| Assay ID | Title | Year | Journal | Article |
|---|
| AID1802356 | Inhibitor Competition Assay from Article 10.1021/acschembio.6b00776: \\LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.\\ | 2017 | ACS chemical biology, 01-20, Volume: 12, Issue:1
| LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation. |
| AID1802398 | Enzymatic HDAC Activity Assay from Article 10.1074/jbc.M113.490706: \\Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.\\ | 2013 | The Journal of biological chemistry, Sep-13, Volume: 288, Issue:37
| Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. |
| AID1801572 | In-vitro HDAC Enzymatic Endpoint Assay from Article 10.1021/acschembio.5b00640: \\An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in u00DF-Cell Protection.\\ | 2016 | ACS chemical biology, Feb-19, Volume: 11, Issue:2
| An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. |
| AID1802399 | Proteros Reporter Displacement Assay from Article 10.1074/jbc.M113.490706: \\Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.\\ | 2013 | The Journal of biological chemistry, Sep-13, Volume: 288, Issue:37
| Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. |
| AID1797850 | HDAC Enzyme Activity Assay from Article 10.1021/jm701079h: \\Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.\\ | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID1313955 | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID303026 | Inhibition of human recombinant HDAC4 at 20 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID303027 | Inhibition of human recombinant HDAC5 at 20 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID316935 | Inhibition of HDAC5 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID320811 | Inhibition of HDAC4 | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID1410048 | Induction of IFNgamma1 production in human PBMC at 3 uM after 2 days by ELISA | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID1202591 | Cytotoxicity against human KB cells after 72 hrs by MTS assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids. |
| AID320815 | Inhibition of HDAC8 | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID1313957 | Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as dissociation rate constant after 60 mins | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID316893 | Inhibition of HDAC8 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID487224 | Inhibition of recombinant HDAC1 | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Inside HDAC with HDAC inhibitors. |
| AID1410012 | Reactivation of latent HIV1 infected in human U1 cells assessed as increase in p24 production after 48 hrs by ELISA relative to vorinostat | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID316892 | Inhibition of HDAC1 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID1068882 | Selectivity for HDAC1/2 (unknown origin) over HDAC8 (unknown origin) | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. |
| AID1410052 | Selectivity ratio of IC50 for full length human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 insect cells to IC50 for full length human recombinant C-terminal His-tagged HDAC2 expresse | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID316899 | Inhibition of HDAC6 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID1068886 | Selectivity for HDAC1/2 (unknown origin) over HDAC4 (unknown origin) | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. |
| AID487228 | Inhibition of recombinant HDAC8 | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Inside HDAC with HDAC inhibitors. |
| AID320808 | Inhibition of HDAC1 | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID320822 | Volume of distribution at steady state in rat at 2 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID320812 | Inhibition of HDAC5 | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID1313958 | Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as dissociation rate constant after 60 mins by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID1068888 | Inhibition of wild-type FLAG-tagged HDAC1 (unknown origin) expressed in Jurkat cells after 2 hrs by Fluor de lys staining-based fluorimetric analysis | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. |
| AID316931 | Inhibition of HDAC3 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID303017 | Inhibition of human recombinant HDAC8 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID320824 | Normalized AUC in rat at 4 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID320825 | Cmax in rat at 4 mg/kg, po | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID1313942 | Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID303023 | Inhibition of human recombinant HDAC2 at 20 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID320826 | Oral bioavailability in rat at 4 mg/kg | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID303016 | Inhibition of human recombinant HDAC3 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID748114 | Inhibition of HDAC1 (unknown origin) after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11
| Discovery of the first histone deacetylase 6/8 dual inhibitors. |
| AID1313935 | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID320820 | Inhibition of human ERG | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID316898 | Inhibition of HDAC2 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID1410023 | Cytotoxicity against human J-Lat (A2) cells assessed as effect on cell viability at 0.3 uM after 72 hrs by flow cytometric analysis | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID303021 | Inhibition of HDAC in human HCT116 cells at 60 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID1068885 | Selectivity for HDAC1/2 (unknown origin) over HDAC5 (unknown origin) | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. |
| AID320809 | Inhibition of HDAC2 | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID303029 | Inhibition of human recombinant HDAC7 at 20 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID316934 | Inhibition of HDAC4 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID320823 | Half life in rat at 2 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID1068884 | Selectivity for HDAC1/2 (unknown origin) over HDAC6 (unknown origin) | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. |
| AID1068889 | Inhibition of FLAG-tagged HDAC1 S113A mutant (unknown origin) expressed in Jurkat cells after 2 hrs by Fluor de lys staining-based fluorimetric analysis | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. |
| AID320814 | Inhibition of HDAC7 | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID1313956 | Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as association rate constant after 60 mins | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID320828 | Toxicity in human HCT116 cells xenografted mouse assessed as adverse effect at 45 mg/kg, ip qd for 10 days | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID1410049 | Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using substrate after 90 mins by colorimetric method | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID1313936 | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID1313971 | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID303028 | Inhibition of human recombinant HDAC6 at 20 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID1410014 | Selectivity index, ratio of CC50 for human U937 cells to EC50 for reactivation of latent HIV1 infected in human U1 cells | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID303014 | Inhibition of human recombinant HDAC1 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID303020 | Cytotoxicity against human mammary epithelial cells by MTT assay | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID303015 | Inhibition of human recombinant HDAC2 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID487227 | Inhibition of recombinant HDAC6 | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Inside HDAC with HDAC inhibitors. |
| AID1313973 | Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate preincubated for 3 hrs measured after 60 mins by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID1068883 | Selectivity for HDAC1/2 (unknown origin) over HDAC7 (unknown origin) | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. |
| AID1313943 | Inhibition of full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as residence time by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID1068887 | Selectivity ratio of IC50 for HDAC1 S113A mutant (unknown origin) to IC50 for wild-type HDAC1 (unknown origin) | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. |
| AID320827 | Antitumor activity against human HCT116 cells xenografted mouse assessed as tumor growth inhibition at 30 mg/kg, ip qd for 21 days | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID316936 | Inhibition of HDAC7 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID1410013 | Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo luminescent cell viability assay | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID1313940 | Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID303018 | Inhibition of HDAC in 293T cells | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID1313941 | Inhibition of full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate assessed as residence time by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID320817 | Antiproliferative activity against human HCT116 cells assessed as cell viability | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID303022 | Inhibition of human recombinant HDAC1 at 20 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID748113 | Inhibition of HDAC2 (unknown origin) after 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11
| Discovery of the first histone deacetylase 6/8 dual inhibitors. |
| AID1410018 | Reactivation of latent HIV1 infected in human J-Lat A2 cells assessed as increase in GFP positive cells at 0.3 uM after 72 hrs by flow cytometric analysis relative to control | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID1410051 | Selectivity ratio of IC50 for full length human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 insect cells to IC50 for full length human recombinant C-terminal FLAG/His-tagged HDAC1 exp | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID1410050 | Inhibition of full length human recombinant C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using substrate after 90 mins by colorimetric method | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID1410011 | Reactivation of latent HIV1 infected in human U1 cells assessed as increase in p24 production after 48 hrs by ELISA | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID303024 | Inhibition of human recombinant HDAC3 at 20 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID487225 | Inhibition of recombinant HDAC2 | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Inside HDAC with HDAC inhibitors. |
| AID320813 | Inhibition of HDAC6 | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID303025 | Inhibition of human recombinant HDAC8 at 20 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID303019 | Cytotoxicity against human HCT116 cells by MTT assay | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
| AID320810 | Inhibition of HDAC3 | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID320829 | Toxicity in human HCT116 cells xenografted mouse assessed as adverse effect at 60 mg/kg, ip qd for 8 days | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID1313954 | Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID1410056 | Cytotoxicity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo luminescent cell viability assay | 2018 | ACS medicinal chemistry letters, Mar-08, Volume: 9, Issue:3
| Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. |
| AID1313972 | Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate preincubated for 3 hrs measured after 60 mins by flu | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
| Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
| AID487226 | Inhibition of recombinant HDAC3 | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Inside HDAC with HDAC inhibitors. |
| AID320821 | Clearance in rat at 2 mg/kg, iv | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
| AID316941 | Inhibition of HDAC9 | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
| Histone deacetylase inhibitors: from bench to clinic. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2013 | The Journal of biological chemistry, Sep-13, Volume: 288, Issue:37
| Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |