Compounds > 6-phosphogluconic acid
Page last updated: 2024-09-24

6-phosphogluconic acid

Description

gluconic acid-6-phosphate: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

6-phospho-D-gluconate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of 6-phospho-D-gluconic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

6-phospho-D-gluconic acid : A gluconic acid phosphate having the phosphate group at the 6-position. It is an intermediate in the pentose phosphate pathway. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID91493
CHEMBL ID1230513
CHEBI ID48928
SCHEMBL ID50297
MeSH IDM0053124

Synonyms (34)

Synonym
chembl1230513 ,
bdbm50045357
6-phosphogluconic acid
6pg ,
6-phospho-d-gluconate
C00345
DB02076
1PGP ,
6-phospho-d-gluconic acid
6-o-phosphono-d-gluconic acid
CHEBI:48928 ,
921-62-0
8BFF71FD-2D1E-48A7-BA6D-83CC49D8B9EB
BMSE000198
gluconic acid-6-phosphate
d-gluconic acid 6-(dihydrogen phosphate)
6-phosphogluconate
(2r,3s,4r,5r)-2,3,4,5-tetrahydroxy-6-phosphonooxyhexanoic acid
unii-w31wk7b8u0
einecs 213-069-9
w31wk7b8u0 ,
AKOS015916651
SCHEMBL50297
6-phosphogluconic acid barium salt
d-gluconic acid, 6-(dihydrogen phosphate)
(2r,3s,4r,5r)-2,3,4,5-tetrahydroxy-6-(phosphonooxy)hexanoic acid
DTXSID00872623
6-p-gluconate
d-gluconic acid 6-phosphate
Q245501
CS-0062500
HY-113514
(2r,3s,4r,5r)-2,3,4,5-tetrahydroxy-6-(phosphonooxy)hexanoicacid
PD060249

Roles (1)

RoleDescription
fundamental metaboliteAny metabolite produced by all living cells.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
gluconic acid phosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (17)

6-phosphogluconic acid is involved in 17 pathway(s), involving a total of 137 unique proteins and 934 unique compounds

PathwayProteinsCompounds
Pentose Phosphate Pathway1527
Glucose-6-phosphate Dehydrogenase Deficiency1527
Ribose-5-phosphate Isomerase Deficiency1527
Transaldolase Deficiency1527
Warburg Effect4652
Pentose phosphate cycle ( Pentose phosphate cycle )2225
Pentose phosphate pathway in senescent cells510
superpathway of central carbon metabolism346
superpathway of glycolysis and Entner-Doudoroff023
Central carbon metabolism019
Relationship between glutathione and NADPH036
Pentose phosphate pathway05
Pentose phosphate pathway 2011
Pentose phosphate metabolism05
Cori cycle121
Metabolism overview078
Biochemical pathways: part I0466
Metabolic reprogramming in colon cancer029

Protein Targets (2)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, 6-PHOSPHOGLUCONATE DEHYDROGENASEOvis aries (sheep)Kd2.00002.00002.00002.0000AID977611
6-phosphogluconolactonase Trypanosoma bruceiKd10.000010.000010.000010.0000AID1179556
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID7240log Kd which is the binding affinity against 6-phosphogluconate dehydrogenase2002Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13
SMall Molecule Growth 2001 (SMoG2001): an improved knowledge-based scoring function for protein-ligand interactions.
AID1179556Binding affinity to Trypanosoma brucei 6-phospho-gluconalactonase by NMR analysis2014Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
Elements and modulation of functional dynamics.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB1994Structure (London, England : 1993), Jul-15, Volume: 2, Issue:7
Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism.
AID1811Experimentally measured binding affinity data derived from PDB1994Structure (London, England : 1993), Jul-15, Volume: 2, Issue:7
Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (154)

TimeframeStudies, This Drug (%)All Drugs %
pre-199068 (44.16)18.7374
1990's35 (22.73)18.2507
2000's22 (14.29)29.6817
2010's26 (16.88)24.3611
2020's3 (1.95)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (1.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other157 (98.13%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
phosphoglycolate[no description available]medium10carboxyalkyl phosphateEscherichia coli metabolite;
mouse metabolite
palmitic acid[no description available]medium10long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite
phenethylamine[no description available]medium10alkaloid;
aralkylamine;
phenylethylamine		Escherichia coli metabolite;
human metabolite;
mouse metabolite
benzamidine[no description available]medium10benzenes;
carboxamidine		serine protease inhibitor
histidine[no description available]medium30amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
xylitol[no description available]medium10
3-phenylpropylamine[no description available]medium10benzenes;
phenylalkylamine;
primary amino compound
1-deoxynojirimycin[no description available]medium102-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid		anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
nitroaniline[no description available]medium10
abbott 77003[no description available]medium10
amprenavir[no description available]medium10carbamate ester;
sulfonamide;
tetrahydrofuryl ester		antiviral drug;
HIV protease inhibitor
2-deoxy-2,3-dehydro-n-acetylneuraminic acid[no description available]medium10N-acetylneuraminic acids
4-fluorobenzylamine[no description available]medium10
brinzolamide[no description available]medium10sulfonamide;
thienothiazine		antiglaucoma drug;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
a 76889[no description available]medium10
methanesulfonamide[no description available]medium10
4-phenylbutylamine[no description available]medium10benzenes;
phenylalkylamine;
primary amino compound
methotrexate[no description available]medium10dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
n-acetylseryl-leucyl-asparaginyl(phenylalanyl-hydroxyethylamino-prolyl)isoleucyl-valyl methyl ester[no description available]medium10
h 142[no description available]medium10
h 256[no description available]medium10
n-valyltryptophan[no description available]medium10peptide
cp 71362[no description available]medium10
arabinose[no description available]medium10L-arabinoseEscherichia coli metabolite;
mouse metabolite
galactose[no description available]medium10D-galactopyranoseepitope;
mouse metabolite
phosphoramidon[no description available]medium10deoxyaldohexose phosphate;
dipeptide		bacterial metabolite;
EC 3.4.24.11 (neprilysin) inhibitor;
EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor
retinol[no description available]medium10retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite
phosphonoacetohydroxamate[no description available]medium10hydroxamic acid;
organic phosphonate
tacrolimus[no description available]medium20macrolide lactambacterial metabolite;
immunosuppressive agent
a 76928[no description available]medium10
xk 263[no description available]medium10
phenylalanyl-prolyl-arginine[no description available]medium10oligopeptide
glycyllysine[no description available]medium10dipeptidemetabolite
leucine hydroxamate[no description available]medium10
pepstatin[no description available]medium10pentapeptide;
secondary carboxamide		bacterial metabolite;
EC 3.4.23.* (aspartic endopeptidase) inhibitor
streptomyces pepsin inhibitor[no description available]medium10
cp 81282[no description available]medium10
trimethoprim[no description available]medium10aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
lactose[no description available]medium10lactose
1-naphthylphenylamine[no description available]medium10naphthalenes
2-isobutyl-3-methoxypyrazine[no description available]medium10
enterobactin[no description available]medium10catechols;
crown compound;
macrotriolide;
polyphenol		bacterial metabolite;
siderophore
sinefungin[no description available]medium10adenosines;
non-proteinogenic alpha-amino acid		antifungal agent;
antimicrobial agent
2-(sec-butyl)-4,5-dihydrothiazole[no description available]medium10
biotin[no description available]medium10biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
beta-D-ribopyranose[no description available]medium10D-ribopyranose
pnu 142372[no description available]medium10
pnu 107859[no description available]medium10
sirolimus[no description available]medium10antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine[no description available]medium10imidazoles
copper gluconate[no description available]medium1580organic molecular entity
alpha-hydroxyglutarate[no description available]medium102-hydroxydicarboxylic acid;
dicarboxylic fatty acid		metabolite;
mouse metabolite
nad[no description available]medium130organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
nadp[no description available]medium350
ribulose 5-phosphate[no description available]medium70ribulose 5-phosphatemouse metabolite
reparixin[no description available]medium10monoterpenoid
paclitaxel[no description available]medium10taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
gluconic acid[no description available]medium110gluconic acidchelator;
Penicillium metabolite
6-phosphogluconolactone[no description available]medium10organophosphate oxoanionhuman metabolite;
Saccharomyces cerevisiae metabolite
chitosan[no description available]medium10
glycogen[no description available]medium10
8-epi-prostaglandin f2alpha[no description available]medium10F2-isoprostanebiomarker;
bronchoconstrictor agent;
vasoconstrictor agent
6-aminonicotinamide[no description available]medium140aminopyridine;
monocarboxylic acid amide;
primary amino compound		antimetabolite;
EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor;
teratogenic agent
dinoprost[no description available]medium10monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite
erythrose 4-phosphate[no description available]medium70erythrose phosphateEscherichia coli metabolite;
human metabolite;
mouse metabolite
lactic acid[no description available]medium602-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
2-ketogluconate[no description available]medium30keto-D-gluconic acidbacterial metabolite
phosphoenolpyruvate[no description available]medium50carboxyalkyl phosphate;
monocarboxylic acid		fundamental metabolite
dihydroxyacetone phosphate[no description available]medium20glycerone phosphates;
primary alpha-hydroxy ketone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
alpha-glycerophosphoric acid[no description available]medium10glycerol monophosphatealgal metabolite;
human metabolite
dihydroxyacetone[no description available]medium10ketotriose;
primary alpha-hydroxy ketone		antifungal agent;
Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
glycerol[no description available]medium30alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
deuterium[no description available]medium20dihydrogen
3-phosphoglycerate[no description available]medium50monophosphoglyceric acid;
tetronic acid derivative		algal metabolite;
fundamental metabolite
4-phosphoerythronate[no description available]medium204-phosphoerythronic acidEscherichia coli metabolite;
mouse metabolite
fructose 2,6-diphosphate[no description available]medium50D-fructofuranose 2,6-bisphosphatehuman metabolite;
mouse metabolite
2-phospholactic acid[no description available]medium10carboxyalkyl phosphate
dehydroepiandrosterone[no description available]medium3017-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid		androgen;
human metabolite;
mouse metabolite
fructose-1,6-diphosphate[no description available]medium30
succinic acid[no description available]medium10alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid		anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
malic acid[no description available]medium302-hydroxydicarboxylic acid;
C4-dicarboxylic acid		food acidity regulator;
fundamental metabolite
acetyl coenzyme a[no description available]medium20acyl-CoAacyl donor;
coenzyme;
effector;
fundamental metabolite
fumaric acid[no description available]medium10butenedioic acidfood acidity regulator;
fundamental metabolite;
geroprotector
pyruvic acid[no description available]medium402-oxo monocarboxylic acidcofactor;
fundamental metabolite
sedoheptulose 7-phosphate[no description available]medium30ketoheptose phosphate;
sedoheptulose derivative		Escherichia coli metabolite;
human metabolite;
mouse metabolite
fumarates[no description available]medium10butenedioate;
C4-dicarboxylate		human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
adenosine diphosphate[no description available]medium20adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
vancomycin[no description available]medium10glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
xylose[no description available]medium10D-xylose
glyoxylic acid[no description available]medium102-oxo monocarboxylic acid;
aldehydic acid		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2-carboxyarabinitol 1,5-biphosphate[no description available]medium10ribonic acid phosphate
2-phosphoglycerate[no description available]medium10monophosphoglyceric acid;
tetronic acid derivative
glucosamine[no description available]medium10D-glucosamineEscherichia coli metabolite;
geroprotector;
mouse metabolite
methylphenazonium methosulfate[no description available]medium10azaheterocycle sulfate salt;
phenazines
2-keto-3-deoxy-6-phosphogluconate[no description available]medium50ketoaldonic acid phosphateEscherichia coli metabolite
hydrogen[no description available]medium10elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
arabinonate-5-phosphate[no description available]medium10
phosphorus[no description available]medium30monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
ribulose[no description available]medium20ribuloseEscherichia coli metabolite;
human metabolite
glyceraldehyde 3-phosphate[no description available]medium20glyceraldehyde 3-phosphatemouse metabolite
2,3,4,6-tetrachlorophenol[no description available]medium10tetrachlorophenolxenobiotic metabolite
2,4,5-trichlorophenol[no description available]medium10trichlorophenol
thyroxine[no description available]medium102-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
ribose-5-phosphate[no description available]medium40D-ribose 5-phosphate
fructose-6-phosphate[no description available]medium70D-fructose 6-phosphate
mannitol[no description available]medium10mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
D-fructopyranose[no description available]medium30cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
ribose[no description available]medium10D-ribose;
ribopyranose
pentamidine[no description available]medium10aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
tungstate[no description available]medium10divalent inorganic anion;
tungsten oxoanion
molybdenum[no description available]medium10chromium group element atommicronutrient
potassium chloride[no description available]medium10inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
toluene[no description available]medium10methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
mocetinostat[no description available]medium10aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
dihydroxyphenylalanine[no description available]medium20hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
phosphoribosyl pyrophosphate[no description available]medium205-O-phosphono-D-ribofuranosyl diphosphateEscherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite
p-aminohippuric acid[no description available]medium10N-acylglycineDaphnia magna metabolite
niacinamide[no description available]medium50pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
galactose[no description available]medium10D-galactose;
galactopyranose		Escherichia coli metabolite;
mouse metabolite
nitrates[no description available]medium10monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
iodoacetamide[no description available]medium20
pyridoxal phosphate[no description available]medium20methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate		coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
dimethylnitrosamine[no description available]medium10nitrosaminegeroprotector;
mutagen
isocitric acid[no description available]medium10secondary alcohol;
tricarboxylic acid		fundamental metabolite
adenosine monophosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
xylulose 1,5-bisphosphate[no description available]medium10xylulose phosphateEC 4.1.1.39 (ribulose-bisphosphate carboxylase) inhibitor
ribulose-1,5 diphosphate[no description available]medium20ribulose phosphateEscherichia coli metabolite;
plant metabolite
alanine[no description available]medium20alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
creatine[no description available]medium10glycine derivative;
guanidines;
zwitterion		geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical
arginine[no description available]medium10arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
poly(sodium vinyl sulfonate)[no description available]medium10
2-(n-morpholino)ethanesulfonic acid[no description available]medium10MES;
organosulfonic acid;
zwitterion
phosphorus radioisotopes[no description available]medium10
uridine diphosphate glucose[no description available]medium10UDP-D-glucosefundamental metabolite
citric acid, anhydrous[no description available]medium10tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
urea[no description available]medium10isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
3-acetylpyridine-adenine dinucleotide phosphate[no description available]medium10
lysine[no description available]medium20aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
methionine[no description available]medium10aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
cysteine[no description available]medium20cysteiniumfundamental metabolite
6-phosphonoglucono-delta-lactone[no description available]medium10aldonolactone phosphateEscherichia coli metabolite;
mouse metabolite
tannins[no description available]medium10
isothiuronium[no description available]medium10
hydrogen carbonate[no description available]medium10carbon oxoanioncofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
sodium dodecyl sulfate[no description available]medium10organic sodium saltdetergent;
protein denaturant
dihydrotestosterone[no description available]medium1017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
sapropterin[no description available]medium105,6,7,8-tetrahydrobiopterincoenzyme;
cofactor;
diagnostic agent;
human metabolite
deoxyglucose[no description available]medium10
ethylmaleimide[no description available]medium10maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
3-aminopyridine adenine dinucleotide[no description available]medium10
17-ketosteroids[no description available]medium10
3-aminobenzamide[no description available]medium10benzamides;
substituted aniline		EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
tetradecanoylphorbol acetate[no description available]medium10acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
5-methylnicotinamide[no description available]medium10
potassium fluoride[no description available]medium10fluoride salt;
potassium salt		NMR chemical shift reference compound;
poison
fluorides[no description available]medium10halide anion;
monoatomic fluorine
sepharose[no description available]medium10
diethyl pyrocarbonate[no description available]medium10acyclic carboxylic anhydride
p-chloromercuribenzoic acid[no description available]medium10chlorine molecular entity;
mercuribenzoic acid
alpha-ketoglutaric acid[no description available]low00oxo dicarboxylic acidfundamental metabolite
beta-alanine[no description available]low00amino acid zwitterion;
beta-amino acid		agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter
betaine[no description available]low00amino-acid betaine;
glycine derivative		fundamental metabolite
betaine hydrochloride[no description available]low00quaternary ammonium ionfundamental metabolite
cysteine[no description available]low00alpha-amino acid;
amino acid zwitterion;
polar amino acid;
sulfur-containing amino acid		fundamental metabolite
alanine[no description available]low00alpha-amino acid;
amino acid zwitterion		fundamental metabolite
glycine[no description available]low00alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
glyceraldehyde[no description available]low00aldotriosefundamental metabolite
glyceric acid[no description available]low00trionic acidfundamental metabolite
glycolaldehyde[no description available]low00glycolaldehydesfundamental metabolite;
human metabolite
thioctic acid[no description available]low00dithiolanes;
heterocyclic fatty acid;
thia fatty acid		fundamental metabolite;
geroprotector
phenylpyruvic acid[no description available]low002-oxo monocarboxylic acidchromogenic compound;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
fundamental metabolite
putrescine[no description available]low00alkane-alpha,omega-diamineantioxidant;
fundamental metabolite
spermidine[no description available]low00polyazaalkane;
triamine		autophagy inducer;
fundamental metabolite;
geroprotector
spermine[no description available]low00polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
nadp[no description available]low00NADPfundamental metabolite
uridine[no description available]low00uridinesdrug metabolite;
fundamental metabolite;
human metabolite
tyrosine[no description available]low00amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
thymidine monophosphate[no description available]low00thymidine 5'-monophosphatefundamental metabolite
2'-deoxy-5'-adenosine monophosphate[no description available]low002'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-monophosphate		fundamental metabolite
pseudouridine[no description available]low00pseudouridinesfundamental metabolite
uridine diphosphate xylose[no description available]low00UDP-sugarfundamental metabolite
serum p-component[no description available]low00citrate anion;
tricarboxylic acid trianion		fundamental metabolite
adenosine[no description available]low00adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
homocysteine[no description available]low00amino acid zwitterion;
homocysteine;
serine family amino acid		fundamental metabolite;
mouse metabolite
s-adenosylhomocysteine[no description available]low00adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide		cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite
aconitic acid[no description available]low00aconitic acidfundamental metabolite
riboflavin[no description available]low00flavin;
vitamin B2		anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite
mannose 1-phosphate[no description available]low00mannose phosphatefundamental metabolite;
human metabolite
adenosine triphosphate[no description available]low00nucleoside 5'-triphoshate(4-)cofactor;
fundamental metabolite;
human metabolite
adenosine diphosphate[no description available]low00nucleoside 5'-diphosphate(3-)fundamental metabolite;
human metabolite
adenosine monophosphate[no description available]low00nucleoside 5'-monophosphate(2-)cofactor;
fundamental metabolite;
human metabolite
guanosine[no description available]low00guanosines;
purines D-ribonucleoside		fundamental metabolite
hypoxanthine[no description available]low00nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite
inosine diphosphate[no description available]low00inosine phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Adenocarcinoma0low10
Adenocarcinoma, Basal Cell0low10
Adenocarcinoma, Granular Cell0low10
Adenocarcinoma, Oxyphilic0low10
Adenocarcinoma, Tubular0low10
Adenoma, Malignant0low10
Adrenal Cancer0low10
Adrenal Gland Cancer0low10
Adrenal Gland Neoplasms0low10
Adrenal Neoplasm0low10
African Sleeping Sickness0low10
African Trypanosomiasis0low10
Aging0low10
Anoxia, Brain0low10
Anoxia, Cerebral0low10
Anoxic Brain Damage0low10
Anoxic Encephalopathy0low10
Astrocytoma, Grade IV0low10
Bacteremia0low10
Benign Neoplasms0low50
Body Weight0low10
Brain Anoxia0low10
Brain Hypoxia0low10
Breast Cancer0low20
Breast Carcinoma0low20
Breast Neoplasms0low20
Breast Tumors0low20
Cancer0low50
Cancer of Breast0low20
Cancer of the Adrenal Gland0low10
Cancer of the Breast0low20
Carcinoma, Cribriform0low10
Carcinoma, Ductal, Breast0low10
Carcinoma, Granular Cell0low10
Carcinoma, Infiltrating Duct0low10
Carcinoma, Invasive Ductal, Breast0low10
Carcinoma, Mammary Ductal0low10
Carcinoma, Tubular0low10
Cardiac Failure0low10
Cerebral Anoxia0low10
Cerebral Hypoxia0low10
Congestive Heart Failure0low10
Deficiency of Glucose-6-Phosphate Dehydrogenase0low20
Deficiency, Glucosephosphate Dehydrogenase0low20
Deficiency, GPD0low20
Dental Plaque0low10
Diabetes Mellitus, Adult-Onset0low10
Diabetes Mellitus, Ketosis-Resistant0low10
Diabetes Mellitus, Maturity-Onset0low10
Diabetes Mellitus, Non Insulin Dependent0low10
Diabetes Mellitus, Non-Insulin-Dependent0low10
Diabetes Mellitus, Noninsulin Dependent0low10
Diabetes Mellitus, Noninsulin-Dependent0low10
Diabetes Mellitus, Slow-Onset0low10
Diabetes Mellitus, Stable0low10
Diabetes Mellitus, Type 20low10
Diabetes Mellitus, Type II0low10
Disease Models, Animal0low10
Encephalomyelitis0low10
Encephalomyelitis, Inflammatory0low10
Encephalopathy, Hypoxic0low10
Endotoxin Shock0low10
Experimental Mammary Neoplasms0low10
Experimental Neoplasms0low10
Extravascular Hemolysis0low10
Female Genital Diseases0low10
Female Genital Neoplasms0low10
G6PD Deficiency0low20
Genital Diseases, Female0low10
Genital Neoplasms, Female0low10
Giant Cell Glioblastoma0low10
Glioblastoma0low10
Glioblastoma Multiforme0low10
Glucose 6 Phosphate Dehydrogenase Deficiency0low20
Glucose-6-Phosphate Dehydrogenase Deficiency0low20
Glucosephosphate Dehydrogenase Deficiencies0low20
Glucosephosphate Dehydrogenase Deficiency0low20
GPD Deficiency0low20
Gynecologic Diseases0low10
Gynecologic Neoplasms0low10
Haemolysis0low10
Heart Decompensation0low10
Heart Failure0low10
Heart Failure, Congestive0low10
Heart Failure, Left-Sided0low10
Heart Failure, Right-Sided0low10
Hemolysis0low10
Hemolytic Anemia Due to G6PD Deficiency0low20
Human Mammary Carcinoma0low20
Hypoxia, Brain0low10
Hypoxia, Cerebral0low10
Hypoxic Brain Damage0low10
Hypoxic Encephalopathy0low10
Inflammatory Encephalomyelitis0low10
Intravascular Hemolysis0low10
Invasive Ductal Carcinoma, Breast0low10
Invasiveness, Neoplasm0low10
Left-Sided Heart Failure0low10
Malignancy0low50
Malignant Melanoma0low10
Malignant Neoplasm of Breast0low20
Malignant Neoplasms0low50
Malignant Tumor of Breast0low20
Mammary Cancer0low20
Mammary Carcinoma, Human0low20
Mammary Ductal Carcinoma0low10
Mammary Neoplasm, Human0low20
Mammary Neoplasms, Experimental0low10
Mammary Neoplasms, Human0low20
Maturity-Onset Diabetes0low10
Maturity-Onset Diabetes Mellitus0low10
Melanoma0low10
Metastase0low10
Metastases, Neoplasm0low10
Metastasis0low10
Metastasis, Neoplasm0low10
MODY0low10
Myeloencephalitis0low10
Myocardial Failure0low10
Nagana0low10
Neoplasia0low50
Neoplasm0low50
Neoplasm Invasion0low10
Neoplasm Invasiveness0low10
Neoplasm Metastases0low10
Neoplasm Metastasis0low10
Neoplasms0low50
Neoplasms, Adrenal Gland0low10
Neoplasms, Benign0low50
Neoplasms, Breast0low20
Neoplasms, Experimental0low10
Neoplasms, Experimental Mammary0low10
Neoplasms, Female Genital0low10
Neoplasms, Gynecologic0low10
NIDDM0low10
Noninsulin-Dependent Diabetes Mellitus0low10
Obesity0low10
Pheochromocytoma0low20
Pheochromocytoma, Extra-Adrenal0low20
Plaque, Dental0low10
Pregnancy0low10
Right-Sided Heart Failure0low10
Sensitivity and Specificity0low20
Septic Shock0low10
Shock, Endotoxic0low10
Shock, Septic0low10
Shock, Toxic0low10
Starvation0low10
Toxic Shock0low10
Toxic Shock Syndrome0low10
Trypanosomiasis, African0low10
Tumors0low50
Tumors, Breast0low20
Type 2 Diabetes0low10
Type 2 Diabetes Mellitus0low10

Research Highlights

Dosage (2)

ArticleYear
The Entner-Doudoroff pathway in Helicobacter pylori.
Archives of biochemistry and biophysics, Aug-01, Volume: 312, Issue: 2		1994
Effect of endotoxin and glucocorticoid pretreatment on hexose monophosphate shunt activity in rat liver.
Circulatory shock, Volume: 9, Issue: 1		1982
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]