Page last updated: 2024-12-08

absynthin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

absynthin: isolated from diferent species of the genus Artemisia; antiparasitic cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

absinthin : A dimeric sesquiterpene lactone that is produced by the plant Artemisia absinthium (Wormwood). The bitter tasting constituent of Absinthe. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
ArtemisiagenusA plant genus of the family ASTERACEAE with strong-smelling foliage. It is a source of SANTONIN and other cytotoxic TERPENES.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Artemisia absinthiumspeciesA plant species of the genus ARTEMISIA, family ASTERACEAE that has been used in ABSINTHE. The oil contains neurotoxic 1-thujone and d-isothujone.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID442138
CHEMBL ID4647301
CHEBI ID2366
SCHEMBL ID873059
MeSH IDM0204251

Synonyms (24)

Synonym
absynthin
(1r,2r,5s,8s,9s,12s,13r,14s,15s,16r,17s,20s,21s,24s)-12,17-dihydroxy-3,8,12,17,21,25-hexamethyl-6,23-dioxaheptacyclo[13.9.2.0(1,16).0(2,14).0(4,13).0(5,9).0(20,24)]hexacosa-3,25-diene-7,22-dione
CHEBI:2366
(+)-absinthin
nsc-407315
C09286
absinthin
1362-42-1
S3288
unii-oe5992o64p
oe5992o64p ,
nsc 407315
absinthiin
SCHEMBL873059
chief bitter principle of artemisia absinthium
absinthin [mi]
AC-35046
HY-N0742
CS-0009774
Q332313
DTXSID70929294
CHEMBL4647301
gtpl12458
FS-6929
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
anti-inflammatory agentAny compound that has anti-inflammatory effects.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
sesquiterpene lactoneAny member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
organic heteroheptacyclic compound
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID1663316Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced iNOS mRNA level at 10 uM incubated for 18 hrs by qRT-PCR analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663318Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as increase in cytosolic calcium level at 1 mM by Fluo-2-AM dye based fluorescence assay2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663324Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antioxidant activity by measuring reduction in PMA-induced superoxide anion generation at 10 uM preincubated for 1 hr followed by PMA addition and measured after 30 mins by cyto2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663333Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced IL-1beta gene expression at 10 uM incubated for 18 hrs by qRT-PCR analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663326Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antioxidant activity by measuring reduction in PMA-induced superoxide anion generation at 10 uM preincubated for 1 hr followed by PMA addition and measured after 30 mins in pres2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663336Agonist activity at human TAS2R46 expressed in PMA-induced human BEAS2B cells assessed as antiinflammatory activity by measuring increase in IL-4 gene expression at 1 uM incubated for 18 hrs by qRT-PCR analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663323Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced superoxide anion generation at 1 uM preincubated for 1 hr followed by PMA addition and measured after 30 mins by 2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663328Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced iNOS protein level at 10 uM incubated for 18 hrs by TRITC-phalloidin/DAPI staining based analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663334Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced IL-1beta gene expression at 1 uM incubated for 18 hrs in presence of 1 uM TAS2R46 antagonist 3HDC by qRT-PCR anal2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663317Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as effect on cytosolic calcium level at microM concentration by Fluo-2-AM dye based fluorescence assay2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663331Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced MUC5AC gene expression at 1 to 10 uM incubated for 18 hrs by qRT-PCR analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663319Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as increase in cytosolic calcium level at 1 mM in presence of 100 uM TAS2R46 antagonist 3HDC by Fluo-2-AM dye based fluorescence assay2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663330Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced MUC5AC expression at 1 uM incubated for 18 hrs by TRITC-phalloidin/DAPI staining based analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663335Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced IL-1beta gene expression at 10 uM incubated for 18 hrs in presence of 1 uM TAS2R46 antagonist 3HDC by qRT-PCR ana2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663321Effect on basal superoxide anion production in human BEAS2B cells expressing human TAS2R46 at 1 uM after 1 hr by cytochrome C reduction assay2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663325Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antioxidant activity by measuring reduction in PMA-induced superoxide anion generation at 1 uM preincubated for 1 hr followed by PMA addition and measured after 30 mins in prese2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663337Agonist activity at human TAS2R46 expressed in PMA-induced human BEAS2B cells assessed as antiinflammatory activity by measuring increase in IL-4 gene expression at 10 uM incubated for 18 hrs by qRT-PCR analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663339Agonist activity at human TAS2R46 expressed in PMA-induced human BEAS2B cells assessed as antiinflammatory activity by measuring increase in IL-10 gene expression at 10 uM incubated for 18 hrs by qRT-PCR analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663322Effect on basal superoxide anion production in human BEAS2B cells expressing human TAS2R46 at 10 uM after 1 hr by cytochrome C reduction assay2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663332Agonist activity at human TAS2R46 expressed in human BEAS2B cells assessed as antiinflammatory activity by measuring reduction in PMA-induced IL-1beta gene expression at 1 uM incubated for 18 hrs by qRT-PCR analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
AID1663338Agonist activity at human TAS2R46 expressed in PMA-induced human BEAS2B cells assessed as antiinflammatory activity by measuring increase in IL-10 gene expression at 1 uM incubated for 18 hrs by qRT-PCR analysis2020Journal of natural products, 06-26, Volume: 83, Issue:6
Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's3 (27.27)29.6817
2010's6 (54.55)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.54 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.03 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]