| Assay ID | Title | Year | Journal | Article |
|---|
| AID138548 | Ex vivo inhibition of LTB4 production in mouse whole blood at 10 mg/kg | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
| Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase. |
| AID92878 | Inhibition of leukotriene B4 production in human whole blood | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
| Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase. |
| AID1322074 | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC method | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
| Thermodynamic properties of leukotriene A |
| AID1322073 | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC method | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
| Thermodynamic properties of leukotriene A |
| AID1322071 | Binding affinity to human C-terminal His6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H assessed as change in melting temperature at 500 uM by sypro orange dye based differential scanning fluorimetric analysis | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
| Thermodynamic properties of leukotriene A |
| AID1322069 | Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
| Thermodynamic properties of leukotriene A |
| AID99749 | Inhibition of leukotriene A4 hydrolase in human recombinant assay | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
| Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase. |
| AID1322078 | Non-competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mi | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
| Thermodynamic properties of leukotriene A |
| AID1322075 | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC method | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
| Thermodynamic properties of leukotriene A |
| AID138547 | Oral potency for Ex vivo inhibition of LTB4 production in mouse whole blood | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
| Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase. |
| AID1322077 | Binding affinity to human C-terminal His6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H assessed as change in melting temperature at 0.5 mM by circular dichroism spectroscopic analysis | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
| Thermodynamic properties of leukotriene A |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1441701 | Binding affinity to recombinant human LTA4H hydrolase assessed as change in melting temperature at 10 uM by SYPRO orange dye-based thermofluor assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. |
| AID99745 | Inhibition of human leukotriene A4 hydrolase (LTA-4). | 2002 | Journal of medicinal chemistry, Aug-01, Volume: 45, Issue:16
| Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. |
| AID130250 | Effective dose measured for mouse ex vivo whole blood LTB-4 production; Range is from 1-3. | 2002 | Journal of medicinal chemistry, Aug-01, Volume: 45, Issue:16
| Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. |
| AID92856 | Inhibition of human whole blood LTB-4 production (Leukotriene B-4). | 2002 | Journal of medicinal chemistry, Aug-01, Volume: 45, Issue:16
| Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |