Compounds > irisolidone
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irisolidone

Description

irisolidone: isolated from the flowers and rhizomes of Pueraria thunbergiana; structure in first source [MeSH]

Irisolidone : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID5281781
CHEMBL ID265945
SCHEMBL ID1974327
CHEBI ID5972
MeSH IDM0384413

Synonyms (27)

Synonym
2345-17-7
irisolidone
CHEMBL265945
chebi:5972 ,
LMPK12050384
4'-o-methyltectorigenin
5,7-dihydroxy-6,4'-dimethoxyisoflavone
5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)chromen-4-one
4'-o-methoxytectorigenin
081orx70zr ,
isoflavone, 5,7-dihydroxy-4',6-dimethoxy-
5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4h-chromen-4-one
unii-081orx70zr
4'-methoxytectorigenin
SCHEMBL1974327
AC-34234
5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4h-1-benzopyran-4-one
AKOS037515268
HY-N2412
Q27106953
BCP33583
4'-o-methyltectorigeni
FT-0776503
CS-0022613
MS-24603
DTXSID30946104
E88606

Drug Classes (1)

ClassDescription
4'-methoxyisoflavonesAny methoxyisoflavone which has a methoxy group at the 4-position of the phenyl substituent.

Bioassays (19)

Assay IDTitleYearJournalArticle
AID323486Inhibition of hydrogen peroxide-induced lipid peroxidation in chinese hamster V79-4 cells assessed as TBARS per mg of protein at 1 ug/mL2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323495Protective effect on hydrogen peroxide-induced damage in chinese hamster V79-4 cells in presence of U0126 by MTT assay2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323491Decrease in hydrogen peroxide-induced 8-OHdG in chinese hamster V79-4 cells at 50 ug/mL2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323496Activation of ERK in chinese hamster V79-4 cells assessed as phosphorylated ERK within 6 hrs2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323481DPPH radical scavenging activity at 10 ug/ml after 30 mins2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323484ROS scavenging activity in chinese hamster V79-4 cells at 10 ug/mL after 30 mins by DCF-DA method2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323488Inhibition of hydrogen peroxide-induced lipid peroxidation in chinese hamster V79-4 cells assessed as TBARS per mg of protein at 50 ug/mL2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323493Protective effect on hydrogen peroxide-induced cell damage in chinese hamster V79-4 cells assessed as decrease in apoptotic sub-G1 DNA content at 50 ug/ml by flow cytometry2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323483ROS scavenging activity in chinese hamster V79-4 cells at 1 ug/mL after 30 mins by DCF-DA method2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323482DPPH radical scavenging activity at 50 ug/ml after 30 mins2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323489Decrease in hydrogen peroxide-induced 8-OHdG in chinese hamster V79-4 cells at 1 ug/mL2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323492Protection against hydrogen peroxide-induced apoptosis in chinese hamster V79-4 cells assessed as cell survival by MTT assay2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323498Effect on hydrogen peroxide-induced DNA damage in chinese hamster V79-4 cells assessed as decrease in phospho H2A.X expression2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323485ROS scavenging activity in chinese hamster V79-4 cells at 50 ug/mL after 30 mins by DCF-DA method2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323490Decrease in hydrogen peroxide-induced 8-OHdG in chinese hamster V79-4 cells at 10 ug/mL2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323494Protective effect on hydrogen peroxide-induced cell damage in chinese hamster V79-4 cells assessed as decrease in DNA fragmentation level at 50 ug/ml by ELISA2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323480DPPH radical scavenging activity at 1 ug/ml after 30 mins2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323487Inhibition of hydrogen peroxide-induced lipid peroxidation in chinese hamster V79-4 cells assessed as TBARS per mg of protein at 10 ug/mL2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.
AID323497Increase in transcriptional activity of AP1 transfected in V79-4 cells by luciferase assay2008Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
ISSN: 1464-3391		Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect.

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (56.25)29.6817
2010's7 (43.75)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
irisflorentin
0
4'-methoxyisoflavones00low000000
ononin
0
4'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
monosaccharide derivative		plant metabolite00low000000
biochanin a
0
4'-methoxyisoflavones;
7-hydroxyisoflavones		antineoplastic agent;
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor		00low000000
formononetin
0
4'-methoxyisoflavones;
7-hydroxyisoflavones		phytoestrogen;
plant metabolite		00low000000
7,3'-dihydroxy-4'-methoxyisoflavone
0
4'-methoxyisoflavones;
7-hydroxyisoflavones		antioxidant;
metabolite		00low000000
2'-hydroxyformononetin
0
4'-methoxyisoflavones;
7-hydroxyisoflavones		anti-inflammatory agent00low000000
7-hydroxy-6,4'-dimethoxyisoflavone
0
4'-methoxyisoflavones;
7-hydroxyisoflavones		plant metabolite00low000000
iridin
0
4'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative		plant metabolite00low000000
4'-methoxy-3',5,7-trihydroxyisoflavone
0
4'-methoxyisoflavones;
7-hydroxyisoflavones		00low000000
3-(3,4-dimethoxyphenyl)-5,7-dihydroxy-2-methyl-1-benzopyran-4-one
0
4'-methoxyisoflavones00low000000
calycosin-7-o-beta-d-glucopyranoside
0
4'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative		00low000000
irigenin
0
4'-methoxyisoflavones;
hydroxyisoflavone		plant metabolite00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
kakkalide
1
2008200816.0medium000100
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
tert-butylhydroperoxide
1
alkyl hydroperoxideantibacterial agent;
oxidising agent		2005200519.0low000100
glucose, (beta-d)-isomer
1
D-glucopyranoseepitope;
mouse metabolite		2009200915.0low000100
tyloxapol
1
2007200717.0low000100
homoorientin
1
flavone C-glycoside;
tetrahydroxyflavone		antineoplastic agent;
radical scavenger		2009200915.0low000100
isoflavanone
1
isoflavanones2008200816.0low000100
isovitexin
1
C-glycosyl compound;
trihydroxyflavone		EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite		2009200915.0low000100
glycosides
7
2006201713.1medium000340
dinoprostone
1
prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic		2011201113.0low000010
apigenin
1
trihydroxyflavoneantineoplastic agent;
metabolite		2009200915.0low000100
luteolin
1
3'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist		2009200915.0low000100
genistein
2
7-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor		2001201516.0low000110
irilone
1
hydroxyisoflavone;
organic heterotricyclic compound;
oxacycle		antineoplastic agent;
immunomodulator;
metabolite		2009200915.0low000100
tectoridin
1
7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
methoxyisoflavone;
monosaccharide derivative		plant metabolite2006200618.0low000100
tectorigenin
4
7-hydroxyisoflavones;
methoxyisoflavone		anti-inflammatory agent;
plant metabolite		2001201515.2medium000220
mocetinostat
1
aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent		201720177.0low000010
interleukin-8
1
201720177.0low000010
kakkalide
7
2006201713.1high000340
phytoestrogens
1
2006200618.0low000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Acute Liver Injury, Drug-Induced0
1
2005200519.0low000100
Anaplastic Astrocytoma0
1
2008200816.0low000100
Astrocytoma0
1
2008200816.0low000100
Chemical and Drug Induced Liver Injury0
1
2005200519.0low000100
Encephalitis, JC Polyomavirus0
1
2006200618.0low000100
Gastritis0
1
201720177.0low000010
Hyperlipemia0
1
2007200717.0low000100
Hyperlipidemias0
1
2007200717.0low000100
Inflammation0
1
2011201113.0low000010
Innate Inflammatory Response0
1
2011201113.0low000010
Leukoencephalopathy, Progressive Multifocal0
1
2006200618.0low000100
Liver Diseases0
1
2005200519.0low000100
Liver Dysfunction0
1
2005200519.0low000100
Polyomavirus Infections0
1
2006200618.0low000100
Sensitivity and Specificity0
1
201520159.0low000010

Pharmacokinetics (1)

ArticleYear
Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, , Nov-15, Volume: 1005		2015

Bioavailability (1)

ArticleYear
Metabolism and excretion of kakkalide and its metabolites in rat urine, bile, and feces as determined by HPLC/UV and LC/MS/MS.
Planta medica, , Volume: 79, Issue:16		2013

Dosage (1)

ArticleYear
Excretion of tectorigenin in rat urine orally administrated at different dosages by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.
European journal of drug metabolism and pharmacokinetics, , Volume: 40, Issue:3		2015