440827 | Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus at 20 uM after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1260647 | Inhibition of human recombinant HDAC11 at 20 uM using Boc-Lys(Tfa)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID306827 | Inhibition of human HDAC8 by [3H]acetyl histone peptide assay | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. |
| AID1514625 | Inhibition of HDAC class 1/2b in human Jurkat cells using Boc-Lys-Ac as substrate preincubated for 2 hrs followed by substrate addition and measured after 3 hrs by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID1816954 | Inhibition of recombinant human HDAC4 using Boc-Lys (trifluoroacetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by micro plate reader analysis | 2021 | Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
| Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPARĪ³ and HDACs: Design, Synthesis, and Investigations of their |
| AID1260638 | Inhibition of human recombinant HDAC2 at 20 uM using Boc-Lys(Ac)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID1065638 | Inhibition of human recombinant HDAC4 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID1514624 | Inhibition of HDAC class 2a/HDAC8 in human Jurkat cells using Boc-Lys-TFA as substrate preincubated for 2 hrs followed by substrate addition and measured after 3 hrs by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID1065632 | Inhibition of human recombinant full length HDAC8 using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID440822 | Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1260642 | Inhibition of human recombinant HDAC6 at 20 uM using Boc-Lys(Ac)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID1514620 | Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID1065637 | Inhibition of human recombinant HDAC5 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID1514621 | Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system using Ac-Arg-Gly-Lys(Ac) as substrate measured after 60 mins by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID440825 | Inhibition of recombinant HDAC8 expressed in baculovirus after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1260645 | Inhibition of human recombinant HDAC9 at 20 uM using Boc-Lys(Tfa)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID440824 | Inhibition of recombinant N-terminal FLAG-tagged HDAC6 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
| AID1260644 | Inhibition of human recombinant HDAC8 at 20 uM using Ac-RHK(Ac)K(Ac)-AMC as substrate after 30 to 60 mins by microplate reader assay | | | |
| AID1065633 | Inhibition of human recombinant full length HDAC6 after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
| Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
| AID1514622 | Inhibition of human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | 2019 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 29, Issue:1
| Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. |
| AID1802373 | HDAC Enzyme Assay from Article 10.1074/jbc.M113.496281: \\Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.\\ | 2013 | The Journal of biological chemistry, Aug-30, Volume: 288, Issue:35
| Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |