Page last updated: 2024-11-12
kukoamine b
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
kukoamine B: an anti-sepsis agent isolated from Lycium chinense; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
Flora | Rank | Flora Definition | Family | Family Definition |
---|---|---|---|---|
Lycium | genus | A plant genus of the family SOLANACEAE. Members contain CEREBROSIDES and SCOPOLETIN.[MeSH] | Solanaceae | A plant family of the order SOLANALES, class MAGNOLIOPSIDA. Among the most noted are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.[MeSH] |
Cross-References
ID Source | ID |
---|---|
PubMed CID | 10346914 |
CHEBI ID | 81221 |
SCHEMBL ID | 15255727 |
MeSH ID | M0557225 |
Synonyms (21)
Synonym |
---|
C17616 |
kukoamine b |
CHEBI:81221 |
SCHEMBL15255727 |
AC-34135 |
164991-67-7 |
n-(3-aminopropyl)-3-(3,4-dihydroxyphenyl)-n-{4-[(3-{[3-(3,4-dihydroxyphenyl)propanoyl]amino}propyl)amino]butyl}propanamide |
n-[3-[4-[3-aminopropyl-[3-(3,4-dihydroxyphenyl)propanoyl]amino]butylamino]propyl]-3-(3,4-dihydroxyphenyl)propanamide |
AKOS032945996 |
Q27155167 |
FT-0686650 |
mfcd29904539 |
unii-xze94lc57w |
kukoamine b mesylate |
n-(3-aminopropyl)-3-(3,4-dihydroxyphenyl)-n-(4-((3-(3-(3,4-dihydroxyphenyl)propanamido)propyl)amino)butyl)propanamide |
HY-N2393 |
CS-0022595 |
benzenepropanamide, n-(3-aminopropyl)-n-(4-((3-((3-(3,4-dihydroxyphenyl)-1-oxopropyl)amino)propyl)amino)butyl)-3,4-dihydroxy- |
XZE94LC57W , |
n-(3-aminopropyl)-n-(4-((3-((3-(3,4-dihydroxyphenyl)-1-oxopropyl)amino)propyl)amino)butyl)-3,4-dihydroxybenzenepropanamide |
MS-29817 |
Research Excerpts
Overview
Kukoamine B (KB) is a novel cationic alkaloid that interferes with LPS binding to TLR4.
Excerpt | Reference | Relevance |
---|---|---|
"Kukoamine B (KB) is a novel cationic alkaloid that interferes with LPS binding to TLR4." | ( Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes. Chen, Q; Fan, S; Liu, X; Lu, Y; Wang, N; Yang, D; Yang, Y; Zheng, J; Zheng, X, 2016) | 2.6 |
Toxicity
Pharmacokinetics
Dosage Studied
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
Class | Description |
---|---|
amine | A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (17)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 11 (64.71) | 24.3611 |
2020's | 6 (35.29) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 29.64
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (29.64) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 3 (17.65%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 14 (82.35%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |