Page last updated: 2024-09-28

Cardiac Free Wall Rupture

Disease-related laceration or tearing of tissues of the heart, including the free-wall MYOCARDIUM; HEART SEPTUM; PAPILLARY MUSCLES; CHORDAE TENDINEAE; and any of the HEART VALVES. Pathological rupture usually results from myocardial infarction (HEART RUPTURE, POST-INFARCTION).

Synonyms(5)

Synonym
Cardiac Rupture
Ventricular Free Wall Rupture
Heart Rupture
Free Wall Rupture, Heart
Cardiac Free Wall Rupture

Research Excerpts

Overview

ExcerptReference
"BACKGROUND Cardiac rupture is responsible for nearly 15% of all in-hospital deaths among patients with myocardial infarction (MI) given thrombolytic agents."( Antman, EM; Ball, SP; Becker, RC; Cannon, CP; Hochman, JS; Rizzo, MJ; Spencer, FA, 1999)
"Cardiac rupture is a catastrophic complication that occurs after acute myocardial infarction (MI) and, at present, there are no effective pharmacological strategies for preventing this condition."( Bin, J; Cao, S; Chen, B; Fu, Y; Huang, Q; Huang, X; Kitakaze, M; Liao, Y; Lu, D; Xu, D; Zhang, J, 2014)
"Cardiac rupture is a fatal complication after myocardial infarction (MI)."( Arai, S; Fujino, T; Ide, T; Ikeda, M; Inoue, T; Matsuo, Y; Saku, K; Sunagawa, K, 2016)
"Cardiac rupture is a fatal complication following myocardial infarction (MI)."( Abe, K; Furusawa, S; Ide, T; Ikeda, M; Ikeda, S; Ishikita, A; Ishimaru, K; Matsushima, S; Miyamoto, HD; Okabe, K; Tadokoro, T; Tsutsui, H, 2022)

Research

Studies (88)

TimeframeStudies, This Condition (%)All Conditions %
pre-199039 (44.32)23.3326
1990's9 (10.23)12.5806
2000's18 (20.45)18.1394
2010's18 (20.45)28.8240
2020's4 (4.55)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
toluene0low10
aspirin0low30
atenolol0medium22
amphetamine0low10
fentanyl0low20
furosemide0low10
glutaral0low10
hydralazine0low20
ibuprofen0low20
lidocaine0low10
indomethacin0low10
mebendazole0low10
metoprolol0medium32
midazolam0low10
milrinone0low10
molsidomine0low10
nifedipine0low10
nitroglycerin0low80
oxprenolol0low10
4-phenylbutyric acid0low10
pifithrin0low10
pindolol0low10
prazosin0low10
procainamide0low10
propranolol0low20
prednisolone0low10
phentolamine0low10
hydroxyproline0low10
aldosterone0low10
prednisone0low10
edetic acid0low10
methicillin0low10
ampicillin0low10
methylprednisolone0low10
isosorbide dinitrate0low40
thiophenes0low10
methysergide0low10
deoxycytidine0low10
d-alpha tocopherol0low10
enbucrilate0low20
silver0low10
technetium0low10
gadolinium0low10
isosorbide-5-mononitrate0low10
4-methoxyamphetamine0low30
dobutamine0low50
vecuronium bromide0low10
captopril0low10
fomesafen0low20
gemcitabine0low10
simendan0low10
fibrinogen0low20
ivabradine0low10
proline0low10
docetaxel anhydrous0low10
olmesartan0low10
angiotensin ii0low20
atropine0low20
cocaine0low10
etomidate0low10
digoxin0low10
diosmin0low10
enalapril0low10
gadolinium dtpa0low10
mocetinostat0low30
technetium tc 99m sestamibi0low10
sodium pertechnetate tc 99m0low10
methylcellulose0low10
transforming growth factor beta0low20
hirudin0medium11

Protein Targets (802)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0729
5-hydroxytryptamine receptor 2A08210
5-hydroxytryptamine receptor 1A013519
5-hydroxytryptamine receptor 1B010212
5-hydroxytryptamine receptor 1D0527
5-hydroxytryptamine receptor 1F0527
5-hydroxytryptamine receptor 2B0628
5-hydroxytryptamine receptor 60123
Sodium-dependent serotonin transporter0617
Sodium-dependent serotonin transporter0405
5-hydroxytryptamine receptor 7 0123
5-hydroxytryptamine receptor 5A0123
5-hydroxytryptamine receptor 5B0123
5-hydroxytryptamine receptor 3A0123
5-hydroxytryptamine receptor 4 0123
5-hydroxytryptamine receptor 3B0123
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE130013
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
mitogen-activated protein kinase 17007
survival motor neuron protein isoform d6006
Histone deacetylase 30404
Histone deacetylase 40303
Histone deacetylase 10404
Histone deacetylase 70303
Histone deacetylase 20404
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0202
Histone deacetylase 80303
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60303
Histone deacetylase 90202
Histone deacetylase 50303
AR protein280028
glucocorticoid receptor [Homo sapiens]160016
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 25005
geminin160016
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0336
Androgen receptor0404
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10103
Guanine nucleotide-binding protein G2002
Solute carrier family 22 member 30101
Phenylethanolamine N-methyltransferase0202
Cytochrome P450 2A60101
Substance-P receptor0101
Cytochrome P450 2A50101
Sodium-dependent dopamine transporter0404
Sigma non-opioid intracellular receptor 10303
Beta-2 adrenergic receptor0237
Sigma non-opioid intracellular receptor 10213
Chain A, Mutant Al2 6e7p9g0011
Chain A, Beta-lactamase8008
Chain A, 2-oxoglutarate Oxygenase100010
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Chain A, Cruzipain3003
Beta-lactamase 0001
acid sphingomyelinase1001
GLS protein9009
GLI family zinc finger 3180018
apical membrane antigen 1, AMA11001
retinoic acid nuclear receptor alpha variant 1140014
farnesoid X nuclear receptor9009
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20113
Metallo-beta-lactamase VIM-11 0001
euchromatic histone-lysine N-methyltransferase 2190019
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
chromobox protein homolog 1110011
thyroid hormone receptor beta isoform 2140014
DNA polymerase beta3003
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)7007
DNA polymerase kappa isoform 16006
Carbonic anhydrase 10708
Carbonic anhydrase 20708
60 kDa heat shock protein, mitochondrial0101
Beta-lactamase OXA-70001
Solute carrier family 15 member 10303
Solute carrier family 15 member 10303
Spike glycoprotein110112
10 kDa heat shock protein, mitochondrial0101
Angiopoietin-1 receptor0011
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Thiosulfate sulfurtransferase0101
Metallo-beta-lactamase VIM-130102
Efflux transporter 0001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Class D beta-lactamase0001
60 kDa chaperonin 0101
Metallo-beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
10 kDa chaperonin 0101
Metallo-b-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0113
Beta-lactamase VIM-1 0102
ATP-dependent phosphofructokinase8008
glucocerebrosidase5005
histone acetyltransferase KAT2A isoform 15005
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0336
Type-2 angiotensin II receptor0303
Type-2 angiotensin II receptor0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 84004
thioredoxin reductase120012
aldehyde dehydrogenase 1 family, member A1130013
thyroid stimulating hormone receptor7007
hypothetical protein, conserved2002
cytochrome P450 family 3 subfamily A polypeptide 4180018
EWS/FLI fusion protein9009
estrogen-related nuclear receptor alpha190019
estrogen nuclear receptor alpha260026
cytochrome P450 2D69009
peroxisome proliferator-activated receptor delta5005
Rac1 protein0011
IDH16006
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 13003
muscarinic acetylcholine receptor M17007
lethal factor (plasmid)8008
Prostaglandin-H2 D-isomerase0202
ATP-binding cassette sub-family C member 3019019
Multidrug resistance-associated protein 4019019
Solute carrier family 22 member 60606
Prostaglandin G/H synthase 1 0304
Prostaglandin G/H synthase 2 0304
Bile salt export pump028028
Epidermal growth factor receptor0404
Fatty acid-binding protein, liver0404
Integrin beta-35106
Myeloperoxidase0202
Prostaglandin G/H synthase 10506
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb5106
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10707
Adenosine receptor A10303
Adenosine receptor A2a0415
Substance-P receptor0303
Prostaglandin G/H synthase 20819
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0202
Nuclear receptor ROR-gamma6118
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-183314
Prostaglandin G/H synthase 20505
Rho-associated protein kinase 20202
Nicotinate phosphoribosyltransferase0303
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Canalicular multispecific organic anion transporter 1018018
Sigma non-opioid intracellular receptor 109110
regulator of G-protein signaling 47007
Beta-1 adrenergic receptor 0135
D(1A) dopamine receptor6006
lamin isoform A-delta10200020
Gamma-aminobutyric acid receptor subunit pi82313
Urease0101
Beta-2 adrenergic receptor010414
Beta-1 adrenergic receptor010414
Beta-3 adrenergic receptor0448
Gamma-aminobutyric acid receptor subunit beta-182313
Gamma-aminobutyric acid receptor subunit delta82313
Gamma-aminobutyric acid receptor subunit gamma-282313
Gamma-aminobutyric acid receptor subunit alpha-582313
Gamma-aminobutyric acid receptor subunit alpha-382313
Gamma-aminobutyric acid receptor subunit gamma-182313
Gamma-aminobutyric acid receptor subunit alpha-282313
Alpha-1D adrenergic receptor09316
Gamma-aminobutyric acid receptor subunit alpha-482313
Gamma-aminobutyric acid receptor subunit gamma-382313
Gamma-aminobutyric acid receptor subunit alpha-682313
Alpha-1A adrenergic receptor06416
Alpha-1B adrenergic receptor05312
Gamma-aminobutyric acid receptor subunit beta-382313
Gamma-aminobutyric acid receptor subunit beta-282313
TAR DNA-binding protein 433003
GABA theta subunit82313
Gamma-aminobutyric acid receptor subunit epsilon82313
nuclear receptor subfamily 1, group I, member 3110011
retinoid X nuclear receptor alpha110011
pregnane X nuclear receptor130013
cystic fibrosis transmembrane conductance regulator0101
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 08010
5-hydroxytryptamine receptor 4010010
Muscarinic acetylcholine receptor M20329
Muscarinic acetylcholine receptor M40216
Muscarinic acetylcholine receptor M10316
Muscarinic acetylcholine receptor M30215
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M50216
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M10329
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30328
5-hydroxytryptamine receptor 2C011112
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor5006
5-hydroxytryptamine receptor 70404
Reverse transcriptase/RNaseH 0012
Muscarinic acetylcholine receptor0112
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
15-lipoxygenase, partial3003
phosphopantetheinyl transferase5005
Microtubule-associated protein tau7007
Thrombopoietin3003
thioredoxin glutathione reductase3003
peripheral myelin protein 22 isoform 13003
M-phase phosphoprotein 84004
transient receptor potential cation channel subfamily V member 11001
Prothrombin0101
Renin0101
Neprilysin0101
Neprilysin0101
Leukotriene A-4 hydrolase0314
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme 0516
Angiotensin-converting enzyme0708
Leukotriene A-4 hydrolase0101
Thymidine phosphorylase0011
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0303
Angiotensin-converting enzyme0404
Beta-lactamase TEM0101
Mu-type opioid receptor0314
Beta-lactamase 0304
Beta-lactamase 0303
Angiotensin-converting enzyme 2 0213
Chain A, Ferritin light chain1001
NFKB1 protein, partial4004
G9009
arylsulfatase A7007
aryl hydrocarbon receptor140014
cytochrome P450 2C19 precursor4004
transcriptional regulator ERG isoform 32002
flap endonuclease 15005
cytochrome P450 3A4 isoform 18008
neuropeptide S receptor isoform A2002
Bile salt export pump0606
Interferon beta140014
HLA class I histocompatibility antigen, B alpha chain 9009
Albumin0538
Lanosterol 14-alpha demethylase0101
Inositol hexakisphosphate kinase 19009
cytochrome P450 2C9, partial9009
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein0202
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20213
D0202
Alpha-2B adrenergic receptor0459
Alpha-2C adrenergic receptor0459
Alpha-2A adrenergic receptor0459
Liver carboxylesterase 10001
Sodium-dependent noradrenaline transporter 0404
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Glutamate receptor ionotropic, NMDA 1 0202
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40101
D(2) dopamine receptor0303
Gamma-aminobutyric acid receptor subunit epsilon0101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium-dependent dopamine transporter 0404
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Potassium voltage-gated channel subfamily H member 2012012
Leukotriene B4 receptor 10102
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Glutamate receptor ionotropic, NMDA 3B0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Leukotriene B4 receptor 20102
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0303
USP1 protein, partial9009
activating transcription factor 66006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
heat shock protein beta-13003
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 31001
Cellular tumor antigen p53160016
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Thymidine kinase 2 0101
Deoxycytidine kinase0002
Probable deoxycytidylate deaminase0001
Cytidine deaminase0002
AAA family ATPase 0002
PAX80001
RAR-related orphan receptor gamma120012
SMAD family member 25005
ATAD5 protein, partial8008
PPM1D protein6006
SMAD family member 35005
TDP1 protein180018
STAT3, partial0101
Smad32002
estrogen receptor 2 (ER beta)8008
progesterone receptor9009
67.9K protein6006
peroxisome proliferator activated receptor gamma9009
vitamin D (1,25- dihydroxyvitamin D3) receptor140014
alpha-galactosidase4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
thyroid stimulating hormone receptor4004
v-jun sarcoma virus 17 oncogene homolog (avian)7007
NPC intracellular cholesterol transporter 1 precursor3003
cellular tumor antigen p53 isoform a6006
tumor necrosis factor2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
ras-related protein Rab-9A4004
nuclear factor erythroid 2-related factor 2 isoform 1130013
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
nuclear receptor ROR-gamma isoform 17007
Solute carrier organic anion transporter family member 1A40203
Voltage-dependent calcium channel gamma-2 subunit6006
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10202
Sodium/potassium-transporting ATPase subunit beta-1 0101
ATP-dependent translocase ABCB109013
Cytochrome P450 3A40505
Replicase polyprotein 1ab0112
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Glutamate receptor 26006
ATP-dependent translocase ABCB10202
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
ATPase family AAA domain-containing protein 59009
Ataxin-2130013
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30304
Solute carrier organic anion transporter family member 1B10304
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Luciferase9009
acetylcholinesterase8008
Histone H2A.x7007
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
Inhibitor of nuclear factor kappa-B kinase subunit beta0102
Lysine-specific histone demethylase 1A0101
Aurora kinase B0202
dopamine D1 receptor2002
glp-1 receptor, partial3003
Fumarate hydratase4004
GALC protein2002
polyprotein4004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
mu-type opioid receptor isoform MOR-10011
huntingtin isoform 22002
5-hydroxytryptamine receptor 2A0011
Carbonic anhydrase 120304
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30303
Aldo-keto reductase family 1 member B10202
Polyunsaturated fatty acid lipoxygenase ALOX150303
POU domain, class 2, transcription factor 10001
Alpha-2B adrenergic receptor08214
Carbonic anhydrase 40304
Carbonic anhydrase 60304
Carbonic anhydrase 5A, mitochondrial0304
D(3) dopamine receptor0606
Carbonic anhydrase 70304
Carbonic anhydrase 90304
Carbonic anhydrase 130101
Carbonic anhydrase 150202
Carbonic anhydrase 140304
Carbonic anhydrase 5B, mitochondrial0304
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
nuclear receptor subfamily 1, group I, member 24004
Serum paraoxonase/arylesterase 10303
Kinesin-like protein KIF110101
Nucleotide-binding oligomerization domain-containing protein 20101
hypoxia-inducible factor 1 alpha subunit7007
Eyes absent homolog 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
endonuclease IV3003
peripheral myelin protein 227007
Multidrug and toxin extrusion protein 10606
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit beta0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit beta0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
potassium voltage-gated channel subfamily H member 2 isoform d3003
Nuclear receptor subfamily 1 group I member 20022
D(2) dopamine receptor0415
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0202
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0213
Kappa-type opioid receptor0101
Histamine H1 receptor0202
Mu-type opioid receptor0325
Delta-type opioid receptor0314
Kappa-type opioid receptor0202
Kappa-type opioid receptor0314
Mu-type opioid receptor0101
thyrotropin-releasing hormone receptor1001
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0808
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20707
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0202
Carbonic anhydrase 130203
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Chain A, DEOXYNUCLEOSIDE KINASE0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0112
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Equilibrative nucleoside transporter 10101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Parkin4004
pyruvate kinase1001
cytochrome P450 2D6 isoform 14004
pyruvate kinase PKM isoform b1001
N-glycosylase/DNA lyase0101
Ornithine decarboxylase1001
Aspartate aminotransferase, cytoplasmic0101
Lactoperoxidase0101
Single-stranded DNA cytosine deaminase1001
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Proton-coupled amino acid transporter 10202
Amino acid transporter0202
nonstructural protein 14004
muscleblind-like protein 1 isoform 13003
Acid-sensing ion channel 30101
Dihydrofolate reductase0101
Albumin0101
Albumin0011
Cholinesterase0101
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0204
UDP-glucuronosyltransferase 2B70102
Acetylcholinesterase0505
Prostaglandin G/H synthase 10202
Caspase-10203
Prostaglandin G/H synthase 2 0203
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30303
Caspase-30202
Caspase-40202
Caspase-50202
Caspase-90202
Acid-sensing ion channel 10101
Fatty-acid amide hydrolase 10202
Prostaglandin G/H synthase 20203
Solute carrier family 22 member 60303
Prostaglandin G/H synthase 1 0203
Solute carrier family 22 member 80303
Dehydrogenase/reductase SDR family member 90101
Chain A, membrane-associated prostaglandin E synthase-20101
bromodomain adjacent to zinc finger domain 2B4004
cytochrome P450 2C9 precursor4004
vitamin D3 receptor isoform VDRA5005
serine/threonine-protein kinase mTOR isoform 13003
Prostaglandin E synthase0101
3',5'-cyclic-AMP phosphodiesterase 0202
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Aldo-keto reductase family 1 member B10202
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0202
Indoleamine 2,3-dioxygenase 10202
Nitric oxide synthase, inducible0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70002
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 20011
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 10011
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 40011
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50202
Sodium channel protein type 4 subunit alpha0202
Sodium channel protein type 5 subunit alpha0303
Sodium channel protein type 9 subunit alpha0202
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0202
histone deacetylase 9 isoform 33003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Tyrosine-protein kinase ABL10202
Methionine aminopeptidase0101
Proto-oncogene tyrosine-protein kinase Src0202
Vascular endothelial growth factor receptor 20101
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 12002
Calmodulin-domain protein kinase 10101
Solute carrier family 22 member 80101
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
DNA polymerase III, partial1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
Alpha-2A adrenergic receptor07314
D(1A) dopamine receptor0314
5-hydroxytryptamine receptor 2A0617
5-hydroxytryptamine receptor 2B0819
5-hydroxytryptamine receptor 60415
Cytochrome P450 2D60404
Beta-1 adrenergic receptor0327
Beta-1 adrenergic receptor0202
Translocator protein0101
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
Phosphodiesterase 0101
Vpr1001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Aurora kinase A0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Dual specificity protein kinase TTK0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Inner centromere protein0101
Phosphodiesterase 0101
Nuclear receptor corepressor 10101
Integrin beta-10101
Integrin alpha-40101
Cytochrome P450 2C190202
Nuclear receptor corepressor 20101
pregnane X receptor2002
beta-2 adrenergic receptor1001
polyunsaturated fatty acid lipoxygenase ALOX122002
perilipin-50101
perilipin-10101
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Glutathione reductase, mitochondrial0202
Cytochrome P450 1A20202
Adenosine receptor A30314
Phospholipase A2, membrane associated0001
Alpha-1B adrenergic receptor07411
Voltage-dependent L-type calcium channel subunit alpha-1C0303
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Platelet-activating factor receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Adenosine receptor A2a0213
Adenosine receptor A10202
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Sodium channel protein type 1 subunit alpha0101
C-C chemokine receptor type 20202
Alpha-1A adrenergic receptor07411
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Potassium voltage-gated channel subfamily A member 10101
C-terminal-binding protein 11001
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0405
Myosin light chain kinase, smooth muscle0101
Transient receptor potential cation channel subfamily A member 10011
Potassium channel subfamily K member 2 0101
Indoleamine 2,3-dioxygenase 20101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Sodium channel protein type 2 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Platelet glycoprotein VI0011
ClpP1001
Hsf1 protein0011
estrogen receptor beta isoform 10101
Alpha-1A adrenergic receptor0123
Alpha-1A adrenergic receptor0202
Alpha-2C adrenergic receptor05312
Alpha-1B adrenergic receptor0202
Alpha-1D adrenergic receptor05410
Nuclear receptor subfamily 3 group C member 3 0404
Nischarin0101
luciferase1001
Luciferin 4-monooxygenase0101
5-hydroxytryptamine receptor 1A0325
Beta-2 adrenergic receptor0204
5-hydroxytryptamine receptor 1B0415
lysosomal alpha-glucosidase preproprotein1001
interferon gamma precursor0001
Solute carrier family 22 member 20303
Solute carrier family 22 member 30202
Beta-casein0101
Interstitial collagenase0101
Matrix metalloproteinase-90101
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2A adrenergic receptor0101
Alpha-mannosidase 2C10011
Bromodomain-containing protein 20202
5-hydroxytryptamine receptor 1D0101
Alpha-2B adrenergic receptor0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Type-1 angiotensin II receptor0101
D(1A) dopamine receptor1001
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Multidrug and toxin extrusion protein 20202
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
Solute carrier family 22 member 10101
Sterol O-acyltransferase 10101
Solute carrier family 22 member 20101
Acetylcholinesterase 0101
DNA (cytosine-5)-methyltransferase 10101
Sterol O-acyltransferase 10101
Solute carrier family 22 member 10202
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
DNA (cytosine-5)-methyltransferase 3-like0101
DNA (cytosine-5)-methyltransferase 3A0101
Glutamate 5-kinase0001
Cytochrome P450 2C80101
D(3) dopamine receptor0101
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
Neuromedin-K receptor0011
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Vasopressin V1a receptor0112
Beta-2 adrenergic receptor0101
Nuclear receptor subfamily 2 group E member 10022
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
BRCA11001
Ubiquitin carboxyl-terminal hydrolase isozyme L50101
Endolysin0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]