Page last updated: 2024-11-13

pogostone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Pogostone: volatile oil of Pogostemon cablin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PogostemongenusGenus in the Lamiaceae family. VOLATILE OILS from several species of Pogostemon are used in PERFUME; INSECT REPELLENTS; and ALTERNATIVE THERAPIES.[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]
Pogostemon cablinspecies[no description available]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID54695756
CHEBI ID138756
SCHEMBL ID131729
MeSH IDM0464476

Synonyms (25)

Synonym
pogostone
CHEBI:138756
dhelwangin
S9094
23800-56-8
4-hydroxy-6-methyl-3-(4-methylpentanoyl)-2-pyrone
SCHEMBL131729
2h-pyran-2-one, 4-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-
4-hydroxy-6-methyl-3-(4-methylpentanoyl)-2h-pyran-2-one
AC-34255
AKOS028108224
AKOS026745813
4-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2h-pyran-2-one, 9ci
FT-0705026
4-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2h-pyran-2-one
HY-N1416
mfcd09837856
DTXSID001019967
6-methyl-3-(4-methylpentanoyl)-4-oxidanyl-pyran-2-one
QG8U8GA5EP ,
CCG-266750
CS-0016840
MS-23260
4-hydroxy-6-methyl-3-(4-methylpentanoyl)pyran-2-one
unii-qg8u8ga5ep

Research Excerpts

Overview

Pogostone (PO) is a major component of Pogostemon cablin. It has a variety of pharmacological properties, including antiinflammatory, and immunosuppressive activities, and antioxidant.

ExcerptReferenceRelevance
"Pogostone (PO) is a major component of the essential oil from"( Pogostone attenuates adipose tissue inflammation by regulating the adipocyte-macrophage crosstalk
Dong, W; Li, D; Peng, C; Wang, Z; Xing, Z; Yang, C; Yu, T, 2022
)
2.89
"Pogostone (PO) is a major component of Pogostemon cablin which has a variety of pharmacological properties, including antiinflammatory, and immunosuppressive activities, and antioxidant."( Protective effect of pogostone on murine norovirus infected-RAW264.7 macrophages through inhibition of NF-κB/NLRP3-dependent pyroptosis.
Chen, J; Hou, Z; Ling, Q; Shen, J; Shi, L; Yang, T; Ye, Q; Zhao, J; Zhou, H, 2021
)
1.66
"Pogostone is an important constituent of Pogostemon cablin (Blanco) Benth., and possesses various known bioactivities. "( LC-MS/MS determination of pogostone in rat plasma and its application in pharmacokinetic studies.
Chen, H; Chen, J; Lai, X; Li, C; Li, Q; Li, Y; Qin, Z; Su, Z; Wu, X; Yi, Y, 2013
)
2.13
"Pogostone is an important constituent of Pogostemon cablin, and possesses various bioactivitys."( Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells.
Cao, ZX; Huang, J; Lei, S; Li, YZ; Peng, C; Wang, WW; Xie, XF; Xiong, L; Yang, YT; Yu, S, 2017
)
2.62

Actions

ExcerptReferenceRelevance
"Pogostone does not inhibit the expression of MCR-1."( Pogostone Enhances the Antibacterial Activity of Colistin against MCR-1-Positive Bacteria by Inhibiting the Biological Function of MCR-1.
Deng, X; Fang, T; Li, L; Shen, X; Tan, W; Xie, S; Zhan, B, 2022
)
2.89

Treatment

ExcerptReferenceRelevance
"Pogostone pretreatment significantly raised the depressed activities of superoxide dismutase, glutathione and catalase, while reduced the elevated malonaldehyde level compared with indomethacin-induced group."( The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats.
Chen, HM; Chen, XY; Fu, LD; Huang, XQ; Lai, XP; Liang, YZ; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Zhang, X; Zhang, ZB; Zheng, YF, 2016
)
1.44

Pharmacokinetics

The validated method was successfully applied to the preclinical pharmacokinetic investigation of pogostone in rats after intravenous (5, 10 and 20 mg/kg) and oral administration.

ExcerptReferenceRelevance
" The validated method was successfully applied to the preclinical pharmacokinetic investigation of pogostone in rats after intravenous (5, 10 and 20 mg/kg) and oral administration (5, 10 and 20 mg/kg)."( LC-MS/MS determination of pogostone in rat plasma and its application in pharmacokinetic studies.
Chen, H; Chen, J; Lai, X; Li, C; Li, Q; Li, Y; Qin, Z; Su, Z; Wu, X; Yi, Y, 2013
)
0.91
" The method was successfully applied to a pharmacokinetic study after the oral administration of pogostone to beagle dogs."( A gas chromatography-mass spectrometry method for the determination of pogostone in canine plasma and its application to a pharmacokinetic study.
Gong, X; Li, Y; Peng, C; Xiong, L; Zhang, R,
)
0.58

Bioavailability

ExcerptReferenceRelevance
" Finally, the oral absolute bioavailability of pogostone in rats was calculated to be 70."( LC-MS/MS determination of pogostone in rat plasma and its application in pharmacokinetic studies.
Chen, H; Chen, J; Lai, X; Li, C; Li, Q; Li, Y; Qin, Z; Su, Z; Wu, X; Yi, Y, 2013
)
0.95
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic ketoneA ketone in which the carbonyl group is attached to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (36)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (13.89)29.6817
2010's25 (69.44)24.3611
2020's6 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.25 (24.57)
Research Supply Index3.66 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (7.89%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other35 (92.11%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]