negative regulation of cell migration involved in sprouting angiogenesis

Definition

Target type: biologicalprocess

Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]

Negative regulation of cell migration involved in sprouting angiogenesis is a complex process that involves the coordinated action of various signaling pathways and molecular mechanisms. It plays a crucial role in controlling the formation of new blood vessels from pre-existing ones, a process known as angiogenesis. Sprouting angiogenesis, the primary mode of angiogenesis in many tissues, involves the migration and proliferation of endothelial cells (ECs), which form the lining of blood vessels.

During sprouting angiogenesis, ECs receive signals from surrounding cells and tissues that initiate the migration process. These signals can be growth factors, such as vascular endothelial growth factor (VEGF), or other molecules that activate specific signaling pathways. The activation of these pathways leads to the expression of genes involved in cell motility, cytoskeletal remodeling, and cell adhesion.

The negative regulation of cell migration in sprouting angiogenesis is essential for maintaining the proper balance between the formation of new blood vessels and the prevention of excessive vascular growth. This regulation involves a variety of mechanisms, including:

- **Inhibition of growth factor signaling:** Several mechanisms can inhibit the signaling pathways activated by growth factors, such as VEGF, which promote EC migration. For instance, specific inhibitors can bind to and block the activity of VEGF receptors on ECs, preventing their activation.
- **Activation of anti-angiogenic factors:** Some factors, such as thrombospondin-1 (TSP-1), have anti-angiogenic properties. These factors can suppress EC migration by interfering with the formation of new blood vessels or by promoting the degradation of existing ones.
- **Modulation of cell adhesion:** Cell migration requires the controlled detachment of cells from the extracellular matrix (ECM), followed by their attachment to new locations. Negative regulators can interfere with these adhesion events, preventing EC migration.
- **Cytoskeletal regulation:** The cytoskeleton provides structural support and facilitates cell movement. Negative regulators can influence the organization and dynamics of the cytoskeleton, inhibiting EC migration.

Overall, the negative regulation of cell migration in sprouting angiogenesis ensures that new blood vessels form in a controlled and organized manner. It prevents the excessive formation of blood vessels, which can lead to various pathological conditions, including tumor growth and inflammatory diseases. This complex process involves multiple molecular mechanisms and signaling pathways, highlighting the delicate balance required for normal blood vessel formation and function.'
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Proteins (5)

Compounds (349)