Labor Pain

Pain associated with OBSTETRIC LABOR in CHILDBIRTH. It is caused primarily by UTERINE CONTRACTION as well as pressure on the CERVIX; BLADDER; and the GASTROINTESTINAL TRACT. Labor pain mostly occurs in the ABDOMEN; the GROIN; and the BACK.

Synonym
Labor Pain
Obstetric Pain

Excerpt	Reference
"Labor pain is often described as the worst pain in a woman's life, but the experience is highly variable."	( Conell-Price, J; Evans, JB; Flood, P; Hong, D; Shafer, S, 2008)
"The labor pain is one of the most severe pains that a woman could ever be suffered."	( Arslantaş, MK; Arslantaş, R; Ozyuvaci, E, 2012)
"Labor pain is probably the most painful event in a woman's life."	( Chang, Y; Chen, YL; Yeh, YL, 2013)
"Labor pain is one of the most agonizing pains experienced by all delivered women."	( Monisha, N; Poomalar, GK, 2023)
"Labor pain is among the most severe types of physical pain that women may experience during their lifetime."	( Carmeli, J; Erez, O; Garmi, G; Salim, R; Zafran, N; Zuarez-Easton, S, 2023)
"Labor pain is complex, paradoxical and varied in every parturient woman."	( Akhlaghi, F; Dastjerd, F; Erfanian Arghavanian, F; Esmaily, H; Kordi, M; Sazegarnia, A, 2023)

Excerpt	Reference
"Labor pain has been reported as a severe pain and can be considered as a model of acute visceral pain."	( Auler, JO; Böhmer, AE; Félix, EA; Giordani, AT; Hansel, G; Mendes, FF; Oses, JP; Portela, LV; Posso, IP; Schmidt, AP; Soares, FA; Souza, DO, 2015)
"Management of labor pain has been a crucial component in maternity care."	( Akhlaghi, F; Dastjerd, F; Erfanian Arghavanian, F; Esmaily, H; Kordi, M; Sazegarnia, A, 2023)

Excerpt	Reference
"Despite being less effective in treating labor pain than neuraxial analgesic modalities, nitrous oxide serves the needs and preferences of a subset of laboring parturients."	( Baysinger, CL; Lopez, BM; Richardson, MG, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	29 (7.55)	23.3326
1990's	0 (0.00)	12.5806
2000's	89 (23.18)	18.1394
2010's	211 (54.95)	28.8240
2020's	55 (14.32)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	3	1
phloroglucinol	low	1	0
glycine	low	2	0
acetanilide	low	1	0
nitrous oxide	medium	39	7
thiamine	low	5	0
3,4-methylenedioxyamphetamine	low	1	0
acetaminophen	medium	4	3
bupivacaine	medium	50	32
chlorpromazine	low	2	0
clonidine	medium	8	4
diazepam	low	1	0
diclofenac	medium	2	1
droperidol	medium	1	1
fentanyl	medium	59	34
glutethimide	low	1	0
hydroxyzine	low	3	0
lidocaine	medium	4	3
iohexol	low	1	0
ketamine	low	1	0
meperidine	medium	43	17
meprobamate	low	1	0
methadone	low	2	0
apnea	low	3	0
neostigmine	medium	4	2
papaverine	medium	3	2
prilocaine	medium	1	1
procaine	low	1	0
promethazine	medium	2	1
sevoflurane	low	2	0
sulfanilamide	low	1	0
reserpine	low	1	0
pentylenetetrazole	low	1	0
aminopyrine	low	1	0
adenosine diphosphate	low	1	0
chloroform	low	1	0
chloroprocaine	low	1	0
xenon	low	1	0
tramadol	medium	4	2
sufentanil	medium	18	11
fomesafen	medium	4	1
remifentanil	medium	47	13
adenosine	low	1	0
methotrimeprazine	low	1	0
levobupivacaine	medium	16	12
entonox	medium	8	4
atropine	medium	1	1
ropivacaine	medium	41	25
hydroxydione	low	1	0
oxytocin	medium	16	7
pentazocine	medium	2	1
dipyrone	low	1	0
buprenorphine	low	2	0
6-thioxanthine	low	1	0
capsaicin	low	2	0
drotaverin	medium	2	2
dinoprostone	low	1	0
apigenin	medium	1	1
vitamin k semiquinone radical	low	1	0
humulene	low	1	0
misoprostol	low	1	0
codeine	low	2	0
hydromorphone	medium	4	2
naloxone	low	1	0
oxycodone	low	1	0
morphine	medium	14	7
dexmedetomidine	medium	4	3
nalbuphine	medium	3	1
levallorphan	low	1	0
heroin	medium	7	2
pregabalin	medium	1	1
butylscopolammonium bromide	medium	5	4
mocetinostat	low	1	0
scopolamine hydrobromide	low	2	0
dynorphins	low	1	0
beta-endorphin	low	4	0
cardiovascular agents	low	2	0
piperidines	medium	36	10
interleukin-8	low	1	0
adrenomedullin	low	1	0
exudates	medium	1	1
guanosine diphosphate	low	1	0
guanosine	low	1	0
leptin	low	1	0

Protein Targets (911)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	3	1	4
5-hydroxytryptamine receptor 2A	0	3	1	4
5-hydroxytryptamine receptor 1A	0	10	2	12
Sodium-dependent noradrenaline transporter	0	8	0	8
Sodium-dependent dopamine transporter	0	3	1	4
5-hydroxytryptamine receptor 1B	0	8	1	9
5-hydroxytryptamine receptor 1D	0	0	1	1
5-hydroxytryptamine receptor 1F	0	0	1	1
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	6	1	7
Sodium-dependent serotonin transporter	0	3	1	4
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Sodium-dependent dopamine transporter	0	4	0	4
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
ClpP	1	0	0	1
67.9K protein	4	0	0	4
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
RAR-related orphan receptor gamma	11	0	0	11
ATAD5 protein, partial	10	0	0	10
GLS protein	10	0	0	10
Microtubule-associated protein tau	11	0	0	11
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
thyroid stimulating hormone receptor	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
progesterone receptor	8	0	0	8
EWS/FLI fusion protein	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	12	0	0	12
estrogen-related nuclear receptor alpha	16	0	0	16
estrogen nuclear receptor alpha	23	0	0	23
peroxisome proliferator activated receptor gamma	8	0	0	8
aryl hydrocarbon receptor	3	0	0	3
chromobox protein homolog 1	15	0	0	15
thyroid hormone receptor beta isoform 2	14	0	0	14
peripheral myelin protein 22	14	0	0	14
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	6	1	17
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	16
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	3
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Bile salt export pump	0	29	0	29
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	6	0	7
Carbonic anhydrase 2	0	6	1	8
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	2	1	4
Cytochrome P450 1A2	0	2	1	4
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	5	2	7
Cytochrome P450 2D6	0	6	1	7
Cytochrome P450 2C9	0	4	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	10	6	1	17
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	10	6	1	17
Gamma-aminobutyric acid receptor subunit gamma-2	10	6	2	18
UDP-glucuronosyltransferase 1-6	0	2	0	3
Glutamate receptor 2	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	10	6	1	17
Gamma-aminobutyric acid receptor subunit alpha-3	10	6	1	17
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
Carbonic anhydrase 4	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	10	6	1	17
Gamma-aminobutyric acid receptor subunit alpha-2	10	6	1	17
Gamma-aminobutyric acid receptor subunit alpha-4	10	6	1	17
Gamma-aminobutyric acid receptor subunit gamma-3	10	6	1	17
Gamma-aminobutyric acid receptor subunit alpha-6	10	6	1	17
Carbonic anhydrase 5A, mitochondrial	0	3	0	4
Prostaglandin G/H synthase 2	0	2	0	3
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	5	0	0	5
Cytochrome P450 2J2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	10	6	2	18
Gamma-aminobutyric acid receptor subunit beta-3	10	6	1	17
Gamma-aminobutyric acid receptor subunit beta-2	10	6	2	18
Carbonic anhydrase 9	0	4	0	4
GABA theta subunit	10	6	1	17
Canalicular multispecific organic anion transporter 1	0	15	0	15
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	10	6	1	17
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
toxin B	0	0	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
glucocorticoid receptor [Homo sapiens]	12	0	0	12
Polyphenol oxidase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	18	0	0	18
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	12	0	0	12
NPYLR7B	0	0	1	1
arylsulfatase A	7	0	0	7
IDH1	6	0	0	6
Histone H2A.x	6	0	0	6
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
mitogen-activated protein kinase 1	9	0	0	9
flap endonuclease 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	6	0	0	6
survival motor neuron protein isoform d	6	0	0	6
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Purine nucleoside phosphorylase	0	1	0	2
Epidermal growth factor receptor	0	2	0	2
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	2	5
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	2	2	5
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	3
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	1	0	3
Adenosine receptor A1	0	1	1	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	1	2	4
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	2	3
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	2	6
Adenosine receptor A2a	0	1	2	3
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	4	0	5
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	4	0	5
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	4	0	5
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	4	0	5
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	2	3
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	24	11	38
Delta-type opioid receptor	0	17	4	24
Kappa-type opioid receptor	0	19	8	30
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	7	0	0	7
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	2	2
P2Y purinoceptor 11	0	0	1	1
P2Y purinoceptor 12	0	1	1	2
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, Ferritin light chain	4	0	0	4
Luciferase	6	0	0	6
interleukin 8	4	0	0	4
thioredoxin reductase	11	0	0	11
15-lipoxygenase, partial	6	0	0	6
GLI family zinc finger 3	13	0	0	13
estrogen receptor 2 (ER beta)	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
pregnane X nuclear receptor	15	0	0	15
G	8	0	0	8
peroxisome proliferator-activated receptor delta	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
thyroid hormone receptor beta isoform a	4	0	0	4
histone deacetylase 9 isoform 3	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
geminin	13	0	0	13
lamin isoform A-delta10	19	0	0	19
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Inositol hexakisphosphate kinase 1	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
ORF73	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, Cruzipain	4	0	0	4
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein Kinase Ii Subunit Alpha	0	1	0	1
endonuclease IV	2	0	0	2
BRCA1	1	0	0	1
RGS12	1	0	0	1
phosphopantetheinyl transferase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
USP1 protein, partial	6	0	0	6
NFKB1 protein, partial	3	0	0	3
PPM1D protein	3	0	0	3
TDP1 protein	17	0	0	17
Thrombopoietin	4	0	0	4
apical membrane antigen 1, AMA1	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
farnesoid X nuclear receptor	4	0	0	4
cytochrome P450 2D6	13	0	0	13
Neuraminidase	0	2	0	2
glucocerebrosidase	3	0	0	3
Parkin	1	0	0	1
pyruvate kinase	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Replicase polyprotein 1ab	0	3	4	7
cytochrome P450 2D6 isoform 1	8	0	0	8
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
heat shock protein beta-1	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
DNA polymerase kappa isoform 1	5	0	0	5
M-phase phosphoprotein 8	4	0	0	4
pyruvate kinase PKM isoform b	1	0	0	1
neuropeptide S receptor isoform A	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Aldo-keto reductase family 1 member B10	0	3	0	3
G2/mitotic-specific cyclin-B2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Lysozyme C-1	0	1	0	1
Cationic trypsin	0	1	0	1
Transthyretin	0	0	2	4
Estrogen receptor	0	1	0	1
Glucocorticoid receptor	0	0	0	1
Cellular tumor antigen p53	10	0	0	10
Amyloid-beta precursor protein	0	1	0	1
Integrin beta-3	2	0	0	2
Myeloperoxidase	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Beta-glucuronidase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	5	0	5
Seed linoleate 13S-lipoxygenase-1	0	1	0	3
ATP-dependent translocase ABCB1	0	7	1	10
Neutrophil elastase	0	2	0	2
Integrin alpha-IIb	2	0	0	2
Ornithine decarboxylase	1	0	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Replicase polyprotein 1a	0	3	4	7
Replicase polyprotein 1ab	0	3	4	7
Replicase polyprotein 1ab	0	4	4	8
Replicase polyprotein 1ab	0	3	4	7
Androgen receptor	0	1	0	2
Sialidase	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	0	2
Aromatase	0	1	0	1
Angiotensin-converting enzyme	0	5	0	5
Cystic fibrosis transmembrane conductance regulator	0	1	1	2
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Pyruvate kinase PKM	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	3	7
Urease subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
G2/mitotic-specific cyclin-B	0	1	0	1
Mucin-1	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	2	6
Casein kinase II subunit alpha'	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	6	0	6
Amine oxidase [flavin-containing] B	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	1
Proteasome subunit beta type-5	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	2	6
Substance-P receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	3	7
Multidrug resistance-associated protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Homeobox protein Nkx-2.5	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Histamine H2 receptor	7	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-2	0	4	2	6
Xanthine dehydrogenase/oxidase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Estrogen receptor	0	0	1	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Beta-secretase 1	0	2	0	3
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	3	1	0	4
Lactoperoxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
MO15-related protein kinase Pfmrk	0	1	0	1
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Cyclin homolog	0	1	0	1
Transcription factor GATA-4	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Mitogen-activated protein kinase 14	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Substance-K receptor	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	2
Integrase	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Casein kinase II subunit alpha 3	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Estrogen receptor beta	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	1	0	1
Aurora kinase B	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Myocilin	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
NADPH oxidase 4	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Estrogen receptor beta	0	0	1	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Sialidase-2	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
ATP-dependent phosphofructokinase	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
Bloom syndrome protein isoform 1	4	0	0	4
D(1A) dopamine receptor	4	0	0	4
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	14	0	18
5-hydroxytryptamine receptor 4	0	8	0	8
Muscarinic acetylcholine receptor M2	0	7	1	11
Muscarinic acetylcholine receptor M4	0	10	1	13
Muscarinic acetylcholine receptor M1	0	7	1	10
Muscarinic acetylcholine receptor M3	0	6	1	9
Muscarinic acetylcholine receptor M4	0	6	1	9
Muscarinic acetylcholine receptor M5	0	6	1	9
Muscarinic acetylcholine receptor M5	0	9	1	12
Muscarinic acetylcholine receptor M2	0	7	2	12
Muscarinic acetylcholine receptor M1	0	8	1	12
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	7	1	10
Alpha-1D adrenergic receptor	0	11	1	12
5-hydroxytryptamine receptor 2C	0	8	0	8
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	5	0	5
Muscarinic acetylcholine receptor	0	1	1	2
histone acetyltransferase KAT2A isoform 1	9	0	0	9
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	1	3
Potassium channel subfamily K member 9	0	1	0	1
Kappa-type opioid receptor	0	9	1	10
Chain A, Beta-lactamase	5	0	0	5
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	3	1	4
Lysine-specific histone demethylase 1A	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Spike glycoprotein	12	2	4	18
D(2) dopamine receptor	0	3	1	5
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	1	4
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	0	1	1
Proteasome subunit beta type-11	0	0	0	1
acetylcholinesterase	6	0	0	6
Fumarate hydratase	2	0	0	2
caspase 7, apoptosis-related cysteine protease	2	0	0	2
NADPH oxidase 1	0	1	0	1
polyprotein	2	0	0	2
Snq2p	0	0	0	3
caspase-3	2	0	0	2
Adenylate cyclase type 1	0	2	0	2
thyroid stimulating hormone receptor	3	0	0	3
Caspase-7	1	0	0	1
Spike glycoprotein	0	2	4	6
vitamin D3 receptor isoform VDRA	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
caspase-3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	3	0	0	3
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Transmembrane protease serine 2	0	2	4	6
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Albumin	0	1	3	5
Albumin	0	0	2	2
Major prion protein	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	2	4	6
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2A adrenergic receptor	0	9	3	12
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
D(2) dopamine receptor	0	9	0	10
Alpha-1B adrenergic receptor	0	5	0	5
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	8	1	9
Alpha-2C adrenergic receptor	0	9	2	11
D	0	3	0	3
D(3) dopamine receptor	0	4	0	4
Alpha-2B adrenergic receptor	0	5	0	5
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	6	0	7
D(4) dopamine receptor	0	4	0	5
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	5	0	5
UDP-glucuronosyltransferase 1A4	0	1	0	2
Alpha-2A adrenergic receptor	0	5	0	5
Alpha-1D adrenergic receptor	0	5	0	5
Histamine H2 receptor	0	4	0	4
D(1B) dopamine receptor	0	3	0	3
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
5-hydroxytryptamine receptor 2A	0	8	0	8
Trypanothione reductase	0	4	0	4
D(4) dopamine receptor	0	3	0	3
Histamine H1 receptor	0	1	0	1
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	8	0	8
Glutamate receptor ionotropic, NMDA 1	0	5	1	6
D(3) dopamine receptor	0	8	0	9
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	3	0	3
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	6	0	6
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	5	1	6
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	1	6
Glutamate receptor ionotropic, NMDA 2B	0	5	1	6
Glutamate receptor ionotropic, NMDA 2C	0	5	1	6
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	15	0	15
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	5	1	6
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	5	1	6
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	10	0	10
Angiotensin-converting enzyme 2	0	2	4	6
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	5	1	6
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	3
Alpha-1A adrenergic receptor	0	0	2	2
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	9	1	12
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Mu-type opioid receptor	0	9	1	10
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	3	0	3
Multidrug and toxin extrusion protein 1	0	3	0	3
Nischarin	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Kappa-type opioid receptor	0	5	2	9
Mu-type opioid receptor	0	6	2	11
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	4	4
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	5	0	0	5
Fatty acid-binding protein, liver	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Translocator protein	0	1	2	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
N-acetyltransferase Eis	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Delta-type opioid receptor	0	10	3	14
Mu-type opioid receptor	0	12	4	19
Kappa-type opioid receptor	0	7	3	11
Sigma non-opioid intracellular receptor 1	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	2	0	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, ELONGATION FACTOR TU (EF-TU)	0	0	1	1
Chain A, Elongation Factor G	0	0	1	1
Chain A, ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3	0	0	1	1
Chain A, Eukaryotic peptide chain release factor GTP-binding subunit	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, interferon-inducible GTPase	0	0	1	1
Chain A, interferon-inducible GTPase	0	0	1	1
Chain A, Elongation factor 2	0	0	1	1
Chain A, Guanine nucleotide-binding protein G(i), alpha-1 subunit	0	0	1	1
72 kDa type IV collagenase	0	1	0	1
Matrilysin	0	1	0	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Liver carboxylesterase 1	0	0	0	2
Histamine H4 receptor	0	1	0	1
Acetylcholinesterase	0	5	0	5
Cholinesterase	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Nuclear receptor corepressor 2	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	2	2
ATP-dependent translocase ABCB1	0	2	0	2
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Cholinesterase	0	3	0	3
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Alpha-synuclein	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
huntingtin isoform 2	1	0	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
nonstructural protein 1	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Caspase-7	1	0	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Protein argonaute-2	0	0	1	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (384)

Protein Targets (911)

Labor Pain

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (384)

Drugs Studied (100)

Protein Targets (911)