Embolism, Cholesterol

Blocking of a blood vessel by CHOLESTEROL-rich atheromatous deposits, generally occurring in the flow from a large artery to small arterial branches. It is also called arterial-arterial embolization or atheroembolism which may be spontaneous or iatrogenic. Patients with spontaneous atheroembolism often have painful, cyanotic digits of acute onset.

Synonym
Embolism, Cholesterol

Excerpt	Reference
"Therefore cholesterol embolism is a serious complication of aortic atherosclerosis and often holds a poor prognosis."	( Claudel, JP; Coppéré, B; Ninet, J, 1995)
"The prognosis of cholesterol embolism is often poor, and no treatment is presently available."	( Avignon, A; Monnier, L; Radauceanu, A; Ribstein, J, 1998)
"Cholesterol embolism is a serious disease with a high morbidity and mortality rate."	( Grenader, T; Lifschitz, M; Shavit, L, 2005)
"Cholesterol embolism is a disease caused by distal showering of cholesterol crystal released from disintegration of arterial atheromatous plaques."	( Andreu, FJ; Enguita, AB; Gutiérrez Solís, E; Gutiérrez, E; Igarzábal, A; Morales, E; Praga, M; Rivera, F; Rodríguez Jornet, A; Vozmediano, C, 2010)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.50)	23.3326
1990's	38 (18.91)	12.5806
2000's	101 (50.25)	18.1394
2010's	45 (22.39)	28.8240
2020's	16 (7.96)	9.53

Drug	Relationship Strength	Studies	Trials
coumarin	low	2	0
n(g),n(g')-dimethyl-l-arginine	low	1	0
dalteparin	low	2	0
uric acid	low	1	0
aspirin	medium	12	1
candesartan	low	2	0
cilostazol	low	2	0
dipyridamole	low	3	0
hydroxyurea	low	2	0
mesalamine	low	1	0
nimodipine	medium	1	1
pentoxifylline	medium	1	1
sarpogrelate	low	1	0
ticlopidine	medium	16	2
prednisolone	low	15	0
serine	low	1	0
colchicine	low	1	0
medroxyprogesterone acetate	low	1	0
valine	low	1	0
arginine	low	2	0
methylprednisolone	low	4	0
pyrroles	low	2	0
thiazoles	low	1	0
fluorobenzenes	low	2	0
chenodeoxycholic acid	low	1	0
c.i. 42510	low	1	0
vancomycin	low	1	0
gallium citrate	low	1	0
iso-sulfan blue	low	1	0
lovastatin	low	1	0
simvastatin	low	7	0
pravastatin	low	1	0
clopidogrel	medium	14	2
atorvastatin	low	2	0
valsartan	low	1	0
adenosine	low	1	0
tretoquinol	low	1	0
xenon radioisotopes	low	1	0
homocysteine	low	3	0
mci 9038	low	1	0
n,n-dimethylarginine	low	1	0
cortisone	low	1	0
alprostadil	low	1	0
iloprost	low	9	0
gallium	low	1	0
gadolinium dtpa	low	1	0
mocetinostat	low	3	0
edoxaban	low	1	0
cardiovascular agents	low	1	0
natriuretic peptide, brain	low	1	0
acenocoumarol	low	2	0
warfarin	medium	18	1
daptomycin	low	1	0
folic acid	low	1	0
eye	low	4	0

Protein Targets (644)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Luciferase	8	0	0	8
RAR-related orphan receptor gamma	13	0	0	13
retinoid X nuclear receptor alpha	17	0	0	17
G	10	0	0	10
peroxisome proliferator activated receptor gamma	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
thyroid stimulating hormone receptor	7	0	0	7
chromobox protein homolog 1	8	0	0	8
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
geminin	14	0	0	14
muscleblind-like protein 1 isoform 1	5	0	0	5
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Guanine nucleotide-binding protein G	4	0	0	4
Inositol hexakisphosphate kinase 1	10	0	0	10
cytochrome P450 2C9, partial	10	0	0	10
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	22	0	0	22
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	21	0	0	21
estrogen nuclear receptor alpha	27	0	0	27
NPYLR7B	0	0	2	2
arylsulfatase A	4	0	0	4
IDH1	8	0	0	8
Histone H2A.x	7	0	0	7
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	2	0	0	2
flap endonuclease 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	8	0	0	8
survival motor neuron protein isoform d	6	0	0	6
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
Rap guanine nucleotide exchange factor 3	2	0	0	2
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	5	2	8
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	10	0	0	10
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	2	1	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	1	2	4
Adenosine receptor A2b	0	1	1	3
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	2	7
Adenosine receptor A2a	0	3	1	4
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
TDP1 protein	15	0	0	15
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	16
Bile salt export pump	0	21	0	21
Cellular tumor antigen p53	14	0	0	14
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	14	0	14
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	10	0	0	10
phosphopantetheinyl transferase	4	0	0	4
NFKB1 protein, partial	5	0	0	5
GLS protein	7	0	0	7
thyroid stimulating hormone receptor	10	0	0	10
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	6	0	0	6
DNA polymerase iota isoform a (long)	8	0	0	8
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	5	0	0	5
Cytochrome P450 3A4	0	3	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
EWS/FLI fusion protein	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
estrogen-related nuclear receptor alpha	18	0	0	18
cytochrome P450 2D6	10	0	0	10
glucocerebrosidase	3	0	0	3
peroxisome proliferator-activated receptor delta	10	0	0	10
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase kappa isoform 1	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	4	0	6
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Substance-P receptor	0	1	0	2
Prostaglandin G/H synthase 2	0	8	0	8
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	9	1	0	10
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Cruzipain	4	0	0	4
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
GLI family zinc finger 3	15	0	0	15
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
pregnane X nuclear receptor	17	0	0	17
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
caspase-3	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
Caspase-7	2	0	0	2
vitamin D3 receptor isoform VDRA	7	0	0	7
thyroid hormone receptor beta isoform a	6	0	0	6
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
Solute carrier organic anion transporter family member 2B1	0	2	0	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	6	0	6
ATP-dependent translocase ABCB1	0	5	0	6
Insulin receptor	0	4	0	4
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Histone deacetylase 1	0	4	0	4
Histone deacetylase 2	0	4	0	4
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Histone deacetylase 6	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Solute carrier organic anion transporter family member 1B1	0	5	0	8
progesterone receptor	11	0	0	11
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
acetylcholinesterase	6	0	0	6
USP1 protein, partial	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
Aldo-keto reductase family 1 member B1	0	4	0	4
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	3	0	3
Cytochrome P450 2C9	0	6	0	6
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Type-1A angiotensin II receptor	0	1	2	3
Type-1 angiotensin II receptor	0	4	1	7
Type-1 angiotensin II receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Leukotriene B4 receptor 2	0	0	2	2
farnesoid X nuclear receptor	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Alpha-2A adrenergic receptor	0	3	1	4
Vitamin D3 receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	2	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Ileal sodium/bile acid cotransporter	0	1	0	1
TAR DNA-binding protein 43	5	0	0	5
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	1	1	2
endonuclease IV	5	0	0	5
Thrombopoietin	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
peripheral myelin protein 22 isoform 1	6	0	0	6
cytochrome P450 2C9 precursor	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	11
cytochrome P450 3A4 isoform 1	9	0	0	9
M-phase phosphoprotein 8	3	0	0	3
lamin isoform A-delta10	10	0	0	10
neuropeptide S receptor isoform A	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	9	0	0	9
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit delta	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	9	0	0	9
Histamine H2 receptor	4	0	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Spike glycoprotein	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-2	9	0	0	9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
GABA theta subunit	9	0	0	9
Gamma-aminobutyric acid receptor subunit epsilon	9	0	0	9
nonstructural protein 1	5	0	0	5
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2B6	0	3	0	3
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Cytochrome P450 2C19	0	5	0	5
Rap guanine nucleotide exchange factor 4	4	0	0	4
P2Y purinoceptor 12	0	1	0	1
Chain A, Beta-lactamase	8	0	0	8
Chain A, Ferritin light chain	7	0	0	7
PAX8	0	0	0	1
pregnane X receptor	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	4	0	0	4
PPM1D protein	4	0	0	4
Smad3	4	0	0	4
polyprotein	4	0	0	4
67.9K protein	2	0	0	2
aryl hydrocarbon receptor	4	0	0	4
activating transcription factor 6	4	0	0	4
cytochrome P450 2D6 isoform 1	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
dopamine D1 receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
heat shock protein beta-1	5	0	0	5
Glucocorticoid receptor	0	10	3	18
Sex hormone-binding globulin	0	0	2	2
Glycine receptor subunit alpha-1	0	10	0	10
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	2	0	2
GALC protein	1	0	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
Exportin-1	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 2A6	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Beta-secretase 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	2	0	4
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
acid sphingomyelinase	2	0	0	2
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Microtubule-associated protein tau	2	0	0	2
DNA polymerase III, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
isocitrate dehydrogenase 1, partial	2	0	0	2
LANA	0	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
snurportin-1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Caspase-7	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Inositol monophosphatase 1	3	0	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Coagulation factor X	0	4	0	4
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
glp-1 receptor, partial	3	0	0	3
DNA polymerase beta	1	0	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Alpha-synuclein	2	0	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	3
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	0	1	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	0	1	1
Prostacyclin receptor	0	1	1	2
Prostaglandin D2 receptor	0	0	1	1
histone deacetylase 9 isoform 3	1	0	0	1
Chain A, Antigen Cd11a (p180)	0	1	0	1
15-lipoxygenase, partial	2	0	0	2
thioredoxin glutathione reductase	2	0	0	2
PINK1	3	0	0	3
Parkin	4	0	0	4
bcl-2-related protein A1	0	1	0	1
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Neutrophil elastase	0	1	0	1
Androgen receptor	0	7	0	7
Integrin alpha-L	0	1	1	2
Substance-K receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Prothrombin	0	2	1	3
Prothrombin	0	1	0	1
Plasminogen	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Cationic trypsin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Estrogen receptor	0	3	1	4
Progesterone receptor	0	4	1	6
Mineralocorticoid receptor	0	3	1	4
Androgen receptor	0	4	2	6
Androgen receptor	0	0	1	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Estrogen receptor beta	0	3	1	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Tumor necrosis factor	0	2	0	2
Neuraminidase	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Cholinesterase	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Cholinesterase	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
photoreceptor-specific nuclear receptor	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Bile salt export pump	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Thromboxane A2 receptor	0	0	0	1
Type-1B angiotensin II receptor	0	1	0	1
Squalene synthase	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Albumin	0	0	2	2
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (201)

Protein Targets (644)

Embolism, Cholesterol

Synonyms(1)

Research Excerpts

Overview

Research

Studies (201)

Drugs Studied (69)

Protein Targets (644)