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dimemorfan

Description

dimemorfan: RN given refers to parent cpd without isomeric designation; synonym At 17 refers to phosphate[1:1] salt; structure [MeSH]

dimemorfan : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	3037918
CHEMBL ID	2106325
SCHEMBL ID	499349
CHEBI ID	135048
MeSH ID	M0059769

Synonyms (33)

Synonym
dimemorfan
CHEBI:135048
dimemorfan [inn]
36309-01-0
36304-82-2
at 17
3,17-dimethylmorphinan
d-3-methyl-n-methylmorphinan
623oac38yu ,
dimemorfano [inn-spanish]
dimemorfanum [inn-latin]
einecs 252-963-3
dimemorfanum
dimemorfano
3,n-dimethylmorphinan [iupac]
(+)-3,17-dimethylmorphinan
dimemorfane [inn-french]
unii-623oac38yu
dimemorfane
dimemorphan
morphinan, 3,17-dimethyl-, (9alpha,13alpha,14alpha)-
3,n-dimethylmorphinan
n,3-dimethylmorphinan
CHEMBL2106325
dimemorfan [who-dd]
dimemorfan [mi]
SCHEMBL499349
Q5277240
DB13810
(1s,9s,10s)-4,17-dimethyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
us11535596, compound dimemorfan (dim)
bdbm587503
DTXSID301043335

Drug Classes (1)

Class	Description
morphinane alkaloid	An isoquinoline alkaloid based on a morphinan skeleton and its substituted derivatives.

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (23.81)	18.7374
1990's	1 (4.76)	18.2507
2000's	9 (42.86)	29.6817
2010's	6 (28.57)	24.3611
2020's	0 (0.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (9.09%)	5.53%
Reviews	1 (4.55%)	6.00%
Case Studies	1 (4.55%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (81.82%)	84.16%

Substance	Classes	Roles	Relationship Strength
racemethorphan	aromatic ether; morphinane alkaloid; morphinane-like compound; organic heterotetracyclic compound		low
LSM-1535	morphinane alkaloid		low
pseudomorphine	morphinane alkaloid		low
diprenorphine	morphinane alkaloid		low
buprenorphine	morphinane alkaloid	delta-opioid receptor antagonist; kappa-opioid receptor antagonist; mu-opioid receptor agonist; opioid analgesic	low
etorphine	alcohol; morphinane alkaloid	opioid analgesic; opioid receptor agonist; sedative	low
codeine	morphinane alkaloid; organic heteropentacyclic compound	antitussive; drug allergen; environmental contaminant; opioid analgesic; opioid receptor agonist; prodrug; xenobiotic	low
dihydrocodeine	morphinane alkaloid		low
hydromorphone	morphinane alkaloid; organic heteropentacyclic compound	mu-opioid receptor agonist; opioid analgesic	low
nalmefene	morphinane alkaloid		low
nalorphine	morphinane alkaloid		low
naloxone	morphinane alkaloid; organic heteropentacyclic compound; tertiary alcohol	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist	low
oxymorphone	morphinane alkaloid		low
morphine	morphinane alkaloid; organic heteropentacyclic compound; tertiary amino compound	anaesthetic; drug allergen; environmental contaminant; geroprotector; mu-opioid receptor agonist; opioid analgesic; plant metabolite; vasodilator agent; xenobiotic	low
beta-funaltrexamine	morphinane alkaloid		low
pholcodine	morphinane alkaloid; organic heteropentacyclic compound	antitussive; drug allergen; mu-opioid receptor agonist; opioid analgesic	low
thebaine	morphinane alkaloid; organic heteropentacyclic compound		low
ethylmorphine	morphinane alkaloid		low
levorphanol	morphinane alkaloid		low
metopon	morphinane alkaloid		low
levallorphan	morphinane alkaloid		low
dihydromorphine	morphinane alkaloid		low
morphine-6-glucuronide	morphinane alkaloid		low
dextrorphan	morphinane alkaloid		low
butorphanol	morphinane alkaloid	antitussive; kappa-opioid receptor agonist; mu-opioid receptor agonist; opioid analgesic	low
desomorphine	morphinane alkaloid		low
nicomorphine	morphinane alkaloid		low
salutaridine	morphinane alkaloid	anti-HBV agent; metabolite	low
sinomenine	morphinane alkaloid		low
morphinone	morphinane alkaloid		low
oripavine	ether; morphinane alkaloid; organic heteropentacyclic compound; organic hydroxy compound; tertiary amino compound	bacterial xenobiotic metabolite; opioid analgesic	low
heroin	morphinane alkaloid	mu-opioid receptor agonist; opioid analgesic; prodrug	low
neopine	morphinane alkaloid; organic heteropentacyclic compound		low
6-o-monoacetylmorphine	morphinane alkaloid		low
normorphine	morphinane alkaloid		low
morphine-3-glucuronide	morphinane alkaloid		low
naltrindole benzofuran	morphinane alkaloid		low
codeine-6-glucuronide	morphinane alkaloid		low
morphinans	isoquinoline alkaloid fundamental parent; morphinane alkaloid		low
norcodeine	morphinane alkaloid		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's
sk&f-38393	1	benzazepine; catechols; secondary amino compound		2004	2004	20.0	low	0	0	0	1	0
3-methylcholanthrene	1	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent	1984	1984	40.0	low	0	1	0	0	0
bay-k-8644	1	(trifluoromethyl)benzenes; C-nitro compound; dihydropyridine; methyl ester		2004	2004	20.0	low	0	0	0	1	0
haloperidol	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist	2004	2004	20.0	low	0	0	0	1	0
ketoconazole	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine		2005	2005	19.0	low	0	0	0	1	0
lansoprazole	1	benzimidazoles; pyridines; sulfoxide	anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor	2007	2007	17.0	low	0	0	0	1	0
orphenadrine	1	ether; tertiary amino compound	antidyskinesia agent; antiparkinson drug; H1-receptor antagonist; muscarinic antagonist; muscle relaxant; NMDA receptor antagonist; parasympatholytic	2005	2005	19.0	low	0	0	0	1	0
phenobarbital	2	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative	1984	2005	29.5	low	0	1	0	1	0
potassium chloride	1	inorganic chloride; inorganic potassium salt; potassium salt	fertilizer	2004	2004	20.0	low	0	0	0	1	0
trimeprazine	1	phenothiazines		2012	2012	12.0	low	0	0	0	0	1
carbachol	1	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic	2004	2004	20.0	low	0	0	0	1	0
phencyclidine	1	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug	2004	2004	20.0	low	0	0	0	1	0
diphenhydramine hydrochloride	9	hydrochloride; organoammonium salt	anti-allergic agent; antiemetic; antiparkinson drug; antipruritic drug; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; sedative	1983	2017	22.8	medium	1	3	1	2	3
kainic acid	1	dicarboxylic acid; L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid	antinematodal drug; excitatory amino acid agonist	2005	2005	19.0	low	0	0	0	1	0
phenazocine	2			2003	2004	20.5	low	0	0	0	2	0
tetradecanoylphorbol acetate	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator	2008	2008	16.0	low	0	0	0	1	0
glutamic acid	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical	2008	2008	16.0	low	0	0	0	1	0
pre 084	1	morpholines		2008	2008	16.0	low	0	0	0	1	0
atropine	1			2004	2004	20.0	low	0	0	0	1	0
n-formylmethionine leucyl-phenylalanine	1	tripeptide		2008	2008	16.0	low	0	0	0	1	0
norlevorphanol	1			2008	2008	16.0	low	0	0	0	1	0
codeine	1	morphinane alkaloid; organic heteropentacyclic compound	antitussive; drug allergen; environmental contaminant; opioid analgesic; opioid receptor agonist; prodrug; xenobiotic	1983	1983	41.0	low	0	1	0	0	0
dihydrocodeine	1	morphinane alkaloid		1983	1983	41.0	low	0	1	0	0	0
thebaine	1	morphinane alkaloid; organic heteropentacyclic compound		1983	1983	41.0	low	0	1	0	0	0
levorphanol	2	morphinane alkaloid		1984	1989	37.5	low	0	2	0	0	0
dextromethorphan	6	6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene	antitussive; environmental contaminant; neurotoxin; NMDA receptor antagonist; oneirogen; prodrug; xenobiotic	1983	2008	29.3	low	0	3	1	2	0
dextrorphan	1	morphinane alkaloid		1999	1999	25.0	low	0	0	1	0	0
morphinans	21	isoquinoline alkaloid fundamental parent; morphinane alkaloid		1965	2017	22.1	high	2	5	1	10	5
mocetinostat	1	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent	2008	2008	16.0	low	0	0	0	1	0
scopolamine hydrobromide	1			2003	2003	21.0	low	0	0	0	1	0
2'-hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan	2			2003	2004	20.5	low	0	0	0	2	0

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	pre-1990	2000's	2010's
Absence Seizure	0	2	2004	2005	19.5	low	0	2	0
Amnesia	0	1	2003	2003	21.0	low	0	1	0
Amnesia-Memory Loss	0	1	2003	2003	21.0	low	0	1	0
Anterior Cerebral Circulation Infarction	0	1	2008	2008	16.0	low	0	1	0
Brain Infarction	0	1	2008	2008	16.0	low	0	1	0
Brain Ischemia	0	1	2008	2008	16.0	low	0	1	0
Carcinoma, Ehrlich Tumor	0	2	1983	1984	40.5	low	2	0	0
Cerebral Ischemia	0	1	2008	2008	16.0	low	0	1	0
Chronic Disease	0	1	2007	2007	17.0	low	0	1	0
Chronic Illness	0	1	2007	2007	17.0	low	0	1	0
Complications, Pregnancy	0	1	1965	1965	59.0	low	1	0	0
Cough	1	2	2007	2015	13.0	low	0	1	1
Disease Models, Animal	0	1	2008	2008	16.0	low	0	1	0
Endotoxin Shock	0	1	2008	2008	16.0	low	0	1	0
Esophageal Reflux	0	1	2007	2007	17.0	low	0	1	0
Experimental Neoplasms	0	1	1984	1984	40.0	low	1	0	0
Gastroesophageal Reflux	0	1	2007	2007	17.0	low	0	1	0
Inflammation	0	1	2008	2008	16.0	low	0	1	0
Injury, Ischemia-Reperfusion	0	1	2008	2008	16.0	low	0	1	0
Innate Inflammatory Response	0	1	2008	2008	16.0	low	0	1	0
Placenta Accreta	0	1	1965	1965	59.0	low	1	0	0
Placenta Increta	0	1	1965	1965	59.0	low	1	0	0
Pregnancy	0	1	1965	1965	59.0	low	1	0	0
Reperfusion Injury	0	1	2008	2008	16.0	low	0	1	0
Rhinitis, Vasomotor	0	1	2007	2007	17.0	low	0	1	0
Rupture, Spontaneous	0	1	1965	1965	59.0	low	1	0	0
Sarcoma 180	0	2	1983	1984	40.5	low	2	0	0
Seizures	0	2	2004	2005	19.5	low	0	2	0
Sensitivity and Specificity	0	1	2015	2015	9.0	low	0	0	1
Shock, Septic	0	1	2008	2008	16.0	low	0	1	0
Uterine Rupture	0	1	1965	1965	59.0	low	1	0	0
Vasomotor Rhinitis	0	1	2007	2007	17.0	low	0	1	0

Pharmacokinetics (3)

Article	Year
Pharmacokinetics of dimemorfan phosphate tablets in healthy Chinese volunteers. European journal of clinical pharmacology, , Volume: 73, Issue:6	2017
Simple and sensitive LC-MS/MS-based assay for the quantification of dimemorfan in human plasma for use in a pharmacokinetic study. Biomedical chromatography : BMC, , Volume: 29, Issue:5	2015
Cytochrome P450 2D6*10 genotype affects the pharmacokinetics of dimemorfan in healthy Chinese subjects. European journal of drug metabolism and pharmacokinetics, , Volume: 40, Issue:4	2015

Dosage (2)

Article	Year
Pharmacokinetics of dimemorfan phosphate tablets in healthy Chinese volunteers. European journal of clinical pharmacology, , Volume: 73, Issue:6	2017
Cytochrome P450 2D6*10 genotype affects the pharmacokinetics of dimemorfan in healthy Chinese subjects. European journal of drug metabolism and pharmacokinetics, , Volume: 40, Issue:4	2015