2,3-dimethylhydroquinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,3-dimethylhydroquinone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	69100
CHEMBL ID	1269256
SCHEMBL ID	68013
MeSH ID	M0505410

Synonyms (49)

Synonym
AC-1261
1321-28-4
2,3-dmhydrop
1,4-benzenediol, dimethyl-
hydroquinone,3-dimethyl-
nsc-108080
2,3-xylohydroquinone
o-xylene-3,6-diol
o-xylohydroquinone
2,3-dimethylhydroquinone
608-43-5
nsc108080
2,3-dimethylbenzene-1,4-diol
1,4-benzenediol, 2,3-dimethyl-
inchi=1/c8h10o2/c1-5-6(2)8(10)4-3-7(5)9/h3-4,9-10h,1-2h
2,3-dimethylhydroquinone, 97%
D3877
3,6-dihydroxy-o-xylene
2,3-dimethylbenzene-1,4-diol;2,3-dimethylhydroquinone
A832918
AKOS003632178
f0l7hg609j ,
nsc 108080
unii-f0l7hg609j
hydroquinone, 2,3-dimethyl-
xylohydroquinone
ai3-02932
hydroquinone, dimethyl-
einecs 215-317-1
CHEMBL1269256
1,4-dihydroxy-2,3-dimethylbenzene
2,3-dimethyl-1,4-benzenediol
STL146345
FT-0609688
SCHEMBL68013
2,3 dimethyl hydroquinone
2,3-dimethyl-benzene-1,4-diol
2,3-dimethyl-hydroquinone
AM808242
BBL027769
mfcd00009997
2,3-dimethyl-1,4-benzenediol #
DS-1328
J-507036
CS-W005767
DTXSID50870679
Q27277483
SY035521
EN300-54724

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay ID	Title	Year	Journal	Article
AID1571460	Antiproliferative activity against human U251MG cells after 72 hrs by sulforhodamine B assay	2018	MedChemComm, Nov-01, Volume: 9, Issue:11	Towards identifying potent new hits for glioblastoma.
AID526733	Antifungal activity against Candida tropicalis KCCM 50662 after 1 day	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Synthesis and antifungal activity of benzofuran-5-ols.
AID1571461	Antiproliferative activity against human IN1472 cells after 72 hrs by sulforhodamine B assay	2018	MedChemComm, Nov-01, Volume: 9, Issue:11	Towards identifying potent new hits for glioblastoma.
AID1571463	Antiproliferative activity against human IN1760 cells after 72 hrs by sulforhodamine B assay	2018	MedChemComm, Nov-01, Volume: 9, Issue:11	Towards identifying potent new hits for glioblastoma.
AID526734	Antifungal activity against Candida krusei KCCM 11655 after 1 day	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Synthesis and antifungal activity of benzofuran-5-ols.
AID526732	Antifungal activity against Candida albicans KCCM 50235 after 1 day	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Synthesis and antifungal activity of benzofuran-5-ols.
AID526737	Antifungal activity against Aspergillus flavus KCCM 11899 after 2 days	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Synthesis and antifungal activity of benzofuran-5-ols.
AID526735	Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Synthesis and antifungal activity of benzofuran-5-ols.
AID1571462	Antiproliferative activity against human IN1528 cells after 72 hrs by sulforhodamine B assay	2018	MedChemComm, Nov-01, Volume: 9, Issue:11	Towards identifying potent new hits for glioblastoma.
AID1571459	Antiproliferative activity against human U87MG cells after 72 hrs by sulforhodamine B assay	2018	MedChemComm, Nov-01, Volume: 9, Issue:11	Towards identifying potent new hits for glioblastoma.
AID526736	Antifungal activity against Aspergillus niger KCTC 1231 after 2 days	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Synthesis and antifungal activity of benzofuran-5-ols.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (33.33)	29.6817
2010's	4 (66.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.45

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.45 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.77 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.45)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2-cresol 2-cresol: RN given refers to parent cpd. o-cresol : A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene.	2.17	1	cresol	human xenobiotic metabolite
guaiacol Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747). methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.. guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.	2.17	1	guaiacols	disinfectant; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; expectorant; plant metabolite
hydroquinone [no description available]	7.74	3	benzenediol; hydroquinones	antioxidant; carcinogenic agent; cofactor; Escherichia coli metabolite; human xenobiotic metabolite; mouse metabolite; skin lightening agent
indole [no description available]	2.17	1	indole; polycyclic heteroarene	Escherichia coli metabolite
phenol [no description available]	2.17	1	phenols	antiseptic drug; disinfectant; human xenobiotic metabolite; mouse metabolite
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	2.17	1	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
fluconazole Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.	2.05	1	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic
flucytosine Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.. flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.	2.05	1	aminopyrimidine; nucleoside analogue; organofluorine compound; pyrimidine antifungal drug; pyrimidone	prodrug
salicylamide salamide: a major impurity of hydrochlorothiazide; structure in first source	2.17	1	phenols; salicylamides	antirheumatic drug; non-narcotic analgesic
2-aminophenol [no description available]	2.06	1	aminophenol	bacterial metabolite
2,3,4,6-tetrachlorophenol 2,3,4,6-tetrachlorophenol: RN given refers to parent cpd; see also record for tetrachlorophenol with locants for chloro groups not specified. 2,3,4,6-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6.	2.06	1	tetrachlorophenol	xenobiotic metabolite
2-nitrophenol nitrophenol : Any member of the class of phenols or substituted phenols carrying at least 1 nitro group.	2.17	1	2-nitrophenols
2-phenylphenol 2-phenylphenol: RN given refers to parent cpd; structure. biphenyl-2-ol : A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits.	2.17	1	hydroxybiphenyls	antifungal agrochemical; environmental food contaminant
4-phenylphenol 4-phenylphenol: RN given refers to cpd without isomeric designation. biphenyl-4-ol : A member of the class of hydroxybiphenyls that is biphenyl carrying a hydroxy group at position 4.	2.17	1	hydroxybiphenyls
2-methyl-1,4-hydroquinone 2-methyl-1,4-hydroquinone: structure given in first source. toluquinol : A member of the class of hydroquinones that is hydroquinone in which one of the benzene hydrogens has been replaced by a methyl group.	2.13	1	hydroquinones	angiogenesis inhibitor; anti-inflammatory agent; Penicillium metabolite
2-amino-4-chlorophenol 2-amino-4-chlorophenol: causes contact dermititis	2.06	1
2,5-dimethyl-4-benzoquinone [no description available]	2.05	1
2,3,5-trimethylquinol 2,3,5-trimethylquinol: reducing agent. 2,3,5-trimethylhydroquinone : A member of the class of hydroquinones that is hydroquinone substituted by methyl groups at positions 2, 3 and 5.	2	1	hydroquinones; methylbenzene
2-(2'-hydroxyphenyl)benzoxazole 2-(2'-hydroxyphenyl)benzoxazole: structure in first source. 2-(1,3-benzoxazol-2-yl)phenol : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole substituted by a 2-hydroxyphenyl group at position 2.	2.17	1	1,3-benzoxazoles; phenols	geroprotector
2-phenylindole alpha-phenylindole: RN given refers to parent cpd	2.17	1	phenylindole
2-(2'-hydroxyphenyl)benzimidazole 2-(2'-hydroxyphenyl)benzimidazole: structure in first source	2.17	1
2-(2-hydroxyphenyl)benzothiazole 2-(1,3-benzothiazol-2-yl)phenol : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by a 2-hydroxyphenyl group at position 2.	2.17	1	benzothiazoles; phenols	geroprotector
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	2.13	1	cephalosporin	fungal metabolite
phenoxazine phenoxazine: RN given refers to 10H-phenoxazine. 10H-phenoxazine : A member of the class of phenoxazines that is morpholine which is ortho-fused to two benzene rings at positions 2-3 and 5-6.	2.06	1	phenoxazine	ferroptosis inhibitor; radical scavenger
beta-lactams 2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.	2.13	1	beta-lactam antibiotic allergen; beta-lactam
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.03	1
2-(2-methoxyphenyl)-1H-indole [no description available]	2.17	1	phenylindole
laccase Laccase: A copper-containing oxidoreductase enzyme that catalyzes the oxidation of 4-benzenediol to 4-benzosemiquinone. It also has activity towards a variety of O-quinols and P-quinols. It primarily found in FUNGI and is involved in LIGNIN degradation, pigment biosynthesis and detoxification of lignin-derived products.	2.13	1
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	2	1	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.13	1
Infections, Staphylococcal [description not available]	2.13	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.13	1

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