integrin alpha10-beta1 complex
Definition
Target type: cellularcomponent
An integrin complex that comprises one alpha10 subunit and one beta1 subunit. [PMID:12297042]
The integrin alpha10-beta1 complex is a transmembrane protein heterodimer, a type of cell adhesion molecule, that mediates cell-matrix interactions. This complex is primarily found in epithelial cells, particularly those lining the basement membrane of various tissues. It plays a crucial role in regulating cell migration, proliferation, and differentiation during development and tissue regeneration.
The alpha10 and beta1 subunits each contain a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. The extracellular domain of alpha10 subunit is responsible for binding to specific extracellular matrix (ECM) proteins, mainly collagen IV, while the beta1 subunit contributes to cell-cell interactions.
The alpha10-beta1 complex resides within the plasma membrane and is associated with various intracellular proteins that regulate its activity. These include:
* **Focal adhesion kinase (FAK):** A key signaling molecule that activates downstream pathways involved in cell survival, proliferation, and migration.
* **Talin:** A protein that links the integrin cytoplasmic tail to the actin cytoskeleton, facilitating cell adhesion and migration.
* **Kindlin:** A protein that enhances integrin binding to ECM proteins and promotes integrin activation.
* **Vinculin:** A protein that strengthens the connection between integrins and the actin cytoskeleton, contributing to cell adhesion stability.
The alpha10-beta1 complex plays an important role in various cellular processes, including:
* **Basement membrane formation:** Integrin alpha10-beta1 is critical for assembling and maintaining the integrity of basement membranes, which serve as structural and regulatory barriers between epithelial cells and underlying tissues.
* **Cell migration:** This complex facilitates cell migration during development and tissue repair, enabling cells to move along ECM gradients.
* **Cell proliferation:** By modulating signaling pathways, alpha10-beta1 influences cell growth and proliferation.
* **Cell differentiation:** This complex contributes to the specialization of epithelial cells into distinct cell types.
Dysregulation of the alpha10-beta1 complex has been linked to various pathological conditions, including cancer progression, wound healing complications, and autoimmune diseases. Understanding the structure and function of this complex is crucial for developing targeted therapies for these conditions.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Integrin beta-1 | An integrin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P05556] | Homo sapiens (human) |
Compounds (17)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| haloperidol | haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) | aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol | antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist |
| 1,3-ditolylguanidine | 1,3-ditolylguanidine: structure given in first source; a selective ligand for the sigma binding sites in the brain | toluenes | |
| tirofiban | tirofiban : A member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group. Tirofiban: Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME. | L-tyrosine derivative; piperidines; sulfonamide | anticoagulant; fibrin modulating drug; platelet glycoprotein-IIb/IIIa receptor antagonist |
| arginyl-glycyl-aspartic acid | arginyl-glycyl-aspartic acid: amino acid sequence of basic unit of widespread cellular recognition system | oligopeptide | |
| arginyl-glycyl-aspartyl-serine | arginyl-glycyl-aspartyl-serine: corresponds to cell attachment site of fibronectin; located near carboxyl-terminal region of alpha-chain of fibrinogen; inhibits platelet aggregation & fibrinogen binding to activated platelets | ||
| glycyl-arginyl-glycyl-aspartyl-serine | glycyl-arginyl-glycyl-aspartyl-serine: synthetic peptide from fibronectins; inhibits experimental metastasis of murine melanoma cells | ||
| d-arg-gly-asp-trp | arginyl-glycyl-aspartyl-tryptophan: a synthetic RGD-containing peptide | ||
| l 738167 | L 738167: structure in first source | ||
| cilengitide | Cilengitide: an alphaVbeta3 integrin antagonist that paralyzes cancer cells | oligopeptide | |
| l 734217 | L 734217: fibrinogen receptor antagonist; structure given in first source | ||
| cyclopamine | piperidines | glioma-associated oncogene inhibitor | |
| arginyl-glycyl-aspartyl-phenylalanine | |||
| cyclic(arg-gly-asp-d-phe-val) | |||
| mk-0429 | |||
| mocetinostat | mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11). mocetinostat: undergoing phase II clinical trials for treatment of cancer | aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline | antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent |
| tr 14035 | N-(2,6-dichlorobenzoyl)-4-(2',6'-bismethoxyphenyl)phenylalanine: TR-14035 is the (L)-isomer; an antagonist of both alpha4beta1 and beta7 integrins; structure in first source | ||
| bio 1211 | BIO 1211: integrin alpha4beta1 inhibitor; structure in first source |