Page last updated: 2024-12-06

cetalkonium chloride

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Description

Cetalkonium chloride is a quaternary ammonium compound used as an antiseptic and disinfectant. It has a broad spectrum of activity against bacteria, fungi, and viruses. Cetalkonium chloride is typically synthesized by reacting cetyl alcohol with a quaternary ammonium salt. Its mechanism of action involves disrupting cell membranes and interfering with the function of enzymes. The compound is used in various personal care products, including mouthwashes, hand sanitizers, and shampoos. Research on cetalkonium chloride focuses on its efficacy against specific microorganisms, its safety for human use, and potential new applications.'

cetalkonium chloride: Note: Bonjela is a multimeaning drug name. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID31202
CHEMBL ID1644450
SCHEMBL ID59931
MeSH IDM0311978

Synonyms (122)

Synonym
hexadecyl dimethyl benzyl ammonium chloride
ammonium, benzyldimethylhexadecyl-, chloride
einecs 204-526-3
n-hexadecyl-n,n-dimethylbenzenemethanaminium chloride
dehyquart cdb
benzyldimethylcetylammonium chloride
cetyl dimethyl benzyl ammonium chloride
nsc 32942
cloruro de cetalconio [inn-spanish]
benzenemethanaminium, n-hexadecyl, n,n-dimethyl-, chloride
cetalkonium chloride [usan:inn:ban]
cetalkonii chloridum [inn-latin]
ai3-03464
cdbac
chlorure de cetalkonium [inn-french]
benzenemethanaminium, n-hexadecyl-n,n-dimethyl-, chloride
rodalon
cetalconio cloruro [dcit]
ammonium, benzylhexadecyldimethyl-, chloride
c25h46cln
cetol
ammonyx t
spilan
benzylhexadecyldimethylammonium chloride
dmcbac
hexadecyldimethylbenzylammonium chloride
cetylbenzyldimethylammonium chloride
benzyldimethylhexadecylammonium chloride
hexadecylbenzyldimethylammonium chloride
banicol
win 357
122-18-9
cetalkonium chloride
benzylcetyldimethylammonium chloride
zettyn
baktonium
benzenemethanaminium, n,n-dimethyl-, chloride
cetyldimethylbenzylammonium chloride
cetyl zephiran
bonjela
dimethylbenzylhexadecylammonium chloride
cetylon
nsc-32942
dehyquart cbb
acinol
ammonyx g
zettyn chloride
benzaletas
tetraseptan
nsc32942
n-hexadecyldimethylbenzylammonium chloride
dimethylbenzylcetylammonium chloride
bicetonium
n-benzyl-n-cetyldimethylammonium chloride
zettyn (tn)
cetalkonium chloride (usan/inn)
D03448
benzyldimethylhexadecylammonium chloride, cationic detergent
NCGC00167582-01
B0237
A804855
benzenemethaminium, n-hexadecyl-n,n-dimethyl, chloride
CHEMBL1644450
acquat cdac
sanisol c
benzyl hexadecyl dimethyl ammonium chloride
benzenemethanaminium, n-hexadecyl-n,n-dimethyl-, chloride (1:1)
85474o1n9d ,
cetalconio cloruro
unii-85474o1n9d
cetalkonii chloridum
dsstox_cid_21665
dsstox_rid_82703
tox21_301833
NCGC00255210-01
cas-63449-41-2
dtxcid1021665
NCGC00255704-01
dtxsid3041665 ,
dsstox_gsid_48122
tox21_302079
cas-122-18-9
tox21_112574
chlorure de cetalkonium
cloruro de cetalconio
benzylcetyldimethylammonium chloride hydrate
FT-0625070
SC10040
n-benzyl-n,n-dimethylhexadecan-1-aminium chloride
cetalkonium chloride [inn]
cetalkonium chloride [who-dd]
cetalkonium chloride [mi]
cetalkonium chloride [mart.]
cetalkonium chloride [vandf]
cetalkonium chloride [usan]
cetalkonium chloride [inci]
AKOS015914910
BP-30079
SCHEMBL59931
tox21_112574_1
NCGC00344524-01
benzyldimethyl-n-hexadecylammonium chloride
SXPWTBGAZSPLHA-UHFFFAOYSA-M
n-benzyl-n,n-dimethyl-1-hexadecanaminium chloride
W-109454
benzylhexadecyldimethylammonium (chloride)
cetalkonium (chloride)
mfcd00011625
benzyldimethylhexadecylammonium chloride, >=97.0% (dried material, at)
HY-B1597
CS-0013522
benzyldimethylhexadecylammonium chloride, vetec(tm) reagent grade, 97%
benzyl-hexadecyl-dimethylazanium;chloride
benylcetyldimethylammonium chloride
F16465
AS-17528
Q18345315
[4-(2-butyl)piperazin-1-yl]aceticacid
benzyldimethylhexadecylammonium chloride 100 microg/ml in acetonitrile
n-benzyl-n,n-dimethylhexadecan-1-aminiumchloride
EN300-7401498
benzyl(hexadecyl)dimethylazanium chloride

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" These in vivo and ex vivo experimental approaches demonstrated that ocular surface toxicity was reduced by using an emulsion instead of a traditional solution and that a CKC emulsion was safe for future ocular administration."( Reduction of quaternary ammonium-induced ocular surface toxicity by emulsions: an in vivo study in rabbits.
Baudouin, C; Brignole-Baudouin, F; Faure, MO; Lambert, G; Liang, H; Mao, Z; Rabinovich-Guilatt, L; Riancho, L; Warnet, JM, 2008
)
0.35

Bioavailability

ExcerptReferenceRelevance
"01) and a very low bioavailability (AUC=524+/-403 microg min/ml)."( Influence of absorption enhancers on the pharmacokinetic properties of non-oral beta-lactam-cefpirom using the rabbit (Chinchilla) in vivo model.
Härtl, A; Mrestani, Y; Neubert, RH, 2006
)
0.33
" However, the bioavailability of drugs following eye instillations of eye drops is very low."( Benefits of cetalkonium chloride cationic oil-in-water nanoemulsions for topical ophthalmic drug delivery.
Daull, P; Garrigue, JS; Lallemand, F, 2014
)
0.78
"One of the most efficient ways to improve drug bioavailability is to increase the precorneal residence time of the eye drop formulations."( Benefits of cetalkonium chloride cationic oil-in-water nanoemulsions for topical ophthalmic drug delivery.
Daull, P; Garrigue, JS; Lallemand, F, 2014
)
0.78
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (51)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency81.11400.007215.758889.3584AID1224835
acetylcholinesteraseHomo sapiens (human)Potency53.43010.002541.796015,848.9004AID1347395; AID1347397; AID1347398
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency38.69603.189029.884159.4836AID1224846; AID1224894
RAR-related orphan receptor gammaMus musculus (house mouse)Potency30.69940.006038.004119,952.5996AID1159521; AID1159523
SMAD family member 2Homo sapiens (human)Potency44.19980.173734.304761.8120AID1346859; AID1346924
Fumarate hydrataseHomo sapiens (human)Potency35.48130.00308.794948.0869AID1347053
SMAD family member 3Homo sapiens (human)Potency44.19980.173734.304761.8120AID1346859; AID1346924
TDP1 proteinHomo sapiens (human)Potency1.06630.000811.382244.6684AID686978; AID686979
GLI family zinc finger 3Homo sapiens (human)Potency2.14840.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency29.23800.000221.22318,912.5098AID1259243; AID1259247; AID743035; AID743036; AID743042; AID743053; AID743054; AID743063
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency66.49240.013326.981070.7614AID1346978
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency71.23450.000657.913322,387.1992AID1259377; AID1259378; AID1259394
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency67.90370.001022.650876.6163AID1224838; AID1224893
progesterone receptorHomo sapiens (human)Potency65.69200.000417.946075.1148AID1346784; AID1346795
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency15.48710.01237.983543.2770AID1645841
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency30.28810.000214.376460.0339AID720691; AID720692; AID720719
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency31.30570.003041.611522,387.1992AID1159552; AID1159553; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency28.38320.000817.505159.3239AID1159527; AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency16.96230.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency53.12100.375827.485161.6524AID743217; AID743220; AID743239
estrogen nuclear receptor alphaHomo sapiens (human)Potency40.22730.000229.305416,493.5996AID1259244; AID1259248; AID743069; AID743075; AID743077; AID743078; AID743079; AID743080; AID743091
GVesicular stomatitis virusPotency38.90180.01238.964839.8107AID1645842
cytochrome P450 2D6Homo sapiens (human)Potency0.19500.00108.379861.1304AID1645840
polyproteinZika virusPotency35.48130.00308.794948.0869AID1347053
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency39.25450.001024.504861.6448AID743212; AID743215; AID743227
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency42.86630.001019.414170.9645AID743140; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency46.75690.023723.228263.5986AID743223
caspase-3Homo sapiens (human)Potency66.49240.013326.981070.7614AID1346978
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency34.83090.001723.839378.1014AID743083
thyroid stimulating hormone receptorHomo sapiens (human)Potency35.86430.001628.015177.1139AID1224843; AID1224895
activating transcription factor 6Homo sapiens (human)Potency59.75980.143427.612159.8106AID1159516; AID1159519
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency51.396619.739145.978464.9432AID1159509; AID1159518
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency35.03740.057821.109761.2679AID1159526; AID1159528
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency35.48130.10009.191631.6228AID1346983
Histone H2A.xCricetulus griseus (Chinese hamster)Potency146.82400.039147.5451146.8240AID1224845; AID1224896
Caspase-7Cricetulus griseus (Chinese hamster)Potency79.39560.006723.496068.5896AID1346980
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency22.38720.01789.637444.6684AID588834
caspase-3Cricetulus griseus (Chinese hamster)Potency79.39560.006723.496068.5896AID1346980
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency13.06300.000323.4451159.6830AID743065; AID743066; AID743067
heat shock protein beta-1Homo sapiens (human)Potency47.82780.042027.378961.6448AID743210; AID743228
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency52.02170.000627.21521,122.0200AID743202
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency43.95200.001557.789015,848.9004AID1259244
Interferon betaHomo sapiens (human)Potency31.23600.00339.158239.8107AID1347407; AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency38.90180.01238.964839.8107AID1645842
Cellular tumor antigen p53Homo sapiens (human)Potency40.47520.002319.595674.0614AID651631; AID720552
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency43.95200.001551.739315,848.9004AID1259244
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency7.94330.009610.525035.4813AID1479145
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency38.90180.01238.964839.8107AID1645842
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency13.65390.011917.942071.5630AID651632; AID720516
Ataxin-2Homo sapiens (human)Potency15.67100.011912.222168.7989AID651632
cytochrome P450 2C9, partialHomo sapiens (human)Potency38.90180.01238.964839.8107AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (185)

Processvia Protein(s)Taxonomy
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
adaptive immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of T cell anergyHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
defense responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
detection of bacteriumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-12 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-6 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protection from natural killer cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
innate immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of dendritic cell differentiationHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class IbHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
inositol phosphate metabolic processInositol hexakisphosphate kinase 1Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
cell population proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of B cell proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
nuclear DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
signal transduction in response to DNA damageATPase family AAA domain-containing protein 5Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
isotype switchingATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of isotype switching to IgG isotypesATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloadingATPase family AAA domain-containing protein 5Homo sapiens (human)
regulation of mitotic cell cycle phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of cell cycle G2/M phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of receptor internalizationAtaxin-2Homo sapiens (human)
regulation of translationAtaxin-2Homo sapiens (human)
RNA metabolic processAtaxin-2Homo sapiens (human)
P-body assemblyAtaxin-2Homo sapiens (human)
stress granule assemblyAtaxin-2Homo sapiens (human)
RNA transportAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (55)

Processvia Protein(s)Taxonomy
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
signaling receptor bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
peptide antigen bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein-folding chaperone bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol heptakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
ATP bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 1-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 3-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP hydrolysis activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloader activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
RNA bindingAtaxin-2Homo sapiens (human)
epidermal growth factor receptor bindingAtaxin-2Homo sapiens (human)
protein bindingAtaxin-2Homo sapiens (human)
mRNA bindingAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (42)

Processvia Protein(s)Taxonomy
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
Golgi membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
endoplasmic reticulumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi apparatusHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
cell surfaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
ER to Golgi transport vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
secretory granule membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
phagocytic vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
early endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
recycling endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular exosomeHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lumenal side of endoplasmic reticulum membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
MHC class I protein complexHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular spaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
external side of plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
fibrillar centerInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
cytosolInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusInositol hexakisphosphate kinase 1Homo sapiens (human)
cytoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
Elg1 RFC-like complexATPase family AAA domain-containing protein 5Homo sapiens (human)
nucleusATPase family AAA domain-containing protein 5Homo sapiens (human)
cytoplasmAtaxin-2Homo sapiens (human)
Golgi apparatusAtaxin-2Homo sapiens (human)
trans-Golgi networkAtaxin-2Homo sapiens (human)
cytosolAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
membraneAtaxin-2Homo sapiens (human)
perinuclear region of cytoplasmAtaxin-2Homo sapiens (human)
ribonucleoprotein complexAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (83)

Assay IDTitleYearJournalArticle
AID1810061Antibiofilm activity against Staphylococcus epidermidis ATCC14990 assessed as inhibition of CV-staining/biomass formation measured after overnight incubation by biofilm inhibition assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1575544Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 assessed as as reduction in bacterial load by measuring reduction in colony forming units at 50 uM preincubated for 1 min followed by subculturing and further incubate2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1722941Antibacterial activity against Klebsiella pneumoniae ATTC 13883 measured after overnight incubation by microtitre plate based spectrophotometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1810060Antibiofilm activity against methicillin-resistant Staphylococcus aureus SAP 0017 assessed as inhibition of CV-staining/biomass formation measured after overnight incubation by biofilm inhibition assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID551748Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 12 to 18 hrs by twofold dilution method2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID1722949Antibiofilm activity against Klebsiella pneumoniae ATTC 13883 incubated for 24 hrs under shaking condition by turbidometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1810063Antibiofilm activity against methicillin-resistant Staphylococcus aureus USA300 LAC assessed as minimal biofilm eradication concentration required for complete inhibition of bacterial growth by Calgary biofilm device assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1575565Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 at 50 uM after 5 to 10 mins by time-kill kinetic assay relative to control2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1575554Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 at 50 uM treated with 18 days old solution of test compound for 10 mins relative to control2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1722946Antibiofilm activity against Escherichia coli ATTC 489 incubated for 24 hrs under shaking condition by turbidometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1722940Antibacterial activity against Acinetobacter baumannii 17918 measured after overnight incubation by microtitre plate based spectrophotometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID551746Antibacterial activity against Staphylococcus aureus ATCC 25923 after 12 to 18 hrs by twofold dilution method2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID1810065Antibiofilm activity against Staphylococcus epidermidis ATCC14990 assessed as biofilm eradication concentration by Calgary biofilm device assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1722937Antibacterial activity against Pseudomonas aeruginosa PAO1 measured after overnight incubation by microtitre plate based spectrophotometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1575555Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 assessed as as reduction in bacterial load by measuring reduction in colony forming units at 50 uM treated with 111 days old solution of test compound for 10 mins fol2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID551751Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 12 to 18 hrs by twofold dilution method2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID1810064Antibiofilm activity against methicillin-resistant Staphylococcus aureus SAP 0017 assessed as biofilm eradication concentration by Calgary biofilm device assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID551744Antibacterial activity against Mycobacterium smegmatis ATCC 14468 after 12 to 18 hrs by twofold dilution method2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID551749Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 12 to 18 hrs by twofold dilution method2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID1722943Antibiofilm activity against methicillin-resistant Staphylococcus aureus USA300 LAC incubated for 24 hrs under shaking condition by turbidometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1575556Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 at 50 uM treated with 111 days old solution of test compound for 10 mins relative to control2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1722942Antibiofilm activity against methicillin-resistant Staphylococcus aureus SAP0017 incubated for 24 hrs under shaking condition by turbidometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1810057Antimicrobial activity against Staphylococcus epidermidis ATCC14990 assessed as inhibition of bacterial growth incubated for 18 to 20 hrs by broth microdilution assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1575545Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 assessed as as reduction in bacterial load by measuring reduction in colony forming units at 50 uM preincubated for 3 min followed by subculturing and further incubate2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1722944Antibiofilm activity against Pseudomonas aeruginosa PA14 incubated for 24 hrs under shaking condition by turbidometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1575571Cytotoxicity against human HEK293 cells assessed as reduction in viability at 25 uM after 48 hrs by MTT assay relative to control2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID551745Antibacterial activity against Escherichia coli ATCC 25922 after 12 to 18 hrs by twofold dilution method2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID551747Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 12 to 18 hrs by twofold dilution method2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID1722947Antibiofilm activity against Acinetobacter baumannii 5015 incubated for 24 hrs under shaking condition by turbidometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1722936Antibacterial activity against Pseudomonas aeruginosa PA14 measured after overnight incubation by microtitre plate based spectrophotometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1722945Antibiofilm activity against Pseudomonas aeruginosa PAO1 incubated for 24 hrs under shaking condition by turbidometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1722935Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 LAC measured after overnight incubation by microtitre plate based spectrophotometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1150899Critical micelle concentration of the compound1976Journal of medicinal chemistry, Jun, Volume: 19, Issue:6
Effect of chain length on critical micelle formation and protein binding of quaternary ammonium compounds.
AID1722939Antibacterial activity against Acinetobacter baumannii 5015 measured after overnight incubation by microtitre plate based spectrophotometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1810055Antimicrobial activity against methicillin-resistant Staphylococcus aureus USA300 LAC assessed as inhibition of bacterial growth incubated for 18 to 20 hrs by broth microdilution assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1722938Antibacterial activity against Escherichia coli ATTC 489 measured after overnight incubation by microtitre plate based spectrophotometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1810066Antibiofilm activity against Enterococcus faecium assessed as biofilm eradication concentration by Calgary biofilm device assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1575557Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 assessed as as reduction in bacterial load by measuring reduction in colony forming units at 50 uM treated with 18 days old solution of test compound for 10 mins foll2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1575537Cytotoxicity against human HEK293 cells after 48 hrs by MTT assay2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1810062Antibiofilm activity against Enterococcus faecium assessed as inhibition of CV-staining/biomass formation measured after overnight incubation by biofilm inhibition assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1150900Binding affinity to bovine serum albumin after overnight incubation by equilibrium dialysis1976Journal of medicinal chemistry, Jun, Volume: 19, Issue:6
Effect of chain length on critical micelle formation and protein binding of quaternary ammonium compounds.
AID1575563Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 at 50 uM after 1 min by time-kill kinetic assay relative to control2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1722948Antibiofilm activity against Acinetobacter baumannii 17918 incubated for 24 hrs under shaking condition by turbidometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1575564Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 at 50 uM after 3 mins by time-kill kinetic assay relative to control2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1810058Antimicrobial activity against Enterococcus faecium assessed as inhibition of bacterial growth incubated for 18 to 20 hrs by broth microdilution assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID551750Antibacterial activity against Enterococcus faecalis ATCC 29212 after 12 to 18 hrs by twofold dilution method2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID1810056Antimicrobial activity against methicillin-resistant Staphylococcus aureus SAP 0017 assessed as inhibition of bacterial growth incubated for 18 to 20 hrs by broth microdilution assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1722934Antibacterial activity against methicillin-resistant Staphylococcus aureus SAP0017 measured after overnight incubation by microtitre plate based spectrophotometric method2020Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
AID1810059Antibiofilm activity against methicillin-resistant Staphylococcus aureus USA300 LAC assessed as inhibition of CV-staining/biomass formation measured after overnight incubation by biofilm inhibition assay2021Journal of medicinal chemistry, 11-25, Volume: 64, Issue:22
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.
AID1575546Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC BAA 1707 assessed as as reduction in bacterial load by measuring reduction in colony forming units at 50 uM preincubated for 5 to 10 min followed by subculturing and further in2019MedChemComm, May-01, Volume: 10, Issue:5
Rapid kill assessment of an
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (47)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (12.77)18.7374
1990's3 (6.38)18.2507
2000's17 (36.17)29.6817
2010's12 (25.53)24.3611
2020's9 (19.15)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 44.99

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index44.99 (24.57)
Research Supply Index3.89 (2.92)
Research Growth Index5.07 (4.65)
Search Engine Demand Index64.65 (26.88)
Search Engine Supply Index1.98 (0.95)

This Compound (44.99)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.08%)6.00%
Case Studies4 (8.33%)4.05%
Observational0 (0.00%)0.25%
Other43 (89.58%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]