2-methyl-3-(4-phenylpiperidino)propionohydroxamic acid hydrochloride profile

2-methyl-3-(4-phenylpiperidino)propionohydroxamic acid hydrochloride: RN given refers to HCl; do not confuse with either the fungal metabolite K-76 terpene or K 76 carboxylic acid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	159950
MeSH ID	M0044538

Synonym
1-piperidinepropionohydroxamic acid, alpha-methyl-4-phenyl-, monohydrochloride
alpha-methyl-4-phenyl-1-piperidinepropionohydroxamic acid monohydrochloride
23573-89-9
2-methyl-3-(4-phenylpiperidino)propionohydroxamic acid hydrochloride
DTXSID80946371
n-hydroxy-2-methyl-3-(4-phenylpiperidin-1-yl)propanimidic acid--hydrogen chloride (1/1)
n-hydroxy-2-methyl-3-(4-phenylpiperidin-1-yl)propanamide;hydrochloride

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (10.00)	18.7374
1990's	6 (60.00)	18.2507
2000's	3 (30.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
bis(5-amidino-2-benzimidazolyl)methane bis(5-amidino-2-benzimidazolyl)methane: aromatic diamidine which has a significant suppressive effect on the cytopathology & yield of respiratory synctial (RS) virus; RN given refers to parent cpd	1.97	1
nafamostat nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic	2.39	2	benzoic acids; guanidines
cv 3988 CV 3988: platelet activating factor antagonist; structure given in first source	2.05	1
k 76 carboxylic acid K 76 carboxylic acid: effective in blocking formation of chemotactic factor for tumor cells from human complement; oxidized product of sesquiterpene derivative K 76 from fungus Stachybotrys complementi; do not confuse with hydroxamic acid K-76	1.99	1
tak 044 TAK 044: endothelin receptor antagonist	2	1
1,2-bis(5-amidino-2-benzimidazolyl)ethane 1,2-bis(5-amidino-2-benzimidazolyl)ethane: RN given refers to parent cpd	1.97	1
tacrolimus Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.	2.4	2	macrolide lactam	bacterial metabolite; immunosuppressive agent
sesquiterpenes [no description available]	1.99	1
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	1.99	1	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent
mannans [no description available]	2.05	1

Condition	Relationship Strength	Studies
Anaphylactic Reaction [description not available]	2.44	2
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	2.44	2
Thrombopenia [description not available]	2.02	1
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	2.02	1
Acid Aspiration Syndrome [description not available]	1.99	1
Pneumonia, Aspiration A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.	1.99	1
Extravascular Hemolysis [description not available]	1.98	1
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	1.98	1
Colitis Gravis [description not available]	1.98	1
Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.	1.98	1
Bright Disease A historical classification which is no longer used. It described acute glomerulonephritis, acute nephritic syndrome, or acute nephritis. Named for Richard Bright.	1.97	1
Hypersensitivity, Type III [description not available]	1.97	1
Glomerulonephritis Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.	1.97	1

2-methyl-3-(4-phenylpiperidino)propionohydroxamic acid hydrochloride

Description

Cross-References

Synonyms (7)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.67

Study Types