Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis

A rare central nervous system demyelinating condition affecting children and young adults. Pathologic findings include a large, sharply defined, asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy. Concentric sclerosis of Balo is differentiated from diffuse cerebral sclerosis of Schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. (From Adams et al., Principles of Neurology, 6th ed, p914; Dev Neurosci 1991;13(4-5):267-73)

Synonym
Progressive Sclerosing Poliodystrophy
Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis
Alpers Disease
Alpers-Huttenlocher Syndrome
Alpers' Disease
Schilder Disease
Schilder's Disease
Neuronal Degeneration Of Childhood With Liver Disease, Progressive
Alpers Syndrome
Progressive Neuronal Degeneration of Childhood with Liver Disease
Myelinoclastic Diffuse Sclerosis
Alpers Progressive Infantile Poliodystrophy
Encephalitis Periaxialis
Encephalitis Periaxialis Concentrica
Encephalitis Periaxialis Diffusa
Diffuse Cerebral Sclerosis of Schilder
Balo Concentric Sclerosis
Balo's Concentric Sclerosis
Alpers' Syndrome
Cerebral Sclerosis, Diffuse
Sudanophilic Cerebral Sclerosis
Poliodystrophia Cerebri

Excerpt	Reference
"Alpers disease is a neurodegenerative disorder of childhood characterized by early developmental delay, intractable seizures, and death in childhood."	( Armstrong, DL; Burke, B; Dobyns, WB; Schwabe, MJ, 1997)
"Alpers syndrome is a progressive encephalopathy of early onset, characterized by rapid and severe developmental delay, intractable seizures and liver involvement in a previously healthy child."	( Chrétien, D; Cormier-Daire, V; de Lonlay, P; Gauthier-Villars, M; Jacquemin, E; Landrieu, P; Munnich, A; Rötig, A; Rustin, P, 2001)
"Schilder's myelinoclastic diffuse sclerosis is a rare sporadic demyelinating disease that usually affects children between 5 and 14 years old."	( Cakmakçi, H; Dirik, E; Kovanlikaya, A; Kurul, S, 2003)
"Balo's concentric sclerosis is a severe demyelinating disease with poor prognosis."	( Airas, L; Erjanti, H; Kurki, T; Marttila, RJ, 2005)
"Alpers syndrome is an autosomal recessive mitochondrial DNA depletion disorder that affects children and young adults."	( Chan, SS; Copeland, WC; Longley, MJ; Naviaux, RK, 2005)
"Alpers' disease is an important differential diagnosis in childhood refractory convulsive status epilepticus."	( Bast, T; Duncan, AJ; Ebinger, F; Harting, I; Rahman, S; Rating, D; Schmitt, B; Taanman, JW; Wohlrab, G; Wolf, NI, 2009)
"Balo concentric sclerosis is an infrequent variant of a demyelinating disease related to multiple sclerosis, initially thought to have an acute presentation and a fatal outcome."	( Andrade Magdaleno, Mde L; Fernández De Lara, Y; Lavenant Borja, MI; Nader Kawachi, JA; Peñaherrera, CA, 2016)

Excerpt	Reference
"Most patients with Alpers syndrome have been found to be compound heterozygotes, carrying two pathogenic mutations in trans at the POLG locus."	( Chan, SS; Copeland, WC; Longley, MJ; Naviaux, RK, 2005)

Excerpt	Reference
"A patient with hepatic cirrhosis due to Alpers disease is described who had a significantly raised plasma alanine aminotransferase (ALT) activity of 247 U/L which returned to normal (18 U/L) shortly after commencing treatment with the anticonvulsant drug, vigabatrin."	( Coakley, J; Sekaninova, S; Williams, A, 1998)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	351 (76.97)	23.3326
1990's	45 (9.87)	12.5806
2000's	24 (5.26)	18.1394
2010's	32 (7.02)	28.8240
2020's	4 (0.88)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
adipic acid	low	1	0
beta-alanine	low	1	0
1-butanol	low	1	0
carnitine	low	2	0
choline	low	5	0
creatine	low	5	0
lactic acid	low	4	0
formaldehyde	low	1	0
glycine	low	2	0
hydrogen	low	1	0
iodine	low	1	0
dihydroxyphenylalanine	low	1	0
pipecolic acid	low	4	0
inositol	low	1	0
nitrous oxide	low	1	0
palmitic acid	low	4	0
pyridoxine	low	1	0
pyruvic acid	low	1	0
sulfuric acid	low	1	0
thymine	low	1	0
phenytoin	low	1	0
adrenic acid	low	1	0
amantadine	low	1	0
theophylline	low	1	0
amobarbital	low	1	0
azathioprine	low	1	0
azelaic acid	low	1	0
caffeine	low	1	0
carmustine	low	1	0
chlorpromazine	low	1	0
clofibrate	low	1	0
diazepam	low	4	0
pentetic acid	low	1	0
valproic acid	low	15	0
erythrosine	low	1	0
haloperidol	low	1	0
ethidium	low	1	0
imipramine	medium	3	1
isoniazid	low	1	0
midazolam	low	1	0
ethylmaleimide	low	1	0
phenobarbital	low	1	0
piracetam	low	1	0
pirenzepine	low	1	0
stearic acid	low	1	0
thalidomide	low	1	0
theobromine	medium	1	1
vigabatrin	low	1	0
prednisolone	low	6	0
thymidine	low	1	0
aldosterone	low	2	0
penicillamine	low	1	0
prednisone	low	6	0
pentylenetetrazole	low	1	0
alanine	low	2	0
serine	low	4	0
aspartic acid	low	13	0
lysine	low	2	0
cyanides	low	1	0
uridine	low	1	0
bromodeoxyuridine	medium	4	1
galactose	low	16	0
tyrosine	low	1	0
leucine	low	3	0
lactose	low	1	0
methionine	low	1	0
phenylalanine	low	3	0
desoxycorticosterone	low	2	0
cycloheximide	low	1	0
ornithine	low	1	0
asparagine	low	1	0
histidine	low	1	0
valine	low	1	0
threonine	low	6	0
tryptophan	low	1	0
isoleucine	low	2	0
arginine	low	2	0
ethyl chloride	low	1	0
taurocholic acid	low	1	0
methylprednisolone	low	20	0
behenic acid	low	3	0
yohimbine	low	1	0
thiamine pyrophosphate	low	1	0
acridines	low	2	0
kainic acid	low	2	0
hexacosanoic acid	low	18	0
cyanogen bromide	low	1	0
chlormethiazole	low	1	0
lignoceric acid	low	11	0
fucose	low	3	0
mannose	low	2	0
mercury	low	1	0
silver	low	1	0
technetium	low	4	0
gadolinium	low	5	0
gold	low	1	0
galactosamine	low	1	0
galactose	low	4	0
trolamine salicylate	medium	2	1
phytanic acid	low	4	0
levamisole	low	3	0
phenyl acetate	low	2	0
levobunolol	low	1	0
propiconazole	low	1	0
fomesafen	medium	5	1
n-acetylaspartic acid	low	13	0
methotrexate	low	1	0
xylose	low	1	0
proline	low	1	0
cortisone	low	4	0
3-nitrotyrosine	low	1	0
wortmannin	low	1	0
lanatosides	low	1	0
glycogen	low	6	0
fibrin	low	2	0
glucosamine	low	1	0
carnosine	low	1	0
inositol 3-phosphate	low	1	0
strychnine	low	2	0
arachidonic acid	low	1	0
retinol	low	2	0
oleic acid	medium	5	1
eicosapentaenoic acid	low	1	0
bromochloroacetic acid	low	1	0
dimethyl fumarate	low	1	0
glycosides	low	1	0
isomethyleugenol	low	2	0
palmitoyl coenzyme a	low	1	0
flunarizine	low	1	0
cinnarizine	low	1	0
nadp	low	1	0
17-ketosteroids	low	7	0
myelin basic protein	low	6	0
sphingosine	low	5	0
psychosine	low	2	0
erucic acid	medium	2	1
cholesteryl oleate	low	1	0
arsenic	low	1	0
sulfur	medium	2	1
fumarates	medium	1	1
cysteine	low	1	0
phosphorus	low	1	0
triolein	low	1	0
selenium	low	1	0
tetracosatetraenoic acid	low	1	0
i(3)so3-galactosylceramide	low	46	0
gadolinium dtpa	low	4	0
mocetinostat	low	1	0
homocarnosine	low	1	0
pituitrin	low	1	0
enerbol	low	2	0
acid phosphatase	low	22	0
nad	low	2	0
cosyntropin	low	1	0
oligonucleotides	low	1	0
anticodon	low	1	0
phosphatidylcholines	low	12	0
ubiquinone	low	1	0
sodium ethylxanthate	low	1	0
glycolipids	medium	83	1
interleukin-8	low	1	0
chondroitin	low	3	0
phrenosin	low	1	0
hyaluronoglucosaminidase	low	2	0
lactoferrin	low	1	0
guanine	low	1	0
folic acid	low	1	0
neopterin	low	1	0
olanzapine	low	1	0
eye	low	8	0

Protein Targets (1,186)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	4	0	0	4
thioredoxin reductase	24	0	0	24
USP1 protein, partial	20	0	0	20
TDP1 protein	38	0	0	38
vitamin D3 receptor isoform VDRA	15	0	0	15
importin subunit beta-1 isoform 1	7	0	0	7
flap endonuclease 1	12	0	0	12
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	13	0	0	13
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
geminin	39	0	0	39
DNA polymerase kappa isoform 1	17	0	0	17
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	6	4	10
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	2	3
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	7	0	0	7
Fatty acid-binding protein 5	0	4	2	6
Fatty acid-binding protein 5	0	0	2	2
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	27	0	0	27
aldehyde dehydrogenase 1 family, member A1	30	0	0	30
glucocorticoid receptor [Homo sapiens]	31	0	0	31
farnesoid X nuclear receptor	20	0	0	20
estrogen nuclear receptor alpha	44	0	0	44
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
Cellular tumor antigen p53	28	0	0	28
Glutamate receptor 2	15	2	1	18
Choline O-acetyltransferase	0	1	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
phosphopantetheinyl transferase	25	0	0	25
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
pyruvate kinase PKM isoform a	1	0	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Tubulin--tyrosine ligase	0	2	0	2
Chain A, Ferritin light chain	11	0	0	11
Microtubule-associated protein tau	20	0	0	20
Smad3	6	0	0	6
alpha-galactosidase	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
DNA topoisomerase 2-alpha	0	0	0	1
Acetylcholinesterase	0	3	0	3
RAR-related orphan receptor gamma	33	0	0	33
GLI family zinc finger 3	33	0	0	33
AR protein	42	0	0	42
cytochrome P450 family 3 subfamily A polypeptide 4	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	34	0	0	34
cytochrome P450 2D6	13	0	0	13
peroxisome proliferator-activated receptor delta	18	0	0	18
thyroid hormone receptor beta isoform a	16	0	0	16
histone acetyltransferase KAT2A isoform 1	18	0	0	18
lethal factor (plasmid)	11	0	0	11
lamin isoform A-delta10	24	0	0	24
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Carbonic anhydrase 1	0	4	0	14
Carbonic anhydrase 2	0	4	1	15
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	4
Glutamate receptor ionotropic, NMDA 1	0	12	2	18
Proton-coupled amino acid transporter 1	0	9	0	10
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	12
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	4	0	4
Mineralocorticoid receptor	0	3	3	6
Androgen receptor	0	4	0	4
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	4
acetylcholinesterase	12	0	0	12
NFKB1 protein, partial	5	0	0	5
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
thyroid stimulating hormone receptor	14	0	0	14
regulator of G-protein signaling 4	14	0	0	14
EWS/FLI fusion protein	13	0	0	13
putative alpha-glucosidase	1	0	0	1
thyroid hormone receptor beta isoform 2	28	0	0	28
heat shock protein beta-1	9	0	0	9
peripheral myelin protein 22	17	0	0	17
Solute carrier family 22 member 2	0	2	0	4
Solute carrier family 22 member 1	0	4	0	6
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	13	1	2	16
Glutamate receptor ionotropic, NMDA 2A	0	10	2	16
Glutamate receptor ionotropic, NMDA 2B	0	10	2	16
Glutamate receptor ionotropic, NMDA 2C	0	10	2	16
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	10	2	16
Solute carrier family 22 member 1	0	3	0	4
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	10	2	16
Multidrug and toxin extrusion protein 1	0	4	0	4
Solute carrier family 22 member 2	0	4	0	5
Glutamate receptor ionotropic, NMDA 3A	0	10	2	16
ATP-dependent phosphofructokinase	25	0	0	25
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, Beta-lactamase	7	0	0	7
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Cruzipain	4	0	0	4
15-lipoxygenase, partial	7	0	0	7
thioredoxin glutathione reductase	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
Bloom syndrome protein isoform 1	20	0	0	20
cellular tumor antigen p53 isoform a	7	0	0	7
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
nuclear receptor ROR-gamma isoform 1	14	0	0	14
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
cytochrome P450 3A4 isoform 1	12	0	0	12
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	2	0	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	12	6	1	19
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Prostaglandin G/H synthase 1	0	4	0	5
Trypsin	0	3	0	3
Coagulation factor VII	0	3	0	3
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Aromatase	0	3	0	3
Tissue factor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	12	6	1	19
Gamma-aminobutyric acid receptor subunit delta	12	6	1	19
Gamma-aminobutyric acid receptor subunit gamma-2	12	6	2	20
Gamma-aminobutyric acid receptor subunit alpha-5	12	6	1	19
Gamma-aminobutyric acid receptor subunit alpha-3	12	6	1	19
Gamma-aminobutyric acid receptor subunit gamma-1	12	6	1	19
Gamma-aminobutyric acid receptor subunit alpha-2	12	6	1	19
Gamma-aminobutyric acid receptor subunit alpha-4	12	6	1	19
Gamma-aminobutyric acid receptor subunit gamma-3	12	6	1	19
Gamma-aminobutyric acid receptor subunit alpha-6	12	6	1	19
Prostaglandin G/H synthase 2	0	1	1	3
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Histamine H2 receptor	9	1	0	11
10 kDa heat shock protein, mitochondrial	0	1	0	1
Calmodulin	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	12	6	2	20
Gamma-aminobutyric acid receptor subunit beta-3	12	6	1	19
Gamma-aminobutyric acid receptor subunit beta-2	12	6	2	20
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Prostaglandin G/H synthase 2	0	5	0	6
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
GABA theta subunit	12	6	1	19
Gamma-aminobutyric acid receptor subunit epsilon	12	6	1	19
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	5	0	5
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
GLS protein	16	0	0	16
cytochrome P450 2C19 precursor	5	0	0	5
chromobox protein homolog 1	22	0	0	22
muscarinic acetylcholine receptor M1	16	0	0	16
Cytochrome P450 3A4	0	7	0	10
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	6
Amino acid transporter	0	3	0	3
arylsulfatase A	17	0	0	17
Metabotropic glutamate receptor 6	0	0	2	2
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
interleukin 8	4	0	0	4
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	17	0	0	17
Fumarate hydratase	8	0	0	8
SMAD family member 3	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
retinoid X nuclear receptor alpha	23	0	0	23
estrogen-related nuclear receptor alpha	36	0	0	36
pregnane X nuclear receptor	21	0	0	21
G	9	0	0	9
polyprotein	8	0	0	8
P53	2	0	0	2
peroxisome proliferator activated receptor gamma	22	0	0	22
IDH1	13	0	0	13
aryl hydrocarbon receptor	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
thyroid stimulating hormone receptor	12	0	0	12
activating transcription factor 6	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
Histone H2A.x	10	0	0	10
peripheral myelin protein 22 isoform 1	12	0	0	12
hemoglobin subunit beta	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
survival motor neuron protein isoform d	8	0	0	8
M-phase phosphoprotein 8	10	0	0	10
muscleblind-like protein 1 isoform 1	4	0	0	4
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	20	0	22
Bile salt export pump	0	9	0	10
Bile salt export pump	0	35	0	36
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Nuclear receptor ROR-gamma	9	0	0	9
Inositol hexakisphosphate kinase 1	9	0	0	9
Canalicular multispecific organic anion transporter 1	0	18	0	18
ATPase family AAA domain-containing protein 5	13	0	0	13
Ataxin-2	16	0	0	16
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	9	0	0	9
Chain A, Diaminopimelate decarboxylase	0	1	0	1
Chain B, Diaminopimelate decarboxylase	0	1	0	1
estrogen receptor 2 (ER beta)	18	0	0	18
TAR DNA-binding protein 43	11	0	0	11
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
pregnane X receptor	7	0	0	7
progesterone receptor	19	0	0	19
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
DNA polymerase beta	4	0	0	4
Potassium channel subfamily K member 2	0	2	3	5
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	3	2	5
Adenosine receptor A3	0	4	0	4
Replicase polyprotein 1ab	0	4	2	6
Amine oxidase [flavin-containing] A	0	1	0	1
Adenosine receptor A1	0	7	0	12
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	4	3	9
Adenosine receptor A2b	0	2	0	4
Adenosine receptor A2b	0	4	0	6
Adenosine receptor A1	0	3	2	9
Adenosine receptor A2a	0	4	0	11
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	2	1	3
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	3	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	3	1	4
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	3	4
Endochitinase B1	0	2	0	2
Muscarinic acetylcholine receptor	0	1	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Guanine deaminase	0	1	0	2
endonuclease IV	9	0	0	9
huntingtin isoform 2	1	0	0	1
Glutathione reductase, mitochondrial	0	3	0	3
Alpha-synuclein	5	1	0	6
Glutathione reductase	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
cytochrome P450 2D6 isoform 1	7	0	0	7
cytochrome P450 2C9 precursor	4	0	0	4
Carbonic anhydrase 4	0	3	0	9
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
D(1A) dopamine receptor	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	18	0	0	18
UDP-glucuronosyltransferase 2B7	0	4	0	6
UDP-glucuronosyltransferase 1-6	0	2	0	3
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	2	0	6
UDP-glucuronosyltransferase 2B10	0	2	0	2
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	3	0	0	3
caspase 7, apoptosis-related cysteine protease	2	0	0	2
NADPH oxidase 1	0	1	0	1
67.9K protein	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	21	0	0	21
Snq2p	0	0	0	2
caspase-3	2	0	0	2
Adenylate cyclase type 1	0	3	0	3
Caspase-7	2	0	0	2
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
mitogen-activated protein kinase 1	8	0	0	8
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	1	2	3
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
5-hydroxytryptamine receptor 4	0	8	1	9
Epidermal growth factor receptor	0	2	0	2
Albumin	0	1	2	4
Albumin	0	0	3	3
Major prion protein	0	0	3	3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Integrin beta-3	3	0	0	3
Cytochrome P450 1A2	0	2	1	4
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	1	2	3
Aldo-keto reductase family 1 member B1	0	9	0	9
Muscarinic acetylcholine receptor M2	0	6	0	6
Muscarinic acetylcholine receptor M4	0	11	0	11
ATP-dependent translocase ABCB1	0	4	0	8
Muscarinic acetylcholine receptor M1	0	6	1	7
Muscarinic acetylcholine receptor M3	0	5	1	6
Muscarinic acetylcholine receptor M4	0	5	1	6
Integrin alpha-IIb	3	0	0	3
5-hydroxytryptamine receptor 1A	0	6	1	7
5-hydroxytryptamine receptor 2C	0	8	0	9
Muscarinic acetylcholine receptor M5	0	6	1	7
Muscarinic acetylcholine receptor M5	0	12	0	12
Alpha-2A adrenergic receptor	0	12	1	13
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Cytochrome P450 2D6	0	5	1	6
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M1	0	11	2	14
Cytochrome P450 2C9	0	7	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Angiotensin-converting enzyme	0	6	0	6
D(2) dopamine receptor	0	14	1	18
5-hydroxytryptamine receptor 2A	0	8	0	8
Alpha-1B adrenergic receptor	0	11	1	12
Sphingomyelin phosphodiesterase	0	2	0	2
Alpha-2B adrenergic receptor	0	12	0	12
Alpha-2C adrenergic receptor	0	12	0	12
D	0	7	0	7
D(3) dopamine receptor	0	8	0	8
5-hydroxytryptamine receptor 1A	0	18	1	19
Alpha-2B adrenergic receptor	0	8	1	9
D(2) dopamine receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	11	0	11
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	8	0	10
D(4) dopamine receptor	0	6	1	10
D(1B) dopamine receptor	0	3	0	5
Adenylate cyclase type 3	0	3	0	3
Alpha-2C adrenergic receptor	0	8	1	9
Alpha-2A adrenergic receptor	0	8	1	9
Alpha-1D adrenergic receptor	0	9	1	10
Sodium-dependent noradrenaline transporter	0	11	1	12
Sodium-dependent dopamine transporter	0	5	0	5
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	12	0	12
D(1B) dopamine receptor	0	6	0	6
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	3	0	3
Adenylate cyclase type 4	0	3	0	3
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	12	0	12
5-hydroxytryptamine receptor 2C	0	9	0	9
5-hydroxytryptamine receptor 1B	0	12	0	12
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	7	0	7
5-hydroxytryptamine receptor 2B	0	7	0	7
Histamine H1 receptor	0	2	1	3
Sodium-dependent serotonin transporter	0	14	0	14
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	4	0	4
Histamine H1 receptor	0	12	1	13
Mu-type opioid receptor	0	8	1	9
D(3) dopamine receptor	0	10	1	14
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 4 subunit alpha	0	4	0	5
Adenylate cyclase type 8	0	3	0	3
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	12	0	12
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	11	1	12
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	3	1	0	4
5-hydroxytryptamine receptor 6	0	8	0	8
5-hydroxytryptamine receptor 7	0	3	0	3
Cytochrome P450 2J2	0	7	0	7
Gastrin/cholecystokinin type B receptor	0	2	0	2
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	9	0	10
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Sodium-dependent dopamine transporter	0	7	0	7
Adenylate cyclase type 6	0	3	0	3
Adenylate cyclase type 5	0	3	0	3
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	13	0	13
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	4	0	4
Nuclear receptor subfamily 3 group C member 3	0	5	0	5
Adenylyl cyclase 7	0	3	0	3
Proteasome subunit alpha-type 8	0	0	0	1
D	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	5	0	5
Proteasome subunit beta type-7	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	10	0	10
Angiotensin-converting enzyme 2	0	1	2	3
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	3	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	2	0	3
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
Estrogen receptor 1	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
PINK1	1	0	0	1
Parkin	1	0	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
estrogen receptor beta isoform 1	0	1	0	1
neuropeptide S receptor isoform A	3	0	0	3
Cruzipain	0	1	0	1
Inositol monophosphatase 1	7	0	0	7
GALC protein	4	0	0	4
Fatty acid-binding protein, liver	0	5	1	6
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor alpha	2	0	4	6
dopamine D1 receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	9	0	9
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase 15	0	1	0	5
glp-1 receptor, partial	5	0	0	5
PPM1D protein	4	0	0	4
RPL19A	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
COUP transcription factor 2 isoform a	0	1	0	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	3
Solute carrier family 22 member 3	0	1	0	1
Gamma-aminobutyric acid	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	3	7
Translocator protein	0	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	4	2	6
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Glutamate receptor 1	1	2	1	4
Glutamate receptor 3	1	2	1	4
Glutamate receptor 4	1	2	1	4
Caspase-7	2	0	0	2
Kelch-like ECH-associated protein 1	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Retinoic acid receptor RXR-alpha	0	1	0	1
Oxoeicosanoid receptor 1	0	1	0	1
Genome polyprotein	0	1	1	2
Luciferase	9	0	0	9
hypothetical protein, conserved	1	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
Monoglyceride lipase	0	1	0	1
14 kDa phosphohistidine phosphatase	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	0	1	1
Prostaglandin D2 receptor 2	0	1	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
glucocerebrosidase	3	0	0	3
Thymidylate synthase	0	4	0	4
Thymidylate synthase	0	3	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	2	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	2	0	5
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	1	0	6
Carbonic anhydrase 3	0	1	0	5
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
Carbonic anhydrase 6	0	2	0	7
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	7
Carbonic anhydrase 7	0	2	0	7
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	3
Carbonic anhydrase 9	0	2	0	7
Carbonic anhydrase 13	0	2	0	6
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	6
Carbonic anhydrase 5B, mitochondrial	0	2	0	7
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	2
Hsf1 protein	0	0	3	4
transcriptional regulator ERG isoform 3	7	0	0	7
Histone deacetylase 3	0	5	0	5
Gamma-aminobutyric acid type B receptor subunit 2	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Histone deacetylase 4	0	4	0	4
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Histone deacetylase 1	0	5	0	5
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	4	0	4
Histone deacetylase 8	0	4	0	4
Platelet glycoprotein VI	0	0	1	1
Histone deacetylase 6	0	4	0	4
Gamma-aminobutyric acid type B receptor subunit 1	0	1	1	2
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	4	0	4
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Glycine receptor subunit alpha-1	0	2	1	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	9	0	10
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
nonstructural protein 1	5	0	0	5
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Integrin alpha-4	0	2	0	2
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
Histamine H1 receptor	0	3	0	3
Sodium-dependent serotonin transporter	0	3	0	3
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	0	4
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	4
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	4
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase 13	0	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Cytochrome P450 2C19	0	2	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Envelope glycoprotein	0	0	1	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Transporter	0	3	0	3
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
Amyloid-beta precursor protein	0	2	0	2
Sodium/myo-inositol cotransporter 2	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Myeloperoxidase	0	2	0	2
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	2	0	2
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 5	0	0	1	1
Glutamate receptor ionotropic, kainate 2	0	2	2	4
Glutamate receptor 1	0	1	1	2
Glutamate receptor 2	0	1	1	2
Glutamate receptor 3	0	0	1	1
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor 4	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
PAX8	0	0	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	7	0	7
Intestinal-type alkaline phosphatase	0	5	0	5
Phospholipase A-2-activating protein	0	5	0	5
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
5'-nucleotidase	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Alpha-mannosidase 2C1	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	3
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Sterol O-acyltransferase 1	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Fatty acid-binding protein, liver	0	1	1	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
DNA topoisomerase 1	0	2	0	2
Protein kinase C alpha type	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	3
Sterol O-acyltransferase 1	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
STAT3, partial	0	1	0	1
Kruppel-like factor 5	0	1	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
Acetylcholinesterase	0	5	0	5
Toll-like receptor 2	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Peroxisomal sarcosine oxidase	0	0	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Pyridoxal kinase	0	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
Ileal sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	4	1	6
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Chain A, Arginase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nrf2	1	0	0	1
WRN	1	0	0	1
Vpr	1	0	0	1
endoribonuclease toxin MazF	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	1	2
Serine/threonine-protein kinase PLK4	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	1	2
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Serine/threonine-protein kinase PLK1	0	2	0	2
Myosin light chain kinase, smooth muscle	0	1	0	1
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Serine/threonine-protein kinase PLK3	0	2	0	2
Serine/threonine-protein kinase PLK2	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	0	1
POsterior Segregation	0	0	1	1
Estrogen receptor beta	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Estrogen receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis

Synonyms(22)

Research Excerpts

Overview

Context

Treatment

Research

Studies (456)

Protein Targets (1,186)

Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis

Synonyms(22)

Research Excerpts

Overview

Context

Treatment

Research

Studies (456)

Drugs Studied (200)

Protein Targets (1,186)