Spotted Fever Group Rickettsiosis

A group of arthropod-borne diseases caused by spotted fever bio-group members of RICKETTSIA. They are characterized by fever, headache, and petechial (spotted) rash.

Synonym
Spotted Fever Group Rickettsiosis

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	11 (45.83)	28.8240
2020's	13 (54.17)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	2
foxes	low	2
mocetinostat	low	1
tetracycline	low	1
minocycline	low	1
exudates	low	1
rifampin	low	1

Protein Targets (243)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
GLS protein	1	0	0	1
TDP1 protein	2	0	0	2
EWS/FLI fusion protein	3	0	0	3
estrogen nuclear receptor alpha	4	0	0	4
Albumin	0	1	2	3
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Cytochrome P450 2C9	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	4	0	4
PPM1D protein	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
G	1	0	0	1
cytochrome P450 2D6	1	0	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Integrin beta-1	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
Leukotriene A-4 hydrolase	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Histone deacetylase 4	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, Cruzipain	1	0	0	1
interleukin 8	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
AR protein	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
glucocorticoid receptor [Homo sapiens]	2	0	0	2
retinoid X nuclear receptor alpha	3	0	0	3
pregnane X nuclear receptor	1	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Bile salt export pump	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Bile salt export pump	0	4	0	4
NH(3)-dependent NAD(+) synthetase	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Histamine H2 receptor	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
thioredoxin reductase	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
geminin	2	0	0	2
survival motor neuron protein isoform d	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Histone H2A.x	1	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
glp-1 receptor, partial	1	0	0	1
GLI family zinc finger 3	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
estrogen-related nuclear receptor alpha	1	0	0	1
IDH1	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
chromobox protein homolog 1	1	0	0	1
thyroid hormone receptor beta isoform 2	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
streptokinase A precursor	0	0	1	1
twin arginine protein translocation system - TatA protein	0	0	0	1
lamin isoform A-delta10	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
GABA theta subunit	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Spotted Fever Group Rickettsiosis

Synonyms(1)

Research

Studies (24)

Protein Targets (243)

Spotted Fever Group Rickettsiosis

Synonyms(1)

Research

Studies (24)

Drugs Studied (10)

Protein Targets (243)