Koehler Disease

Any of a group of bone disorders involving one or more ossification centers (EPIPHYSES). It is characterized by degeneration or NECROSIS followed by revascularization and reossification. Osteochondrosis often occurs in children causing varying degrees of discomfort or pain. There are many eponymic types for specific affected areas, such as tarsal navicular (Kohler disease) and tibial tuberosity (Osgood-Schlatter disease).

Synonym
Osteochondrosis
Navicular Osteochondrosis
Koehler Disease
Osgood-Schlatter Disease
Koehler's Disease

Excerpt	Reference
"Osteochondrosis has a multifactorial aetiology and this study focused on the role of minerals, particularly phosphorus, in the development of the disease."	( Botha, K; De Brouwer, C; Jacobs, L; Köster, H; Meissner, H; Neser, J; Prozesky, L; Shepstone, C; Van der Veen, G; Van Zyl, J; Viljoen, H, 2016)
"Osteochondrosis has a multifactorial aetiology and we propose that an increased requirement for nutrients for velvet production and increased weight-bearing stress (behaviour and rapid weight gain) may lead to progression of osteochondrosis and ALD in these deer."	( Dittmer, KE; Edgar, S; Pinckney, G; Thompson, KG, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	42 (49.41)	23.3326
1990's	0 (0.00)	12.5806
2000's	2 (2.35)	18.1394
2010's	29 (34.12)	28.8240
2020's	12 (14.12)	9.53

Drug	Relationship Strength	Studies	Trials
methanol	low	1	0
niacinamide	low	2	0
urea	low	1	0
antipyrine	low	1	0
lidocaine	medium	2	1
procaine	low	1	0
prednisolone	low	2	0
norethandrolone	low	1	0
pilocarpine	medium	1	1
lysine	low	1	0
aminopyrine	low	1	0
meglumine	low	1	0
d-alpha tocopherol	low	1	0
titanium	low	1	0
tricalcium phosphate	low	2	0
calcium sulfate	low	1	0
radon	medium	1	1
trolamine salicylate	low	5	0
triamcinolone	low	1	0
fomesafen	low	1	0
fluorodeoxyglucose f18	low	1	0
1,3,6,8-pyrene tetrasulfonate	low	1	0
glucuronic acid	low	1	0
u 73122	low	1	0
atropine	low	1	0
pilocarpic acid	medium	1	1
cortisone	low	1	0
fibrin	low	3	0
tretinoin	low	1	0
dinoprostone	medium	1	1
calcitriol	low	1	0
leukotriene b4	low	1	0
cholecalciferol	low	1	0
phosphorus	low	1	0
selenium	low	1	0
mocetinostat	low	2	0
cardiovascular agents	low	2	0
transforming growth factor beta	low	1	0
flavin mononucleotide	low	2	0
chondroitin sulfates	low	1	0
inosine diphosphate	low	2	0
leptin	low	2	0

Protein Targets (334)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Ferritin light chain	4	0	0	4
Luciferase	4	0	0	4
interleukin 8	2	0	0	2
thioredoxin reductase	7	0	0	7
15-lipoxygenase, partial	2	0	0	2
RAR-related orphan receptor gamma	8	0	0	8
GLS protein	5	0	0	5
GLI family zinc finger 3	10	0	0	10
thyroid stimulating hormone receptor	4	0	0	4
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	9	0	0	9
pregnane X nuclear receptor	9	0	0	9
estrogen nuclear receptor alpha	13	0	0	13
G	3	0	0	3
peroxisome proliferator-activated receptor delta	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
chromobox protein homolog 1	8	0	0	8
thyroid hormone receptor beta isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
geminin	10	0	0	10
lamin isoform A-delta10	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Glutamate receptor 2	3	0	0	3
Nicotinate phosphoribosyltransferase	0	2	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
ORF73	0	0	1	1
ATAD5 protein, partial	2	0	0	2
USP1 protein, partial	5	0	0	5
glucocorticoid receptor [Homo sapiens]	11	0	0	11
67.9K protein	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	7
Bile salt export pump	0	9	0	9
Cytochrome P450 2C9	0	4	1	6
Cytochrome P450 2J2	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	6	0	6
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
AR protein	10	0	0	10
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	2	8
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M3	0	4	1	8
Muscarinic acetylcholine receptor M4	0	4	1	8
Muscarinic acetylcholine receptor M5	0	4	1	8
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M2	0	4	1	9
Muscarinic acetylcholine receptor M1	0	3	3	9
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M3	0	2	1	5
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Vitamin D3 receptor	0	0	1	1
PPM1D protein	2	0	0	2
Microtubule-associated protein tau	5	0	0	5
thioredoxin glutathione reductase	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
mitogen-activated protein kinase 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	3	0	0	3
peripheral myelin protein 22	3	0	0	3
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	0	1	2
Cytochrome P450 3A4	0	3	2	6
Androgen receptor	0	3	0	3
Cytochrome P450 2D6	0	2	1	3
Vitamin D3 receptor	0	2	3	8
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	3	5
Cytochrome P450 2C19	0	2	1	3
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, Cruzipain	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
farnesoid X nuclear receptor	4	0	0	4
peroxisome proliferator activated receptor gamma	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	4	0	0	4
DNA polymerase kappa isoform 1	2	0	0	2
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
Cellular tumor antigen p53	5	0	0	5
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Glycine receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Nuclear receptor ROR-gamma	1	1	1	3
10 kDa heat shock protein, mitochondrial	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
GABA theta subunit	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
pregnane X receptor	2	0	0	2
TDP1 protein	5	0	0	5
progesterone receptor	4	0	0	4
regulator of G-protein signaling 4	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
heat shock protein beta-1	4	0	0	4
flap endonuclease 1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	3	0	0	3
Glucocorticoid receptor	0	6	1	12
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	1	0	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Histone H2A.x	2	0	0	2
Spike glycoprotein	2	0	0	2
Leukotriene B4 receptor 1	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	1
IDH1	1	0	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
EWS/FLI fusion protein	1	0	0	1
cytochrome P450 2D6	1	0	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
aryl hydrocarbon receptor	3	0	0	3
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
arylsulfatase A	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Cytochrome P450 2A6	0	1	1	2
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
ATP-dependent phosphofructokinase	2	0	0	2
luciferase	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nonstructural protein 1	1	0	0	1
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Adenosine receptor A3	0	2	0	2
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Alpha-1D adrenergic receptor	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Alpha-synuclein	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
glp-1 receptor, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Smad3	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Telomerase reverse transcriptase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Context

Research

Studies (85)

Protein Targets (334)

Koehler Disease

Synonyms(5)

Research Excerpts

Context

Research

Studies (85)

Drugs Studied (54)

Protein Targets (334)