quinovic acid profile

Quinovic acid is a triterpenoid compound found in the bark of Cinchona species. It is known for its diverse biological activities, including anti-inflammatory, antimicrobial, and anti-cancer properties. Research has shown that quinovic acid can inhibit the growth of various cancer cell lines, including leukemia, breast, and colon cancer. It is also studied for its potential to modulate immune responses and protect against oxidative stress. The synthesis of quinovic acid involves a complex series of reactions, and efforts are underway to develop efficient and sustainable methods for its production. Due to its promising biological activities and potential therapeutic applications, quinovic acid is an active area of research.'

quinovic acid: from Mitragyna stipulosa (Rubiaceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Mitragyna stipulosa	species	[no description available]	Rubiaceae	The Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH]

ID Source	ID
PubMed CID	120678
CHEMBL ID	4463264
SCHEMBL ID	547774
MeSH ID	M0447619

Synonym
3-beta-hydroxyurs-12-ene-27,28-dioic acid
urs-12-ene-27,28-dioic acid, 3-hydroxy-, (3-beta)-
urs-12-ene-27,28-dioic acid, 3-beta-hydroxy-
quinovic acid
brn 3113936
quinovaic acid
chinova acid
chinovic acid
(3-beta)-3-hydroxyurs-12-ene-27,28-dioic acid
465-74-7
(1s,2r,4as,6ar,6ar,6br,8ar,10s,12ar,14bs)-10-hydroxy-1,2,6b,9,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1h-picene-4a,6a-dicarboxylic acid
(3beta)-3-hydroxyurs-12-ene-27,28-dioic acid
4-10-00-02197 (beilstein handbook reference)
9jp167t0zn ,
unii-9jp167t0zn
SCHEMBL547774
quinovic acid [mi]
urs-12-ene-27,28-dioic acid, 3-hydroxy-, (3.beta.)-
3.beta.-hydroxyurs-12-ene-27,28-dioic acid
CHEMBL4463264
AKOS032948452
FS-9901
DTXSID10963591
3-hydroxyurs-12-ene-27,28-dioic acid
Q27272637
A872248

Assay ID	Title	Year	Journal	Article
AID1615642	Bactericidal activity against Haemophilus influenzae type b ATCC 49247 incubated for 24 hrs followed by transferring to freshly prepared broth medium and measured after 24 hrs by M7-A9 microdilution method	2019	Journal of natural products, 09-27, Volume: 82, Issue:9	Constituents from
AID1615641	Antibacterial activity against Haemophilus influenzae type b ATCC 49247 incubated for 24 hrs by M7-A9 microdilution method	2019	Journal of natural products, 09-27, Volume: 82, Issue:9	Constituents from
AID1615643	Ratio of MBC to MIC for Haemophilus influenzae type b ATCC 49247 by M7-A9 microdilution method	2019	Journal of natural products, 09-27, Volume: 82, Issue:9	Constituents from
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (8.33)	18.2507
2000's	4 (33.33)	29.6817
2010's	5 (41.67)	24.3611
2020's	2 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.21	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
oleanolic acid [no description available]	2.42	2	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.01	1	D-glucopyranose	epitope; mouse metabolite
beta-amyrin beta-amyrin: alpha-amyrin is also available; a 5 ring triterpene derived from oleanane that differs from alpha-amyrin in having the 29-carbon at the 20 position; RN given refers to (3 beta)-isomer. beta-amyrin : A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.	2.01	1	pentacyclic triterpenoid; secondary alcohol	Aspergillus metabolite; plant metabolite
pomolic acid pomolic acid: from Rosa woodsii & Hyptis capitata; structure in first source	2.21	1	triterpenoid	metabolite
gamma-sitosterol clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.	2	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols	marine metabolite; plant metabolite
glycosides [no description available]	3.32	6
cytellin cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982	2	1
beta-escin [no description available]	2.52	2
oleanane oleanane: from the aerial roots of Ficus microcarpa; structure in first source	7.02	1	terpenoid fundamental parent; triterpene
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	2.11	1	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent
glucagon-like peptide 1 Glucagon-Like Peptide 1: A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.	2.13	1
incretins Incretins: Peptides which stimulate INSULIN release from the PANCREATIC BETA CELLS following oral nutrient ingestion, or postprandially.	2.13	1

Condition	Relationship Strength	Studies
Breast Cancer [description not available]	2.25	1
Cancer of Lung [description not available]	2.25	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.25	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.25	1
Bladder Cancer [description not available]	7.1	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.1	1
Bleeding [description not available]	2.11	1
Cystitis Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.	7.11	1
Hemorrhage Bleeding or escape of blood from a vessel.	2.11	1
Black Fever [description not available]	2.03	1
Leishmaniasis, Visceral A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.	2.03	1

quinovic acid

Description

Cross-References

Synonyms (26)

Research Excerpts

Bioassays (3)

Research

Studies (12)

Market Indicators

Research Demand Index: 22.98

Study Types