collagen binding involved in cell-matrix adhesion

Definition

Target type: molecularfunction

Any collagen binding that occurs as part of cell-matrix adhesion. [GOC:dos]

Collagen binding is a crucial molecular function involved in cell-matrix adhesion. It refers to the interaction of specific proteins, primarily integrins and other cell surface receptors, with collagen molecules within the extracellular matrix (ECM). This interaction plays a pivotal role in maintaining cell structure, regulating cell behavior, and facilitating signal transduction.

Firstly, collagen binding provides structural support and integrity to cells and tissues. Collagen, a fibrous protein abundant in the ECM, forms a robust network that provides tensile strength and resistance to mechanical stress. Integrins, transmembrane receptors that bind to collagen, anchor cells to this network, thus maintaining cell shape and preventing cellular detachment.

Secondly, collagen binding plays a key role in cell signaling and communication. Integrin engagement with collagen triggers intracellular signaling cascades, activating downstream pathways that regulate cell growth, differentiation, migration, and apoptosis. This intricate interplay between collagen binding and signaling pathways ensures proper tissue development and homeostasis.

Thirdly, collagen binding is essential for wound healing and tissue repair. When tissues are injured, collagen binding facilitates the recruitment of cells, such as fibroblasts and immune cells, to the site of injury. These cells contribute to the formation of new collagen fibers and the eventual repair of damaged tissue.

In conclusion, collagen binding is a fundamental molecular function that underpins cell-matrix adhesion. It provides structural support, regulates cell behavior, and facilitates signaling, making it essential for tissue development, homeostasis, and repair.'
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Proteins (2)

Compounds (17)