Minimally Conscious State

Vegetative state refers to the neurocognitive status of individuals with severe brain damage, in whom physiologic functions (sleep-wake cycles, autonomic control, and breathing) persist, but awareness (including all cognitive function and emotion) is abolished.

Synonym
Persistent Vegetative State
Permanent Vegetative State
Vegetative State
Vegetative State, Persistent
Prolonged Post-Traumatic Unawareness
Posttraumatic Unawareness State
Persistent Unawareness State
PVS (Persistent Vegetative State)
Post-Traumatic Unawareness State
Post-Comatose Unawareness State
Postcomatose Unawareness State
Minimally Conscious State
Transient Vegetative State
Post-Traumatic Vegetative State

Excerpt	Reference
"Permanent vegetative state is defined as the impaired level of consciousness longer than 12 months after traumatic causes and 3 months after non-traumatic causes of brain injury."	( An, YS; Im, SH; Kim, HS; Kim, YW, 2010)

Excerpt	Reference
"Sporadic cases of dramatic recovery from persistent vegetative state after intrathecal administration of baclofen have been reported."	( Hori, T; Taira, T, 2007)
"Case reports of the use of zolpidem in Permanent Vegetative States (PVS) have led to interest by the media and court judgements defining treatment with such drugs."	( Dawson, K; Lewis, S; McDonald, C; Pentland, B; Pringle, AM; Singh, R; Smith, S, 2008)
"Sporadic cases of recovery from persistent vegetative state (PVS) after administration of intrathecal baclofen (ITB) have been reported without giving any possible explanation for its paradoxical effect."	( Govoni, S; Mura, E; Onorati, P; Pistoia, F; Sarà, M, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	107 (20.62)	23.3326
1990's	201 (38.73)	12.5806
2000's	99 (19.08)	18.1394
2010's	95 (18.30)	28.8240
2020's	17 (3.28)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	3	0
choline	low	3	0
creatine	low	3	0
lactic acid	low	2	0
glycine	low	1	0
methanol	low	1	0
melatonin	low	1	0
nitrous oxide	low	1	0
thiamine	low	1	0
3,4-methylenedioxyamphetamine	low	7	0
3-methoxytyramine	low	1	0
phenytoin	low	1	0
hydroxyindoleacetic acid	low	1	0
acetaminophen	low	1	0
acetazolamide	medium	2	1
amantadine	medium	14	1
baclofen	low	13	0
bupivacaine	low	1	0
clotiazepam	low	1	0
dantrolene	low	2	0
amphetamine	low	1	0
diphenhydramine	low	1	0
flumazenil	low	4	0
guaifenesin	low	1	0
hydralazine	low	1	0
ibuprofen	low	1	0
ifosfamide	low	1	0
isoflurane	low	2	0
ketamine	low	2	0
methadone	low	1	0
methylphenidate	medium	4	1
midazolam	low	1	0
modafinil	low	1	0
phenobarbital	low	2	0
propranolol	low	1	0
sevoflurane	low	2	0
tofisopam	medium	1	1
zolpidem	medium	22	4
dextroamphetamine	medium	1	1
prednisone	low	1	0
alanine	low	1	0
aspartic acid	low	5	0
apomorphine	low	2	0
levodopa	medium	6	1
tyrosine	low	1	0
tryptophan	low	1	0
isosorbide dinitrate	low	1	0
cyclohexanol	low	1	0
thiophenes	low	1	0
dimethoxyphenylethylamine	low	1	0
vanillic acid	low	1	0
methoxyhydroxyphenylglycol	low	1	0
acetylcysteine	low	1	0
vancomycin	low	1	0
metanephrine	low	1	0
silver	low	1	0
technetium	low	1	0
ozone	low	1	0
selegiline	low	1	0
bromocriptine	low	2	0
4-methoxyamphetamine	low	147	0
glutamic acid	low	2	0
paclitaxel	low	1	0
propiconazole	low	1	0
fomesafen	low	6	0
fenoxycarb	low	1	0
mifepristone	low	1	0
n 0437, (-)-isomer	low	1	0
cathinone	low	1	0
venlafaxine hydrochloride	low	1	0
n-acetylaspartic acid	low	4	0
xenon radioisotopes	low	1	0
1,7-phenanthroline	medium	1	1
fluorodeoxyglucose f18	medium	25	2
2-(4-bromo-2,5-dimethoxyphenyl)ethylamine	low	1	0
deoxyglucose	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
oxytocin	low	1	0
inositol 3-phosphate	low	1	0
cocaine	low	1	0
amygdalin	low	1	0
mercaptopurine	low	1	0
pica	low	1	0
raclopride	medium	1	1
freedom	low	183	0
myelin basic protein	low	1	0
deamino arginine vasopressin	low	1	0
cysteine	medium	3	2
radium	medium	1	1
mocetinostat	low	1	0
losartan potassium	medium	1	1
technetium tc 99m exametazime	low	3	0
enerbol	low	19	0
ziconotide	low	1	0
ro13-9904	low	1	0
acyclovir	low	1	0
inosine pranobex	low	1	0
carbidopa	low	1	0
technetium tc 99m bicisate	medium	3	2

Protein Targets (1,034)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
geminin	23	0	0	23
lamin isoform A-delta10	22	0	0	22
Guanine nucleotide-binding protein G	4	0	0	4
5-hydroxytryptamine receptor 2C	0	8	6	14
5-hydroxytryptamine receptor 2A	0	8	7	15
5-hydroxytryptamine receptor 2A	0	8	2	10
5-hydroxytryptamine receptor 2B	0	8	6	14
Trace amine-associated receptor 1	0	0	3	3
thyroid stimulating hormone receptor	11	0	0	11
mitogen-activated protein kinase 1	5	0	0	5
muscarinic acetylcholine receptor M1	10	0	0	10
D(2) dopamine receptor	0	7	4	11
5-hydroxytryptamine receptor 1A	0	12	7	20
Sodium-dependent noradrenaline transporter	0	12	1	13
Sodium-dependent dopamine transporter	0	7	3	10
5-hydroxytryptamine receptor 1B	0	8	6	14
5-hydroxytryptamine receptor 1D	0	4	6	10
5-hydroxytryptamine receptor 1F	0	4	6	10
5-hydroxytryptamine receptor 6	0	2	6	8
Sodium-dependent serotonin transporter	0	12	3	15
Sodium-dependent serotonin transporter	0	9	2	12
5-hydroxytryptamine receptor 7	0	3	6	9
5-hydroxytryptamine receptor 5A	0	2	6	8
5-hydroxytryptamine receptor 5B	0	2	6	8
5-hydroxytryptamine receptor 3A	0	2	6	8
Sodium-dependent dopamine transporter	0	11	1	12
5-hydroxytryptamine receptor 4	0	2	6	8
5-hydroxytryptamine receptor 3B	0	2	6	8
RAR-related orphan receptor gamma	14	0	0	14
ATAD5 protein, partial	9	0	0	9
GLS protein	17	0	0	17
Microtubule-associated protein tau	8	0	0	8
Smad3	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
progesterone receptor	12	0	0	12
EWS/FLI fusion protein	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	19	0	0	19
retinoid X nuclear receptor alpha	14	0	0	14
estrogen-related nuclear receptor alpha	18	0	0	18
estrogen nuclear receptor alpha	26	0	0	26
peroxisome proliferator activated receptor gamma	12	0	0	12
aryl hydrocarbon receptor	11	0	0	11
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform 2	17	0	0	17
peripheral myelin protein 22	16	0	0	16
cytochrome P450 3A4 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	7	10	1	18
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	15
Solute carrier family 22 member 6	0	4	0	5
Carbonic anhydrase 12	0	4	1	10
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	5	0	5
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	22	0	22
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	1	16
Carbonic anhydrase 2	0	5	1	15
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	3	2	6
Cytochrome P450 1A2	0	4	0	5
Prostaglandin G/H synthase 1	0	4	0	4
Carbonic anhydrase 3	0	4	1	10
Cytochrome P450 3A4	0	11	0	11
Cytochrome P450 2D6	0	6	0	6
Cytochrome P450 2C9	0	10	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	7	10	1	18
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	7	10	1	18
Gamma-aminobutyric acid receptor subunit gamma-2	7	10	3	20
UDP-glucuronosyltransferase 1-6	0	2	0	3
Glutamate receptor 2	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	7	10	1	18
Gamma-aminobutyric acid receptor subunit alpha-3	7	10	1	18
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	3
Carbonic anhydrase 4	0	4	1	9
Prostaglandin G/H synthase 1	0	4	0	4
Carbonic anhydrase 6	0	5	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	7	10	1	18
Gamma-aminobutyric acid receptor subunit alpha-2	7	10	1	18
Gamma-aminobutyric acid receptor subunit alpha-4	7	10	1	18
Gamma-aminobutyric acid receptor subunit gamma-3	7	10	1	18
Gamma-aminobutyric acid receptor subunit alpha-6	7	10	1	18
Carbonic anhydrase 5A, mitochondrial	0	4	1	10
Prostaglandin G/H synthase 2	0	2	0	3
Carbonic anhydrase 7	0	4	1	9
Nuclear receptor ROR-gamma	3	0	0	3
Cytochrome P450 2J2	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	7	10	3	20
Gamma-aminobutyric acid receptor subunit beta-3	7	10	1	18
Gamma-aminobutyric acid receptor subunit beta-2	7	10	3	20
Carbonic anhydrase 9	0	4	1	10
GABA theta subunit	7	10	1	18
Canalicular multispecific organic anion transporter 1	0	14	0	14
Carbonic anhydrase 15	0	2	0	6
Carbonic anhydrase 13	0	4	0	7
Gamma-aminobutyric acid receptor subunit epsilon	7	10	1	18
Carbonic anhydrase 14	0	4	1	10
Carbonic anhydrase 5B, mitochondrial	0	4	1	10
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	9	0	0	9
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	19	0	0	19
GALC protein	3	0	0	3
GLI family zinc finger 3	19	0	0	19
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
glucocorticoid receptor [Homo sapiens]	16	0	0	16
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	16	0	0	16
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	29	0	0	29
Bloom syndrome protein isoform 1	13	0	0	13
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
survival motor neuron protein isoform d	8	0	0	8
muscleblind-like protein 1 isoform 1	4	0	0	4
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	4	0	4
Cytochrome P450 2A6	0	2	0	2
Androgen receptor	0	5	0	5
Translocator protein	0	3	0	3
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	1	7
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	2
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	3	1	6
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	4	0	4
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase	0	1	0	4
Kappa-type opioid receptor	0	2	0	2
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	4
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	10	2	15
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	4	0	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
Carbonic anhydrase 4	0	2	0	4
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	6	0	0	6
dopamine D1 receptor	4	0	0	4
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	6	0	0	6
phosphopantetheinyl transferase	16	0	0	16
USP1 protein, partial	8	0	0	8
NFKB1 protein, partial	6	0	0	6
Thrombopoietin	3	0	0	3
AR protein	28	0	0	28
regulator of G-protein signaling 4	15	0	0	15
farnesoid X nuclear receptor	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
D(1A) dopamine receptor	9	0	0	9
heat shock protein beta-1	4	0	0	4
flap endonuclease 1	7	0	0	7
Histone deacetylase 3	0	4	0	4
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	3	0	3
Ataxin-2	12	0	0	12
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	11	0	0	11
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, Ferritin light chain	8	0	0	8
Thymidine kinase	0	1	0	1
TDP1 protein	18	0	0	18
activating transcription factor 6	5	0	0	5
Histone H2A.x	6	0	0	6
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Solute carrier family 22 member 1	0	4	0	8
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	1	0	2
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Thymidine kinase	0	1	0	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	10	2	15
Proton-coupled amino acid transporter 1	0	4	0	4
Adenosine deaminase	0	0	0	1
signal transducer and activator of transcription 6, interleukin-4 induced	2	0	0	2
putative alpha-glucosidase	1	0	0	1
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Solute carrier family 22 member 2	0	1	0	3
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	4	0	1	5
Glutamate receptor ionotropic, NMDA 2A	0	9	2	14
Glutamate receptor ionotropic, NMDA 2C	0	9	2	14
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	9	2	14
Solute carrier family 22 member 1	0	4	0	5
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	9	2	14
Multidrug and toxin extrusion protein 1	0	1	0	1
Solute carrier family 22 member 2	0	4	0	5
Glutamate receptor ionotropic, NMDA 3A	0	9	2	14
Solute carrier family 22 member 3	0	1	0	1
Phenylethanolamine N-methyltransferase	0	3	0	3
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	4
Sigma non-opioid intracellular receptor 1	0	1	1	2
neuropeptide S receptor isoform A	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Luciferase	11	0	0	11
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
estrogen receptor 2 (ER beta)	9	0	0	9
cytochrome P450 2D6	10	0	0	10
peroxisome proliferator-activated receptor delta	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	14	0	0	14
thyroid stimulating hormone receptor	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
cytochrome P450 2D6 isoform 1	7	0	0	7
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C19 precursor	5	0	0	5
cytochrome P450 2C9 precursor	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
vitamin D3 receptor isoform VDRA	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
nuclear receptor ROR-gamma isoform 1	9	0	0	9
lethal factor (plasmid)	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	1	0	4
Cellular tumor antigen p53	15	0	0	15
Integrin beta-3	5	1	1	7
Integrin alpha-IIb	5	0	1	6
5-hydroxytryptamine receptor 1A	0	3	1	4
Tryptophan 5-hydroxylase 1	0	2	0	2
D(2) dopamine receptor	0	10	5	17
Alpha-1B adrenergic receptor	0	4	1	5
D	0	4	0	4
D(3) dopamine receptor	0	4	0	4
Alpha-2B adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	3	0	3
D(1A) dopamine receptor	0	5	4	11
D(4) dopamine receptor	0	7	1	9
D(1B) dopamine receptor	0	2	0	3
Alpha-2C adrenergic receptor	0	4	1	5
Alpha-2A adrenergic receptor	0	4	1	5
Alpha-1D adrenergic receptor	0	3	1	4
D(1B) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	1	3
D(3) dopamine receptor	0	8	1	10
Alpha-1A adrenergic receptor	0	4	1	5
Histamine H2 receptor	6	0	0	7
5-hydroxytryptamine receptor 7	0	2	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	1	0	1
D	0	3	0	3
ATPase family AAA domain-containing protein 5	8	0	0	8
Sigma non-opioid intracellular receptor 1	0	7	0	7
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	5
67.9K protein	6	0	0	6
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Genome polyprotein	0	1	1	2
Fumarate hydratase	4	0	0	4
pregnane X nuclear receptor	18	0	0	18
G	7	0	0	7
polyprotein	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
5-hydroxytryptamine receptor 4	0	6	0	6
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	7	1	10
Beta-1 adrenergic receptor	0	4	1	5
Alpha-2A adrenergic receptor	0	6	2	9
Alpha-2B adrenergic receptor	0	6	1	8
Alpha-2C adrenergic receptor	0	3	2	6
ATP-dependent translocase ABCB1	0	3	1	4
Alpha-1D adrenergic receptor	0	2	1	4
5-hydroxytryptamine receptor 2C	0	6	2	8
Alpha-synuclein	0	3	0	3
5-hydroxytryptamine receptor 2B	0	6	1	7
5-hydroxytryptamine receptor 6	0	4	1	5
Inositol hexakisphosphate kinase 1	7	0	0	7
cytochrome P450 2C9, partial	7	0	0	7
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-2	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	5	0	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	3	8
Gamma-aminobutyric acid receptor subunit beta-1	0	5	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	3	8
Liver carboxylesterase 1	0	0	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	3	8
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	3	8
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	1	6
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	1	6
Sodium-dependent dopamine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Transporter	0	5	0	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Vasopressin V2 receptor	0	3	2	5
Oxytocin receptor	0	2	3	5
Vasopressin V1a receptor	0	4	3	7
Vasopressin V1b receptor	0	2	2	4
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	2	1	3
Amine oxidase [flavin-containing] B	0	3	0	4
Amine oxidase [flavin-containing] A	0	5	0	5
Amine oxidase [flavin-containing] B	0	5	1	6
Amine oxidase [flavin-containing] B	0	4	0	4
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
P53	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
huntingtin isoform 2	3	0	0	3
Aldo-keto reductase family 1 member B1	0	3	0	3
Muscarinic acetylcholine receptor M2	0	3	1	4
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M1	0	3	1	4
Angiotensin-converting enzyme	0	2	0	2
Muscarinic acetylcholine receptor M3	0	3	1	4
Histamine H1 receptor	0	0	0	1
Histamine H1 receptor	0	2	0	2
Histamine N-methyltransferase	0	0	0	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	1	0	1
Histamine H3 receptor	0	0	0	1
endonuclease IV	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
TAR DNA-binding protein 43	4	0	0	4
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
transcriptional regulator ERG isoform 3	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	4	0	0	4
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	3	0	3
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	1	2	3
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Parkin	2	0	0	2
pyruvate kinase	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	4	0	4
Ornithine decarboxylase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	2	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
hypothetical protein, conserved	2	0	0	2
alpha-galactosidase	1	0	0	1
IDH1	4	0	0	4
peripheral myelin protein 22 isoform 1	5	0	0	5
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
M-phase phosphoprotein 8	6	0	0	6
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
nonstructural protein 1	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
DNA polymerase kappa isoform 1	5	0	0	5
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Epidermal growth factor receptor	0	4	0	4
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	1	4	5
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	3	0	3
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
UDP-glucuronosyltransferase 2B7	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	1	0	1
Substance-P receptor	0	4	0	4
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Acetylcholinesterase	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
apical membrane antigen 1, AMA1	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
Polyphenol oxidase 2	0	2	0	5
Plasma kallikrein	0	0	0	3
Tyrosine-protein kinase Lck	0	2	0	2
Tyrosine-protein kinase Fyn	0	3	0	3
Tyrosinase	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	2	0	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
interleukin 8	1	0	0	1
ClpP	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	3	1	4
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
thioredoxin glutathione reductase	4	0	0	4
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Mu-type opioid receptor	0	5	1	6
Delta-type opioid receptor	0	4	1	5
Kappa-type opioid receptor	0	4	1	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Mas-related G-protein coupled receptor member X2	0	0	1	1
Aldehyde oxidase 1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Chain A, Cruzipain	2	0	0	2
Glucocorticoid receptor	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Estrogen receptor	1	2	1	4
Glucocorticoid receptor	1	4	3	10
Progesterone receptor	0	2	1	5
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	1	1	3
Glucocorticoid receptor	0	1	0	1
Glycine receptor subunit alpha-1	0	4	0	4
Mineralocorticoid receptor	1	2	1	5
Coagulation factor VII	0	1	0	1
Androgen receptor	1	2	1	4
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tissue factor	0	1	0	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Mitogen-activated protein kinase 14	0	2	0	2
Progesterone receptor	0	0	1	1
Estrogen receptor beta	1	2	1	4
Glucocorticoid receptor	0	1	0	1
PPM1D protein	1	0	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Transporter	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Genome polyprotein	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Fibroblast growth factor receptor 1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Substance-K receptor	0	2	0	2
Cholecystokinin receptor type A	0	3	1	4
Melanocortin receptor 5	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	2	0	2
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	2	0	2
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	2	0	2
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Beta-2 adrenergic receptor	0	2	1	3
Adenosine receptor A3	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	3
Beta-3 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, APH(2')-Id	0	1	0	1
glucose-6-phosphate dehydrogenase	0	1	0	1
Nrf2	1	0	0	1
DNA polymerase III, partial	1	0	0	1
Neuraminidase	0	2	0	2
glucocerebrosidase	1	0	0	1
hexokinase	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
galactokinase	1	0	0	1
interferon gamma precursor	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
DNA polymerase beta	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
Maltase-glucoamylase, intestinal	0	1	0	1
NUAK family SNF1-like kinase 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
B2 bradykinin receptor	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
Arginase	0	1	0	1
Pancreatic triacylglycerol lipase	0	2	0	2
Prothrombin	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Cationic trypsin	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Chymotrypsin-like elastase family member 1	0	1	0	1
Beta-lactamase	0	1	0	1
Protein E6	0	1	0	1
Neuraminidase	0	1	0	1
Interstitial collagenase	0	1	1	2
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Beta-lactamase	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Epoxide hydrolase 1	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Procathepsin L	0	0	1	1
Tyrosine-protein kinase Yes	0	1	0	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	0	1
Insulin-like growth factor 1 receptor	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	3
Neutrophil elastase	0	2	0	2
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	2	0	2
Hepatocyte growth factor receptor	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	2	1	3
Calmodulin-1	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Alpha-amylase 1A	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Sialidase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 2	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	1	2
Cyclin-dependent kinase 4	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Sucrase-isomaltase, intestinal	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Urease subunit alpha	0	2	0	2
Serine/threonine-protein kinase B-raf	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Chymotrypsinogen B	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Casein kinase II subunit alpha'	0	2	0	2
Amine oxidase [flavin-containing] A	0	3	0	3
5'-nucleotidase	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-dependent kinase 2	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Cytosol aminopeptidase	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Tyrosine-protein kinase receptor UFO	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Trypsin-3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Macrophage metalloelastase	0	1	0	1
Glutathione reductase	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Collagenase 3	0	1	0	1
1-deoxy-D-xylulose 5-phosphate reductoisomerase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Prolyl endopeptidase	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
C-C chemokine receptor type 4	0	1	0	1
Serine/threonine-protein kinase Nek2	0	1	0	1
Oligo-1,6-glucosidase IMA1	0	1	0	1
Serine/threonine-protein kinase PLK1	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Monocarboxylate transporter 1	0	1	0	1
Beta-secretase 1	0	2	0	2
Anthrax toxin receptor 2	0	2	0	2
Casein kinase II subunit beta	0	2	0	2
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	0	4
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Heat shock factor protein 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Cyclin homolog	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Focal adhesion kinase 1	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	1	0	1
ELAV-like protein 3	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
ELAV-like protein 1	0	1	0	1
Serine/threonine-protein kinase N1	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	1	0	1
Casein kinase II subunit alpha 3	0	2	0	2
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Aldo-keto reductase family 1 member C21	0	2	0	2
Enoyl-acyl-carrier protein reductase	0	3	0	3
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Aurora kinase B	0	1	0	1
Chymotrypsin-C	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Phosphodiesterase	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
Serine/threonine-protein kinase Nek6	0	1	0	1
NADPH oxidase 4	0	1	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	1	2
Sialidase-2	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	3
Type-1 angiotensin II receptor	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
Amine oxidase [flavin-containing] B	0	0	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiopurine S-methyltransferase	0	1	0	1
Alpha-glucosidase MAL12	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(14)

Research Excerpts

Overview

Treatment

Research

Studies (519)

Protein Targets (1,034)

Minimally Conscious State

Synonyms(14)

Research Excerpts

Overview

Treatment

Research

Studies (519)

Drugs Studied (118)

Protein Targets (1,034)