BOOP

An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a pneumonia-like illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.

Synonym
BOOP
Cryptogenic Organizing Pneumonia
Bronchiolitis Obliterans Organizing Pneumonia

Excerpt	Reference
"BOOP is responsive to oral corticosteroids, which are the mainstay of therapy."	( Fadem, JJ; Watson, D, 1995)
"Although BOOP is being more frequently recognized as bilateral disease to the best of our knowledge, only three previous cases of unilateral disease have been recognized and reported."	( Campbell, JC; Dewan, N; Kanwar, BA; O'Donohue, WJ; Shehan, CJ, 1996)
"Idiopathic BOOP is a clinicopathological entity defined histopathologically by the presence of granulation tissue in bronchioles, alveolar ducts and alveoli."	( Korzeniewska-Koseła, M; Kuś, J; Meleniewska-Maciszewska, A; Stelmaszczyk, W; Słodkowska, J; Wesołowski, S; Zołnowska, B, 1997)
"BOOP is essentially idiopathic, but associations to other conditions exist."	( Demedts, M; Lamont, J; Verbeken, E; Verschakelen, J, 1998)
"BOOP is a pathological-anatomical entity."	( Beaumont, F; Boersema, B; Broekman, JM; Peeters, HR, 2001)
"BOOP is considered as a nonspecific response to many types of lung injury, including drugs, radiation, an underlying hematologic malignant neoplasm, autoimmune diseases, bacterial or virus infection, or an underlying lung disease, or occurs idiopathically."	( Breitbart, A; Egerer, G; Goldschmidt, H; Ho, AD; Möller, P; Spaeth, A; Witzens, M, 2001)
"The cause of BOOP is often never found; it is believed, however, that in this instance it occurred as a result of carbamazepine therapy started seven weeks earlier."	( Banka, R; Ward, MJ, 2002)
"The pathogeny of R-BOOP is not direct toxicity of irradiation because untreated areas can also be affected."	( Balme, B; Dalle, S; Ronger-Savlè, S; Skowron, F; Thomas, L, 2004)
"BOOP is a common and potentially serious adverse event in cardiac transplant patients switched from a CI to SIR, especially when SIR is started late post-transplantation."	( Cleveland, JC; Cool, CD; Frisk, R; Ireland, N; Keller, K; Lindenfeld, JA; Lowes, BD; Simon, SF; Stepien, L; Wolfel, EE; Zamora, MR; Zolty, R, 2005)
"The cause of BOOP is often not certain."	( Allen, D; Burke, E; Drake, M; Elborn, S; Gleadhill, I; Kettle, P; Macartney, C; Magee, N; Noone, P, 2005)
"BOOP is characterised by inflammation of the bronchioles and surrounding tissue in the lungs."	( Bofill, M; Cigudosa, JC; de la Calle-Martin, O; Martinez-Gallo, M; Nomdedeu, JF; Puy, C; Rodriguez-Arias, JM; Rodriguez-Sanchez, JL; Ruiz-Hernandez, R, 2008)
"Cryptogenic organizing pneumonia is an idiopathic form of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia)."	( Durham, C; Funkhouser, WK; Henke, DC; Kuhn, JM; Pathak, V, 2014)
"Cryptogenic organizing pneumonia is a rare manifestation of Sweet's syndrome, which may be complicated by respiratory failure."	( Alamani, M; Kaltsas, G; Kampolis, CF; Moschovi, M; Tzelepis, E; Vlachadami, I, 2016)
"Bronchiolitis obliterans organizing pneumonia is an interstitial lung disease rarely occurring after radiotherapy probably due to an activation of autoimmune processes."	( Alterio, D; Bazzani, F; Donghi, SM; Fanetti, G; Ferrari, A; Jereczek-Fossa, BA; Orecchia, R; Pounou Kamga, FA, 2018)
"BOOP is a rare pulmonary manifestation in lupus."	( Baisya, R; Devarasetti, PK; Narayanan, R; Rajasekhar, L; Sreejitha, KS; Uppin, SG, 2021)

Excerpt	Reference
"BOOP has often been reported as a pulmonary manifestation of collagen vascular diseases, mainly rheumatoid arthritis (RA), but the association of BOOP and PM has rarely been documented."	( Imasaki, T; Ishikawa, A; Ogura, T; Takahashi, T; Tanaka, S; Yoshii, A, 1996)
"Childhood BOOP has been described in several reports."	( Epler, GR, 1998)
"Although BOOP has previously been described as one of the pulmonary manifestations of WG, other more specific histologic features of WG such as capillaritis or necrotizing vasculitis were lacking."	( Ramos, LG; Staud, R, 2001)
"BOOP has been recognized as a complication of lung and bone marrow transplantation, but the mechanism is unknown."	( DeAngelo, AJ; Ouellette, D, 2002)

Excerpt	Reference
"Reports of bronchiolitis obliterans organizing pneumonia (BOOP) occurring in women after radiation therapy for breast cancer have suggested that radiation to the lung could participate in the development of BOOP."	( Cordier, JF; Crestani, B; Dalphin, JC; Roden, S; Valeyre, D; Wallaert, B, 1998)
"This case suggests that bronchiolitis obliterans organizing pneumonia may be a distinct pulmonary complication in cystic fibrosis and improve with specific therapy."	( Biesterfeld, S; Friedrichs, F; Häusler, M; Kentrup, H; Kusenbach, G; Meilicke, R, 2000)
"We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG)."	( Ramos, LG; Staud, R, 2001)
"Radiotherapy-induced bronchiolitis obliterans organizing pneumonia (R-BOOP) is one of the pulmonary manifestations due to recent advances in radiotherapy of breast carcinoma."	( Balme, B; Dalle, S; Ronger-Savlè, S; Skowron, F; Thomas, L, 2004)
"Except for a temporal exacerbation of bronchiolitis obliterans organizing pneumonia, she has been free from disease for more than a year without other treatments against lymphoma."	( Chiba, S; Izutsu, K; Kako, S; Kanda, Y; Kurokawa, M; Motokura, T; Oshima, K; Sato, H, 2007)
"We report a case of cryptogenic organizing pneumonia secondary to amiodarone treatment, its clinical course with significant improvement of clinical symptoms within a few days after discontinuation of amiodarone treatment and administration of corticosteroids."	( Kaliman, JF; Schima, W; Schindler, K, 2010)
"We describe a case of cryptogenic organizing pneumonia (COP) occurring in a 78-year-old woman after receiving 2 cycles of modified FOLFOX6 as adjuvant chemotherapy for treatment of resected nonmetastatic colon cancer."	( Dalvi, AG; Dretler, R; Hap, J; Shogbon, AO, 2013)
"Effective macrolide treatment of BOOP has been reported anecdotally."	( Bonella, F; Cai, M; Costabel, U; Dai, H; Guzman, J; Sarria, R, 2013)
"We present an extremely rare case of cryptogenic organizing pneumonia following therapy with azacitidine and a review of the relevant literature."	( Abuqayas, B; Alnimer, Y; Alrabi, K; Salah, S, 2016)
"We described a case of bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for a recurrent lung cancer."	( Alterio, D; Bazzani, F; Donghi, SM; Fanetti, G; Ferrari, A; Jereczek-Fossa, BA; Orecchia, R; Pounou Kamga, FA, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	62 (20.00)	12.5806
2000's	138 (44.52)	18.1394
2010's	92 (29.68)	28.8240
2020's	18 (5.81)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
nickel	low	1	0
nitric acid	low	2	0
phenytoin	low	1	0
amiodarone	low	24	0
azathioprine	low	10	0
busulfan	low	1	0
carbamazepine	low	4	0
chlorambucil	low	1	0
clomipramine	low	1	0
dapsone	low	1	0
etidronate	low	1	0
flecainide	low	1	0
fluorouracil	low	6	0
hydroxyurea	low	1	0
ifosfamide	low	1	0
khellin	low	1	0
lamotrigine	low	1	0
leflunomide	low	1	0
loxoprofen	low	1	0
mesalamine	low	2	0
papaverine	low	1	0
phenobarbital	low	1	0
risedronic acid	low	1	0
sotalol	low	1	0
sulfasalazine	low	4	0
temozolomide	low	1	0
thalidomide	low	1	0
ticlopidine	low	1	0
prednisolone	low	71	0
prednisone	medium	64	1
cytidine monophosphate	low	1	0
ampicillin	low	1	0
cytarabine	low	2	0
methylprednisolone	low	37	0
thiophenes	low	1	0
pyrazines	low	1	0
azacitidine	low	3	0
erythromycin	low	1	0
deoxycytidine	low	4	0
ethambutol	low	1	0
titanium	low	1	0
chromium	low	1	0
camptothecin	low	1	0
trolamine salicylate	low	1	0
titanium dioxide	low	1	0
triamcinolone	low	1	0
tetrachloroethylene	low	1	0
ursodeoxycholic acid	low	1	0
amoxicillin	low	2	0
paclitaxel	low	1	0
etoposide	low	2	0
ribavirin	low	1	0
pirfenidone	low	1	0
epirubicin	low	1	0
pravastatin	low	1	0
cidofovir anhydrous	low	1	0
gemcitabine	low	3	0
duloxetine hydrochloride	low	1	0
emtricitabine	low	3	0
capecitabine	low	1	0
adenosine	low	1	0
cephalosporin c	low	2	0
fluorodeoxyglucose f18	medium	4	1
voriconazole	low	2	0
clarithromycin	low	12	0
methotrexate	low	10	0
docetaxel anhydrous	low	1	0
levofloxacin	low	1	0
atropine	low	1	0
cortisone	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	2	0
bortezomib	low	1	0
carboplatin	low	1	0
fibrin	low	7	0
oleic acid	low	1	0
tacrolimus	low	4	0
cocaine	low	1	0
mycophenolic acid	low	2	0
zithromax	low	2	0
decitabine	low	2	0
tenofovir	low	3	0
micafungin	low	1	0
bromochloroacetic acid	low	2	0
bucillamine	low	3	0
propylthiouracil	low	2	0
mercaptopurine	low	1	0
tamoxifen	low	2	0
calcitriol	low	1	0
acitretin	low	1	0
sirolimus	low	5	0
fumarates	low	1	0
cysteine	low	3	0
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid	low	1	0
everolimus	low	1	0
nitrofurantoin	low	6	0
mocetinostat	low	2	0
crizotinib	low	1	0
scopolamine hydrobromide	low	1	0
1-arabinofuranosylcytosine-5'-stearylphosphate	low	1	0
cardiovascular agents	low	2	0
piperidines	low	1	0
interleukin-8	low	2	0
alectinib	low	1	0
minocycline	low	2	0
ceritinib	low	2	0
daptomycin	low	1	0
vitamin b 12	low	1	0
cyclosporine	low	11	0
thromboplastin	low	1	0
levoleucovorin	low	4	0
dacarbazine	low	1	0
ganciclovir	low	1	0
pemetrexed	low	1	0

Protein Targets (1,592)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Cytochrome P450 2C9	0	17	0	18
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Luciferase	9	0	0	9
USP1 protein, partial	18	0	0	18
TDP1 protein	48	0	0	48
Microtubule-associated protein tau	11	0	0	11
AR protein	46	0	0	46
aldehyde dehydrogenase 1 family, member A1	26	0	0	26
glucocorticoid receptor [Homo sapiens]	32	0	0	32
estrogen nuclear receptor alpha	56	0	0	56
peroxisome proliferator activated receptor gamma	25	0	0	25
euchromatic histone-lysine N-methyltransferase 2	34	0	0	34
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	24	0	0	24
vitamin D3 receptor isoform VDRA	9	0	0	9
thyroid hormone receptor beta isoform 2	32	0	0	32
flap endonuclease 1	8	0	0	8
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	4	0	0	4
geminin	45	0	0	45
peripheral myelin protein 22	22	0	0	22
survival motor neuron protein isoform d	19	0	0	19
histone acetyltransferase KAT2A isoform 1	12	0	0	12
ATP-binding cassette sub-family C member 3	0	47	0	47
Multidrug resistance-associated protein 4	0	47	0	48
Bile salt export pump	0	10	0	10
Bile salt export pump	0	59	0	59
Rap guanine nucleotide exchange factor 3	5	0	0	5
Cellular tumor antigen p53	29	0	0	29
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	20	0	0	20
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	7	0	0	7
retinoid X nuclear receptor alpha	28	0	0	28
NPYLR7B	0	0	1	1
arylsulfatase A	15	0	0	15
IDH1	15	0	0	15
Histone H2A.x	18	0	0	18
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
mitogen-activated protein kinase 1	10	0	0	10
nuclear receptor ROR-gamma isoform 1	13	0	0	13
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	7	6	13
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	5	1	6
Insulin receptor	0	2	5	8
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	1	5	7
Adenosine receptor A3	0	8	2	11
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	2	5	8
Inosine-5'-monophosphate dehydrogenase 2	0	3	4	7
Endoplasmin	0	1	1	2
Glutamate receptor 2	16	1	0	17
Inosine-5'-monophosphate dehydrogenase 1	0	3	0	3
Fibroblast growth factor receptor 2	0	1	1	3
Fibroblast growth factor receptor 4	0	1	1	3
Fibroblast growth factor receptor 3	0	2	1	4
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	3
Adenosine receptor A1	0	1	1	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	5	2	8
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	6	2	9
Adenosine receptor A2a	0	1	1	2
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	5	6
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	3	0	3
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	1	4
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
EWS/FLI fusion protein	35	0	0	35
Bone morphogenetic protein receptor type-1B	0	0	5	5
Cell division cycle 7-related protein kinase	0	0	4	4
Serine/threonine-protein kinase PLK4	0	0	5	5
ATP-dependent RNA helicase DDX3X	0	0	5	5
Pyridoxal kinase	0	0	5	5
Citron Rho-interacting kinase	0	0	5	5
Serine/threonine-protein kinase Chk1	0	0	6	6
Aurora kinase A	0	0	5	5
Cyclin-G-associated kinase	0	1	5	6
Ephrin type-B receptor 6	0	0	5	5
Peroxisomal acyl-coenzyme A oxidase 3	0	0	5	5
Receptor-interacting serine/threonine-protein kinase 2	0	0	5	5
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	5	5
Dynamin-like 120 kDa protein, mitochondrial	0	0	5	5
Eukaryotic translation initiation factor 5B	0	0	4	4
Rho-associated protein kinase 2	0	1	5	6
Serine/threonine-protein kinase ULK1	0	0	5	5
Serine/threonine-protein kinase/endoribonuclease IRE1	0	1	5	6
Ribosomal protein S6 kinase alpha-5	0	0	5	5
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	5	5
Ribosomal protein S6 kinase alpha-4	0	0	5	5
Serine/threonine-protein kinase 16	0	0	5	5
Cyclin-dependent kinase-like 5	0	0	4	4
Serine/threonine-protein kinase 10	0	0	5	5
Serine/threonine-protein kinase D3	0	1	5	6
Structural maintenance of chromosomes protein 2	0	0	5	5
Mitogen-activated protein kinase kinase kinase 6	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	5	5
Serine/threonine-protein kinase LATS1	0	0	5	5
Serine/threonine-protein kinase PAK 4	0	0	5	5
Tyrosine-protein kinase ABL1	0	4	6	10
High affinity nerve growth factor receptor	0	2	5	7
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	4	4
ADP/ATP translocase 2	0	0	5	5
Protein kinase C beta type	0	1	5	6
Tyrosine-protein kinase Lck	0	3	5	8
Tyrosine-protein kinase Fyn	0	5	5	10
Cyclin-dependent kinase 1	0	1	5	6
Glycogen phosphorylase, liver form	0	0	5	5
Tyrosine-protein kinase Fes/Fps	0	0	5	5
Adenine phosphoribosyltransferase	0	0	5	5
Tyrosine-protein kinase Yes	0	0	5	5
Tyrosine-protein kinase Lyn	0	1	5	6
Proto-oncogene tyrosine-protein kinase receptor Ret	0	3	5	8
Insulin-like growth factor 1 receptor	0	2	5	7
Signal recognition particle receptor subunit alpha	0	0	5	5
Cytochrome c1, heme protein, mitochondrial	0	0	5	5
Hepatocyte growth factor receptor	0	4	5	9
Tyrosine-protein kinase HCK	0	0	5	5
Proto-oncogene tyrosine-protein kinase ROS	0	5	1	6
Tyrosine-protein kinase Fgr	0	2	4	6
Serine/threonine-protein kinase A-Raf	0	0	5	5
Mast/stem cell growth factor receptor Kit	0	2	1	3
Glycogen phosphorylase, brain form	0	0	5	5
Breakpoint cluster region protein	0	0	5	5
Serine/threonine-protein kinase pim-1	0	0	5	5
DNA topoisomerase 2-alpha	0	3	6	17
Cyclin-dependent kinase 4	0	1	5	6
ADP/ATP translocase 3	0	0	5	5
Proto-oncogene tyrosine-protein kinase Src	0	3	5	8
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	5	5
Serine/threonine-protein kinase B-raf	0	0	5	5
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	5	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	5	5
Tyrosine-protein kinase Fer	0	0	5	5
Protein kinase C alpha type	0	1	5	7
cAMP-dependent protein kinase catalytic subunit alpha	0	0	5	5
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	5	5
Casein kinase II subunit alpha'	0	0	5	5
Ras-related protein Rab-6A	0	0	5	5
Ephrin type-A receptor 1	0	0	5	5
Multifunctional protein ADE2	0	0	5	5
cAMP-dependent protein kinase catalytic subunit gamma	0	0	4	4
cAMP-dependent protein kinase catalytic subunit beta	0	0	5	5
Ferrochelatase, mitochondrial	0	0	5	5
Ribosomal protein S6 kinase beta-1	0	1	5	6
Tyrosine-protein kinase JAK1	0	2	5	7
Cyclin-dependent kinase 2	0	1	6	7
Beta-adrenergic receptor kinase 1	0	0	5	5
Probable ATP-dependent RNA helicase DDX6	0	0	5	5
Mitogen-activated protein kinase 3	0	0	5	5
MAP/microtubule affinity-regulating kinase 3	0	0	5	5
Deoxycytidine kinase	0	0	5	8
Mitogen-activated protein kinase 1	0	1	5	6
Ephrin type-A receptor 2	0	1	5	6
Ephrin type-B receptor 2	0	1	5	6
Non-receptor tyrosine-protein kinase TYK2	0	1	5	6
UMP-CMP kinase	0	0	4	5
Phosphatidylethanolamine-binding protein 1	0	0	5	5
Wee1-like protein kinase	0	0	5	5
Heme oxygenase 2	0	0	5	5
S-adenosylmethionine synthase isoform type-2	0	0	5	5
DnaJ homolog subfamily A member 1	0	0	5	5
RAC-alpha serine/threonine-protein kinase	0	0	5	5
RAC-beta serine/threonine-protein kinase	0	1	5	6
Dual specificity protein kinase TTK	0	0	5	5
DNA replication licensing factor MCM4	0	0	5	5
Myosin-10	0	0	4	4
Vascular endothelial growth factor receptor 2	0	4	1	5
Dual specificity mitogen-activated protein kinase kinase 2	0	0	5	5
Receptor-type tyrosine-protein kinase FLT3	0	2	5	7
Bone morphogenetic protein receptor type-1A	0	0	5	5
Activin receptor type-1B	0	0	5	5
TGF-beta receptor type-1	0	0	5	5
TGF-beta receptor type-2	0	0	5	5
Electron transfer flavoprotein subunit beta	0	0	4	4
Tyrosine-protein kinase CSK	0	0	5	5
Glycine--tRNA ligase	0	0	5	5
Protein kinase C iota type	0	1	5	6
Exosome RNA helicase MTR4	0	0	5	5
Tyrosine-protein kinase Tec	0	0	5	5
Tyrosine-protein kinase ABL2	0	1	5	6
Tyrosine-protein kinase FRK	0	0	5	5
G protein-coupled receptor kinase 6	0	0	5	5
Tyrosine-protein kinase SYK	0	1	5	6
26S proteasome regulatory subunit 6B	0	1	5	6
Mitogen-activated protein kinase 8	0	0	5	5
Mitogen-activated protein kinase 9	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 3	0	0	5	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	5	5
Casein kinase I isoform alpha	0	0	5	5
Casein kinase I isoform delta	0	0	5	5
MAP kinase-activated protein kinase 2	0	0	5	5
Elongation factor Tu, mitochondrial	0	0	5	5
Choline-phosphate cytidylyltransferase A	0	0	4	4
Cysteine--tRNA ligase, cytoplasmic	0	0	5	5
Casein kinase I isoform epsilon	0	0	5	5
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	5	5
Dual specificity protein kinase CLK1	0	0	5	5
Dual specificity protein kinase CLK2	0	0	5	5
Dual specificity protein kinase CLK3	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	5	5
Glycogen synthase kinase-3 beta	0	1	5	6
Cyclin-dependent kinase 7	0	1	5	6
Cyclin-dependent kinase 9	0	0	5	5
Ras-related protein Rab-27A	0	0	5	5
Interleukin-1 receptor-associated kinase 1	0	0	5	5
Ribosomal protein S6 kinase alpha-3	0	0	5	5
Serine/threonine-protein kinase Nek2	0	0	5	5
Serine/threonine-protein kinase Nek3	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 6	0	0	5	5
Serine/threonine-protein kinase PLK1	0	0	5	5
LIM domain kinase 1	0	0	5	5
LIM domain kinase 2	0	0	5	5
Mitogen-activated protein kinase 10	0	0	5	5
Tyrosine--tRNA ligase, cytoplasmic	0	0	5	5
5'-AMP-activated protein kinase subunit gamma-1	0	0	5	5
Ephrin type-B receptor 3	0	0	5	5
Ephrin type-A receptor 5	0	0	5	5
Ephrin type-B receptor 4	0	1	5	6
Ephrin type-A receptor 4	0	0	5	5
Adenylate kinase 2, mitochondrial	0	0	5	6
Spike glycoprotein	17	0	4	21
Ras-related protein Rab-10	0	0	5	5
Actin-related protein 3	0	0	5	5
Actin-related protein 2	0	0	5	5
GTP-binding nuclear protein Ran	0	0	5	5
Casein kinase I isoform gamma-2	0	0	5	5
Cyclin-dependent kinase 3	0	0	4	4
Cyclin-dependent kinase 6	0	0	5	5
Cyclin-dependent-like kinase 5	0	0	5	5
Cyclin-dependent kinase 16	0	0	5	5
Cyclin-dependent kinase 17	0	0	5	5
ATP-dependent 6-phosphofructokinase, platelet type	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 1	0	0	5	5
DNA topoisomerase 2-beta	0	1	6	14
Protein kinase C theta type	0	1	5	6
Activin receptor type-1	0	0	5	5
Macrophage-stimulating protein receptor	0	1	5	6
Focal adhesion kinase 1	0	0	5	5
Protein kinase C zeta type	0	1	3	4
Protein kinase C delta type	0	1	5	6
Tyrosine-protein kinase BTK	0	2	5	7
Cyclin-dependent kinase 18	0	0	3	3
Activated CDC42 kinase 1	0	0	5	5
Epithelial discoidin domain-containing receptor 1	0	0	5	5
Potassium voltage-gated channel subfamily H member 2	0	21	0	22
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	5	5
Tyrosine-protein kinase Mer	0	2	4	6
Serine/threonine-protein kinase 4	0	0	5	5
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 5	0	0	5	5
Mitogen-activated protein kinase 7	0	0	5	5
Serine/threonine-protein kinase PAK 2	0	1	5	6
Serine/threonine-protein kinase 3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 1	0	0	5	5
Integrin-linked protein kinase	0	0	5	5
Rho-associated protein kinase 1	0	0	5	5
Non-receptor tyrosine-protein kinase TNK1	0	0	5	5
Serine/threonine-protein kinase ATR	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	5	5
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	5	5
Activin receptor type-2B	0	0	5	5
Bone morphogenetic protein receptor type-2	0	0	5	5
Protein-tyrosine kinase 6	0	0	5	5
cGMP-dependent protein kinase 1	0	0	5	5
Cyclin-dependent kinase 13	0	0	5	5
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	5	5
Protein-tyrosine kinase 2-beta	0	0	5	5
Maternal embryonic leucine zipper kinase	0	0	5	5
Structural maintenance of chromosomes protein 1A	0	0	5	5
Chromodomain-helicase-DNA-binding protein 4	0	0	5	5
Peroxisomal acyl-coenzyme A oxidase 1	0	0	5	5
Cyclin-dependent kinase 10	0	0	2	2
Ephrin type-A receptor 7	0	0	4	4
Delta(24)-sterol reductase	0	0	5	5
Ribosomal protein S6 kinase alpha-1	0	0	5	5
Dual specificity testis-specific protein kinase 1	0	0	5	5
Myosin light chain kinase, smooth muscle	0	0	5	5
Mitogen-activated protein kinase 11	0	0	5	5
Serine/threonine-protein kinase STK11	0	0	5	5
Serine/threonine-protein kinase N1	0	0	5	5
Serine/threonine-protein kinase N2	0	1	5	6
Mitogen-activated protein kinase 14	0	2	5	7
Calcium/calmodulin-dependent protein kinase type IV	0	0	5	5
Mitogen-activated protein kinase kinase kinase 11	0	0	5	5
MAP kinase-activated protein kinase 3	0	0	2	2
Discoidin domain-containing receptor 2	0	0	5	5
AP2-associated protein kinase 1	0	0	5	5
Myosin light chain kinase 3	0	0	5	5
Uncharacterized aarF domain-containing protein kinase 5	0	0	4	4
Putative heat shock protein HSP 90-beta 2	0	0	5	5
Rab-like protein 3	0	0	3	3
Serine/threonine-protein kinase MRCK alpha	0	0	5	5
Serine/threonine-protein kinase MRCK gamma	0	0	5	5
Acyl-CoA dehydrogenase family member 10	0	0	5	5
Serine/threonine-protein kinase N3	0	0	5	5
Serine/threonine-protein kinase ULK3	0	0	5	5
Uncharacterized protein FLJ45252	0	0	5	5
Acyl-CoA dehydrogenase family member 11	0	0	5	5
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	5	5
Serine/threonine-protein kinase MARK2	0	0	5	5
ATP-dependent RNA helicase DHX30	0	0	5	5
Serine/threonine-protein kinase TAO1	0	0	5	5
STE20-related kinase adapter protein alpha	0	0	5	5
Myosin-14	0	0	5	5
AarF domain-containing protein kinase 1	0	0	5	5
ATP-dependent RNA helicase DDX42	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 3	0	1	5	6
MAP kinase-activated protein kinase 5	0	0	4	4
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	2	2
Misshapen-like kinase 1	0	0	4	4
Atypical kinase COQ8A, mitochondrial	0	0	5	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	5	5
Mitogen-activated protein kinase 15	0	0	5	5
Serine/threonine-protein kinase Nek9	0	0	5	5
ATP-dependent RNA helicase DDX1	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	5	5
Aurora kinase B	0	0	5	5
MAP/microtubule affinity-regulating kinase 4	0	0	5	5
Serine/threonine-protein kinase Nek1	0	0	5	5
PAS domain-containing serine/threonine-protein kinase	0	0	4	4
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	5	5
EKC/KEOPS complex subunit TP53RK	0	0	5	5
Dual specificity testis-specific protein kinase 2	0	0	4	4
SRSF protein kinase 1	0	1	1	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	5	5
Mitogen-activated protein kinase kinase kinase 5	0	0	5	5
Mitogen-activated protein kinase kinase kinase 3	0	0	5	5
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	5	5
Nucleolar GTP-binding protein 1	0	0	5	5
Serine/threonine-protein kinase D2	0	0	5	5
NUAK family SNF1-like kinase 2	0	0	4	4
RNA cytidine acetyltransferase	0	0	5	5
Serine/threonine-protein kinase SIK2	0	0	5	5
STE20-like serine/threonine-protein kinase	0	0	5	5
Serine/threonine-protein kinase TAO3	0	0	5	5
dCTP pyrophosphatase 1	0	0	5	5
Dual specificity protein kinase CLK4	0	0	4	4
Echinoderm microtubule-associated protein-like 4	0	3	1	5
Casein kinase I isoform gamma-1	0	0	5	5
Serine/threonine-protein kinase PAK 6	0	0	3	3
Phenylalanine--tRNA ligase beta subunit	0	0	5	5
BMP-2-inducible protein kinase	0	0	5	5
Obg-like ATPase 1	0	0	4	4
Midasin	0	0	5	5
Interleukin-1 receptor-associated kinase 4	0	0	5	5
Mitogen-activated protein kinase kinase kinase 20	0	0	5	5
Cyclin-dependent kinase 12	0	0	5	5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	4	4
Serine/threonine-protein kinase pim-2	0	0	3	3
Serine/threonine-protein kinase 26	0	0	5	5
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	5	5
Serine/threonine-protein kinase NLK	0	0	5	5
5'-AMP-activated protein kinase subunit gamma-2	0	0	5	5
Serine/threonine-protein kinase TBK1	0	0	5	5
Septin-9	0	0	5	5
Ribosomal protein S6 kinase alpha-6	0	0	5	5
TRAF2 and NCK-interacting protein kinase	0	0	5	5
Serine/threonine-protein kinase TAO2	0	0	5	5
ALK tyrosine kinase receptor	0	6	5	12
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Serine/threonine-protein kinase ICK	0	0	4	4
RAC-gamma serine/threonine-protein kinase	0	0	5	5
Serine/threonine-protein kinase SIK3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 2	0	0	5	5
Thyroid hormone receptor-associated protein 3	0	0	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	5	5
Receptor-interacting serine/threonine-protein kinase 3	0	0	5	5
Serine/threonine-protein kinase MRCK beta	0	0	5	5
Interleukin-1 receptor-associated kinase 3	0	0	5	5
Casein kinase I isoform gamma-3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 4	0	0	5	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
acetylcholinesterase	13	0	0	13
phosphopantetheinyl transferase	14	0	0	14
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
RAR-related orphan receptor gamma	32	0	0	32
SMAD family member 2	7	0	0	7
ATAD5 protein, partial	14	0	0	14
Fumarate hydratase	16	0	0	16
NFKB1 protein, partial	8	0	0	8
PPM1D protein	16	0	0	16
SMAD family member 3	7	0	0	7
Thrombopoietin	9	0	0	9
caspase 7, apoptosis-related cysteine protease	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
thyroid stimulating hormone receptor	17	0	0	17
estrogen receptor 2 (ER beta)	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	26	0	0	26
progesterone receptor	21	0	0	21
retinoic acid nuclear receptor alpha variant 1	33	0	0	33
estrogen-related nuclear receptor alpha	34	0	0	34
farnesoid X nuclear receptor	22	0	0	22
pregnane X nuclear receptor	30	0	0	30
G	17	0	0	17
cytochrome P450 2D6	17	0	0	17
polyprotein	16	0	0	16
peroxisome proliferator-activated receptor delta	20	0	0	20
caspase-3	10	0	0	10
thyroid stimulating hormone receptor	15	0	0	15
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
cytochrome P450 2D6 isoform 1	7	0	0	7
cellular tumor antigen p53 isoform a	9	0	0	9
cytochrome P450 2C9 precursor	8	0	0	8
D(1A) dopamine receptor	4	0	0	4
chromobox protein homolog 1	24	0	0	24
thyroid hormone receptor beta isoform a	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	11	0	0	11
heat shock protein beta-1	12	0	0	12
huntingtin isoform 2	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	27	0	0	27
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
urokinase-type plasminogen activator precursor	14	0	0	14
plasminogen precursor	14	0	0	14
urokinase plasminogen activator surface receptor precursor	14	0	0	14
cytochrome P450 3A4 isoform 1	20	0	0	20
muscarinic acetylcholine receptor M1	11	0	0	11
lethal factor (plasmid)	7	0	0	7
lamin isoform A-delta10	31	0	0	31
Gamma-aminobutyric acid receptor subunit pi	20	2	0	22
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
5-hydroxytryptamine receptor 4	0	8	0	8
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	30	0	0	30
HLA class I histocompatibility antigen, B alpha chain	17	0	0	17
Thyroid hormone receptor alpha	0	1	0	1
Integrin beta-3	7	1	0	8
ATP-dependent translocase ABCB1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	8	0	8
Muscarinic acetylcholine receptor M2	0	9	1	13
Muscarinic acetylcholine receptor M4	0	10	1	13
ATP-dependent translocase ABCB1	0	11	4	19
Integrin alpha-IIb	7	0	0	7
Beta-1 adrenergic receptor	0	6	1	7
Muscarinic acetylcholine receptor M5	0	9	1	12
Alpha-2A adrenergic receptor	0	8	0	8
Cytochrome P450 2C8	0	2	0	2
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	10	1	14
Beta-3 adrenergic receptor	0	5	1	6
D(2) dopamine receptor	0	6	0	6
Androgen receptor	0	9	0	9
Gamma-aminobutyric acid receptor subunit beta-1	20	2	0	22
Alpha-1B adrenergic receptor	0	5	0	5
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	8	0	8
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	20	2	0	22
Gamma-aminobutyric acid receptor subunit gamma-2	20	2	0	22
Gamma-aminobutyric acid receptor subunit alpha-5	20	2	0	22
Gamma-aminobutyric acid receptor subunit alpha-3	20	2	0	22
Muscarinic acetylcholine receptor M3	0	9	1	12
ATP-dependent translocase ABCB1	0	5	0	5
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	6	0	6
D(4) dopamine receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	20	2	0	22
Gamma-aminobutyric acid receptor subunit alpha-2	20	2	0	22
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	10	0	10
Histamine H2 receptor	0	6	0	6
Endothelin-1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	20	2	0	22
Gamma-aminobutyric acid receptor subunit gamma-3	20	2	0	22
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	20	2	0	22
B2 bradykinin receptor	0	4	0	4
Sodium-dependent serotonin transporter	0	8	0	8
Melanocortin receptor 4	0	4	0	4
C-8 sterol isomerase	0	2	0	2
Melanocortin receptor 5	0	6	0	6
Mu-type opioid receptor	0	4	0	4
D(3) dopamine receptor	0	6	0	6
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	4	0	7
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	6	0	6
Kappa-type opioid receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	8	0	8
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	4	0	4
Alpha-1A adrenergic receptor	0	6	0	6
Histamine H2 receptor	10	1	0	12
D(1A) dopamine receptor	6	0	0	6
5-hydroxytryptamine receptor 6	0	7	0	7
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	20	2	0	22
Gamma-aminobutyric acid receptor subunit beta-3	20	2	0	22
Gamma-aminobutyric acid receptor subunit beta-2	20	2	0	22
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Sodium-dependent dopamine transporter	0	10	0	10
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Sodium channel protein type 5 subunit alpha	0	5	0	5
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	1	4
Sodium channel protein type 9 subunit alpha	0	5	0	5
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	20	2	0	22
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	17	0	0	17
Canalicular multispecific organic anion transporter 1	0	46	0	47
Sodium channel protein type 2 subunit alpha	0	4	0	4
Ataxin-2	25	0	0	25
Sigma non-opioid intracellular receptor 1	0	10	0	10
Gamma-aminobutyric acid receptor subunit epsilon	20	2	0	22
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	2	0	2
cytochrome P450 2C9, partial	17	0	0	17
ATP-dependent phosphofructokinase	12	0	0	12
Chain A, Beta-lactamase	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	6	0	0	6
Beta-lactamase	0	0	0	1
DNA polymerase iota isoform a (long)	12	0	0	12
DNA polymerase kappa isoform 1	11	0	0	11
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	1	2
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	9	0	9
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	3	0	0	3
Beta-lactamase	0	0	0	1
acid sphingomyelinase	4	0	0	4
GLS protein	12	0	0	12
GLI family zinc finger 3	29	0	0	29
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
DNA polymerase beta	4	0	0	4
Carbonic anhydrase 1	0	8	0	8
Carbonic anhydrase 2	0	9	1	11
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	1
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	1	2	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Thiosulfate sulfurtransferase	0	4	0	4
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	5	0	5
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	5	0	5
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Muscarinic acetylcholine receptor M1	0	5	1	8
Muscarinic acetylcholine receptor M3	0	3	1	6
Muscarinic acetylcholine receptor M4	0	3	1	6
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M2	0	4	2	9
Muscarinic acetylcholine receptor M1	0	0	0	1
Alpha-1D adrenergic receptor	0	6	0	6
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	1	2	6
Muscarinic acetylcholine receptor	0	1	1	2
interleukin 8	9	0	0	9
glp-1 receptor, partial	13	0	0	13
pregnane X receptor	5	0	0	5
Smad3	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	26	0	0	26
67.9K protein	14	0	0	14
Parkin	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	22	0	0	22
aryl hydrocarbon receptor	13	0	0	13
activating transcription factor 6	8	0	0	8
Bloom syndrome protein isoform 1	14	0	0	14
peripheral myelin protein 22 isoform 1	12	0	0	12
hemoglobin subunit beta	5	0	0	5
ras-related protein Rab-9A	5	0	0	5
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Nuclear receptor ROR-gamma	11	0	0	11
Multidrug and toxin extrusion protein 1	0	4	0	4
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
ATPase family AAA domain-containing protein 5	21	0	0	21
Chain A, Ferritin light chain	7	0	0	7
thioredoxin reductase	20	0	0	20
thioredoxin glutathione reductase	8	0	0	8
P53	2	0	0	2
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	10	0	0	10
Protein-arginine deiminase type-4	0	7	0	7
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	4	0	4
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	3	0	3
Prothrombin	0	1	0	3
Chymotrypsinogen A	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase 6	0	3	0	3
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	3
Carbonic anhydrase 5A, mitochondrial	0	4	0	4
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Carbonic anhydrase 7	0	3	0	3
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	1	2
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	4	0	4
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	6	0	7
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	4	0	4
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Carbonic anhydrase 14	0	1	0	1
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
Angiotensin-converting enzyme	0	1	0	1
15-lipoxygenase, partial	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Matrix metalloproteinase-9	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	4	0	5
Cytochrome P450 3A4	0	18	0	19
Androgen receptor	0	4	0	4
Cytochrome P450 2D6	0	8	1	9
Vitamin D3 receptor	0	2	3	6
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	9	0	9
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
DNA topoisomerase	0	1	0	1
glucocerebrosidase	4	0	0	4
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
cytochrome P450 2C19 precursor	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	15	0	0	15
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
relaxin receptor 1 isoform 1	1	0	0	1
Telomerase reverse transcriptase	0	1	0	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	3	1	9
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
Type-2 restriction enzyme HindIII	0	1	0	1
Histone deacetylase 4	0	2	0	2
Ribonuclease pancreatic	0	2	0	2
Inositol monophosphatase 1	6	0	0	6
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Integrase	0	3	0	3
Histone deacetylase 7	0	2	0	2
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
Liver carboxylesterase 1	0	0	0	2
Vpr	2	0	0	2
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	4
Cytochrome P450 2B6	0	4	1	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Tyrosine-protein kinase JAK2	0	2	2	4
Nucleophosmin	0	2	0	2
Replicase polyprotein 1ab	0	2	4	6
Platelet-derived growth factor receptor alpha	0	2	1	3
Transcription factor ETV6	0	1	0	1
Tyrosine-protein kinase ZAP-70	0	1	1	2
Tyrosine-protein kinase JAK3	0	2	1	3
Serine/threonine-protein kinase 38	0	0	2	2
BDNF/NT-3 growth factors receptor	0	2	1	3
Sigma intracellular receptor 2	0	2	0	2
Serine/threonine-protein kinase Nek7	0	0	3	3
Testis-specific serine/threonine-protein kinase 1	0	1	1	2
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	1	2
Long-chain-fatty-acid--CoA ligase 5	0	0	3	3
Serine/threonine-protein kinase 38-like	0	0	2	2
GALC protein	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	11	0	13
Thymidine kinase	0	2	0	2
Solute carrier family 22 member 6	0	1	0	2
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Thymidine kinase	0	0	0	1
Solute carrier family 22 member 6	0	2	0	6
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
streptokinase A precursor	0	0	6	6
Solute carrier organic anion transporter family member 1B1	0	9	0	11
Spike glycoprotein	0	0	4	4
Replicase polyprotein 1ab	0	1	5	6
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Transmembrane protease serine 2	0	0	4	4
Procathepsin L	0	0	4	4
5-hydroxytryptamine receptor 2C	0	5	0	6
Replicase polyprotein 1a	0	0	4	4
Replicase polyprotein 1ab	0	0	4	4
Replicase polyprotein 1ab	0	1	4	5
5-hydroxytryptamine receptor 2A	0	5	0	5
Alpha-2C adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	6	0	6
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	5	0	5
5-hydroxytryptamine receptor 1D	0	3	0	3
Trypanothione reductase	0	2	0	2
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	2	0	2
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 3A	0	2	0	2
Trypanothione reductase	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Envelope glycoprotein	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Angiotensin-converting enzyme 2	0	0	4	4
5-hydroxytryptamine receptor 3B	0	2	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	1	1	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
D	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	0	3
Sodium-dependent serotonin transporter	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	1	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	2	0	2
endonuclease IV	6	0	0	6
dopamine D1 receptor	2	0	0	2
Glucocorticoid receptor	0	10	3	18
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	10	0	10
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
TAR DNA-binding protein 43	6	0	0	6
Leukotriene C4 synthase	0	0	1	1
tyrosine-protein kinase Yes	2	0	0	2
Membrane-associated progesterone receptor component 1	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase 13	0	0	1	1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Sodium-dependent phosphate transport protein 2B	0	1	0	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	1	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
HLA class II histocompatibility antigen gamma chain	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	1	2
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Insulin receptor-related protein	0	0	1	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Vascular endothelial growth factor receptor 1	0	2	1	3
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Protein kinase C eta type	0	1	1	2
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	1	1	2
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Prostaglandin G/H synthase 2	0	4	1	5
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	1	1	2
Serine/threonine-protein kinase receptor R3	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Serine/threonine-protein kinase mTOR	0	3	3	6
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	1	1	2
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 12	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
ALK tyrosine kinase receptor	0	1	0	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Angiopoietin-1 receptor	0	1	0	1
Tyrosine-protein kinase receptor TYRO3	0	1	1	2
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Lysine--tRNA ligase	0	1	0	1
Serine/threonine-protein kinase D1	0	2	1	3
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Macrophage-stimulating protein receptor	0	1	0	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Mixed lineage kinase domain-like protein	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Cyclin-dependent kinase 15	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	2	2
Aurora kinase A-interacting protein	0	1	0	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 24	0	0	2	2
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	4	0	5
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	4
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Orotidine 5'-phosphate decarboxylase	0	1	0	1
Seminal ribonuclease	0	1	0	1
Uridine 5'-monophosphate synthase	0	1	0	1
Beta-galactoside alpha-2,6-sialyltransferase 1	0	1	0	1
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase	0	1	0	1
Orotidine 5'-phosphate decarboxylase	0	1	0	1
Isocitrate lyase	0	1	0	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Myeloperoxidase	0	2	0	2
Dihydrofolate reductase	0	4	0	4
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase 2	0	1	0	1
AAA family ATPase	0	0	0	2
Serum paraoxonase/arylesterase 1	0	4	0	4
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	2	0	2
Alpha-synuclein	5	0	0	5
Albumin	0	1	3	4
Genome polyprotein	0	2	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
60 kDa chaperonin	0	3	0	3
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Cytochrome P450 1B1	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	2	1	3
Pantothenate synthetase	0	1	0	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Regulatory protein E2	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	3
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Tubulin beta-2B chain	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Regulatory-associated protein of mTOR	0	2	0	2
Target of rapamycin complex subunit LST8	0	2	0	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	3	0	0	3
Solute carrier family 22 member 8	0	0	0	2
Aromatase	0	2	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
ClpP	3	0	0	3
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	2	2
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbonic anhydrase 13	0	2	0	2
Stromelysin-1	0	1	1	2
Urease subunit alpha	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Dihydrofolate reductase	0	5	2	7
Sigma non-opioid intracellular receptor 1	0	1	0	1
matrix metalloproteinase 1, partial	0	0	1	1
pyruvate kinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
Tubulin beta-4A chain	0	2	1	4
Tubulin beta chain	0	2	1	4
Tubulin alpha-3C chain	0	2	1	4
Tubulin alpha-1B chain	0	2	1	4
Tubulin alpha-4A chain	0	2	1	4
Tubulin beta-4B chain	0	2	1	4
Fatty-acid amide hydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	3	1	5
Tubulin beta-2A chain	0	2	1	4
Tubulin beta-8 chain	0	2	1	4
Tubulin alpha-3E chain	0	2	1	4
Tubulin alpha-1A chain	0	2	1	4
Tubulin alpha-1C chain	0	2	1	4
Tubulin beta-6 chain	0	2	1	4
Tubulin beta-2B chain	0	2	1	4
Tubulin beta-1 chain	0	2	1	4
Prostaglandin G/H synthase 1	0	3	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
UDP-glucose 6-dehydrogenase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier organic anion transporter family member 2B1	0	4	0	6
Tumor necrosis factor	0	1	1	2
Neuraminidase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Caspase-7	3	0	0	3
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	2	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Thymidylate synthase	0	3	0	3
Thymidylate synthase	0	4	0	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	3	0	3
Bifunctional purine biosynthesis protein ATIC	0	5	0	5
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	2	0	4
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	3	0	4
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Estrogen receptor	0	0	2	3
Estrogen receptor beta	0	0	2	3
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Fatty acid-binding protein, liver	0	0	1	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Fatty acid-binding protein 5	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Integrin alpha-V	0	1	0	1
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	3
Cholecystokinin receptor type A	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Beta-tubulin	0	1	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	2
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Thymidylate synthase	0	1	0	1
Gamma-aminobutyric acid	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Transforming growth factor beta-1 proprotein	0	1	0	1
Mothers against decapentaplegic homolog 3	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Insulin receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	4	1	6
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	4	1	5
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
NS5	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Butyrophilin subfamily 3 member A1	0	0	1	1
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl diphosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
POU domain, class 2, transcription factor 1	0	0	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	1
Chain A, Glutathione S-transferase	0	1	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	2	0	2
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	2	0	2
Splicing factor 3B subunit 3	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Substance-P receptor	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
Adenylate kinase isoenzyme 1	0	0	0	1
Capsid protein	0	0	1	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
procathepsin L isoform 1 preproprotein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Ileal sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
M1-family alanyl aminopeptidase	0	1	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (310)

Protein Targets (1,592)

BOOP

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (310)

Drugs Studied (128)

Protein Targets (1,592)