cornuside profile

cornuside: a bisiridoid glucoside from Cornus officinalis Sieb et Zucc; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Cornus	genus	A plant genus of the family CORNACEAE. It is widely cultivated for the attractive flowers.[MeSH]	Cornaceae	A plant family of the order Cornales, subclass Rosidae, class Magnoliopsida that is a loose grouping of woody ornamentals: 11 of its 14 genera have been placed in single families by some authorities. Some botanists combine members of NYSSACEAE into this family.[MeSH]
Cornus officinalis	species	[no description available]	Cornaceae	A plant family of the order Cornales, subclass Rosidae, class Magnoliopsida that is a loose grouping of woody ornamentals: 11 of its 14 genera have been placed in single families by some authorities. Some botanists combine members of NYSSACEAE into this family.[MeSH]

ID Source	ID
PubMed CID	131348
MeSH ID	M0215562

Synonym
cornuside
methyl (2r,3s,4r)-3-ethenyl-4-[2-(3,4,5-trihydroxybenzoyl)oxyethyl]-2-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2h-pyran-5-carboxylate
131189-57-6
2h-pyran-5-carboxylic acid, 3-ethenyl-2-(beta-d-glucopyranosyloxy)-3,4-dihydro-4-(2-((3,4,5-trihydroxybenzoyl)oxy)ethyl)-, methyl ester, (2s-(2alpha,3beta,4beta))-
Q-100123
cornuside-i
DTXSID20156937
cornuside i
comuside
mfcd21606970

Research Excerpts

Overview

Cornuside (CNS) is a bisiridoid glucoside compound found in the fruit of Cornus officinalis SIEB.

Excerpt	Reference	Relevance
"Cornuside (CNS) is a bisiridoid glucoside compound found in the fruit of Cornus officinalis SIEB."	( Inhibitory functions of cornuside on TGFBIp-mediated septic responses. Bae, JS; Kim, C; Kim, N; Lee, W; Ryu, SH, 2022)	1.75
"Cornuside (CN), which is a product extracted from the fruit of"	( Anti-Septic Functions of Cornuside against HMGB1-Mediated Severe Inflammatory Responses. Bae, JS; Kim, C; Kim, N; Lee, W; Ryu, SH, 2022)	1.75
"Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis SIEB. "	( Protective roles of cornuside in acute myocardial ischemia and reperfusion injury in rats. Jiang, WL; Liu, HZ; Tang, XX; Zhang, SM, 2011)	2.14
"Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. "	( Cornuside suppresses cytokine-induced proinflammatory and adhesion molecules in the human umbilical vein endothelial cells. Kang, DG; Kim, JS; Kwon, TO; Lee, AS; Lee, HS; Moon, MK, 2007)	3.23
"Cornuside is a bisiridoid glucoside compound isolated from the fruit of CORNUS OFFICINALIS Sieb. "	( Endothelial NO/cGMP-dependent vascular relaxation of cornuside isolated from the fruit of Cornus officinalis. Choi, DH; Kang, DG; Kim, JS; Kwon, JW; Kwon, TO; Lee, HS; Lee, JK; Lee, YJ; Moon, MK; Yang, SN, 2007)	2.03

Effects

Excerpt	Reference	Relevance
"Cornuside has been reported to possess immunomodulatory and anti-inflammatory activities."	( Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting nuclear factor-kappa B activation in RAW 264.7 macrophages. Choi, YH; Jin, GY; Li, GZ; Yan, GH, 2011)	2.53

Actions

Cornuside I plays a positive role in promoting osteogenic differentiation of BMSCs. Cornuside could inhibit oxidative stress and neurotransmitter hydrolases, increase ACh and monoamine neurotransmitters.

Excerpt	Reference	Relevance
"Cornuside could inhibit oxidative stress and neurotransmitter hydrolases, increase ACh and monoamine neurotransmitters, which finally contributed to its therapeutic effect on scopolamine induced amnesia."	( Cornuside ameliorates cognitive impairments in scopolamine induced AD mice: Involvement of neurotransmitter and oxidative stress. He, J; He, XL; Li, M; Lian, WW; Liu, LQ; Pan, CH; Wang, YM; Wang, ZX; Xu, JK; Zhang, WK, 2022)	2.89
"Cornuside I plays a positive role in promoting osteogenic differentiation of BMSCs, which was related with activation of PI3K/Akt signaling pathway."	( Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway. Gao, F; Wang, J; Wang, XH; Xia, SL; Zhou, XX, 2021)	3.51

Treatment

Cornuside I treatment significantly improved BMSC proliferation. Cornuside treatment attenuated tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor kappa B (NF-kappaB) p65 translocation in HUVECs.

Excerpt	Reference	Relevance
"Cornuside I treatment significantly improved BMSC proliferation. "	( Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway. Gao, F; Wang, J; Wang, XH; Xia, SL; Zhou, XX, 2021)	3.51
"Cornuside treatment inhibited the formation of liver nitrite, and reduced the overexpression of iNOS and COX-2 proteins, but restored the liver CYP2E1 content as compared with the CCl₄-treated rats."	( Protective effect of cornuside against carbon tetrachloride-induced acute hepatic injury. Choi, YH; Jin, GY; Li, GZ; Song, SZ; Yan, GH, 2011)	1.41
"Cornuside treatment attenuated tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappa B (NF-kappaB) p65 translocation in HUVECs."	( Cornuside suppresses cytokine-induced proinflammatory and adhesion molecules in the human umbilical vein endothelial cells. Kang, DG; Kim, JS; Kwon, TO; Lee, AS; Lee, HS; Moon, MK, 2007)	2.5
"Treatment with cornuside also attenuated polymorphonuclear leukocytes (PMNs) infiltration, decreased myeloperoxidase (MPO) activity in the heart, lowered serum levels of pro-inflammatory factors and reduced phosphorylated IκB-α and nuclear factor kappa B (NF-κB) levels in the heart."	( Protective roles of cornuside in acute myocardial ischemia and reperfusion injury in rats. Jiang, WL; Liu, HZ; Tang, XX; Zhang, SM, 2011)	1.03

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (4.35)	18.2507
2000's	5 (21.74)	29.6817
2010's	8 (34.78)	24.3611
2020's	9 (39.13)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (4.35%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (95.65%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	2.04	1	0	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
nitrites Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)	2.06	1	0	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species	human metabolite
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	7.06	1	0	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
galactose galactopyranose : The pyranose form of galactose.	2.6	1	0	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
furaldehyde Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.	2.04	1	0	aldehyde; furans	Maillard reaction product; metabolite
thiazoles [no description available]	2.03	1	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	5.88	21	1	D-glucopyranose	epitope; mouse metabolite
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2.03	1	0	organic bromide salt	colorimetric reagent; dye
loganin [no description available]	2.46	2	0	beta-D-glucoside; cyclopentapyran; enoate ester; iridoid monoterpenoid; methyl ester; monosaccharide derivative; secondary alcohol	anti-inflammatory agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; EC 3.4.23.46 (memapsin 2) inhibitor; neuroprotective agent; plant metabolite
imipenem, anhydrous Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.	2.05	1	0	beta-lactam antibiotic allergen; carbapenems; zwitterion	antibacterial drug
sweroside [no description available]	2.46	2	0	glycoside
5-hydroxymethylfurfural 5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.	2.04	1	0	arenecarbaldehyde; furans; primary alcohol	indicator; Maillard reaction product
iridoids Iridoids: A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).	3.23	5	0
glycosides [no description available]	2.04	1	0
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.06	1	0	prostaglandins E	human metabolite; mouse metabolite; oxytocic
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	2.05	1	0	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent
scopolamine hydrobromide [no description available]	2.41	1	0
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.41	1	0
morroniside morroniside: from Cornus officinalis; protects cultured human umbilical vein endothelial cells from damage by high ambient glucose; a component of cornel iridoid glycoside; structure in first source	2.04	1	0
cyclic gmp Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.	2.03	1	0	3',5'-cyclic purine nucleotide; guanyl ribonucleotide	Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies	Trials
Blood Poisoning [description not available]	2.52	2	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	4.41	4	1
Innate Inflammatory Response [description not available]	2.88	3	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.88	3	0
Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	7.52	2	0
Cognitive Decline [description not available]	2.9	2	0
Acute Confusional Senile Dementia [description not available]	3.23	4	0
Amnesia-Memory Loss [description not available]	2.41	1	0
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	3.23	4	0
Amnesia Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)	2.41	1	0
Cognitive Dysfunction Diminished or impaired mental and/or intellectual function.	2.9	2	0
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	7.6	1	0
Autoimmune Chronic Hepatitis [description not available]	2.6	1	0
Hepatitis, Autoimmune A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.	2.6	1	0
Injury, Ischemia-Reperfusion [description not available]	2.6	1	0
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	2.6	1	0
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.6	1	0
Allergic Encephalomyelitis [description not available]	2.31	1	0
Age-Related Osteoporosis [description not available]	2.31	1	0
Osteoporosis Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.	2.31	1	0
Aura [description not available]	3.53	1	1
Epilepsy A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)	3.53	1	1
Anaphylactic Reaction [description not available]	2.13	1	0
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	2.13	1	0
Cerebral Ischemia [description not available]	2.05	1	0
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	2.05	1	0
Cardiovascular Stroke [description not available]	2.06	1	0
Injury, Myocardial Reperfusion [description not available]	2.06	1	0
Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	2.06	1	0
Acute Liver Injury, Drug-Induced [description not available]	2.06	1	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.06	1	0

cornuside

Description

Cross-References

Synonyms (10)

Research Excerpts

Overview

Effects

Actions

Treatment

Research

Studies (23)

Market Indicators

Research Demand Index: 22.67

Study Types

cornuside

Description

Related Flora

Cross-References

Synonyms (10)

Research Excerpts

Overview

Effects

Actions

Treatment

Research

Studies (23)

Market Indicators

Research Demand Index: 22.67

Study Types

Related Drugs (20)

Related Conditions (31)