Compounds > 2-methyl-2-(4-methylpent-3-enyl)-2h-chromen-6-ol
Page last updated: 2024-12-07

2-methyl-2-(4-methylpent-3-enyl)-2h-chromen-6-ol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-6-ol: isolated from Aplidium constellatum [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID124963
CHEMBL ID487808
SCHEMBL ID9356402
MeSH IDM0125895

Synonyms (10)

Synonym
cordiachromen a
cordiachromene a
CHEMBL487808
63025-48-9
mmpco
2-methyl-2-(4-methylpent-3-enyl)-2h-chromen-6-ol
2h-1-benzopyran-6-ol, 2-methyl-2-(4-methyl-3-pentenyl)-, (5z,11alpha,13e,15r)-
SCHEMBL9356402
DTXSID20978939
2-methyl-2-(4-methylpent-3-en-1-yl)-2h-1-benzopyran-6-ol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID404113Cytotoxicity against human wild type CEM cells after 72 hrs2005Journal of natural products, Sep, Volume: 68, Issue:9
Meroterpenes from the ascidian Aplidium aff. densum.
AID404112Antimicrobial activity against Micrococcus luteus by broth dilution method2005Journal of natural products, Sep, Volume: 68, Issue:9
Meroterpenes from the ascidian Aplidium aff. densum.
AID339003Antimicrobial activity against Proteus mirabilis
AID404111Antimicrobial activity against Escherichia coli by broth dilution method2005Journal of natural products, Sep, Volume: 68, Issue:9
Meroterpenes from the ascidian Aplidium aff. densum.
AID339000Antimicrobial activity against Pseudomonas aeruginosa
AID338996Antimicrobial activity against methicillin-resistant Staphylococcus aureus
AID338999Antimicrobial activity against Streptococcus faecalis
AID425024Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K12009Journal of natural products, May-22, Volume: 72, Issue:5
Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera.
AID425028Cytotoxicity against human BC1 cells by sulforhodamine B assay2009Journal of natural products, May-22, Volume: 72, Issue:5
Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera.
AID338998Cytotoxicity against mouse P388 cells
AID338997Cytotoxicity against human KB cells
AID425023Antimicrobial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay2009Journal of natural products, May-22, Volume: 72, Issue:5
Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera.
AID425026Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay2009Journal of natural products, May-22, Volume: 72, Issue:5
Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera.
AID336950Antioxidant activity in rat liver microsomes assessed as inhibition of lipid peroxide formation after 30 mins
AID339005Antimicrobial activity against Serratia marcescens
AID425027Cytotoxicity against human KB cells by sulforhodamine B assay2009Journal of natural products, May-22, Volume: 72, Issue:5
Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera.
AID338995Antimicrobial activity against methicillin-sensitive Staphylococcus aureus
AID425029Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay2009Journal of natural products, May-22, Volume: 72, Issue:5
Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera.
AID339004Antimicrobial activity against Morganella morganii
AID339001Antimicrobial activity against Escherichia coli
AID425025Antifungal activity against Candida albicans by XTT assay2009Journal of natural products, May-22, Volume: 72, Issue:5
Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera.
AID336951Inhibition of soybean arachidonate 15-lipoxygenase by oxygen electrode method
AID339002Antimicrobial activity against Klebsiella pneumoniae
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.28 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0510indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.0510carbohydrazideantitubercular agent;
drug allergen
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		2.0510kanamycinsbacterial metabolite
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		1.9810icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0510antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		1.9810aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
artenimol
artenimol: derivative of antimalarial drug artemisinin (quinghaosu)		2.0510
kaolinite
Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: high ridge), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed). kaolin : An aluminosilicate soft white mineral named after the hill in China (Kao-ling) from which it was mined for centuries. In its natural state kaolin is a white, soft powder consisting principally of the mineral kaolinite, and varying amounts of other minerals such as muscovite, quartz, feldspar, and anatase. It is used in the manufacture of china and porcelain and also widely used in the production of paper, rubber, paint, drying agents, and many other products.		1.9810aluminosilicate mineral;
mixture		antidiarrhoeal drug;
excipient
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.0510cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Anasarca
[description not available]		01.9810
Foot Diseases
Anatomical and functional disorders affecting the foot.		01.9810
Granulomas
[description not available]		01.9810
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		01.9810
Granuloma
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.		01.9810