Any EC 3.4.17.* (metallocarboxypeptidase) inhibitor that inhibits the action of angiotensin-converting enzyme 2 (EC 3.4.17.23).
ChEBI ID: 147289
| Member | Definition | Class |
|---|---|---|
| mln 4760 | A L-histidine derivative that is L-histidine in which a hydrogen of the primary amino group is substituted by a (1S)-1-carboxy-3-methylbutyl group and the ring NH group is substituted by a 3,5-dichlorobenzyl group. It is a potent and selective human angiotensin-converting enzyme 2 (ACE2) inhibitor (IC50 = 0.44 nM) which was in clinical development for the treatment of ulcerative colitis. | MLN-4760 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (33.33) | 29.6817 |
| 2010's | 15 (45.45) | 24.3611 |
| 2020's | 7 (21.21) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (5.88%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 32 (94.12%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 16.6686 | 5 | 6 |
| Carboxypeptidase A1 | Bos taurus (cattle) | IC50 | 27.0000 | 1 | 1 |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 1 |