Page last updated: 2024-09-28

Dermatitis, Poison Ivy

An allergic contact dermatitis caused by exposure to plants of the genus Toxicodendron (formerly Rhus). These include poison ivy, poison oak, and poison sumac, all plants that contain the substance urushiol, a potent skin sensitizing agent. (From Dorland, 27th ed)

Synonyms(5)

Synonym
Dermatitis, Toxicodendron
Toxicodendron Dermatitis
Rhus Dermatitis
Dermatitis, Poison Ivy
Poison Ivy Dermatitis

Research Excerpts

Overview

ExcerptReference
"Toxicodendron dermatitis is an underappreciated disease seen in the emergency department."( Argo, KA; Herrington, JM; Lane, AQ; Luth, SK; Massey, RC; Murray, KA, 2023)

Research

Studies (140)

TimeframeStudies, This Condition (%)All Conditions %
pre-199090 (64.29)23.3326
1990's25 (17.86)12.5806
2000's16 (11.43)18.1394
2010's8 (5.71)28.8240
2020's1 (0.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dinitrochlorobenzene0low10
acetone0low10
catechol0low30
chlorine0low10
hydrochloric acid0low10
formaldehyde0low10
glycerol0medium11
iodine0low10
nickel0low60
nitrates0low10
phenol0low10
pyridine0low10
menthol0low10
afloqualone0low10
aspirin0low10
benzocaine0low10
cetyl alcohol0low10
chloral hydrate0low10
diphenhydramine0low20
hydroxyzine0low10
ibuprofen0low10
2-propanol0low10
pentoxifylline0low10
tripelennamine0low30
prednisolone0medium31
thymidine0low10
prednisone0low120
dehydroepiandrosterone0low10
ficusin0low10
fluocinolone acetonide0low20
dinitrofluorobenzene0low10
triamcinolone acetonide0low10
isoprene0low10
methylprednisolone0low30
lawsone0medium11
sym-trinitrobenzene0low10
cyclohexanol0low10
diphenhydramine hydrochloride0low10
quinazolines0low10
fluocinonide0low10
betamethasone0medium21
sodium hydroxide0low10
zinc oxide0low10
ammonium hydroxide0low10
betamethasone valerate0low10
chromium0low20
zirconium0low120
chromates0low10
aluminum sulfate0low20
phenyl acetate0low10
cetylpyridinium chloride anhydrous0low20
triamcinolone0low50
fludrocortisone0low10
alkenes0medium41
3-pentadecacatechol0medium71
delphinidin0low10
octadecyl palmitate0low10
adipostatin a0low10
3-heptadecylcatechol0medium31
cortisone0low30
tacrolimus0medium21
isomethyleugenol0low10
sesquiterpenes0low10
chlorprothixene0low10
oxazolone0low10
zinc oxide0low20
sodium dodecyl sulfate0medium51
naphthoquinones0medium11
linoleic acid0low10
hydrocortisone valerate0low10
clobetasol0medium11
beryllium0low10
phosphorus0low10
simethicone0medium11
mocetinostat0low10
calamine (pharmaceutical preparation)0low10
stearates0low10
urushiol0medium395
interleukin-80low10
chlortetracycline0low10
salicylates0low10
kaolinite0medium11

Protein Targets (504)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit110011
RAR-related orphan receptor gamma180018
GLI family zinc finger 3210021
AR protein320032
aldehyde dehydrogenase 1 family, member A1110011
retinoic acid nuclear receptor alpha variant 1220022
retinoid X nuclear receptor alpha180018
estrogen nuclear receptor alpha350035
peroxisome proliferator-activated receptor delta160016
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a220022
activating transcription factor 68008
v-jun sarcoma virus 17 oncogene homolog (avian)150015
Histone H2A.x5005
thyroid hormone receptor beta isoform a6006
heat shock protein beta-1100010
nuclear factor erythroid 2-related factor 2 isoform 1190019
lamin isoform A-delta10160016
Voltage-dependent calcium channel gamma-2 subunit110011
Glutamate receptor 2110011
TDP1 protein180018
glucocorticoid receptor [Homo sapiens]290029
estrogen-related nuclear receptor alpha260026
thyroid hormone receptor beta isoform 2190019
Prostaglandin G/H synthase 10404
Prostaglandin G/H synthase 20505
cytochrome P450 family 3 subfamily A polypeptide 4100010
aryl hydrocarbon receptor170017
Spike glycoprotein7018
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein7007
Chain B, HADH2 protein7007
Chain A, 2-oxoglutarate Oxygenase6006
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 85005
thioredoxin reductase7007
GLS protein5005
thyroid stimulating hormone receptor7007
hypothetical protein, conserved1001
EWS/FLI fusion protein3003
cytochrome P450 2D69009
glucocerebrosidase1001
Rac1 protein0011
IDH18008
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 2120012
Bloom syndrome protein isoform 13003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA polymerase iota isoform a (long)8008
DNA polymerase kappa isoform 17007
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)5005
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0303
Prostaglandin G/H synthase 2 0202
Bile salt export pump013013
Epidermal growth factor receptor0505
Carbonic anhydrase 10909
Carbonic anhydrase 20909
Fatty acid-binding protein, liver0303
Integrin beta-31102
Myeloperoxidase0101
Seed linoleate 13S-lipoxygenase-10202
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10404
Adenosine receptor A10505
Adenosine receptor A2a0404
Substance-P receptor0202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0202
Nuclear receptor ROR-gamma4004
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-17108
Prostaglandin G/H synthase 20404
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Canalicular multispecific organic anion transporter 10808
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
glp-1 receptor, partial4004
ATAD5 protein, partial7007
USP1 protein, partial110011
nuclear receptor subfamily 1, group I, member 38008
G6006
thyroid stimulating hormone receptor8008
nuclear receptor ROR-gamma isoform 16006
geminin160016
cytochrome P450 3A4 isoform 17007
Gamma-aminobutyric acid receptor subunit pi7007
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 6006
Gamma-aminobutyric acid receptor subunit beta-17007
Gamma-aminobutyric acid receptor subunit delta7007
Gamma-aminobutyric acid receptor subunit gamma-27007
Gamma-aminobutyric acid receptor subunit alpha-57007
Gamma-aminobutyric acid receptor subunit alpha-37007
Gamma-aminobutyric acid receptor subunit gamma-17007
Gamma-aminobutyric acid receptor subunit alpha-27007
Gamma-aminobutyric acid receptor subunit alpha-47007
Gamma-aminobutyric acid receptor subunit gamma-37007
Gamma-aminobutyric acid receptor subunit alpha-67007
Gamma-aminobutyric acid receptor subunit beta-37007
Gamma-aminobutyric acid receptor subunit beta-27007
TAR DNA-binding protein 437007
GABA theta subunit7007
Inositol hexakisphosphate kinase 16006
ATPase family AAA domain-containing protein 5110011
Ataxin-2130013
Gamma-aminobutyric acid receptor subunit epsilon7007
cytochrome P450 2C9, partial6006
pregnane X receptor4004
progesterone receptor170017
farnesoid X nuclear receptor100010
pregnane X nuclear receptor190019
vitamin D (1,25- dihydroxyvitamin D3) receptor130013
nuclear receptor subfamily 1, group I, member 28008
nuclear factor erythroid 2-related factor 2 isoform 28008
galanin receptor type 30101
Glucocorticoid receptor018225
Glycine receptor subunit alpha-1018018
Glycine receptor subunit beta018018
Glycine receptor subunit alpha-2018018
Glycine receptor subunit alpha-3018018
ORF730022
SMAD family member 2100010
SMAD family member 3100010
peroxisome proliferator activated receptor gamma170017
Chain A, Beta-lactamase6006
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Neutrophil gelatinase-associated lipocalin0011
endonuclease IV4004
Nrf21001
15-lipoxygenase, partial2002
NFKB1 protein, partial4004
Microtubule-associated protein tau3003
Thrombopoietin2002
thioredoxin glutathione reductase4004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)9009
estrogen receptor 2 (ER beta)6006
regulator of G-protein signaling 44004
Parkin1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a8008
NPC intracellular cholesterol transporter 1 precursor1001
peripheral myelin protein 22 isoform 15005
chromobox protein homolog 19009
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
DNA polymerase beta1001
flap endonuclease 12002
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
lethal(3)malignant brain tumor-like protein 1 isoform I1001
survival motor neuron protein isoform d5005
M-phase phosphoprotein 82002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Carbonic anhydrase 120202
Cellular tumor antigen p53170017
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30202
3-dehydroquinate synthase0102
Polyunsaturated fatty acid lipoxygenase ALOX150101
Matrix metalloproteinase-90101
Prolyl 4-hydroxylase subunit alpha-10101
Potassium-transporting ATPase subunit beta0001
Potassium-transporting ATPase alpha chain 10001
Carbonic anhydrase 40505
Carbonic anhydrase 60505
Carbonic anhydrase 5A, mitochondrial0303
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Carbonic anhydrase 70303
Histamine H2 receptor2003
D(1A) dopamine receptor1001
Autoinducer 2-binding periplasmic protein LuxP0101
E3 ubiquitin-protein ligase Mdm20101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90303
Arginase-10101
Carbonic anhydrase0202
Carbonic anhydrase 30404
Carbonic anhydrase 150404
Carbonic anhydrase 130303
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0303
phosphoglycerate kinase1001
ATP-dependent phosphofructokinase2002
Chain A, Ferritin light chain2002
acetylcholinesterase6006
caspase 7, apoptosis-related cysteine protease4004
67.9K protein3003
caspase-34004
thyrotropin-releasing hormone receptor1001
vitamin D3 receptor isoform VDRA6006
mitogen-activated protein kinase 15005
Caspase-20011
Inositol monophosphatase 13003
peripheral myelin protein 223003
Carbonic anhydrase0303
Smad35005
Snq2p0001
importin subunit beta-1 isoform 12002
snurportin-12002
Solute carrier family 22 member 1 0101
D(2) dopamine receptor0202
D(1A) dopamine receptor0101
D(1B) dopamine receptor0101
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 7 0101
Pleiotropic ABC efflux transporter of multiple drugs0102
Histamine H1 receptor0707
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 60101
5-hydroxytryptamine receptor 70101
Guanine nucleotide-binding protein G1001
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Histamine H3 receptor0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
P2Y purinoceptor 120101
Protein-arginine deiminase type-40202
dopamine D1 receptor2002
atrial natriuretic peptide receptor 1 precursor1001
Sex hormone-binding globulin0022
Corticosteroid-binding globulin0303
Potassium voltage-gated channel subfamily A member 10011
Multidrug and toxin extrusion protein 10101
Beta-glucuronidase0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0303
Alpha-synuclein2103
G-protein coupled bile acid receptor 10011
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Vascular endothelial growth factor receptor 20101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
CREB-binding protein0101
apical membrane antigen 1, AMA11001
Vpr1001
Rap guanine nucleotide exchange factor 31001
Glutathione S-transferase omega-10101
histone deacetylase 9 isoform 32002
potassium voltage-gated channel subfamily H member 2 isoform d3003
Luciferase8008
phosphopantetheinyl transferase2002
cytochrome P450 2D6 isoform 12002
huntingtin isoform 21001
5-hydroxytryptamine receptor 40202
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M10202
Cytochrome P450 2C9 0505
Angiotensin-converting enzyme0202
Muscarinic acetylcholine receptor M30202
Sodium-dependent noradrenaline transporter 0202
5-hydroxytryptamine receptor 2A0303
5-hydroxytryptamine receptor 2C0202
Histamine H1 receptor0012
5-hydroxytryptamine receptor 2B0202
Histamine N-methyltransferase0001
Cytochrome P450 2J20404
Potassium voltage-gated channel subfamily H member 20303
Sodium channel protein type 5 subunit alpha0101
Solute carrier family 22 member 10101
Nuclear receptor subfamily 3 group C member 3 0202
Calcium release-activated calcium channel protein 10101
Protein orai-20101
Protein orai-30101
Histamine H4 receptor0202
Histamine H3 receptor0001
Solute carrier family 22 member 20101
eyes absent homolog 2 isoform a1001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
Acetylcholinesterase0101
Replicase polyprotein 1a0112
Cytochrome P450 2A60101
Nuclear factor NF-kappa-B p105 subunit0101
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0303
Amine oxidase [flavin-containing] B0101
Beta-secretase 10101
GALC protein1001
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase0101
Chain A, Cruzipain2002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Alpha-1B adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Angiotensin-converting enzyme 2 0011
nonstructural protein 12002
arylsulfatase A3003
transcriptional regulator ERG isoform 31001
muscleblind-like protein 1 isoform 13003
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40101
Bile salt export pump0101
Dihydrofolate reductase0101
Albumin0112
Albumin0101
Albumin0011
Cholinesterase0202
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0102
UDP-glucuronosyltransferase 2B70002
Prostaglandin G/H synthase 10101
Caspase-10101
Prostaglandin G/H synthase 2 0102
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30202
Caspase-30101
Solute carrier organic anion transporter family member 1A10101
Caspase-40101
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Prostaglandin G/H synthase 20101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Solute carrier family 22 member 80101
Dehydrogenase/reductase SDR family member 90101
cellular tumor antigen p53 isoform a1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Dihydroorotate dehydrogenase 0101
Indoleamine 2,3-dioxygenase 10101
Genome polyprotein 0101
Protease 0101
Integrase 0101
Histone-lysine N-methyltransferase SETD70101
Cysteine protease 0101
Tyrosine-protein phosphatase non-receptor type 220101
P2X purinoceptor 70101
histone acetyltransferase KAT2A isoform 13003
Free fatty acid receptor 10011
Sterol O-acyltransferase 10101
Trypsin0101
Fatty acid-binding protein, heart0202
Coagulation factor VII0101
Aromatase0101
Tissue factor0101
Fatty acid-binding protein, adipocyte0202
Tyrosine-protein phosphatase non-receptor type 70101
Sterol O-acyltransferase 10101
Nuclear receptor subfamily 4 group A member 20011
Dual specificity protein phosphatase 30101
Fatty acid-binding protein 50101
Peroxisome proliferator-activated receptor alpha2002
Free fatty acid receptor 40011
Transient receptor potential cation channel subfamily A member 10011
Secreted chorismate mutase0101
Transient receptor potential cation channel subfamily M member 80124
Transient receptor potential cation channel subfamily A member 10011
Transient receptor potential cation channel subfamily M member 80011
PPM1D protein2002
bromodomain adjacent to zinc finger domain 2B1001
Nuclear receptor subfamily 1 group I member 20022
Androgen receptor0303
Nuclear receptor subfamily 1 group I member 20011
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Integrin beta-10101
Cytochrome P450 3A40314
Leukotriene A-4 hydrolase0101
Cytochrome P450 2D60101
Integrin alpha-40101
Cytochrome P450 2C190101
Histone deacetylase 40101
Histone deacetylase 10202
Histone deacetylase 70101
Histone deacetylase 20202
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
Sodium/iodide cotransporter0101
vasopressin V1b receptor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
relaxin receptor 1 isoform 11001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Tumor necrosis factor0101
Adenosine receptor A2b0101
Disintegrin and metalloproteinase domain-containing protein 171001
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chitotriosidase-10213
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Endochitinase B10213
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
alpha-galactosidase2002
Polyphenol oxidase 20001
Endolysin0011
Gamma-aminobutyric acid receptor subunit alpha-10011
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit gamma-20011
Cannabinoid receptor 10101
Gamma-aminobutyric acid receptor subunit beta-20011
Carbonic anhydrase 0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase 130101
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Bifunctional epoxide hydrolase 20101
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Solute carrier organic anion transporter family member 1B10101
Thymidine kinase 0102
Thymidine kinase, cytosolic0204
Thymidine kinase0102
Thymidylate synthase0001
Thymidine phosphorylase0001
Polyunsaturated fatty acid 5-lipoxygenase0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
procathepsin L isoform 1 preproprotein0101
Histamine H1 receptor0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]