Page last updated: 2024-11-12

2',4',6'-tris(methoxymethoxy) chalcone

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Description

2',4',6'-tris(methoxymethoxy) chalcone: structure in first souce [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11646756
CHEMBL ID4569822
SCHEMBL ID16751995
MeSH IDM0498436

Synonyms (8)

Synonym
SCHEMBL16751995
2',4',6'-tris(methoxymethoxy) chalcone
8o4guf7mhz ,
2-propen-1-one, 3-phenyl-1-(2,4,6-tris(methoxymethoxy)phenyl)-
(2e)-3-phenyl-1-(2,4,6-tris(methoxymethoxy)phenyl)-2-propen-1-one
unii-8o4guf7mhz
884317-95-7
CHEMBL4569822
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (49)

Assay IDTitleYearJournalArticle
AID1537694Cytotoxicity against human MIAPaCa2 cells assessed as combinational index at 2.5 uM incubated for 72 hrs in presence of 200 uM 6TP by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537691Cytotoxicity against human MIAPaCa2 cells assessed as combinational index at 2.5 uM incubated for 72 hrs in presence of 25 uM 6TP by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537693Cytotoxicity against human MIAPaCa2 cells assessed as combinational index at 2.5 uM incubated for 72 hrs in presence of 100 uM 6TP by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537677Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 2.5 uM incubated for 72 hrs in presence of 50 uM 6TP by alamar blue assay (Rvb = 13.8 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575598Antiproliferative activity against human U937 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575595Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by alamar blue assay2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575599Antiproliferative activity against human REH cells assessed as reduction in cell viability after 72 hrs by alamar blue assay2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537680Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 5 uM incubated for 72 hrs in presence of 25 uM 6TP by alamar blue assay (Rvb = 6.4 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575616Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as combination index at 2.5 uM after 72 hrs in presence of 25 uM 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575596Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537670Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575604Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as cell death at 5 uM after 72 hrs in presence of 10 uM 6TP by alamar blue assay (Rvb = 6.9%)2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575618Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as combination index at 2.5 uM after 72 hrs in presence of 100 uM 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575621Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as combination index at 5 uM after 72 hrs in presence of 50 uM 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537679Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 5 uM incubated for 72 hrs in presence of 10 uM 6TP by alamar blue assay (Rvb = 6.9 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575605Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as cell death at 5 uM after 72 hrs in presence of 25 uM 6TP by alamar blue assay (Rvb = 6.4%)2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575600Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as cell death at 2.5 uM after 72 hrs in presence of 10 uM 6TP by alamar blue assay (Rvb = 6.9%)2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537696Cytotoxicity against human MIAPaCa2 cells assessed as combinational index at 5 uM incubated for 72 hrs in presence of 50 uM 6TP by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575607Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as cell death at 5 uM after 72 hrs in presence of 100 uM 6TP by alamar blue assay (Rvb = 30.7%)2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575617Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as combination index at 2.5 uM after 72 hrs in presence of 50 uM 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575602Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as cell death at 2.5 uM after 72 hrs in presence of 50 uM 6TP by alamar blue assay (Rvb = 13.8%)2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537704Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 5 uM incubated for 72 hrs by alamar blue assay (Rvb = 0 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537681Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 5 uM incubated for 72 hrs in presence of 50 uM 6TP by alamar blue assay (Rvb = 13.8 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537678Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 2.5 uM incubated for 72 hrs in presence of 100 uM 6TP by alamar blue assay (Rvb = 30.7 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537672Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575603Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as cell death at 2.5 uM after 72 hrs in presence of 100 uM 6TP by alamar blue assay (Rvb = 30.7%)2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575634Synergistic antiproliferative activity against human HeLa cells at 2.5 to 5 uM after 72 hrs in presence of 6TP by alamar blue assay2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575597Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537675Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 2.5 uM incubated for 72 hrs in presence of 10 uM 6TP by alamar blue assay (Rvb = 6.9 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537669Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537673Cytotoxicity against human REH cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537703Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 2.5 uM incubated for 72 hrs by alamar blue assay (Rvb = 0 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575619Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as combination index at 2.5 uM after 72 hrs in presence of 200 uM 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537692Cytotoxicity against human MIAPaCa2 cells assessed as combinational index at 2.5 uM incubated for 72 hrs in presence of 50 uM 6TP by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537695Cytotoxicity against human MIAPaCa2 cells assessed as combinational index at 5 uM incubated for 72 hrs in presence of 25 uM 6TP by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575635Synergistic antiproliferative activity against human A549 cells at 2.5 to 5 uM after 72 hrs in presence of 6TP by alamar blue assay2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537671Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575623Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as combination index at 5 uM after 72 hrs in presence of 200 uM 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537674Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575601Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as cell death at 2.5 uM after 72 hrs in presence of 25 uM 6TP by alamar blue assay (Rvb = 6.4%)2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537697Cytotoxicity against human MIAPaCa2 cells assessed as combinational index at 5 uM incubated for 72 hrs in presence of 100 uM 6TP by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537698Cytotoxicity against human MIAPaCa2 cells assessed as combinational index at 5 uM incubated for 72 hrs in presence of 200 uM 6TP by alamar blue assay2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575620Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as combination index at 5 uM after 72 hrs in presence of 25 uM 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575632Synergistic antiproliferative activity against human U937 cells at 2.5 to 5 uM after 72 hrs in presence of 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575622Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as combination index at 5 uM after 72 hrs in presence of 100 uM 6TP by alamar blue assay based Chou-Talalay method2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1575636Synergistic antiproliferative activity against human REH cells at 2.5 to 5 uM uM after 72 hrs in presence 6TP by alamar blue assay based alamar blue assay2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
AID1537676Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 2.5 uM incubated for 72 hrs in presence of 25 uM 6TP by alamar blue assay (Rvb = 6.4 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1537682Cytotoxicity against human MIAPaCa2 cells assessed as cell viability at 5 uM incubated for 72 hrs in presence of 100 uM 6TP by alamar blue assay (Rvb = 30.7 %)2019MedChemComm, Aug-01, Volume: 10, Issue:8
The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.
AID1575606Synergistic antiproliferative activity against human MIAPaCa2 cells assessed as cell death at 5 uM after 72 hrs in presence of 50 uM 6TP by alamar blue assay (Rvb = 13.8%)2019MedChemComm, May-01, Volume: 10, Issue:5
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's6 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.23 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]