clathrin-dependent extracellular exosome endocytosis

Definition

Target type: biologicalprocess

The clathrin-mediated endocytosis of an extracellular exosome. [PMID:24951588]

Clathrin-dependent extracellular exosome endocytosis is a complex process involving the internalization of exosomes, small membrane-bound vesicles released by cells, into recipient cells through a mechanism mediated by clathrin-coated pits. This process begins with the interaction of exosomes with the plasma membrane of the recipient cell. This interaction can be driven by specific receptors present on the exosomes and the recipient cell, or through non-specific interactions involving electrostatic forces or lipid-lipid interactions. Once the exosome binds to the plasma membrane, it initiates the formation of a clathrin-coated pit. Clathrin, a protein that forms a cage-like structure, assembles around the site of exosome binding, deforming the membrane inward. This deformation leads to the formation of a small vesicle, known as a clathrin-coated vesicle, that encapsulates the exosome. The formation of the clathrin-coated vesicle is facilitated by other proteins, including adaptor proteins, which link clathrin to the membrane, and dynamin, which constricts the neck of the forming vesicle, eventually pinching it off from the plasma membrane. After the vesicle detaches, it loses its clathrin coat and fuses with early endosomes, a compartment within the cell responsible for sorting and delivering internalized materials. The fusion of the exosome-containing vesicle with the early endosome allows the exosome to be delivered to its final destination within the recipient cell, where it can release its cargo, which may include proteins, lipids, or nucleic acids, ultimately influencing the recipient cell's function.'
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Proteins (1)

Compounds (6)