Compounds > anilofos
Page last updated: 2024-12-07

anilofos

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID91687
CHEBI ID81728
SCHEMBL ID36679
MeSH IDM0399879

Synonyms (40)

Synonym
aniloguard
s-4-chloro-n-isopropylcarbaniloylmethyl o,o-dimethyl phosphorodithioate
einecs 264-756-5
o,o-dimethyl s-(2-((4-chlorophenyl)(1-methylethyl)amino)-2-oxoethyl)phosphorodithioate
phosphorodithioic acid, s-(2-((4-chlorophenyl)(1-methylethyl)amino)-2-oxoethyl)-, o,o-dimethyl ester
hoe 574
anilophos
s-4-chloro-n-isopropylcarbanilolylmethyl o,o-dimethyl phosphorodithioate
arozin
s-(2-((4-chlorophenyl)(isopropyl)amino)-2-oxoethyl) o,o-dimethyl dithiophosphate
rico
s-(2-((4-chlorophenyl)(1-methylethyl)amino)-2-oxoethyl) o,o-dimethyl phosphorodithioate
hoe 30374
brn 2395778
anilofos [bsi:iso]
anilofos
64249-01-0
n-(4-chlorophenyl)-2-dimethoxyphosphinothioylsulfanyl-n-propan-2-ylacetamide
C18394
unii-71w48u40s6
71w48u40s6 ,
FT-0630746
AKOS015895538
anilofos [iso]
SCHEMBL36679
CHEBI:81728
DTXSID5058149
s-(2-((4-chlorophenyl)(isopropyl)amino)-2-oxoethyl) o,o-dimethyl phosphorodithioate
NXQDBZGWYSEGFL-UHFFFAOYSA-N
anilofos, pestanal(r), analytical standard
anilofos 10 microg/ml in isooctane
s-2-((4-chlorophenyl)(isopropyl)amino)-2-oxoethyl o,o-dimethyl phosphorodithioate
HY-B2016
Q16760606
CS-0014115
aniloguard; aniloguard 30ec; arozin; hoe 30374; hoe 574
F81300
anilofos 1000 microg/ml in methanol
phosphorodithioic acid, s-[2-[(4-chlorophenyl)(1-methylethyl)amino]-2-oxoethyl] o,o-dimethyl ester
s-[2-(4-chloro-n-isopropylanilino)-2-oxoethyl]-o,o'-dimethyl dithiophosphate

Research Excerpts

Overview

Anilofos is a widely used thionoorganophosphate herbicide. malathion is an insecticide.

ExcerptReferenceRelevance
"Anilofos is an organophosphate compound and is used extensively as a preemergence and early postemergence herbicide for the management of sedges, annual grasses, and some broad-leaved weeds in rice fields. "( Assessment of anilofos-induced mutagenicity in bone marrow and germ cells of Swiss albino mice.
Bagri, P; Kumar, V, 2020)		2.36
"Anilofos is a widely used thionoorganophosphate herbicide, while malathion is a thionoorganophosphate insecticide."( Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study.
Hajare, S; Hazarika, A; Kataria, M; Malik, JK; Sarkar, SN, 2003)		1.29

Toxicity

ExcerptReferenceRelevance
" Oral LD50 was 1681 mg/kg."( Subacute toxicity of anilofos, a new organophosphorus herbicide, in male rats: effect on some physical attributes and acetylcholinesterase activity.
Hazarika, A; Sarkar, SN, 2001)		0.63
"Sets of 346 herbicides in use and 163 no longer in use were collected from open access online sources and compared in silico with cholinesterases inhibitors (ChI) and drugs in terms of physicochemical profile and estimated toxic effects on human health."( Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases.
Katalinić, M; Kolić, D; Kovarik, Z; Pehar, V; Šinko, G; Stepanić, V; Zandona, A, 2023)		0.91
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
anilideAny aromatic amide obtained by acylation of aniline.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's4 (36.36)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.47 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (23.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
malathion
Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.		7.0110diester;
ethyl ester;
organic thiophosphate
fenitrothion
Fenitrothion: An organothiophosphate cholinesterase inhibitor that is used as an insecticide.. fenitrothion : An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.		7.0310C-nitro compound;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
isoproturon
isoproturon : A member of the class of phenylureas that is 1,1-dimethylurea substituted by a p-cumenyl group at position 3. A selective, systemic herbicide used to control annual grasses and broadleaf weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.		7103-(3,4-substituted-phenyl)-1,1-dimethylureaagrochemical;
environmental contaminant;
herbicide;
xenobiotic
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		2.0810aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
chlorophyll a
Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.		2.0810chlorophyll;
methyl ester		cofactor
pheophytin a
pheophytin a: structure given in first source; RN given refers to (3S-(3alpha(2E,7S*,11S*),4beta,21beta))-isomer		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.610
Abnormalities, Autosome
[description not available]		02.2510
Schistosoma mansoni Infection
[description not available]		02.0310
Schistosomiasis mansoni
Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.		02.0310