Page last updated: 2024-09-28

Infectious Keratoconjunctivitis

Infectious diseases of cattle, sheep, and goats, characterized by blepharospasm, lacrimation, conjunctivitis, and varying degrees of corneal opacity and ulceration. In cattle the causative agent is MORAXELLA (MORAXELLA) BOVIS; in sheep, MYCOPLASMA; RICKETTSIA; CHLAMYDIA; or ACHOLEPLASMA; in goats, RICKETTSIA.

Synonyms(2)

Synonym
Keratoconjunctivitis, Infectious
Infectious Keratoconjunctivitis

Research Excerpts

Research

Studies (66)

TimeframeStudies, This Condition (%)All Conditions %
pre-199022 (33.33)23.3326
1990's11 (16.67)12.5806
2000's16 (24.24)18.1394
2010's14 (21.21)28.8240
2020's3 (4.55)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cytosine0low10
formaldehyde0low10
ciprofloxacin0low10
cypermethrin0low30
fenvalerate0low10
furazolidone0low20
gentamicin0medium31
hydroxyurea0low10
sulfacetamide0low10
penicillin g0low30
kanamycin a0low10
cloxacillin0low30
ampicillin0low10
acrylic acid0medium21
framycetin0low10
congo red0low10
erythromycin0low20
fluorescein0medium11
streptomycin0low10
trolamine salicylate0low10
rhamnose0low10
thiamphenicol0medium33
flucythrinate0low10
cidofovir anhydrous0low10
benzathine cloxacillin0low30
benethamine penicillin0low10
cephalosporin c0low20
enrofloxacin0low10
florfenicol0medium33
organophosphonates0low10
cortisone0low10
erythromycin estolate0low10
buprenorphine0low10
sesquiterpenes0low10
phenylephrine hydrochloride0low10
nitrofurazone0low10
beta-escin0medium11
fumagillin0low10
tulathromycin0medium11
mocetinostat0low10
ceftiofur0low20
tilmicosin0medium21
tylosin0medium21
oxytetracycline, anhydrous0medium92
quil a0medium11
pyrethrins0low30
agar0low10
hyaluronoglucosaminidase0low10
cyclosporine0low20
muramidase0low10
acyclovir0low10
ganciclovir0low10
eye0low190
quillaja saponins0medium11

Protein Targets (441)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
glucocorticoid receptor [Homo sapiens]9009
euchromatic histone-lysine N-methyltransferase 2120012
peripheral myelin protein 223003
lamin isoform A-delta108008
Choline O-acetyltransferase 0101
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, ATP-DEPENDENT DNA HELICASE Q14004
Chain A, Ferritin light chain2002
Thymidine kinase 0303
thioredoxin reductase7007
phosphopantetheinyl transferase2002
GLS protein6006
TDP1 protein140014
Smad32002
thyroid stimulating hormone receptor3003
EWS/FLI fusion protein6006
arylsulfatase A2002
activating transcription factor 64004
Histone H2A.x6006
Bloom syndrome protein isoform 15005
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Solute carrier family 22 member 1 0002
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Solute carrier family 22 member 60103
Bile salt export pump0404
Bile salt export pump016016
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20002
Cytochrome P450 2C9 0303
Cytochrome P450 2J20202
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0022
Solute carrier family 22 member 60104
Thymidine kinase 0101
Solute carrier family 22 member 80102
Canalicular multispecific organic anion transporter 10808
Thymidine kinase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, Mutant Al2 6e7p9g0011
Chain A, Beta-lactamase3003
Chain A, 2-oxoglutarate Oxygenase6006
Chain A, Cruzipain2002
Beta-lactamase 0002
acid sphingomyelinase2002
GLI family zinc finger 3110011
apical membrane antigen 1, AMA12002
retinoic acid nuclear receptor alpha variant 18008
farnesoid X nuclear receptor5005
Beta-lactamase 0002
Beta-lactamase 0002
Metallo-beta-lactamase type 20002
Metallo-beta-lactamase VIM-11 0002
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0002
Metallo-beta-lactamase0002
Beta-lactamase 0002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
chromobox protein homolog 17007
thyroid hormone receptor beta isoform 29009
DNA polymerase beta2002
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)4004
geminin100010
DNA polymerase kappa isoform 14004
Carbonic anhydrase 10101
Carbonic anhydrase 20203
60 kDa heat shock protein, mitochondrial0202
Beta-lactamase OXA-70002
Solute carrier family 15 member 10404
Solute carrier family 15 member 10101
Spike glycoprotein5005
10 kDa heat shock protein, mitochondrial0202
Angiopoietin-1 receptor0011
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20303
Thiosulfate sulfurtransferase0202
Metallo-beta-lactamase VIM-130002
Efflux transporter 0103
Beta-lactamase 0001
Beta-lactamase Toho-10002
Beta-lactamase 0103
Class D beta-lactamase0002
60 kDa chaperonin 0202
Metallo-beta-lactamase0001
Solute carrier family 15 member 20303
Beta-lactamase 0001
Beta-lactamase 0002
10 kDa chaperonin 0202
Metallo-b-lactamase 0003
Carbapenem-hydrolyzing beta-lactamase KPC0002
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0003
Beta-lactamase VIM-1 0002
ATP-dependent phosphofructokinase1001
Kappa-type opioid receptor0102
Kappa-type opioid receptor0101
estrogen nuclear receptor alpha160016
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Thymidine kinase0001
aldehyde dehydrogenase 1 family, member A18008
cytochrome P450 2C9 precursor1001
Gamma-aminobutyric acid receptor subunit pi4105
Cytochrome P450 1A20101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Cytochrome P450 3A40303
DNA gyrase subunit B0102
DNA gyrase subunit A0103
DNA gyrase subunit B0103
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
Cytochrome P450 2D60202
DNA topoisomerase 2-alpha0104
Gamma-aminobutyric acid receptor subunit beta-14105
Gamma-aminobutyric acid receptor subunit delta4105
Gamma-aminobutyric acid receptor subunit gamma-24105
Gamma-aminobutyric acid receptor subunit alpha-54105
Gamma-aminobutyric acid receptor subunit alpha-34105
DNA gyrase subunit A0102
Gamma-aminobutyric acid receptor subunit gamma-14105
Gamma-aminobutyric acid receptor subunit alpha-24105
Gamma-aminobutyric acid receptor subunit alpha-44105
Gamma-aminobutyric acid receptor subunit gamma-34105
Gamma-aminobutyric acid receptor subunit alpha-64105
Cytochrome P450 2C190202
Multidrug resistance protein MdtK0011
Histamine H2 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-14105
Gamma-aminobutyric acid receptor subunit beta-34105
Gamma-aminobutyric acid receptor subunit beta-24105
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0002
Potassium voltage-gated channel subfamily H member 20405
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
GABA theta subunit4105
Gamma-aminobutyric acid receptor subunit epsilon4105
Protein-arginine deiminase type-40303
Beta-lactamase 0102
Solute carrier family 22 member 80203
Beta-lactamase TEM0203
Luciferase2002
acetylcholinesterase4004
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma8008
AR protein110011
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 35005
cytochrome P450 family 3 subfamily A polypeptide 46006
estrogen-related nuclear receptor alpha8008
peroxisome proliferator activated receptor gamma7007
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid stimulating hormone receptor6006
v-jun sarcoma virus 17 oncogene homolog (avian)8008
B2 bradykinin receptor0101
Voltage-dependent calcium channel gamma-2 subunit3003
Dihydrofolate reductase0102
Dihydrofolate reductase0101
Chymotrypsinogen A0001
Beta-lactamase0101
Cellular tumor antigen p537007
Amyloid-beta precursor protein0202
Beta-lactamase0002
5-hydroxytryptamine receptor 2A0001
Beta-galactosidase0102
5-hydroxytryptamine receptor 1A0101
Glutamate receptor 23003
Choline O-acetyltransferase0101
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
PH domain leucine-rich repeat-containing protein phosphatase 20101
Chymotrypsin-C0101
endonuclease IV2002
dopamine D1 receptor1001
pregnane X receptor3003
progesterone receptor4004
regulator of G-protein signaling 42002
retinoid X nuclear receptor alpha7007
pregnane X nuclear receptor9009
peroxisome proliferator-activated receptor delta5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
peripheral myelin protein 22 isoform 12002
heat shock protein beta-15005
flap endonuclease 12002
nuclear factor erythroid 2-related factor 2 isoform 19009
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 14004
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M11001
Glucocorticoid receptor0202
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 433003
Multidrug and toxin extrusion protein 10303
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
G3003
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
IDH13003
Deoxycytidine kinase0001
SMAD family member 22002
USP1 protein, partial3003
SMAD family member 32002
Microtubule-associated protein tau3003
nonstructural protein 12002
bromodomain adjacent to zinc finger domain 2B2002
streptokinase A precursor0044
Motilin receptor0011
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK12002
Motilin receptor0112
Rap guanine nucleotide exchange factor 32002
30S ribosomal protein S60314
30S ribosomal protein S70314
50S ribosomal protein L150314
Albumin0011
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10202
60 kDa chaperonin0101
50S ribosomal protein L100314
50S ribosomal protein L110314
50S ribosomal protein L7/L120314
50S ribosomal protein L190314
50S ribosomal protein L10314
50S ribosomal protein L200314
50S ribosomal protein L270314
50S ribosomal protein L280314
50S ribosomal protein L290314
50S ribosomal protein L310314
50S ribosomal protein L31 type B0314
50S ribosomal protein L320314
50S ribosomal protein L330314
50S ribosomal protein L340314
50S ribosomal protein L350314
50S ribosomal protein L360314
30S ribosomal protein S100314
30S ribosomal protein S110314
30S ribosomal protein S120314
30S ribosomal protein S130314
30S ribosomal protein S160314
30S ribosomal protein S180314
30S ribosomal protein S190314
30S ribosomal protein S200314
30S ribosomal protein S20314
30S ribosomal protein S30314
30S ribosomal protein S40314
30S ribosomal protein S50314
30S ribosomal protein S80314
30S ribosomal protein S90314
50S ribosomal protein L130314
50S ribosomal protein L140314
50S ribosomal protein L160314
50S ribosomal protein L230314
30S ribosomal protein S150314
50S ribosomal protein L170314
50S ribosomal protein L210314
50S ribosomal protein L300314
50S ribosomal protein L60314
30S ribosomal protein S140314
30S ribosomal protein S170314
30S ribosomal protein S10314
50S ribosomal protein L180314
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
50S ribosomal protein L20314
50S ribosomal protein L30314
50S ribosomal protein L240314
50S ribosomal protein L40314
50S ribosomal protein L220314
50S ribosomal protein L50314
30S ribosomal protein S210314
50S ribosomal protein L250314
Cytochrome P450 1B10101
Lanosterol 14-alpha demethylase0101
50S ribosomal protein L36 20314
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Solute carrier organic anion transporter family member 1B30202
Solute carrier organic anion transporter family member 1B10202
thyroid hormone receptor beta isoform a3003
nuclear factor NF-kappa-B p105 subunit isoform 11001
transcriptional regulator ERG isoform 33003
twin arginine protein translocation system - TatA protein0001
thyrotropin-releasing hormone receptor1001
histone acetyltransferase KAT2A isoform 13003
Menin0011
Lecithin retinol acyltransferase0101
Lethal factor0101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
Methionine aminopeptidase0101
Methionine aminopeptidase 20101
Methionine aminopeptidase 10101
ClpP1001
Fumarate hydratase2002
NFKB1 protein, partial2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
polyprotein2002
Transitional endoplasmic reticulum ATPase0101
vitamin D3 receptor isoform VDRA3003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10101
Urease subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Carbonic anhydrase 40101
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Carbonic anhydrase 5A, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Urease subunit beta0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Inositol monophosphatase 11001
Gamma-aminobutyric acid receptor subunit alpha-60101
Carbonic anhydrase 90102
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
PPM1D protein1001
cytochrome P450 2D64004
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Histone deacetylase 40101
Histone deacetylase 10202
Histone deacetylase 70101
Histone deacetylase 20202
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
thioredoxin glutathione reductase2002
cellular tumor antigen p53 isoform a1001
importin subunit beta-1 isoform 12002
snurportin-12002
nuclear receptor ROR-gamma isoform 11001
Integrin beta-31001
Integrin alpha-IIb1001
Metabotropic glutamate receptor 50101
Nuclear receptor ROR-gamma1001
Snake venom metalloproteinase BaP10101
NAD(+) hydrolase SARM10202
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
WRN1001
Valosin-containing protein0101
lysosomal alpha-glucosidase preproprotein2002
microphthalmia-associated transcription factor isoform 90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
eukaryotic translation initiation factor 4E isoform 10101
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Neuronal acetylcholine receptor subunit alpha-42002
Neuronal acetylcholine receptor subunit beta-22002
Serum paraoxonase/arylesterase 10202
phosphoglycerate kinase1001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase0001
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Guanine nucleotide-binding protein G1001
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
glp-1 receptor, partial1001
GALC protein1001
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
interleukin 81001
potassium voltage-gated channel subfamily H member 2 isoform d1001
Dihydrofolate reductase 0101
Estrogen receptor0011
Estrogen receptor beta0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]