Page last updated: 2024-11-12

kukoamine b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

kukoamine B: an anti-sepsis agent isolated from Lycium chinense; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
LyciumgenusA plant genus of the family SOLANACEAE. Members contain CEREBROSIDES and SCOPOLETIN.[MeSH]SolanaceaeA plant family of the order SOLANALES, class MAGNOLIOPSIDA. Among the most noted are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.[MeSH]

Cross-References

ID SourceID
PubMed CID10346914
CHEBI ID81221
SCHEMBL ID15255727
MeSH IDM0557225

Synonyms (21)

Synonym
C17616
kukoamine b
CHEBI:81221
SCHEMBL15255727
AC-34135
164991-67-7
n-(3-aminopropyl)-3-(3,4-dihydroxyphenyl)-n-{4-[(3-{[3-(3,4-dihydroxyphenyl)propanoyl]amino}propyl)amino]butyl}propanamide
n-[3-[4-[3-aminopropyl-[3-(3,4-dihydroxyphenyl)propanoyl]amino]butylamino]propyl]-3-(3,4-dihydroxyphenyl)propanamide
AKOS032945996
Q27155167
FT-0686650
mfcd29904539
unii-xze94lc57w
kukoamine b mesylate
n-(3-aminopropyl)-3-(3,4-dihydroxyphenyl)-n-(4-((3-(3-(3,4-dihydroxyphenyl)propanamido)propyl)amino)butyl)propanamide
HY-N2393
CS-0022595
benzenepropanamide, n-(3-aminopropyl)-n-(4-((3-((3-(3,4-dihydroxyphenyl)-1-oxopropyl)amino)propyl)amino)butyl)-3,4-dihydroxy-
XZE94LC57W ,
n-(3-aminopropyl)-n-(4-((3-((3-(3,4-dihydroxyphenyl)-1-oxopropyl)amino)propyl)amino)butyl)-3,4-dihydroxybenzenepropanamide
MS-29817

Research Excerpts

Overview

Kukoamine B (KB) is a novel cationic alkaloid that interferes with LPS binding to TLR4.

ExcerptReferenceRelevance
"Kukoamine B (KB) is a novel cationic alkaloid that interferes with LPS binding to TLR4."( Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes.
Chen, Q; Fan, S; Liu, X; Lu, Y; Wang, N; Yang, D; Yang, Y; Zheng, J; Zheng, X, 2016
)
2.6

Toxicity

ExcerptReferenceRelevance
"Of 44 patients enrolled, adverse events occurred in 28 patients [n = 20, 66."( Safety, tolerability, pharmacokinetics, and efficacy of kukoamine B in patients with sepsis: A randomized phase IIa trial.
Chen, S; Dong, K; Du, B; Feng, Y; Hu, P; Hu, XY; Hu, Z; Jiang, W; Jin, C; Liu, H; Sun, Y; Wang, CY; Wang, D; Wang, H; Wang, T; Yao, X; Zang, B; Zhang, W; Zhao, Q; Zhou, J, 2023
)
1.16
"In patients with sepsis-induced organ failure, KB was safe and well tolerated."( Safety, tolerability, pharmacokinetics, and efficacy of kukoamine B in patients with sepsis: A randomized phase IIa trial.
Chen, S; Dong, K; Du, B; Feng, Y; Hu, P; Hu, XY; Hu, Z; Jiang, W; Jin, C; Liu, H; Sun, Y; Wang, CY; Wang, D; Wang, H; Wang, T; Yao, X; Zang, B; Zhang, W; Zhao, Q; Zhou, J, 2023
)
1.16
" Primary endpoints were adverse events (AEs), and the secondary endpoints were PK parameters of the first administration and the last administration."( Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study.
Chen, S; Cui, C; Dong, K; Hu, P; Jiang, J; Jin, C; Li, L; Liu, H; Wang, H; Wang, T; Wang, Z; Zhao, Q; Zhong, W, 2023
)
0.91
" Treatment-related adverse events (TRAEs) occurred in 8 (44."( Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study.
Chen, S; Cui, C; Dong, K; Hu, P; Jiang, J; Jin, C; Li, L; Liu, H; Wang, H; Wang, T; Wang, Z; Zhao, Q; Zhong, W, 2023
)
0.91
"24 mg/kg are safe and tolerable in healthy volunteers."( Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study.
Chen, S; Cui, C; Dong, K; Hu, P; Jiang, J; Jin, C; Li, L; Liu, H; Wang, H; Wang, T; Wang, Z; Zhao, Q; Zhong, W, 2023
)
0.91

Pharmacokinetics

ExcerptReferenceRelevance
"To assess the appropriateness of the body weight or fixed dosing regimen, a population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients."( Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
Chen, S; Deng, C; Dong, K; Du, B; Hu, P; Hu, X; Jiang, J; Jin, C; Qin, H; Wang, H; Wang, T; Zhao, Q, 2022
)
1.28
" Primary endpoint was safety, and secondary endpoints included pharmacokinetic (PK) parameters, changes in inflammatory mediators' level, and prognostic parameters."( Safety, tolerability, pharmacokinetics, and efficacy of kukoamine B in patients with sepsis: A randomized phase IIa trial.
Chen, S; Dong, K; Du, B; Feng, Y; Hu, P; Hu, XY; Hu, Z; Jiang, W; Jin, C; Liu, H; Sun, Y; Wang, CY; Wang, D; Wang, H; Wang, T; Yao, X; Zang, B; Zhang, W; Zhao, Q; Zhou, J, 2023
)
1.16
" This study aims to evaluate the safety, tolerability, and pharmacokinetic (PK) profile of multiple doses of KB in healthy volunteers."( Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study.
Chen, S; Cui, C; Dong, K; Hu, P; Jiang, J; Jin, C; Li, L; Liu, H; Wang, H; Wang, T; Wang, Z; Zhao, Q; Zhong, W, 2023
)
0.91

Dosage Studied

ExcerptRelevanceReference
"To assess the appropriateness of the body weight or fixed dosing regimen, a population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients."( Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
Chen, S; Deng, C; Dong, K; Du, B; Hu, P; Hu, X; Jiang, J; Jin, C; Qin, H; Wang, H; Wang, T; Zhao, Q, 2022
)
1.28
"24 mg/kg group on the body weight or the fixed dosing regimen."( Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
Chen, S; Deng, C; Dong, K; Du, B; Hu, P; Hu, X; Jiang, J; Jin, C; Qin, H; Wang, H; Wang, T; Zhao, Q, 2022
)
1.07
"Based on the simulation results, a fixed dosing regimen was recommended in the subsequent clinical trials."( Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
Chen, S; Deng, C; Dong, K; Du, B; Hu, P; Hu, X; Jiang, J; Jin, C; Qin, H; Wang, H; Wang, T; Zhao, Q, 2022
)
1.07
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
amineA compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (64.71)24.3611
2020's6 (35.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.64 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index4.64 (4.65)
Search Engine Demand Index27.14 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (17.65%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (82.35%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]