Page last updated: 2024-09-27

Hereditary Autoinflammation Diseases

Hereditary inflammation conditions, characterized by recurrent episodes of systemic inflammation. Common symptoms include recurrent fever, rash, arthritis, fatigue, and secondary AMYLOIDOSIS. Hereditary autoinflammatory diseases are associated with mutations in genes involved in regulation of normal inflammatory process and are not caused by AUTOANTIBODIES, or antigen specific T-LYMPHOCYTES.

Synonyms(6)

Synonym
Hereditary Autoinflammation Diseases
Siegal-Cattan-Mamou Disease
Hereditary Periodic Fever Syndromes
Hereditary Autoinflammatory Diseases
Reimann Periodic Disease
Hereditary Recurrent Fevers

Research Excerpts

Overview

ExcerptReference
"Hereditary autoinflammatory diseases are caused by gene mutations of the innate immune pathway, e."( Bonnekoh, H; Church, MK; Ennis, S; Hofman, ZLM; Holloway, JW; Kirchner, M; Krause, K; Maas, C; Maat, S; Mahnke, NA; Maurer, M; Mertins, P; Pengelly, RJ; Scheffel, J; Wu, J, 2020)

Research

Studies (109)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's5 (4.59)18.1394
2010's67 (61.47)28.8240
2020's37 (33.94)9.53
DrugIndicatedRelationship StrengthStudiesTrials
phosphomevalonic acid0low30
uric acid0low30
alendronate0low10
azathioprine0low10
lomefloxacin0low10
pioglitazone0low10
sulfasalazine0low30
thalidomide0low10
prednisolone0low10
prednisone0low60
uridine diphosphate0low10
colchicine0medium401
arginine0low10
methylprednisolone0low10
citrulline0low10
trolamine salicylate0low230
clodronic acid0low10
simvastatin0low10
fluorodeoxyglucose f180low10
7-hydroxystaurosporine0low10
methotrexate0low10
pheophorbide a0low10
bradykinin0low10
mevalonic acid0low40
thapsigargin0low10
mycophenolic acid0low10
geranylgeranyl pyrophosphate0low10
glycosides0low10
cysteine0low20
staurosporine0low10
mocetinostat0low10
tofacitinib0low20
icatibant0low10
c-peptide0low10
chlorophyll a0low10
incb-0184240low20
baricitinib0medium31
piperidines0low20
interleukin-80low10
calca protein, human0low10
ecallantide0low10
cyclosporine0low10
exudates0low10
cyclic guanosine monophosphate-adenosine monophosphate0low10
eye0low30

Protein Targets (963)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Serine/threonine-protein kinase Chk10336
3-phosphoinositide-dependent protein kinase 10123
Cyclin-dependent kinase 10134
Cyclin-dependent kinase 40134
Cyclin-A20101
G1/S-specific cyclin-D10101
Cyclin-dependent kinase 20246
Chain A, farnesyl pyrophosphate synthase0101
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Acetylcholinesterase0101
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
Farnesyl pyrophosphate synthase 0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase7007
phosphopantetheinyl transferase3003
NFKB1 protein, partial1001
GLS protein2002
thyroid stimulating hormone receptor3003
alpha-galactosidase2002
euchromatic histone-lysine N-methyltransferase 29009
cytochrome P450 2C19 precursor2002
chromobox protein homolog 16006
flap endonuclease 14004
DNA polymerase iota isoform a (long)4004
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)3003
Cytochrome P450 3A40405
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0102
Nitric oxide synthase, brain 0102
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Ferritin light chain4004
interleukin 82002
acetylcholinesterase4004
RAR-related orphan receptor gamma100010
SMAD family member 24004
ATAD5 protein, partial5005
Fumarate hydratase3003
SMAD family member 34004
TDP1 protein110011
GLI family zinc finger 39009
Microtubule-associated protein tau3003
AR protein120012
thioredoxin glutathione reductase2002
nuclear receptor subfamily 1, group I, member 38008
EWS/FLI fusion protein9009
glucocorticoid receptor [Homo sapiens]9009
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha120012
farnesoid X nuclear receptor7007
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha120012
G5005
polyprotein3003
P531001
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma8008
arylsulfatase A3003
IDH16006
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
thyroid stimulating hormone receptor4004
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x6006
Bloom syndrome protein isoform 14004
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 27007
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 19009
geminin9009
peripheral myelin protein 225005
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 14004
lamin isoform A-delta106006
Gamma-aminobutyric acid receptor subunit pi3003
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010011
Bile salt export pump0303
Voltage-dependent calcium channel gamma-2 subunit6006
Bile salt export pump011011
Interferon beta100010
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p539009
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Glutamate receptor 26107
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Nuclear receptor ROR-gamma3003
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
GABA theta subunit3003
Inositol hexakisphosphate kinase 15005
Canalicular multispecific organic anion transporter 109010
ATPase family AAA domain-containing protein 58008
Ataxin-29009
Gamma-aminobutyric acid receptor subunit epsilon3003
Protein-arginine deiminase type-40202
cytochrome P450 2C9, partial5005
PPM1D protein6006
Bone morphogenetic protein receptor type-1B0033
Membrane-associated progesterone receptor component 10022
Serine/threonine-protein kinase PLK40033
ATP-dependent RNA helicase DDX3X0033
Pyridoxal kinase0033
Citron Rho-interacting kinase0033
Aurora kinase A0033
Cyclin-G-associated kinase0235
Ephrin type-B receptor 60033
Peroxisomal acyl-coenzyme A oxidase 30033
Receptor-interacting serine/threonine-protein kinase 20033
Dynamin-like 120 kDa protein, mitochondrial0033
Tyrosine-protein kinase JAK206413
Eukaryotic translation initiation factor 5B0022
Rho-associated protein kinase 20134
Serine/threonine-protein kinase ULK10033
Serine/threonine-protein kinase/endoribonuclease IRE10033
Ribosomal protein S6 kinase alpha-50134
U5 small nuclear ribonucleoprotein 200 kDa helicase0033
Ribosomal protein S6 kinase alpha-40033
Serine/threonine-protein kinase 160033
Serine/threonine-protein kinase 100033
Serine/threonine-protein kinase D30033
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60033
Mitogen-activated protein kinase kinase kinase kinase 40033
Serine/threonine-protein kinase LATS10033
Serine/threonine-protein kinase PAK 40033
Tyrosine-protein kinase ABL10044
Epidermal growth factor receptor0134
Guanine nucleotide-binding protein G(i) subunit alpha-20022
ADP/ATP translocase 20033
Protein kinase C beta type0033
Insulin receptor0134
Tyrosine-protein kinase Lck0134
Tyrosine-protein kinase Fyn0033
Glycogen phosphorylase, liver form0033
Tyrosine-protein kinase Fes/Fps0033
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0033
Tyrosine-protein kinase Lyn0033
Proto-oncogene tyrosine-protein kinase receptor Ret0033
Insulin-like growth factor 1 receptor0033
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0033
Hepatocyte growth factor receptor0033
Tyrosine-protein kinase HCK0033
Platelet-derived growth factor receptor beta0033
Serine/threonine-protein kinase A-Raf0033
Glycogen phosphorylase, brain form0033
Breakpoint cluster region protein0033
Serine/threonine-protein kinase pim-10134
Fibroblast growth factor receptor 10033
DNA topoisomerase 2-alpha0139
ADP/ATP translocase 30033
Inosine-5'-monophosphate dehydrogenase 20224
Proto-oncogene tyrosine-protein kinase Src0033
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0033
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0033
Ribosyldihydronicotinamide dehydrogenase [quinone]0033
Tyrosine-protein kinase Fer0033
Protein kinase C alpha type0134
cAMP-dependent protein kinase catalytic subunit alpha0033
General transcription and DNA repair factor IIH helicase subunit XPD0033
Casein kinase II subunit alpha'0033
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10033
Multifunctional protein ADE20033
cAMP-dependent protein kinase catalytic subunit gamma0033
cAMP-dependent protein kinase catalytic subunit beta0033
Ferrochelatase, mitochondrial0033
Ribosomal protein S6 kinase beta-10134
Tyrosine-protein kinase JAK106514
Beta-adrenergic receptor kinase 10033
Probable ATP-dependent RNA helicase DDX60033
Mitogen-activated protein kinase 3 0033
MAP/microtubule affinity-regulating kinase 30033
Deoxycytidine kinase0033
Mitogen-activated protein kinase 10134
Ephrin type-A receptor 20033
Ephrin type-B receptor 20033
Non-receptor tyrosine-protein kinase TYK206514
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10022
Wee1-like protein kinase0033
Heme oxygenase 20033
S-adenosylmethionine synthase isoform type-20033
DnaJ homolog subfamily A member 10033
RAC-alpha serine/threonine-protein kinase0134
RAC-beta serine/threonine-protein kinase0033
DNA replication licensing factor MCM40022
Myosin-100022
Dual specificity mitogen-activated protein kinase kinase 20033
Receptor-type tyrosine-protein kinase FLT30033
Bone morphogenetic protein receptor type-1A0033
Activin receptor type-1B0033
TGF-beta receptor type-10033
Serine/threonine-protein kinase receptor R30033
TGF-beta receptor type-20033
Electron transfer flavoprotein subunit beta0022
Tyrosine-protein kinase CSK0134
Glycine--tRNA ligase0033
Protein kinase C iota type0033
Exosome RNA helicase MTR40033
Tyrosine-protein kinase Tec0134
Tyrosine-protein kinase ABL20033
Tyrosine-protein kinase FRK0033
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0033
26S proteasome regulatory subunit 6B0033
Mitogen-activated protein kinase 80134
Mitogen-activated protein kinase 90033
Dual specificity mitogen-activated protein kinase kinase 30033
Casein kinase I isoform alpha0033
Casein kinase I isoform delta0033
MAP kinase-activated protein kinase 20134
Elongation factor Tu, mitochondrial0033
Cysteine--tRNA ligase, cytoplasmic0033
Casein kinase I isoform epsilon0033
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0033
Dual specificity protein kinase CLK10033
Dual specificity protein kinase CLK20033
Dual specificity protein kinase CLK30033
Glycogen synthase kinase-3 alpha0033
Glycogen synthase kinase-3 beta0134
Cyclin-dependent kinase 70033
Cyclin-dependent kinase 90033
Ras-related protein Rab-27A0022
Interleukin-1 receptor-associated kinase 10033
Ribosomal protein S6 kinase alpha-30134
Serine/threonine-protein kinase Nek20033
Serine/threonine-protein kinase Nek30033
Tyrosine-protein kinase JAK306313
Dual specificity mitogen-activated protein kinase kinase 60033
LIM domain kinase 10033
LIM domain kinase 20033
Mitogen-activated protein kinase 100033
Tyrosine--tRNA ligase, cytoplasmic0033
5'-AMP-activated protein kinase subunit gamma-10033
Ephrin type-B receptor 30033
Ephrin type-A receptor 50033
Ephrin type-B receptor 40033
Ephrin type-A receptor 40033
Adenylate kinase 2, mitochondrial0033
Adenosine kinase0033
Ras-related protein Rab-100033
Actin-related protein 30033
Actin-related protein 20022
GTP-binding nuclear protein Ran0033
Casein kinase I isoform gamma-20033
Cyclin-dependent kinase 30033
Cyclin-dependent kinase 60033
Cyclin-dependent-like kinase 5 0134
Cyclin-dependent kinase 160033
Cyclin-dependent kinase 170033
ATP-dependent 6-phosphofructokinase, platelet type0033
Dual specificity mitogen-activated protein kinase kinase 10033
DNA topoisomerase 2-beta01411
Protein kinase C theta type0033
Activin receptor type-10033
Macrophage-stimulating protein receptor0033
Focal adhesion kinase 10033
Protein kinase C delta type0033
Tyrosine-protein kinase BTK0134
Activated CDC42 kinase 10033
Epithelial discoidin domain-containing receptor 10033
Mitogen-activated protein kinase kinase kinase kinase 20033
Serine/threonine-protein kinase 40033
5'-AMP-activated protein kinase catalytic subunit alpha-10033
Dual specificity mitogen-activated protein kinase kinase 50033
Mitogen-activated protein kinase 70033
Serine/threonine-protein kinase PAK 20033
Serine/threonine-protein kinase 30033
Mitogen-activated protein kinase kinase kinase 10033
Integrin-linked protein kinase0033
Rho-associated protein kinase 10033
Non-receptor tyrosine-protein kinase TNK10033
Serine/threonine-protein kinase ATR0022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0033
Calcium/calmodulin-dependent protein kinase type II subunit delta0033
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0033
Activin receptor type-2B0033
Bone morphogenetic protein receptor type-20033
Protein-tyrosine kinase 60033
cGMP-dependent protein kinase 1 0033
Cyclin-dependent kinase 130033
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0033
Protein-tyrosine kinase 2-beta0033
Maternal embryonic leucine zipper kinase0033
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40033
Peroxisomal acyl-coenzyme A oxidase 10022
Ephrin type-A receptor 70033
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10033
Dual specificity testis-specific protein kinase 10033
Myosin light chain kinase, smooth muscle0033
Mitogen-activated protein kinase 110134
Serine/threonine-protein kinase STK110033
Serine/threonine-protein kinase N10033
Serine/threonine-protein kinase N20033
Mitogen-activated protein kinase 140134
Calcium/calmodulin-dependent protein kinase type IV0033
Mitogen-activated protein kinase kinase kinase 110033
MAP kinase-activated protein kinase 30011
Discoidin domain-containing receptor 20033
AP2-associated protein kinase 10235
Myosin light chain kinase 30033
Uncharacterized aarF domain-containing protein kinase 50022
Putative heat shock protein HSP 90-beta 20033
Rab-like protein 30022
Serine/threonine-protein kinase MRCK alpha0033
Serine/threonine-protein kinase MRCK gamma0033
Acyl-CoA dehydrogenase family member 100033
Serine/threonine-protein kinase ULK30033
Uncharacterized protein FLJ452520033
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20033
Serine/threonine-protein kinase MARK20033
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10033
STE20-related kinase adapter protein alpha0033
Myosin-140033
AarF domain-containing protein kinase 10033
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30033
MAP kinase-activated protein kinase 50134
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0022
Misshapen-like kinase 10033
Atypical kinase COQ8A, mitochondrial0033
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0033
Mitogen-activated protein kinase 150033
Serine/threonine-protein kinase Nek90033
ATP-dependent RNA helicase DDX10033
Mitogen-activated protein kinase kinase kinase kinase 10033
Aurora kinase B0033
Calcium/calmodulin-dependent protein kinase type 1G0033
Serine/threonine-protein kinase Nek10033
PAS domain-containing serine/threonine-protein kinase0033
Calcium/calmodulin-dependent protein kinase kinase 20033
EKC/KEOPS complex subunit TP53RK0033
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0033
Mitogen-activated protein kinase kinase kinase 50033
Mitogen-activated protein kinase kinase kinase 30033
Eukaryotic translation initiation factor 2-alpha kinase 10033
Nucleolar GTP-binding protein 10033
Serine/threonine-protein kinase D20033
NUAK family SNF1-like kinase 20033
RNA cytidine acetyltransferase0033
Serine/threonine-protein kinase SIK20033
STE20-like serine/threonine-protein kinase 0033
Serine/threonine-protein kinase TAO30033
dCTP pyrophosphatase 10033
Dual specificity protein kinase CLK40033
Casein kinase I isoform gamma-10033
Serine/threonine-protein kinase PAK 60033
Phenylalanine--tRNA ligase beta subunit0033
Isoleucine--tRNA ligase, mitochondrial0022
BMP-2-inducible protein kinase0033
Obg-like ATPase 10011
Midasin0033
Interleukin-1 receptor-associated kinase 40033
Mitogen-activated protein kinase kinase kinase 200033
Cyclin-dependent kinase 120033
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130033
Serine/threonine-protein kinase 260033
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0033
Serine/threonine-protein kinase NLK0033
5'-AMP-activated protein kinase subunit gamma-20033
Serine/threonine-protein kinase TBK10134
Septin-90033
Ribosomal protein S6 kinase alpha-60033
TRAF2 and NCK-interacting protein kinase0033
Serine/threonine-protein kinase TAO20033
Long-chain-fatty-acid--CoA ligase 50022
Serine/threonine-protein kinase ICK0033
RAC-gamma serine/threonine-protein kinase0033
Serine/threonine-protein kinase 38-like0033
Serine/threonine-protein kinase SIK30033
Mitogen-activated protein kinase kinase kinase 20033
Thyroid hormone receptor-associated protein 30033
Mitogen-activated protein kinase kinase kinase kinase 50033
Receptor-interacting serine/threonine-protein kinase 30033
Serine/threonine-protein kinase MRCK beta0033
Interleukin-1 receptor-associated kinase 30033
Serine/threonine-protein kinase 240033
Casein kinase I isoform gamma-30033
Mitogen-activated protein kinase kinase kinase 40033
histone acetyltransferase KAT2A isoform 12002
Angiotensin-converting enzyme 0001
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20011
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
General amino-acid permease GAP10001
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
72 kDa type IV collagenase0101
Stromelysin-10101
Matrix metalloproteinase-90101
Macrophage metalloelastase0101
Chain A, Beta-lactamase2002
Luciferase2002
endonuclease IV1001
PAX80001
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit5005
USP1 protein, partial4004
Thrombopoietin1001
Smad32002
estrogen receptor 2 (ER beta)5005
cytochrome P450 family 3 subfamily A polypeptide 45005
67.9K protein4004
glucocerebrosidase1001
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
nuclear receptor subfamily 1, group I, member 24004
cytochrome P450 2D6 isoform 11001
nuclear receptor subfamily 0 group B member 10101
cytochrome P450 2C9 precursor2002
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 28008
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A2002
steroidogenic factor 10101
caspase-1 isoform alpha precursor2002
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 30101
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10202
Tubulin beta chain0225
ATP-dependent translocase ABCB10417
Tubulin alpha-3C chain0225
ATP-dependent translocase ABCB10202
Histamine H2 receptor2002
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0303
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0202
Similar to alpha-tubulin isoform 1 0202
CREB-binding protein1001
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
Interferon regulatory factor 30011
Stimulator of interferon genes protein0022
Stimulator of interferon genes protein0123
glp-1 receptor, partial3003
caspase 7, apoptosis-related cysteine protease1001
progesterone receptor6006
caspase-31001
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
transactivating tegument protein VP16 [Human herpesvirus 1]0303
nuclear receptor coactivator 3 isoform a0202
Prothrombin0001
Regulatory protein E20011
DNA topoisomerase 10102
Cytochrome P450 2C9 0303
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
UDP-glucuronosyltransferase 1A1 0002
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
Glutamate receptor ionotropic, NMDA 2D0001
Integrase 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30405
Glutamate receptor ionotropic, NMDA 3A0001
Leukotriene C4 synthase0022
tyrosine-protein kinase Yes3003
Cell division cycle 7-related protein kinase0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0022
Serine/threonine-protein kinase 250022
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0022
Serine/threonine-protein kinase RIO30022
Dual specificity mitogen-activated protein kinase kinase 70123
Inhibitor of nuclear factor kappa-B kinase subunit beta0022
Peripheral plasma membrane protein CASK0022
Serine/threonine-protein kinase DCLK10022
Inhibitor of nuclear factor kappa-B kinase subunit alpha0022
Muscle, skeletal receptor tyrosine-protein kinase0022
Mitogen-activated protein kinase 130123
Mitogen-activated protein kinase kinase kinase 130022
Death-associated protein kinase 30022
Mitogen-activated protein kinase kinase kinase 70022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
NUAK family SNF1-like kinase 10022
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0022
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0022
Serine/threonine-protein kinase PAK 30022
Cyclin-dependent kinase-like 50022
Serine/threonine-protein kinase 17B0022
Cyclin-dependent kinase 140022
Serine/threonine-protein kinase OSR10022
Serine/threonine-protein kinase Chk20022
RAF proto-oncogene serine/threonine-protein kinase0022
Receptor tyrosine-protein kinase erbB-20123
High affinity nerve growth factor receptor0022
Cytochrome P450 1A20101
Macrophage colony-stimulating factor 1 receptor0022
Proto-oncogene tyrosine-protein kinase ROS0022
Tyrosine-protein kinase Fgr0022
Wee1-like protein kinase 20022
Uncharacterized serine/threonine-protein kinase SBK30022
Mast/stem cell growth factor receptor Kit0022
Insulin receptor-related protein0022
Platelet-derived growth factor receptor alpha0022
Vascular endothelial growth factor receptor 1 0022
Interferon-induced, double-stranded RNA-activated protein kinase0022
Serine/threonine-protein kinase MAK0022
Cyclin-dependent kinase 11B0022
Fibroblast growth factor receptor 20022
Receptor tyrosine-protein kinase erbB-30022
Fibroblast growth factor receptor 40022
Fibroblast growth factor receptor 30022
Protein kinase C eta type0022
Activin receptor type-2A0022
Ephrin type-A receptor 30022
Ephrin type-A receptor 80022
Leukocyte tyrosine kinase receptor0022
Tyrosine-protein kinase receptor UFO0022
Mitogen-activated protein kinase 40022
G protein-coupled receptor kinase 40022
Dual specificity protein kinase TTK0022
Prostaglandin G/H synthase 20224
Tyrosine-protein kinase receptor Tie-10022
Vascular endothelial growth factor receptor 30022
Vascular endothelial growth factor receptor 20022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0123
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0022
Serine/threonine-protein kinase mTOR0022
Megakaryocyte-associated tyrosine-protein kinase0022
Tyrosine-protein kinase TXK0123
Tyrosine-protein kinase ZAP-700022
Dual specificity mitogen-activated protein kinase kinase 40022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0022
Cyclin-dependent kinase 80022
Tyrosine-protein kinase Blk0123
Cytoplasmic tyrosine-protein kinase BMX0123
cAMP-dependent protein kinase catalytic subunit PRKX0022
Serine/threonine-protein kinase Nek40022
Serine/threonine-protein kinase PLK10022
Death-associated protein kinase 10022
Mitogen-activated protein kinase 120123
5'-AMP-activated protein kinase catalytic subunit alpha-20022
Ephrin type-B receptor 10022
Oxysterols receptor LXR-beta0101
Hormonally up-regulated neu tumor-associated kinase0022
Serine/threonine-protein kinase SIK10022
Receptor-interacting serine/threonine-protein kinase 40022
Spike glycoprotein5005
Cell division control protein 2 homolog0022
Calcium-dependent protein kinase 10022
Casein kinase II subunit alpha0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0022
SRSF protein kinase 20022
Mitogen-activated protein kinase kinase kinase 90022
Serine/threonine-protein kinase PknB0022
Cyclin-dependent kinase-like 10022
Protein kinase C epsilon type0022
Angiopoietin-1 receptor0022
Mitogen-activated protein kinase kinase kinase 100022
Tyrosine-protein kinase receptor TYRO30022
Cyclin-dependent kinase 180022
Tyrosine-protein kinase ITK/TSK0123
Myotonin-protein kinase0022
Mitogen-activated protein kinase kinase kinase 120022
Tyrosine-protein kinase Mer0022
Serine/threonine-protein kinase PAK 10022
cGMP-dependent protein kinase 20022
Serine/threonine-protein kinase PRP4 homolog0022
Receptor-interacting serine/threonine-protein kinase 10022
Calcium/calmodulin-dependent protein kinase type II subunit beta0022
Calcium/calmodulin-dependent protein kinase type 10022
Serine/threonine-protein kinase D10022
Serine/threonine-protein kinase 380022
Receptor tyrosine-protein kinase erbB-40123
Ribosomal protein S6 kinase alpha-20022
Rhodopsin kinase GRK10022
NT-3 growth factor receptor0022
BDNF/NT-3 growth factors receptor0022
Mitogen-activated protein kinase 60022
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0022
Serine/threonine-protein kinase SBK10022
Mitogen-activated protein kinase kinase kinase 190022
Serine/threonine-protein kinase TNNI3K0022
Leucine-rich repeat serine/threonine-protein kinase 20022
Tyrosine-protein kinase JAK2 0011
Serine/threonine-protein kinase Nek50022
Serine/threonine-protein kinase N30011
Dual serine/threonine and tyrosine protein kinase0022
Mitogen-activated protein kinase kinase kinase 150022
Serine/threonine-protein kinase tousled-like 20022
Serine/threonine-protein kinase 32C0022
Serine/threonine-protein kinase pim-30022
Serine/threonine-protein kinase VRK20022
Myosin light chain kinase family member 40022
Homeodomain-interacting protein kinase 10022
Calcium/calmodulin-dependent protein kinase type 1D0022
Cyclin-dependent kinase-like 30022
Serine/threonine-protein kinase BRSK20022
Serine/threonine-protein kinase NIM10022
Serine/threonine-protein kinase ULK20022
Serine/threonine-protein kinase DCLK20022
Calcium/calmodulin-dependent protein kinase kinase 10022
Casein kinase I isoform alpha-like0022
Homeodomain-interacting protein kinase 40022
Myosin-IIIa0022
Ankyrin repeat and protein kinase domain-containing protein 10022
Serine/threonine-protein kinase Nek110022
Serine/threonine-protein kinase BRSK10022
Serine/threonine-protein kinase 350022
Serine/threonine-protein kinase Nek70022
Rhodopsin kinase GRK70022
Serine/threonine-protein kinase 32A0022
Myosin-IIIb0022
Dual specificity tyrosine-phosphorylation-regulated kinase 20022
Cyclin-dependent kinase-like 20022
Serine/threonine-protein kinase Sgk30022
Atypical kinase COQ8B, mitochondrial0022
MAP/microtubule affinity-regulating kinase 40022
Cyclin-dependent kinase 150022
SRSF protein kinase 10022
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0022
Serine/threonine-protein kinase RIO10022
MAP kinase-interacting serine/threonine-protein kinase 10022
Serine/threonine-protein kinase RIO20022
Cyclin-dependent kinase 190022
Transient receptor potential cation channel subfamily M member 60022
Testis-specific serine/threonine-protein kinase 10022
Serine/threonine-protein kinase 330022
Serine/threonine-protein kinase DCLK30022
Myosin light chain kinase 2, skeletal/cardiac muscle0022
Homeodomain-interacting protein kinase 20022
Tyrosine-protein kinase Srms0022
Homeodomain-interacting protein kinase 30022
Serine/threonine-protein kinase PLK30022
MAP kinase-interacting serine/threonine-protein kinase 20022
Serine/threonine-protein kinase Nek60022
SNF-related serine/threonine-protein kinase0022
Serine/threonine-protein kinase LATS20022
Serine/threonine-protein kinase 360022
Serine/threonine-protein kinase 32B0022
Serine/threonine-protein kinase PLK20022
Serine/threonine-protein kinase MARK10022
Serine/threonine-protein kinase pim-20022
Serine/threonine-protein kinase PAK 50022
eIF-2-alpha kinase GCN20022
Phosphatidylinositol 4-kinase beta0022
Histone deacetylase 60202
Serine/threonine-protein kinase 17A0022
STE20/SPS1-related proline-alanine-rich protein kinase0022
Ephrin type-A receptor 60022
Death-associated protein kinase 20022
Serine/threonine-protein kinase tousled-like 10022
ALK tyrosine kinase receptor0022
SRSF protein kinase 30022
Cyclin-dependent kinase 11A0022
Aurora kinase C0022
Calcium/calmodulin-dependent protein kinase type II subunit alpha0022
Microtubule-associated serine/threonine-protein kinase 10022
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0022
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
Potassium voltage-gated channel subfamily H member 20202
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase3003
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
aldehyde dehydrogenase 1 family, member A16006
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
vitamin D3 receptor isoform VDRA3003
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
snurportin-11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 12002
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Carbonic anhydrase 20314
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0303
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 433003
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60002
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Broad substrate specificity ATP-binding cassette transporter ABCG20102
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B2002
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0505
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2D63003
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Cytochrome P450 2D60202
Integrin alpha-40101
Cytochrome P450 2C190202
Histone deacetylase 40101
Histone deacetylase 10202
Histone deacetylase 70101
Histone deacetylase 20202
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
UDP-glucuronosyltransferase 1A90001
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Inosine-5'-monophosphate dehydrogenase 1 0202
Sodium-dependent serotonin transporter0101
Peroxisome proliferator-activated receptor gamma0236
Alpha-synuclein1001
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
GALC protein1001
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
CDGSH iron-sulfur domain-containing protein 10101
Free fatty acid receptor 10011
Peroxisome proliferator-activated receptor gamma0101
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Steryl-sulfatase0101
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Tyrosine-protein phosphatase non-receptor type 10101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0101
Peroxisome proliferator-activated receptor alpha0101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0202
Peroxisome proliferator-activated receptor gamma0112
Carnitine O-palmitoyltransferase 1, liver isoform0101
Peroxisome proliferator-activated receptor alpha0112
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
CDGSH iron-sulfur domain-containing protein 20101
CDGSH iron-sulfur domain-containing protein 10202
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20202
Estrogen receptor beta0202
nuclear receptor ROR-gamma isoform 11001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
PINK11001
regulator of G-protein signaling 41001
Parkin2002
photoreceptor-specific nuclear receptor0101
serine/threonine-protein kinase PLK11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Insulin receptor 0101
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10101
Solute carrier organic anion transporter family member 1B10303
Chain A, Ribosomal protein S6 kinase alpha-10101
Chain X, Tyrosine-protein kinase Lyn0101
Chain A, Dual specificity protein kinase TTK0011
Chain A, Dual specificity protein kinase TTK0011
Chain A, Glutathione S-transferase0101
Replicase polyprotein 1ab0011
histone deacetylase 9 isoform 31001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Solute carrier organic anion transporter family member 2B1 0202
Carbonic anhydrase 10202
Tumor necrosis factor0011
Interstitial collagenase0101
Fibroblast growth factor 10011
Thromboxane-A synthase 0101
Caspase-10101
Flavin reductase (NADPH)0011
Disintegrin and metalloproteinase domain-containing protein 171001
Sodium/bile acid cotransporter0101
Cystine/glutamate transporter0101
Cereblon isoform 40202
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
DNA polymerase III, partial1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor1001
atrial natriuretic peptide receptor 1 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10112
D(1A) dopamine receptor1001
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase JAK20101
Serine/threonine-protein kinase Sgk10101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
Myosin light chain kinase, smooth muscle0011
5-hydroxytryptamine receptor 1A0101
Tubulin alpha-1A chain0011
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
Sigma intracellular receptor 20101
Tyrosine-protein kinase JAK30101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
Dual specificity testis-specific protein kinase 20011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit0101
Seminal ribonuclease0101
Ribonucleoside-diphosphate reductase large subunit0001
Ribonucleoside-diphosphate reductase subunit M20001
P2Y purinoceptor 20011
P2Y purinoceptor 10011
P2Y purinoceptor 40011
Ribonuclease pancreatic0101
UDP-galactopyranose mutase0011
P2Y purinoceptor 60011
P2Y purinoceptor 140011
UDP-galactopyranose mutase0011
P2Y purinoceptor 60011
Ribonucleoside-diphosphate reductase subunit M2 B0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]