Snoring

Rough, noisy breathing during sleep, due to vibration of the uvula and soft palate.

Synonym
Snoring

Excerpt	Reference
"Snoring is a common disorder, and may be associated with obstructive sleep apnoea, although there is little published information on the incidence of apnoea in snorers."	( Allen, MB; Davies, JE; Woodhead, CJ, 1991)
"Snoring is due to the combined effect of several anatomic and physiologic abnormalities in the nasal and pharyngeal segments of the airway."	( Fairbanks, DN, 1984)
"Snoring is not associated with sustained nocturnal hypoxemia, but it is weakly related to lowest nocturnal oxygen saturation."	( Hoffstein, V, 1995)
"A common cause of snoring is palatal flutter which occurs when turbulent air flow causes the flexible soft palate to flutter."	( Brimacombe, J; Laing, D; Sher, M, 1995)
"Snoring is a common disorder usually presenting to otolaryngologists."	( Allen, MB; Woodhead, CJ, 1994)
"Snoring is caused by a vibration of oropharyngeal soft tissues during air flow."	( Bernecker, F; Hörmann, K; Stasche, N, 1993)
"Snoring is a marker for sleep apnea."	( Bingisser, R, 2002)
"Snoring is related to narrowing of the upper airway."	( Cakr-Ozkan, N; Ogutcen-Toller, M; Sakan, B; Sarac, D; Sarac, YS, 2004)
"Habitual snoring is associated with cardiovascular morbidity and mortality, and metabolic abnormalities such as impaired glucose homeostasis."	( Cho, N; In, K; Joo, S; Kang, K; Kim, J; Kimm, K; Lee, S; Shim, J; Shin, C; Yoo, S, 2005)
"Snoring is considered as the most common clinical symptom of obstructive sleep apnea-hypopnea syndrome."	( Asha'ari, ZA; Banabilh, SM; Hamid, SS, 2008)
"Habitual snoring is associated with increased prevalence of enuresis, and brain natriuretic peptide levels are increased in enuretic children with further increases with obstructive sleep apnea."	( Crabtree, VM; Gozal, D; Kheirandish-Gozal, L; Sans Capdevila, O, 2008)
"This indicates that snoring is an independent cause of excess daytime sleepiness and not merely a proxy for sleep apnea."	( Franklin, KA; Lindberg, E; Svensson, M; Theorell-Haglöw, J, 2008)
"Snoring is common among pregnant women and early reports suggest that it may bear a risk to the fetus."	( Arvas, S; Ascher-Landsberg, J; Deutsch, V; Greenfeld, M; Many, A; Sivan, Y; Tauman, R, 2011)
"To assess whether snoring is associated with sudden patient movement during local anesthesia with intravenous sedation."	( Bakri, SJ; Donaldson, MJ; McCannel, CA; Mueller, D; Olson, EJ; Pulido, JS, 2012)
"Snoring is a common symptom among the adult population, and it is the most common complaint in patients with obstructive sleep apnea (OSA) syndrome."	( Chang, ET; Lai, HL; Wang, HM; Yang, MC, 2014)
"Snoring is caused by a vibration of soft tissue in the upper airway induced by respiration during sleep."	( Dreher, A; Heiser, C; Herzog, M; Kühnel, T; Maurer, JT; Pistner, H; Sitter, H; Steffen, A; Stuck, BA; Verse, T, 2015)
"Snoring is a social hindrance problem and it can cause life threatening problems."	( Alp, HH; Bakan, E; Baygutalp, NK; Cokluk, E; Fidan, V, 2015)
"Snoring is caused by the vibration of structures of the oral cavity, such as the soft palate, uvula, tonsils, base of the tongue, epiglottis, and lateral pharyngeal walls."	( Çaliş, ZA; Civelek, Ş; Coşkun, BU; Dizdar, D; Dizdar, SK; Vural, A, 2015)
"Habitual snoring is associated with prediabetes, but only in individuals with TC <5."	( Dou, JT; Lu, ZH; Mu, YM; Wang, BA; Wang, HB; Yan, WH, 2017)
"Snoring is a risk factor of hypertension (OR = 1."	( Chen, J; Chen, WZ; Han, B; Li, YC; Zeng, ZQ, 2020)
"Snoring is a main concern in patients who consult an otolaryngologist (ENT physicians) and patients who have cardiovascular comorbidities or excessive daytime sleepiness who usually consult with other specialists."	( Astorquiza, C; Cabezon, R; Contreras, A; Dreyse, J; Jorquera, J; Labarca, G; Nazar, G; Salas, C, 2019)

Excerpt	Reference
"Snoring has been shown to be the primary sign of a potentially serious medical condition, ie, obstructive sleep apnea."	( Moran, WB; Orr, WC, 1985)

Excerpt	Reference
"Eighteen children were treated for snoring."	( Fairbanks, DN, 1984)
"The present study investigated whether treatment of snoring by uvulopalatopharyngoplasty (UPPP) had an influence on sleep microstructure in nonapnoeic snorers."	( Boudewyns, A; De Backer, W; De Cock, W; Van de Heyning, PH; Wagemans, M; Willemen, M, 1997)
"Oral appliances are used to treat snoring and sleep apnea."	( Hirth, K; Hörmann, K; Mattinger, C; Maurer, JT; Riedel, F; Werner, B, 2000)
"In the treatment of snoring (SN) and sleep-related breathing disorders (SRBD), mandibular advancement devices (MAD) are of increasing importance."	( Anderer, P; Gritsch, F; Gruber, G; Mailath-Pokorny, G; Saletu, A; Saletu, B, 2002)
"Pharmacologic treatment of severe snoring has not been considered to be of great value."	( Dominitz, JA; Hudson, M; Larrain, A; Pope, CE, 2006)
"We assessed the impact of DISE on the treatment plan of snoring patients."	( De Medts, J; Delsupehe, KG; Pilaete, K, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	54 (9.87)	23.3326
1990's	146 (26.69)	12.5806
2000's	139 (25.41)	18.1394
2010's	172 (31.44)	28.8240
2020's	36 (6.58)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
carbon monoxide	low	1	0
n(g),n(g')-dimethyl-l-arginine	low	1	0
cytosine	low	1	0
glycerol	low	1	0
hydrogen carbonate	low	1	0
sulfur dioxide	low	1	0
thymine	low	1	0
uric acid	low	7	0
acetaminophen	medium	1	1
acetazolamide	low	2	0
ambroxol	low	1	0
theophylline	medium	2	1
baclofen	medium	1	1
bupivacaine	medium	2	2
caffeine	medium	2	1
carisoprodol	low	1	0
cetirizine	low	2	0
clonazepam	low	1	0
diazepam	low	1	0
diclofenac	medium	1	1
domperidone	medium	1	1
doxapram	low	1	0
fentanyl	medium	5	1
flumazenil	medium	3	1
flunitrazepam	medium	1	1
gabapentin	low	2	0
guaifenesin	low	2	0
hydroxyzine	low	1	0
ibuprofen	medium	1	1
lidocaine	medium	6	2
imipramine	low	1	0
isradipine	medium	1	1
ketamine	low	1	0
ketoprofen	medium	1	1
lansoprazole	low	1	0
meperidine	low	1	0
metformin	low	1	0
methadone	low	1	0
methylphenidate	medium	1	1
metoprolol	medium	1	1
midazolam	medium	14	1
modafinil	low	1	0
apnea	medium	45	1
nifedipine	low	1	0
omeprazole	low	1	0
oxymetazoline	medium	4	1
propofol	medium	24	2
protriptyline	medium	7	1
ropinirole	low	1	0
sulfamethoxazole	medium	1	1
triazolam	medium	1	1
trimethoprim	medium	1	1
xylometazoline	low	1	0
zolpidem	medium	2	2
zopiclone	medium	1	1
thyroxine	low	2	0
aldosterone	low	3	0
estrone	low	1	0
sucrose	medium	1	1
phenylephrine	medium	2	1
levodopa	low	1	0
methacholine chloride	low	2	0
arginine	low	2	0
triamcinolone acetonide	low	1	0
phencyclidine	low	2	0
isoprene	low	1	0
methylprednisolone	medium	1	1
ephedrine	medium	1	1
2-ethylhexanoic acid tin(ii) salt	low	1	0
dexamethasone 21-phosphate	medium	1	1
malondialdehyde	medium	3	2
sulfur hexafluoride	medium	1	1
neodymium	low	2	0
erbium	medium	2	1
helium	medium	1	1
yttrium	low	3	0
barium sulfate	low	2	0
ozone	low	1	0
trolamine salicylate	low	1	0
cetylpyridinium chloride anhydrous	medium	2	1
amoxicillin	low	1	0
tramadol	low	1	0
substance p	low	1	0
propiconazole	low	1	0
fomesafen	low	2	0
cilazapril, anhydrous	medium	1	1
remifentanil	low	1	0
acridine orange	low	1	0
methotrimeprazine	low	1	0
nicotine	medium	3	1
fibrinogen	low	2	0
homocysteine	low	2	0
levobupivacaine	medium	1	1
cobalt	low	1	0
deoxyglucose	medium	1	1
n,n-dimethylarginine	low	1	0
angiotensin ii	low	1	0
carbocysteine	medium	1	1
trimethoprim, sulfamethoxazole drug combination	medium	1	1
dihydropyridines	medium	1	1
carboplatin	low	1	0
bradykinin	low	1	0
inositol 3-phosphate	low	3	0
pentazocine	low	1	0
mometasone furoate	medium	3	2
oleic acid	medium	1	1
bromochloroacetic acid	low	1	0
picibanil	low	1	0
polidocanol	medium	2	1
cotinine	low	1	0
D-fructopyranose	low	1	0
ranitidine	low	1	0
ovalbumin	low	1	0
dinoprost	low	2	0
8-epi-prostaglandin f2alpha	low	2	0
phenylephrine hydrochloride	medium	84	9
topiramate	low	1	0
dexmedetomidine	low	3	0
fluticasone	medium	1	1
tin	low	1	0
aluminum	low	2	0
butorphanol	medium	1	1
enalapril	low	2	0
cysteine	low	1	0
boron	low	1	0
mocetinostat	low	4	0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	1	0
alpha-synuclein	low	1	0
emamectin benzoate	low	1	0
losartan potassium	low	1	0
dextrothyroxine	low	1	0
pituitrin	low	2	0
jaw	low	4	0
atrial natriuretic factor	low	3	0
beta-endorphin	low	1	0
endothelin-1	medium	2	1
sodium oxybate	low	1	0
sodium tetradecyl sulfate	low	4	0
sodium glutamate	low	1	0
sodium ethylxanthate	low	1	0
piperidines	low	1	0
interleukin-8	low	3	0
natriuretic peptide, brain	medium	8	1
rome	low	1	0
muramidase	low	1	0
exudates	low	7	0
cyclic gmp	low	1	0
deoxyguanosine	medium	1	1
8-hydroxy-2'-deoxyguanosine	medium	1	1
leptin	medium	3	1

Protein Targets (1,050)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent dopamine transporter	0	6	0	6
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
RAR-related orphan receptor gamma	32	0	0	32
ATAD5 protein, partial	14	0	0	14
GLS protein	14	0	0	14
Microtubule-associated protein tau	15	0	0	15
Smad3	6	0	0	6
thyroid stimulating hormone receptor	18	0	0	18
nuclear receptor subfamily 1, group I, member 3	21	0	0	21
progesterone receptor	21	0	0	21
EWS/FLI fusion protein	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	26	0	0	26
retinoid X nuclear receptor alpha	24	0	0	24
estrogen-related nuclear receptor alpha	34	0	0	34
estrogen nuclear receptor alpha	42	0	0	42
peroxisome proliferator activated receptor gamma	19	0	0	19
aryl hydrocarbon receptor	15	0	0	15
chromobox protein homolog 1	23	0	0	23
thyroid hormone receptor beta isoform 2	24	0	0	24
peripheral myelin protein 22	19	0	0	19
cytochrome P450 3A4 isoform 1	20	0	0	20
Gamma-aminobutyric acid receptor subunit pi	20	15	3	38
ATP-binding cassette sub-family C member 3	0	30	0	30
Multidrug resistance-associated protein 4	0	30	0	31
Solute carrier family 22 member 6	0	4	0	4
Carbonic anhydrase 12	0	4	1	9
UDP-glucuronosyltransferase 1A9	0	1	0	4
Bile salt export pump	0	5	0	5
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Bile salt export pump	0	42	0	42
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	11	1	18
Carbonic anhydrase 2	0	12	3	20
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	4	0	6
Prostaglandin G/H synthase 1	0	6	0	6
Carbonic anhydrase 3	0	4	1	8
Cytochrome P450 3A4	0	12	1	15
Cytochrome P450 2D6	0	10	0	10
Cytochrome P450 2C9	0	14	0	15
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	20	15	3	38
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	20	15	3	38
Gamma-aminobutyric acid receptor subunit gamma-2	20	15	5	40
UDP-glucuronosyltransferase 1-6	0	4	0	5
Glutamate receptor 2	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	20	15	3	38
Gamma-aminobutyric acid receptor subunit alpha-3	20	15	3	38
Arachidonate 5-lipoxygenase-activating protein	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	5	0	6
Carbonic anhydrase 4	0	5	1	9
Prostaglandin G/H synthase 1	0	6	0	6
Carbonic anhydrase 6	0	4	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	20	15	3	38
Gamma-aminobutyric acid receptor subunit alpha-2	20	15	3	38
Gamma-aminobutyric acid receptor subunit alpha-4	20	15	3	38
Gamma-aminobutyric acid receptor subunit gamma-3	20	15	3	38
Gamma-aminobutyric acid receptor subunit alpha-6	20	15	3	38
Carbonic anhydrase 5A, mitochondrial	0	4	2	10
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase 7	0	4	1	8
Nuclear receptor ROR-gamma	6	0	0	6
Cytochrome P450 2J2	0	11	0	11
Gamma-aminobutyric acid receptor subunit alpha-1	20	15	5	40
Gamma-aminobutyric acid receptor subunit beta-3	20	15	3	38
Gamma-aminobutyric acid receptor subunit beta-2	20	15	5	40
Carbonic anhydrase 9	0	6	2	12
GABA theta subunit	20	15	3	38
Canalicular multispecific organic anion transporter 1	0	28	0	28
Carbonic anhydrase 15	0	4	0	6
Carbonic anhydrase 13	0	4	0	7
Gamma-aminobutyric acid receptor subunit epsilon	20	15	3	38
Carbonic anhydrase 14	0	4	1	9
Carbonic anhydrase 5B, mitochondrial	0	4	1	9
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	10	0	0	10
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	23	0	0	23
GALC protein	6	0	0	6
GLI family zinc finger 3	30	0	0	30
cytochrome P450 family 3 subfamily A polypeptide 4	22	0	0	22
glucocorticoid receptor [Homo sapiens]	30	0	0	30
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	12	0	0	12
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	39	0	0	39
Bloom syndrome protein isoform 1	15	0	0	15
thyroid hormone receptor beta isoform a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
geminin	34	0	0	34
survival motor neuron protein isoform d	9	0	0	9
muscleblind-like protein 1 isoform 1	6	0	0	6
Carbonic anhydrase	0	2	0	2
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	4	0	4
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	4	1	5
5-hydroxytryptamine receptor 2A	0	7	0	7
Androgen receptor	0	8	0	8
Translocator protein	0	5	2	8
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	6	0	9
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	2	0	3
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	6	0	11
5-hydroxytryptamine receptor 2B	0	4	0	4
Sodium-dependent serotonin transporter	0	9	0	9
Delta-type opioid receptor	0	7	0	9
Cytochrome P450 2C19	0	6	0	8
Delta-type opioid receptor	0	7	1	9
Mu-type opioid receptor	0	8	3	14
Carbonic anhydrase	0	3	0	4
Kappa-type opioid receptor	0	5	0	6
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	3
D(2) dopamine receptor	0	5	1	7
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	10	1	11
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	7	0	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	7	2	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	3	0	3
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	0	7
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	3
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
Carbonic anhydrase 4	0	5	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Telomerase reverse transcriptase	0	1	0	1
Amyloid-beta precursor protein	1	1	0	2
Reverse transcriptase/RNaseH	0	1	0	1
AR protein	37	0	0	37
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	2	3	5
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	4
Guanine nucleotide-binding protein G	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	13	0	0	13
cytochrome P450 2D6	21	0	0	21
glucocerebrosidase	5	0	0	5
cytochrome P450 2D6 isoform 1	12	0	0	12
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
lamin isoform A-delta10	31	0	0	31
Rap guanine nucleotide exchange factor 3	7	0	0	7
Lysosomal acid glucosylceramidase	0	1	0	1
Sodium-dependent serotonin transporter	0	11	0	11
TAR DNA-binding protein 43	9	0	0	9
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	15	0	0	15
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	14	0	0	14
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
DNA polymerase kappa isoform 1	11	0	0	11
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
histone acetyltransferase KAT2A isoform 1	12	0	0	12
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	4	0	4
Type-2 angiotensin II receptor	0	2	0	2
TDP1 protein	27	0	0	27
D(1A) dopamine receptor	10	0	0	10
neuropeptide S receptor isoform A	4	0	0	4
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	12	0	0	12
NFKB1 protein, partial	13	0	0	13
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	12	0	0	12
flap endonuclease 1	11	0	0	11
muscarinic acetylcholine receptor M1	18	0	0	18
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	20	0	0	20
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
regulator of G-protein signaling 4	13	0	0	13
67.9K protein	9	0	0	9
activating transcription factor 6	11	0	0	11
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Angiotensin-converting enzyme	0	1	0	2
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
thyroid stimulating hormone receptor	9	0	0	9
Cellular tumor antigen p53	20	0	0	20
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	4	5
Potassium channel subfamily K member 9	0	2	0	2
Mu-type opioid receptor	0	13	4	18
Delta-type opioid receptor	0	8	1	10
Kappa-type opioid receptor	0	11	2	14
acetylcholinesterase	9	0	0	9
pregnane X nuclear receptor	29	0	0	29
5-hydroxytryptamine receptor 2B	0	9	1	10
Spike glycoprotein	12	0	2	14
Histamine H3 receptor	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
farnesoid X nuclear receptor	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
DNA polymerase beta	2	0	0	2
nuclear receptor ROR-gamma isoform 1	11	0	0	11
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	2	4
Adenosine receptor A3	0	4	0	4
Replicase polyprotein 1ab	0	3	2	5
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	2	0	2
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	5	3	10
Adenosine receptor A2b	0	2	0	4
Adenosine receptor A2b	0	3	0	5
Adenosine receptor A1	0	5	2	11
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	3	4
Endochitinase B1	0	2	0	2
Muscarinic acetylcholine receptor	0	1	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	5
Guanine deaminase	0	2	0	2
Kinesin-like protein KIF11	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
estrogen receptor 2 (ER beta)	16	0	0	16
G	16	0	0	16
vitamin D3 receptor isoform VDRA	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Interferon beta	16	0	0	16
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
Inositol hexakisphosphate kinase 1	16	0	0	16
cytochrome P450 2C9, partial	16	0	0	16
USP1 protein, partial	17	0	0	17
ras-related protein Rab-9A	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	6	0	0	6
Histamine H1 receptor	0	7	0	7
Angiopoietin-1 receptor	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	13	0	13
Multidrug and toxin extrusion protein 1	0	7	0	7
Histamine H4 receptor	0	3	0	3
Chain A, Ferritin light chain	7	0	0	7
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
caspase 7, apoptosis-related cysteine protease	5	0	0	5
peroxisome proliferator-activated receptor delta	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
caspase-3	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	19	0	0	19
thyrotropin-releasing hormone receptor	2	0	0	2
heat shock protein beta-1	11	0	0	11
mitogen-activated protein kinase 1	9	0	0	9
Caspase-2	0	0	1	1
Inositol monophosphatase 1	7	0	0	7
ATPase family AAA domain-containing protein 5	11	0	0	11
Ataxin-2	16	0	0	16
Liver carboxylesterase 1	0	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	0	6
Gamma-aminobutyric acid receptor subunit beta-1	0	5	0	6
Neuronal acetylcholine receptor subunit alpha-4	2	6	3	12
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	0	6
Neuronal acetylcholine receptor subunit beta-2	2	6	3	12
Gamma-aminobutyric acid receptor subunit alpha-1	0	11	9	20
Gamma-aminobutyric acid receptor subunit beta-1	0	8	2	10
Gamma-aminobutyric acid receptor subunit gamma-2	0	11	6	17
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	0	6
Gamma-aminobutyric acid receptor subunit beta-3	0	11	4	15
Translocator protein	0	2	0	2
Translocator protein	0	3	0	3
Cholecystokinin receptor type A	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	10	8	18
Gamma-aminobutyric acid receptor subunit alpha-3	0	10	5	15
Gamma-aminobutyric acid receptor subunit alpha-2	0	10	4	14
Gamma-aminobutyric acid receptor subunit beta-2	0	9	5	14
Gamma-aminobutyric acid receptor subunit alpha-4	0	8	2	10
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	10	2	12
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	0	7
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
Cytochrome P450 2A5	0	2	0	2
Phosphodiesterase	0	3	0	3
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
IDH1	9	0	0	9
Deoxycytidine kinase	0	0	0	1
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Alpha-1B adrenergic receptor	0	0	2	2
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C9 precursor	5	0	0	5
Alpha-2A adrenergic receptor	0	7	4	11
Alpha-1B adrenergic receptor	0	7	0	7
Alpha-1A adrenergic receptor	0	2	2	4
Alpha-2C adrenergic receptor	0	7	2	9
Alpha-2B adrenergic receptor	0	5	1	6
Alpha-2C adrenergic receptor	0	5	1	6
Alpha-2A adrenergic receptor	0	5	1	6
Alpha-1D adrenergic receptor	0	6	0	6
Alpha-1D adrenergic receptor	0	6	1	7
Alpha-1A adrenergic receptor	0	8	0	8
Histamine H2 receptor	10	1	0	11
Chain A, Cruzipain	1	0	0	1
endonuclease IV	5	0	0	5
nonstructural protein 1	6	0	0	6
peripheral myelin protein 22 isoform 1	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
M-phase phosphoprotein 8	5	0	0	5
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	9	0	0	9
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Fatty acid-binding protein, liver	0	4	0	4
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	3	4	8
Albumin	0	0	2	2
ATP-dependent translocase ABCB1	0	9	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
5-hydroxytryptamine receptor 1A	0	8	3	11
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Dihydrofolate reductase	0	5	0	5
Cytochrome c oxidase subunit 2	0	1	0	1
Transthyretin	0	1	1	5
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	3	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	3	0	6
UDP-glucuronosyltransferase 1A4	0	3	0	4
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	5
UDP-glucuronosyltransferase 2B10	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Prostaglandin G/H synthase 2	0	5	0	5
Prostaglandin G/H synthase 2	0	2	0	2
Solute carrier family 22 member 6	0	3	0	5
Prostaglandin G/H synthase 1	0	2	0	3
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 1	0	8	0	10
Prostaglandin G/H synthase 2	0	2	0	2
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 7	0	1	0	2
Solute carrier family 22 member 8	0	3	0	4
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Fumarate hydratase	3	0	0	3
polyprotein	3	0	0	3
Histone H2A.x	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
5-hydroxytryptamine receptor 4	0	8	0	8
Aldo-keto reductase family 1 member B1	0	4	0	4
D(2) dopamine receptor	0	9	1	10
Alpha-2B adrenergic receptor	0	6	0	6
D	0	1	0	2
Retinoic acid receptor RXR-alpha	0	0	3	3
Sodium-dependent noradrenaline transporter	0	11	1	12
5-hydroxytryptamine receptor 2A	0	7	1	8
5-hydroxytryptamine receptor 2C	0	9	0	9
D(3) dopamine receptor	0	6	1	7
5-hydroxytryptamine receptor 3A	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Endothelin-1 receptor	0	1	0	1
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Estrogen receptor	0	3	1	5
Aromatase	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Alpha-synuclein	1	1	0	2
Cytochrome P450 1B1	0	1	0	1
Estrogen receptor beta	0	2	1	4
Ghrelin O-acyltransferase	0	1	0	1
Luciferase	13	0	0	13
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
D(4) dopamine receptor	0	3	1	4
Kappa-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	4	1	8
Sigma non-opioid intracellular receptor 1	0	5	1	6
Sigma non-opioid intracellular receptor 1	0	4	1	5
thioredoxin glutathione reductase	2	0	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
transcriptional regulator ERG isoform 3	3	0	0	3
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	4	0	5
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Epidermal growth factor receptor	0	3	0	3
Albumin	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	2	0	2
Substance-P receptor	0	2	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	2	0	2
Caspase-4	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Snq2p	0	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Major prion protein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	1	4
Sphingomyelin phosphodiesterase	0	1	0	1
D(3) dopamine receptor	0	3	0	3
Sodium-dependent dopamine transporter	0	5	1	6
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 1D	0	1	1	2
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	5	0	6
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	4	0	4
5-hydroxytryptamine receptor 6	0	3	0	3
5-hydroxytryptamine receptor 7	0	3	0	3
D(2) dopamine receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	0	6
Glutamate receptor ionotropic, NMDA 2C	0	5	0	7
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	2	0	2
Envelope glycoprotein	0	0	1	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium channel protein type 9 subunit alpha	0	3	0	3
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	5	0	6
5-hydroxytryptamine receptor 4	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Glutamate receptor ionotropic, NMDA 3B	0	5	0	6
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	3	0	3
Solute carrier family 22 member 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	5	0	6
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Transporter	0	5	1	7
Sodium channel protein type 10 subunit alpha	0	2	0	2
interleukin 8	4	0	0	4
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
15-lipoxygenase, partial	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Chymotrypsinogen A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Parkin	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
serine/threonine-protein kinase PLK1	5	0	0	5
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Microtubule-associated protein tau	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	0	1
Fatty acid synthase	0	4	0	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
WD repeat-containing protein 5	0	2	0	2
Histone-lysine N-methyltransferase 2A	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Cytosolic endo-beta-N-acetylglucosaminidase	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
dopamine D1 receptor	3	0	0	3
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
Polyphenol oxidase 2	0	0	0	1
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Tyrosinase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Kappa-type opioid receptor	0	3	1	6
galanin receptor type 3	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	3	3
Aldehyde oxidase 1	0	1	0	1
PPM1D protein	2	0	0	2
Glucocorticoid receptor	0	7	1	8
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	2	2	4
Beta-3 adrenergic receptor	0	0	2	2
Beta-1 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Transporter	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Progesterone receptor	0	1	1	2
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	1	3
Muscarinic acetylcholine receptor M3	0	2	1	3
Muscarinic acetylcholine receptor M4	0	3	1	4
Muscarinic acetylcholine receptor M2	0	2	1	3
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
pregnane X receptor	2	0	0	2
Thrombopoietin	3	0	0	3
hypothetical protein, conserved	1	0	0	1
beta-2 adrenergic receptor	2	0	0	2
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Muscarinic acetylcholine receptor M2	0	0	0	1
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M1	0	0	0	1
Phospholipase A2, membrane associated	0	0	0	1
Muscarinic acetylcholine receptor M3	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty-acid amide hydrolase 1	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Fatty acid-binding protein, liver	0	0	1	1
Coagulation factor VII	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	0	2
Protein kinase C alpha type	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Fatty acid-binding protein 5	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
ClpP	1	0	0	1
Mcl-1	0	1	0	1
huntingtin isoform 2	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Glutathione S-transferase omega-1	0	1	0	1
chaperonin GroEL	2	0	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	2
Alpha-1A adrenergic receptor	0	3	2	5
Alpha-1B adrenergic receptor	0	3	2	5
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
POU domain, class 2, transcription factor 1	0	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sulfotransferase 1A1	0	1	0	1
Sulfotransferase 2A1	0	1	0	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Glucocorticoid receptor	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(1A) dopamine receptor	0	0	1	1
D(1B) dopamine receptor	0	0	1	1
Free fatty acid receptor 3	0	0	1	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	2	0	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Endothelin-1 receptor	0	1	0	1
Protease	0	1	1	2
Protein-arginine deiminase type-4	0	2	0	2
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Thymidine phosphorylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (547)

Protein Targets (1,050)

Snoring

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (547)

Drugs Studied (179)

Protein Targets (1,050)