Alport Syndrome

Synonym
Hemorrhagic Hereditary Nephritis
Hereditary Nephritis
Hereditary Familial Congenital Hemorrhagic Nephritis
Hereditary Hematuria Syndrome
Alport Syndrome, Autosomal Recessive
Hereditary Interstitial Pyelonephritis
Hematuric Hereditary Nephritis
Alport Syndrome, Autosomal Dominant
Hematuria-Nephropathy-Deafness Syndrome
Hemorrhagic Familial Nephritis
Alport Syndrome, X-Linked
Alport's Syndrome
Alport Syndrome
Congenital Hereditary Hematuria
Nephritis, Familial

Excerpt	Reference
"Alport's syndrome is characterised by morphological and structural changes of the renal basement membranes."	( Bartosch, B; Lubec, G; Popow, C; Vycudilik, W, 1991)
"X-linked Alport syndrome is a hereditary glomerulonephritis in which progressive loss of kidney function is often accompanied by progressive loss of hearing."	( Atkin, CL; Barker, DF; Chow, LT; Gerken, SC; Gregory, MC; Hostikka, SL; Oliphant, AR; Skolnick, MH; Tryggvason, K; Zhou, J, 1990)
"Alport-type hereditary nephritis is a familial disorder which results in progressive renal insufficiency and sensorineural hearing loss."	( Grunfeld, JP; Lockwood, CM; Noel, L; Price, RG; Savage, CO; van den Heuvel, LP; Wong, M, 1989)
"As Alport's syndrome is probably a molecular disorder of basement membrane composition, investigation of the urine on basement membrane components might be a diagnostic aid."	( Monnens, LA; Schröder, CH; Trijbels, JM; van Lith-Zanders, HM; Veerkamp, JH, 1987)
"Alport's syndrome is characterised by progressive haematuric nephritis and high tone sensorineural hearing loss."	( Barratt, TM; Jacobs, M; Jeffrey, BG; Kriss, A; Sa, G; Taylor, D, 1994)
"Autosomal recessive Alport syndrome is a progressive hematuric glomerulonephritis characterized by glomerular basement membrane abnormalities and associated with mutations in either the COL4A3 or the COL4A4 gene, which encode the alpha3 and alpha4 type IV collagen chains, respectively."	( Antignac, C; Boye, E; Cochat, P; Cohen-Solal, L; Forestier, L; Grünfeld, JP; Gubler, MC; Heidet, L; Mollet, G; Palcoux, JB, 1998)
"Alport syndrome is a genetic disorder resulting from mutations in type IV collagen genes."	( Amatucci, A; Bovard, K; Cosgrove, D; Gardner, H; Gilroy, A; Gotwals, P; Kalluri, R; Kotelianski, V; Meehan, D; Miller, C; Rodgers, K, 2000)
"Alport syndrome is a human hereditary glomerulonephritis which results in end-stage renal failure (ESRF) in most cases."	( Andrews, KL; Li, C; Miner, JH; Mudd, JL, 2002)
"Alport syndrome is caused by mutations in type IV collagen alpha3, alpha4, and alpha5 genes."	( Kobayashi, T; Uchiyama, M, 2003)
"Alport syndrome is caused by mutations in genes encoding for the alpha3, alpha4 or alpha5 chain of type IV collagen leading to excessive production of fibrotic tissue and end-stage renal failure."	( Beirowski, B; Gross, O; Koepke, ML; Schulze-Lohoff, E; Segerer, S; Weber, M, 2007)
"Alport syndrome is a hereditary type IV collagen disease leading to progressive renal fibrosis, hearing loss and ocular changes."	( Beirowski, B; Busse, AC; Girgert, R; Gross, O; Kang, HG; Kretzler, M; Kruegel, J; Miosge, N; Müller, GA; Segerer, S; Vogel, WF; Weber, M, 2010)
"Alport syndrome is a genetic disease of collagen IV (α3, 4, 5) resulting in renal failure."	( Dietrich, W; Gapp, B; Kagan, D; Kim, M; Ksiazek, I; Kueng, B; Piaia, A; Shenoy, N; Weber, D, 2015)
"Alport syndrome is an inherited disorder characterized by the association of a progressive haematuric nephropathy with ultrastructural abnormalities of the glomerular basement membranes, a progressive sensorineural hearing loss and sometimes ocular involvement."	( Gubler, MC; Heidet, L, 2016)
"Alport syndrome is a rare hereditary renal disorder with no etiologic therapy."	( Ding, W; Goldstein, BJ; Goncalves, S; Kloosterboer, A; Lambert, G; Mendez, AJ; Ritter, P; Sabater, AL; Shehadeh, LA; Yousefi, K, 2018)
"Alport syndrome is a rare hereditary kidney disease manifested with progressive renal failure."	( Ding, F; Ding, J; Ju, W; Kretzler, M; Li, B; Nair, V; Wang, F; Xiao, H; Yao, Y; Zhang, Y, 2018)
"Alport syndrome is caused by mutations in collagen IV that alter the morphology of renal glomerular basement membrane."	( Abrahamson, DR; Caprioli, RM; Gessel, MM; Hudson, BG; Spraggins, JM; Voziyan, PA, 2019)
"Alport syndrome is a rare genetic disorder that affects as many as 60,000 persons in the USA and a total of 103,000 persons (<5 per 10,000) in the European Union [1, 2]."	( Andreoli, S; Appel, GB; Bangalore, S; Block, GA; Chapman, AB; Chertow, GM; Chin, MP; Gibson, KL; Goldsberry, A; Iijima, K; Inker, LA; Knebelmann, B; Mariani, LH; Meyer, CJ; Nozu, K; O'Grady, M; Pergola, PE; Silva, AL; Stenvinkel, P; Torra, R; Warady, BA, 2021)
"Alport syndrome is the commonest inherited kidney disease and nearly half the pathogenic variants in the COL4A3-COL4A5 genes that cause Alport syndrome result in Gly substitutions."	( Cerkauskaite, A; Chan, MMY; Deltas, C; Gale, DP; Gibson, JT; Hilbert, P; Huang, M; Lipska-Ziętkiewicz, BS; Rothe, H; Sadeghi-Alavijeh, O; Savige, J; Shenelli Croos Dabrera, M; Shukla, K; Storey, H, 2022)

Excerpt	Reference
"Five patients with Alport syndrome were enrolled and SP treatment (25 mg/day) was started."	( Iijima, K; Kaito, H; Kanda, K; Matsuo, M; Nakanishi, K; Nozu, K; Przybyslaw Krol, R; Yoshikawa, N; Yoshiya, K, 2006)
"Treatment of mice with Alport Syndrome with hydroxypropyl-β-cyclodextrin (HPβCD) reduced cholesterol content in the kidneys of mice with Alport Syndrome and protected from the development of albuminuria, renal failure, inflammation and tubulointerstitial fibrosis."	( Bryn, J; Burke, GW; Ducasa, GM; Eddy, S; Fornoni, A; Ge, M; Guzman, J; Kim, JJ; Kretzler, M; Mallela, SK; Martini, S; Mendez, AJ; Merscher, S; Mitrofanova, A; Molina, J; Morales, XA; Pastori, S; Sloan, A; Varona Santos, J; Volosenco, I; Wahl, P, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	64 (26.45)	23.3326
1990's	42 (17.36)	12.5806
2000's	48 (19.83)	18.1394
2010's	61 (25.21)	28.8240
2020's	27 (11.16)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
bromide	low	1	0
creatine	low	3	0
glycine	low	19	0
iodine	low	1	0
nitrites	low	1	0
oxalic acid	low	3	0
pyridoxine	low	2	0
uric acid	low	3	0
urea	low	4	0
amlodipine	medium	2	1
aspirin	low	1	0
azathioprine	low	2	0
bupivacaine	low	1	0
candesartan	low	1	0
carvedilol	low	1	0
clonidine	low	1	0
deferoxamine	low	1	0
fentanyl	low	1	0
furosemide	low	1	0
gentamicin	low	1	0
ethidium	low	1	0
lidocaine	low	1	0
avapro	low	1	0
losartan	medium	2	2
metformin	low	1	0
propofol	low	1	0
sorbitol	low	1	0
hydroxyproline	low	5	0
spironolactone	low	3	0
aldosterone	low	5	0
penicillamine	low	1	0
prednisone	low	3	0
alanine	low	1	0
serine	low	2	0
aspartic acid	low	1	0
glutamine	low	1	0
carbostyril	low	1	0
tyrosine	low	3	0
ficusin	medium	1	1
mannitol	low	1	0
histidine	low	1	0
arginine	low	5	0
methylprednisolone	low	3	0
3,3'-diaminobenzidine	low	1	0
thiophenes	low	2	0
3-amino-9-ethylcarbazole	low	1	0
thiamine pyrophosphate	low	2	0
isoxazoles	low	2	0
pyrazines	low	1	0
testosterone enanthate	low	1	0
oleanolic acid	medium	8	1
hematoxylin	low	1	0
eosine yellowish-(ys)	low	1	0
methylprednisolone hemisuccinate	low	1	0
dithiothreitol	low	1	0
mercury	low	1	0
gadolinium	low	1	0
tricalcium phosphate	low	1	0
clodronic acid	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
fludrocortisone	low	1	0
glutamic acid	low	1	0
ribavirin	low	1	0
diltiazem	low	1	0
ng-nitroarginine methyl ester	low	1	0
captopril	low	1	0
raloxifene hydrochloride	low	1	0
technetium tc 99m mertiatide	low	1	0
valsartan	low	1	0
fibrinogen	low	2	0
levobupivacaine	low	1	0
glucosylgalactosylhydroxylysine	low	3	0
galactosylhydroxylysine	low	3	0
proline	low	2	0
olmesartan	low	2	0
allysine	low	1	0
angiotensin ii	low	2	0
erlotinib hydrochloride	low	1	0
tbc-11251	low	2	0
potassium bromide	low	1	0
sodium bromide	low	1	0
Bardoxolone	medium	2	1
bardoxolone methyl	medium	7	2
tacrolimus	low	2	0
cerivastatin	low	1	0
cgs 27023a	low	1	0
mycophenolic acid	low	3	0
riboflavin	low	1	0
bx 471	low	1	0
glycosides	low	1	0
leuprolide	low	1	0
hydroxylysine	low	5	0
cystine	low	1	0
cathepsin g	low	1	0
calcitriol	low	1	0
vitamin d 2	low	1	0
paricalcitol	low	1	0
sirolimus	low	1	0
deamino arginine vasopressin	low	1	0
barium	low	1	0
lisinopril	low	2	0
benazepril	low	1	0
ramipril	medium	6	2
enalapril	medium	7	3
cysteine	low	4	0
oxalates	low	8	0
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid	low	1	0
i(3)so3-galactosylceramide	low	1	0
bay 12-9566	low	1	0
mocetinostat	low	1	0
tae226	low	1	0
3-hydroxyproline	low	3	0
losartan potassium	low	1	0
empagliflozin	low	2	0
indocyanine green	low	1	0
scopolamine hydrobromide	low	1	0
endothelin-1	low	4	0
ro13-9904	low	1	0
sodium ethylxanthate	low	2	0
piperidines	low	1	0
heparitin sulfate	low	3	0
warfarin	low	1	0
epidermal growth factor	low	1	0
transforming growth factor beta	low	16	0
bay 94-8862	low	1	0
globotriaosylceramide	medium	1	1
nephrin	medium	4	1
cyclosporine	medium	10	2
muramidase	medium	1	1
chondroitin sulfates	low	1	0
acyclovir	low	1	0
guanine	low	1	0
allopurinol	low	1	0
eye	low	9	0

Protein Targets (1,202)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Cytochrome P450 2C9	0	10	0	11
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
Chain A, HADH2 protein	13	0	0	13
Chain B, HADH2 protein	13	0	0	13
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, Ferritin light chain	12	0	0	12
Chain A, Cruzipain	4	0	0	4
Luciferase	10	0	0	10
acid sphingomyelinase	2	0	0	2
glp-1 receptor, partial	5	0	0	5
thioredoxin reductase	12	0	0	12
ClpP	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
RAR-related orphan receptor gamma	18	0	0	18
TDP1 protein	27	0	0	27
GLI family zinc finger 3	16	0	0	16
Microtubule-associated protein tau	11	0	0	11
AR protein	32	0	0	32
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
estrogen receptor 2 (ER beta)	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
progesterone receptor	15	0	0	15
nonstructural protein 1	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
retinoid X nuclear receptor alpha	15	0	0	15
estrogen-related nuclear receptor alpha	24	0	0	24
farnesoid X nuclear receptor	15	0	0	15
pregnane X nuclear receptor	19	0	0	19
estrogen nuclear receptor alpha	34	0	0	34
peroxisome proliferator-activated receptor delta	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
IDH1	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	25	0	0	25
aryl hydrocarbon receptor	9	0	0	9
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Histone H2A.x	10	0	0	10
hemoglobin subunit beta	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
chromobox protein homolog 1	13	0	0	13
thyroid hormone receptor beta isoform 2	18	0	0	18
histone deacetylase 9 isoform 3	3	0	0	3
heat shock protein beta-1	9	0	0	9
huntingtin isoform 2	3	0	0	3
mitogen-activated protein kinase 1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	19	0	0	19
rac GTPase-activating protein 1 isoform a	0	1	0	1
geminin	23	0	0	23
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Cellular tumor antigen p53	19	0	0	19
Glutamate receptor 2	11	3	1	15
Histamine H2 receptor	6	0	0	6
Inositol monophosphatase 1	6	0	0	6
glucocorticoid receptor [Homo sapiens]	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	18	0	0	18
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	11	0	0	11
GLS protein	8	0	0	8
Smad3	7	0	0	7
thyroid stimulating hormone receptor	8	0	0	8
EWS/FLI fusion protein	11	0	0	11
arylsulfatase A	8	0	0	8
Bloom syndrome protein isoform 1	9	0	0	9
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
lamin isoform A-delta10	19	0	0	19
Solute carrier family 22 member 1	0	6	0	8
ATP-binding cassette sub-family C member 3	0	22	0	22
Multidrug resistance-associated protein 4	0	22	0	22
Solute carrier family 22 member 6	0	2	0	3
Bile salt export pump	0	5	0	5
Bile salt export pump	0	29	0	29
Purine nucleoside phosphorylase	0	3	0	3
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2J2	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	0	0	2
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	19	0	19
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Cyclin-dependent kinase 1	0	1	1	2
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	0	3
TAR DNA-binding protein 43	5	0	0	5
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	11	0	0	11
Carbonic anhydrase 1	0	9	0	17
Carbonic anhydrase 2	0	9	0	17
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	7	2	11
Proton-coupled amino acid transporter 1	0	6	0	6
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
thyroid hormone receptor beta isoform a	6	0	0	6
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	4	2	7
Androgen receptor	0	5	0	6
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Guanine nucleotide-binding protein G	2	0	0	2
interleukin 8	4	0	0	4
transcriptional regulator ERG isoform 3	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
survival motor neuron protein isoform d	6	0	0	6
Polyphenol oxidase 2	0	1	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	1	1	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Shiga toxin subunit A	0	2	0	2
Histamine H3 receptor	0	1	0	1
G	13	0	0	13
cytochrome P450 2D6	11	0	0	11
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
nuclear receptor ROR-gamma isoform 1	11	0	0	11
histone acetyltransferase KAT2A isoform 1	11	0	0	11
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium channel subfamily K member 2	0	3	2	5
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
ATP-dependent translocase ABCB1	0	6	0	7
Alpha-2A adrenergic receptor	0	6	1	7
Alpha-2C adrenergic receptor	0	6	1	7
Alpha-2B adrenergic receptor	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	5	1	6
Alpha-1A adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 6	0	4	0	4
Spike glycoprotein	11	0	1	12
Sodium-dependent dopamine transporter	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Potassium channel subfamily K member 2	0	1	0	1
Inositol hexakisphosphate kinase 1	13	0	0	13
cytochrome P450 2C9, partial	13	0	0	13
glucocerebrosidase	5	0	0	5
DNA polymerase kappa isoform 1	7	0	0	7
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	6	4	10
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	8	0	8
Type-1 angiotensin II receptor	0	10	4	19
Type-2 angiotensin II receptor	0	7	0	7
Type-2 angiotensin II receptor	0	6	0	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
NFKB1 protein, partial	1	0	0	1
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	5	0	0	5
flap endonuclease 1	8	0	0	8
DNA polymerase iota isoform a (long)	10	0	0	10
muscarinic acetylcholine receptor M1	8	0	0	8
lethal factor (plasmid)	11	0	0	11
Cytochrome P450 3A4	0	9	0	12
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	3
Nitric oxide synthase, inducible	0	3	1	6
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	7	0	0	7
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	5	2	9
Glutamate receptor ionotropic, NMDA 2B	0	5	2	9
Glutamate receptor ionotropic, NMDA 2C	0	5	2	9
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	5	2	9
Glutamate receptor ionotropic, NMDA 3B	0	5	2	9
Glutamate receptor ionotropic, NMDA 3A	0	5	2	9
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	5	1	6
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	2	1	1	4
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	1	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Adenosine receptor A1	0	1	0	3
Adenosine receptor A2a	0	2	1	5
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	5	0	5
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	14	2	1	17
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
peroxisome proliferator activated receptor gamma	15	0	0	15
lysosomal alpha-glucosidase preproprotein	3	0	0	3
cytochrome P450 3A4 isoform 1	14	0	0	14
Gamma-aminobutyric acid receptor subunit pi	14	1	1	16
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	14	1	1	16
Gamma-aminobutyric acid receptor subunit delta	14	1	1	16
Gamma-aminobutyric acid receptor subunit gamma-2	14	1	1	16
Gamma-aminobutyric acid receptor subunit alpha-5	14	1	1	16
Gamma-aminobutyric acid receptor subunit alpha-3	14	1	1	16
Thromboxane A2 receptor	0	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	14	1	1	16
Gamma-aminobutyric acid receptor subunit alpha-2	14	1	1	16
Endothelin-1 receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	14	1	1	16
Gamma-aminobutyric acid receptor subunit gamma-3	14	1	1	16
Gamma-aminobutyric acid receptor subunit alpha-6	14	1	1	16
Gamma-aminobutyric acid receptor subunit beta-3	14	1	1	16
Gamma-aminobutyric acid receptor subunit beta-2	14	1	1	16
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Sodium/bile acid cotransporter	0	3	0	3
GABA theta subunit	14	1	1	16
Multidrug and toxin extrusion protein 1	0	9	0	9
Gamma-aminobutyric acid receptor subunit epsilon	14	1	1	16
Leukotriene B4 receptor 2	0	0	3	3
acetylcholinesterase	9	0	0	9
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	4	0	0	4
SMAD family member 3	6	0	0	6
thioredoxin glutathione reductase	6	0	0	6
polyprotein	4	0	0	4
P53	1	0	0	1
peripheral myelin protein 22 isoform 1	5	0	0	5
cellular tumor antigen p53 isoform a	3	0	0	3
peripheral myelin protein 22	7	0	0	7
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	2	0	0	2
Protein-arginine deiminase type-4	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Ghrelin O-acyltransferase	0	2	0	2
Kelch-like ECH-associated protein 1	0	0	0	1
PPM1D protein	8	0	0	8
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
Signal transducer and activator of transcription 3	0	2	0	2
Nuclear factor erythroid 2-related factor 2	0	0	2	2
Ubiquitin carboxyl-terminal hydrolase 7	0	1	0	1
Interstitial collagenase	0	4	0	4
72 kDa type IV collagenase	0	5	0	5
Stromelysin-1	0	5	0	5
Matrix metalloproteinase-9	0	5	0	5
Collagenase 3	0	4	0	4
Glucocorticoid receptor	0	7	2	9
Progesterone receptor	0	3	1	4
Androgen receptor	0	4	1	5
Angiotensin-converting enzyme	0	9	1	10
Angiotensin-converting enzyme	0	9	0	10
Liver carboxylesterase 1	0	1	0	2
Angiotensin-converting enzyme	0	5	0	5
Carbonic anhydrase 4	0	5	0	8
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase 15	0	2	0	4
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
interferon gamma precursor	0	0	0	1
C-C chemokine receptor type 1	0	2	1	3
C-C chemokine receptor type 1	0	1	1	2
C-C motif chemokine receptor 1	0	1	0	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	5	0	0	5
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	10	0	0	10
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	0	0	1
Cytochrome P450 2D6	0	3	0	3
Vitamin D3 receptor	0	1	2	5
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	4	0	4
Kappa-type opioid receptor	0	3	1	4
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Aldo-keto reductase family 1 member B1	0	6	0	6
60 kDa chaperonin	0	3	0	3
Adenosine receptor A3	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-3 adrenergic receptor	0	4	1	5
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	6	1	7
5-hydroxytryptamine receptor 1A	0	6	0	6
Sodium-dependent noradrenaline transporter	0	6	0	6
Thromboxane-A synthase	0	1	0	1
Type-1 angiotensin II receptor	0	3	1	4
Alpha-1A adrenergic receptor	0	3	1	4
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
15-lipoxygenase, partial	5	0	0	5
Thrombopoietin	2	0	0	2
Metallo-beta-lactamase type 2	0	1	1	2
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Prothrombin	0	1	1	2
Renin	0	1	0	1
Neprilysin	0	1	0	1
Neprilysin	0	2	0	2
Leukotriene A-4 hydrolase	0	3	1	4
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	4	0	4
Solute carrier family 15 member 1	0	2	0	2
Beta-lactamase TEM	0	1	0	1
Mu-type opioid receptor	0	3	1	4
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	2	1	3
Beta-lactamase class B VIM-2	0	1	1	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	2	0	5
Carbonic anhydrase 3	0	2	0	4
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 6	0	2	0	5
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
Carbonic anhydrase 7	0	2	0	5
Carbonic anhydrase 9	0	3	0	6
Carbonic anhydrase 13	0	1	0	2
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	2	0	5
Carbonic anhydrase 5B, mitochondrial	0	2	0	5
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
D(1A) dopamine receptor	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Toll-like receptor 4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
5-hydroxytryptamine receptor 4	0	4	0	4
Amyloid-beta precursor protein	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	3	0	3
D(1A) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 1B	0	4	0	4
Sodium-dependent serotonin transporter	0	2	0	2
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
D(1A) dopamine receptor	1	0	0	1
Potassium channel subfamily K member 10	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Insulin receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
67.9K protein	7	0	0	7
caspase-3	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyrotropin-releasing hormone receptor	3	0	0	3
vitamin D3 receptor isoform VDRA	5	0	0	5
Caspase-2	0	0	1	1
Chain A, STROMELYSIN-1	0	1	0	1
Chain A, COLLAGENASE 3	0	1	0	1
Lethal factor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Macrophage metalloelastase	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
regulator of G-protein signaling 4	4	0	0	4
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C9 precursor	2	0	0	2
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Alpha-1D adrenergic receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	3	0	3
Adenosine receptor A2b	0	0	1	1
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	1	0	2
Nischarin	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
apical membrane antigen 1, AMA1	2	0	0	2
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Lysine-specific demethylase 4A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	5
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Sodium/glucose cotransporter 1	0	0	1	1
Sodium/glucose cotransporter 2	0	1	1	2
endonuclease IV	2	0	0	2
Solute carrier family 15 member 1	0	1	0	1
Serine/threonine-protein kinase B-raf	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Acetylcholinesterase	0	3	0	3
Replicase polyprotein 1a	0	1	1	2
Cytochrome P450 2A6	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Acetylcholinesterase	0	1	0	1
Beta-secretase 1	0	1	0	1
GALC protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Albumin	0	1	1	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Carbonic anhydrase 13	0	1	0	3
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	4	0	4
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	4	0	4
Amino acid transporter	0	4	0	4
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Guanine deaminase	0	1	0	2
Chain E, Fibrin beta chain	0	1	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	1	0	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
luciferase	1	0	0	1
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
DNA polymerase beta	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Rap guanine nucleotide exchange factor 3	4	0	0	4
Pyruvate kinase PKM	0	1	1	2
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	1	0	2
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	2
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamine synthetase	0	1	0	1
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Squalene synthase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Platelet glycoprotein VI	0	1	3	5
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Type-1 angiotensin II receptor	0	2	1	3
Solute carrier organic anion transporter family member 1B1	0	4	0	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Inosine-5'-monophosphate dehydrogenase 2	0	2	1	3
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	2	0	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Phosphotyrosine protein phosphatase	0	1	0	1
Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]	0	0	1	1
Aldo-keto reductase family 1 member B10	0	2	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Pancreatic alpha-amylase	0	1	0	3
Phospholipase A2	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase beta	0	1	0	1
Receptor-type tyrosine-protein phosphatase C	0	1	0	1
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
DNA topoisomerase 1	0	0	0	1
DNA topoisomerase 2-alpha	0	0	1	2
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	2
Receptor-type tyrosine-protein phosphatase alpha	0	1	0	1
Receptor-type tyrosine-protein phosphatase epsilon	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
M-phase inducer phosphatase 2	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Transcription factor p65	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Env polyprotein	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Prolyl hydroxylase EGLN2	0	0	1	1
Egl nine homolog 1	0	0	1	1
Prolyl hydroxylase EGLN3	0	0	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Transmembrane prolyl 4-hydroxylase	0	0	1	1
Protease	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Cystathionine gamma-lyase	0	1	0	1
pregnane X receptor	3	0	0	3
Glutamate 5-kinase	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Pyridoxal kinase	0	0	1	2
Prolyl 4-hydroxylase, beta polypeptide	0	0	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Estrogen receptor	0	3	1	4
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Estrogen receptor	0	1	0	1
Gastric inhibitory polypeptide receptor	0	1	0	1
Estrogen receptor beta	0	1	0	1
Estrogen receptor beta	0	2	1	3
NS5	0	0	1	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
tumor necrosis factor	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
Caspase-7	1	0	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	1	3
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
Cholinesterase	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	1	1	2
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	1	1	2
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	1	1	2
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	1	1	2
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	1	1	2
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	2	1	3
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	1	1	2
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Vpr	1	0	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, FOCAL ADHESION KINASE 1	0	1	0	1
Chain A, FOCAL ADHESION KINASE 1	0	1	0	1
Chain A, FOCAL ADHESION KINASE 1	0	1	0	1
Chain A, FOCAL ADHESION KINASE 1	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
Endothelin receptor type B	0	1	0	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
eyes absent homolog 2 isoform a	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(15)

Research Excerpts

Overview

Treatment

Research

Studies (242)

Protein Targets (1,202)

Alport Syndrome

Synonyms(15)

Research Excerpts

Overview

Treatment

Research

Studies (242)

Drugs Studied (154)

Protein Targets (1,202)